Diabetes Mellitus and Metabolic Syndrome: Independent Risk Factors for Hepatocellular Carcinoma

2015 ◽  
Vol 110 ◽  
pp. S893-S894
Author(s):  
Allison Kasmari ◽  
Amy Welch ◽  
Guodong Liu ◽  
Douglas Leslie ◽  
Thomas McGarrity ◽  
...  
2013 ◽  
Vol 20 (2) ◽  
pp. 117-122
Author(s):  
Andra-Iulia Suceveanu ◽  
Laura Mazilu ◽  
Doina Catrinoiu ◽  
Adrian-Paul Suceveanu ◽  
Felix Voinea ◽  
...  

AbstractBackground and Aims. Hepatocellular carcinoma (HCC) is one of the most common malignancies. Obesity, together with the underlying liver steatosis, has received increased attention as a risk factor for HCC. Diabetes Mellitus (DM) is also reported to be associated with HCC. We aimed to estimate the risk of HCC in obese and diabetic patients. Material and method. We prospectively analyzed 414 obese and diabetic patients, over a period of 5 years. We evaluated all patients using screening methods such as abdominal ultrasound and serum alpha-fetoprotein every 6 month, in order to detect HCC occurrence. Kaplan-Meier analysis estimated the cumulative incidence of HCC. Univariate and multivariate Cox regression analysis assessed the association between HCC and obesity. Results. Median follow-up was 4.3 years. 11 from 77 cirrhotic obese patients, and 18 from 150 non-cirrhotic obese patients developed HCC (p=ns). 7 from 51 patients with DM and cirrhosis, and 14 from 136 non-cirrhotic patients with DM developed HCC (p=ns). The cumulative incidence of HCC was 2.8%, respectively 2.6%, in cirrhotic patients with obesity or DM, compared with 2.2%, respectively 2.0%, in non-cirrhotic patients with obesity or DM (p=ns). Conclusion. Obesity and DM, along with nonalcoholic fatty liver disease (NAFLD), seems to be independent risk factors for HCC occurrence.


Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 338
Author(s):  
Cameron Haswell ◽  
Ajmol Ali ◽  
Rachel Page ◽  
Roger Hurst ◽  
Kay Rutherfurd-Markwick

Metabolic syndrome (MetS) is a group of metabolic abnormalities, which together lead to increased risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM), as well as reduced quality of life. Dietary nitrate, betalains and anthocyanins may improve risk factors for MetS and reduce the risk of development of CHD and T2DM. Beetroot is a rich source of dietary nitrate, and anthocyanins are present in high concentrations in blackcurrants. This narrative review considers the efficacy of beetroot and blackcurrant compounds as potential agents to improve MetS risk factors, which could lead to decreased risk of CHD and T2DM. Further research is needed to establish the mechanisms through which these outcomes may occur, and chronic supplementation studies in humans may corroborate promising findings from animal models and acute human trials.


Author(s):  
Maksuda Ahmedjanovna Karimova ◽  
◽  
Dilnoza Kakhramanovna Kurbanbaeva ◽  

At the beginning of the third millennium, for mankind, which overcame the epidemic of life-threatening infections during its centuries-old history, the problem of cardiovascular diseases (CVD) came to the fore in relevance among all causes of morbidity and mortality. A significant role in this was played by lifestyle modification associated with limiting physical activity, increasing the calorie content of food, and a steady increase in emotional stress. All of this potentiates the main risk factors for CVD, which are a “negative asset of progress,” namely increased blood pressure (BP), dyslipidemia, diabetes mellitus (DM) and obesity. Since 1988, after G. Reaven's Banting lecture, it is customary to designate the interconnected combination of these pathologies by the single term "metabolic syndrome X".


2017 ◽  
Vol 36 (1) ◽  
pp. 78-88 ◽  
Author(s):  
Christian Labenz ◽  
Vera Prenosil ◽  
Sandra Koch ◽  
Yvonne Huber ◽  
Jens U. Marquardt ◽  
...  

Background/Aim: Individual components of the metabolic syndrome (MS) such as obesity or diabetes mellitus impair the prognosis of patients with hepatocellular carcinoma (HCC) following curative treatment approaches or transarterial therapies. The aim of this retrospective study was to assess the impact of these factors on the overall survival (OS) of patients with advanced HCC treated with sorafenib. Methods: Univariate and multivariate analyses were performed to assess the impact of individual components of the MS on the OS of 152 consecutive patients with advanced HCC treated with sorafenib. Results: The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS. Multivariate analysis showed that Eastern Cooperative Oncology Group Performance Status ≥1 (hazards ratio [HR] 2.03), presence of macrovascular invasion (HR 1.71), Child-Pugh score B/C (HR 2.19), tumor grading G3 (HR 2.17), no prior HCC treatment (HR 2.34), and the presence of 2 or more out of 5 individual components of the MS (HR 0.65) were independent prognostic factors regarding the median OS. Conclusions: Our investigations do not confirm a negative prognostic role of individual components of the MS or the MS itself for patients with advanced HCC treated with sorafenib.


2014 ◽  
Vol 3 (2) ◽  
pp. 1
Author(s):  
Ana Roberta Vilarouca da Silva

No Brasil, a Síndrome Metabólica (SM) é desconhecida em várias regiões, e pouco estudada em diferentes populações. Isso porque, é proveniente da globalização, indicador inerente à modificação do estilo de vida da sociedade. Esta síndrome associa-se a Doenças Crônicas Não-Transmissíveis (DCNT), especialmente as cardiovasculares. E por ser multifatorial, destacam-se os níveis pressóricos e glicêmicos elevados, fatores-problema no desenvolvimento de complicações. A SM é um transtorno complexo representado por um conjunto de fatores de risco cardiovascular (a hipertensão arterial, a dislipidemia, a obesidade visceral e as manifestações de disfunção endotelial), usualmente relacionados à disposição central de gordura e à resistência à insulina(1). As três principais definições clínicas da SM em adultos utilizadas são as propostas pela Organização Mundial de Saúde (OMS), pelo National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) e pela International Diabetes Federation (IDF)(2). E em adolescentes existem adaptações(3-4). Assim, são fatores de risco para SM agregação de excesso de peso ou adiposidade central, hipertensão arterial, elevação dos triglicerídeos, diminuição do colesterol HDL (high density lipoprotein) e intolerância à glicose/resistência à insulina/diabetes mellitus tipo II (DMII). A prevalência de síndrome metabólica é variável, em função dos diferentes critérios diagnósticos utilizados. Na população pediátrica, as frequências de síndrome metabólica variam de 4,2% a 9,2%, com aumento na prevalência quando se consideram crianças e adolescentes obesos para 17,3% e 35,5%. Alguns estudos destacam que os componentes mais frequentes no diagnóstico de síndrome metabólica são a aumentada circunferência abdominal (88,1%) e pressão arterial (47,5%), seguidos de maior concentração de triglicerídeos (23,4%) e de baixo HDL-colesterol (23,3%)(5). Em se tratando do estado do Piauí, a busca à literatura revelou que até o presente momento, existe uma pesquisa em conclusão com foco na SM entre universitários e outras que iniciaram em 2014 com escolares, incluindo crianças e adolescentes de escolas públicas e privadas. Consequentemente, ainda não se conhece a sua prevalência nesses locais, assim como, não se conhece a prevalência da SM em populações específicas, como em adolescentes escolares. Levando em consideração as informações descritas anteriormente sobre os possíveis agravos que a SM pode causar, a associação às doenças cardiovasculares e ao DM2, acredita-se que a pesquisa sobre os fatores de risco para SM seja de extrema importância ao trazer dados iniciais sobre a SM, o que deverá suscitar o planejamento e a implementação de ações que tenham impacto na promoção da saúde dos estudantes.


2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Aimei Li ◽  
Bin Yi ◽  
Yan Liu ◽  
Jianwen Wang ◽  
Qing Dai ◽  
...  

Objectives. As a screening index of diabetic kidney disease (DKD), urinary albumin/creatine ratio (UACR) is commonly used. However, approximately 23.3%-56.6% of DKD patients with estimated glomerular filtration rate eGFR<60 ml/min per 1.73 m2 are normoalbuminuric. Thus, urinary biomarkers of nonalbuminuric renal insufficiency in type 2 diabetes mellitus (T2DM) patients are urgently needed. Methods. This cross-sectional study enrolled 209 T2DM patients with normoalbuminuria whose diabetes duration was more than 5 years. The patients were classified into two groups, NO-CKD (eGFR≥60 ml/min per 1.73 m2, n=165) and NA-DKD (eGFR<60 ml/min per 1.73 m2, n=44). Levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP), plasminogen activator inhibitor-1 (PAI-1), vascular cell adhesion molecule-1 (VCAM-1), and E-cadherin were detected, and their correlations with eGFR, plasma TNF-α, IL-6, endothelin-1 (ET-1), and 8-hydroxydeoxyguanosine (8-OHdG) were assessed. Results. Among patients with renal insufficiency, 26.0% was normoalbuminuric. Compared to the NO-CKD group, the NA-DKD group was older with lower hemoglobin (HB) levels and higher systolic blood pressure (SBP), plasma TNF-α, IL-6, and 8-OHdG levels. Logistic regression analysis suggested that age, TNF-α, and 8-OHdG were independent risk factors for nonalbuminuric renal insufficiency. Compared to the NO-CKD group, the NA-DKD group exhibited significant increases in urinary NGAL and RBP levels but not PAI-1, VCAM-1, and E-cadherin. Urinary NGAL and RBP both correlated negatively with eGFR and positively with plasma IL-6 and 8-OHdG. Multiple linear regression indicated NGAL (β=−0.287, p=0.008) and RBP (β=−44.545, p<0.001) were independently correlated with eGFR. Conclusion. Age, plasma TNF-α, and 8-OHdG are independent risk factors for renal insufficiency in T2DM patients with normoalbuminuria. Urinary NGAL and RBP can serve as noninvasive biomarkers of normoalbuminuric renal insufficiency in T2DM.


2016 ◽  
Vol 21 (4) ◽  
pp. 1043-1050 ◽  
Author(s):  
Bruna Camilo Turi ◽  
Jamile Sanches Codogno ◽  
Rômulo Araújo Fernandes ◽  
Henrique Luiz Monteiro

Abstract This study investigated whether low levels of physical activity in different domains is associated with risk factors for the occurrence of metabolic syndrome or metabolic syndrome itself. Habitual physical activity level was assessed among 963 participants, aged 50 years old or more, using Baecke’s questionnaire. Risk factors for metabolic syndrome followed the recommendations of “The IDF Consensus Worldwide Definition of the Metabolic Syndrome”. All the participants were users of the Brazilian Public Healthcare System. The prevalence of metabolic syndrome was 30.9%. Participants with lower levels of physical activity in leisure-time had higher chances of occurrence of diabetes mellitus, hypercholesterolemia and metabolic syndrome. Occurrence of arterial hypertension was associated with lower levels of sports activities. It was found high rates of risk indicators for the occurrence of metabolic syndrome, as well as for diseases alone as hypertension, diabetes mellitus, hypercholesterolemia, and obesity. Lower involvement in physical activity in different domains increases the prevalence of risk factors for metabolic syndrome.


Hepatology ◽  
2002 ◽  
Vol 36 (5) ◽  
pp. 1206-1213 ◽  
Author(s):  
Manal M. Hassan ◽  
Lu-Yu Hwang ◽  
Chiq J. Hatten ◽  
Mark Swaim ◽  
Donghui Li ◽  
...  

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