Diabetes mellitus, metabolic syndrome and obesity are not significant risk factors for hepatocellular carcinoma in an HBV- and HCV-endemic area of Southern Taiwan

Objective: We aimed to evaluate the risk factors associated with acute renal failure in patients who underwent coronary artery bypass surgery. Methods: One hundred and six patients who developed renal failure after coronary artery bypass grafting (CABG) constituted the study group (RF group), while 110 patients who did not develop renal failure served as a control group (C group). In addition, the RF group was divided into two subgroups: patients that were treated with conservative methods without the need for hemodialysis (NH group) and patients that required hemodialysis (HR group). Risk factors associated with renal failure were investigated. Results: Among the 106 patients that developed renal failure (RF), 80 patients were treated with conservative methods without any need for hemodialysis (NH group); while 26 patients required hemodialysis in the postoperative period (HR group). The multivariate analysis showed that diabetes mellitus and the postoperative use of positive inotropes and adrenaline were significant risk factors associated with development of renal failure. In addition, carotid stenosis and postoperative use of adrenaline were found to be significant risk factors associated with hemodialysis-dependent renal failure (P < .05). The mortality in the RF group was determined as 13.2%, while the mortality rate in patients who did not require hemodialysis and those who required hemodialysis was 6.2% and 34%, respectively. Conclusion: Renal failure requiring hemodialysis after CABG often results in high morbidity and mortality. Factors affecting microcirculation and atherosclerosis, like diabetes mellitus, carotid artery stenosis, and postoperative vasopressor use remain the major risk factors for the development of renal failure.

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Potential of Beetroot and Blackcurrant Compounds to Improve Metabolic Syndrome Risk Factors

Metabolites ◽

10.3390/metabo11060338 ◽

2021 ◽

Vol 11 (6) ◽

pp. 338

Author(s):

Cameron Haswell ◽

Ajmol Ali ◽

Rachel Page ◽

Roger Hurst ◽

Kay Rutherfurd-Markwick

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Risk Factors ◽

Metabolic Syndrome ◽

Metabolic Abnormalities ◽

Dietary Nitrate ◽

Increased Risk ◽

High Concentrations

Metabolic syndrome (MetS) is a group of metabolic abnormalities, which together lead to increased risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM), as well as reduced quality of life. Dietary nitrate, betalains and anthocyanins may improve risk factors for MetS and reduce the risk of development of CHD and T2DM. Beetroot is a rich source of dietary nitrate, and anthocyanins are present in high concentrations in blackcurrants. This narrative review considers the efficacy of beetroot and blackcurrant compounds as potential agents to improve MetS risk factors, which could lead to decreased risk of CHD and T2DM. Further research is needed to establish the mechanisms through which these outcomes may occur, and chronic supplementation studies in humans may corroborate promising findings from animal models and acute human trials.

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Problems Of Metabolic Syndrome

The American Journal of Medical Sciences and Pharmaceutical Research ◽

10.37547/tajmspr/volume03issue06-08 ◽

2021 ◽

Vol 03 (06) ◽

pp. 52-55

Author(s):

Maksuda Ahmedjanovna Karimova ◽

◽

Dilnoza Kakhramanovna Kurbanbaeva ◽

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Metabolic Syndrome ◽

Lifestyle Modification ◽

Syndrome X ◽

Steady Increase ◽

The Third ◽

Calorie Content ◽

Single Term ◽

Life Threatening

At the beginning of the third millennium, for mankind, which overcame the epidemic of life-threatening infections during its centuries-old history, the problem of cardiovascular diseases (CVD) came to the fore in relevance among all causes of morbidity and mortality. A significant role in this was played by lifestyle modification associated with limiting physical activity, increasing the calorie content of food, and a steady increase in emotional stress. All of this potentiates the main risk factors for CVD, which are a “negative asset of progress,” namely increased blood pressure (BP), dyslipidemia, diabetes mellitus (DM) and obesity. Since 1988, after G. Reaven's Banting lecture, it is customary to designate the interconnected combination of these pathologies by the single term "metabolic syndrome X".

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Features of the course of coronavirus infection in patients with diabetes mellitus

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2201-02 ◽

2022 ◽

pp. 18-21

Author(s):

Vladimir Anatolievich Klimov ◽

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Human Population ◽

Fatal Outcome ◽

Significant Risk ◽

Adverse Outcomes ◽

Concomitant Disease ◽

Patients With Diabetes ◽

Coronavirus Infection ◽

Population Mortality

Diabetesmellitus, overweight and the age of a patient over 65 years old are identified by clinicians as themain factors that can complicate the course of the coronavirus infection and increase the likelihood of fatal outcome. Although in the general human population mortality from coronavirus fluctuateswithin 3–5 %, sometimes very significantly differing in individual countries, this level can reach 15–25 % among patientswith diabetes, especially for those receiving insulin therapy. Diabetes mellitus as a concomitant disease in COVID-19 is considered one of the most significant risk factors for the development of adverse outcomes due to a more severe course of infection in conditions of hyperglycemia and other aggravating factors.

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Clinical factors and mortality rates for non-traumatic upper extremity amputations

Journal of Hand Surgery (European Volume) ◽

10.1177/17531934211042720 ◽

2021 ◽

pp. 175319342110427

Author(s):

Yong-Zheng Jonathan Ting ◽

An-Sen Tan ◽

Chi-Peng Timothy Lai ◽

Mala Satku

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Lower Extremity ◽

Upper Extremity ◽

Significant Risk ◽

Arterial Disease ◽

Mortality Rates ◽

Level Of Evidence ◽

Peripheral Arterial ◽

Extremity Amputation

Non-traumatic upper extremity amputations are an increasing concern with the rising prevalence of diabetes mellitus. To ascertain the risk factors and mortality rates for these amputations, the demographic information, amputation history, comorbidities and clinical outcomes of 140 patients who underwent non-traumatic upper extremity amputations between 1 January 2004 and 31 October 2017 were studied. Correlations were assessed using Cochran-Armitage chi-squared tests, odds ratios and multivariate binomial logistic regression as appropriate. Diabetes mellitus, coronary artery disease, end-stage renal failure, peripheral arterial disease and prior lower extremity amputation were significant risk factors for multiple upper extremity amputations. One-year, 2-year and 5-year mortality rates were 12%, 15% and 38%, respectively, following first upper extremity amputation. The risk factors for upper extremity amputations correspond with those for lower extremity amputations, comprising mainly diabetes mellitus and its related comorbidities. The mortality rates for non-traumatic upper extremity amputations highlight their significant burden on patients. Level of evidence: III

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Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib

Digestive Diseases ◽

10.1159/000477578 ◽

2017 ◽

Vol 36 (1) ◽

pp. 78-88 ◽

Cited By ~ 4

Author(s):

Christian Labenz ◽

Vera Prenosil ◽

Sandra Koch ◽

Yvonne Huber ◽

Jens U. Marquardt ◽

...

Keyword(s):

Diabetes Mellitus ◽

Hepatocellular Carcinoma ◽

Metabolic Syndrome ◽

Group Performance ◽

Performance Status ◽

Eastern Cooperative Oncology Group ◽

Advanced Hepatocellular Carcinoma ◽

Advanced Hcc ◽

The Metabolic Syndrome ◽

The Impact

Background/Aim: Individual components of the metabolic syndrome (MS) such as obesity or diabetes mellitus impair the prognosis of patients with hepatocellular carcinoma (HCC) following curative treatment approaches or transarterial therapies. The aim of this retrospective study was to assess the impact of these factors on the overall survival (OS) of patients with advanced HCC treated with sorafenib. Methods: Univariate and multivariate analyses were performed to assess the impact of individual components of the MS on the OS of 152 consecutive patients with advanced HCC treated with sorafenib. Results: The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS. Multivariate analysis showed that Eastern Cooperative Oncology Group Performance Status ≥1 (hazards ratio [HR] 2.03), presence of macrovascular invasion (HR 1.71), Child-Pugh score B/C (HR 2.19), tumor grading G3 (HR 2.17), no prior HCC treatment (HR 2.34), and the presence of 2 or more out of 5 individual components of the MS (HR 0.65) were independent prognostic factors regarding the median OS. Conclusions: Our investigations do not confirm a negative prognostic role of individual components of the MS or the MS itself for patients with advanced HCC treated with sorafenib.

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Predictive value of the risk factors for amputation of lower extremity in patients with diabetic foot in Al-Karama teaching hospital

International Surgery Journal ◽

10.18203/2349-2902.isj20191511 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1549

Author(s):

Mohammed Hillu Surriah ◽

Amir Naif Kadum Al-Imari ◽

Amine Mohammed Bakkour ◽

Riad Rahman Jallod Al-Asadi

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Teaching Hospital ◽

Diabetic Foot ◽

Significant Risk ◽

Female Ratio ◽

Duration Of Diabetes ◽

Long Duration ◽

Control Of Diabetes ◽

Foot Disease

Background: Diabetic foot disease is a foot that exhibits any pathology that results directly from diabetic mellitus or any long-term chronic complication of diabetes mellitus. The aim of the study was to determine the risk factors and indications for amputations among diabetics.Methods: this clinical prospective study includes 120 diabetic foot patients admitted to AL- Karama teaching hospital from 1st January 2015 to 1st January 2019. All patients assessed for age, gender, duration of diabetes, hyperglycemia at admission and control of diabetes, history of smoking, hypertension, assess dominant foot and examination of diabetic foot lesion and classify it according to Meggit-Wagner grading status, indications for amputation and outcome.Results: The male to female ratio was 2:1. Most frequent age group of patients treated by amputation was between 50-80 years. Among patients treated with amputation (68.33%) of patients had diabetes mellitus for 11-20 years. From patients admitted with diabetic foot (53.33%) were smokers. Regarding hypertension (93.33%) of all patients were hypertensive. It was noted that (65%) of patients lesion occur in dominant foot Regarding Wagner's grading system (36.66%) of patients were grade 4 followed by grade 1 (21.66%). regarding mode of treatment (53.33%) of patients treated by amputation and other treated conservatively. Only 3 patients from 60 died while other discharged well after complete treatment.Conclusions: Increasing in age, long duration of diabetes mellitus, poor control of diabetes, smoking and occurrence of lesion in dominant foot all considered as a significant risk factors for increase liability amputation.

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Risk factors for metabolic syndrome in adolescents / Fatores de risco para síndrome metabólica em adolescentes /

Revista de Enfermagem da UFPI ◽

10.26694/reufpi.v3i2.2010 ◽

2014 ◽

Vol 3 (2) ◽

pp. 1

Author(s):

Ana Roberta Vilarouca da Silva

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Metabolic Syndrome ◽

High Density Lipoprotein ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

High Density ◽

Adult Treatment ◽

Adult Treatment Panel ◽

Sindrome Metabolica

No Brasil, a Síndrome Metabólica (SM) é desconhecida em várias regiões, e pouco estudada em diferentes populações. Isso porque, é proveniente da globalização, indicador inerente à modificação do estilo de vida da sociedade. Esta síndrome associa-se a Doenças Crônicas Não-Transmissíveis (DCNT), especialmente as cardiovasculares. E por ser multifatorial, destacam-se os níveis pressóricos e glicêmicos elevados, fatores-problema no desenvolvimento de complicações. A SM é um transtorno complexo representado por um conjunto de fatores de risco cardiovascular (a hipertensão arterial, a dislipidemia, a obesidade visceral e as manifestações de disfunção endotelial), usualmente relacionados à disposição central de gordura e à resistência à insulina(1). As três principais definições clínicas da SM em adultos utilizadas são as propostas pela Organização Mundial de Saúde (OMS), pelo National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) e pela International Diabetes Federation (IDF)(2). E em adolescentes existem adaptações(3-4). Assim, são fatores de risco para SM agregação de excesso de peso ou adiposidade central, hipertensão arterial, elevação dos triglicerídeos, diminuição do colesterol HDL (high density lipoprotein) e intolerância à glicose/resistência à insulina/diabetes mellitus tipo II (DMII). A prevalência de síndrome metabólica é variável, em função dos diferentes critérios diagnósticos utilizados. Na população pediátrica, as frequências de síndrome metabólica variam de 4,2% a 9,2%, com aumento na prevalência quando se consideram crianças e adolescentes obesos para 17,3% e 35,5%. Alguns estudos destacam que os componentes mais frequentes no diagnóstico de síndrome metabólica são a aumentada circunferência abdominal (88,1%) e pressão arterial (47,5%), seguidos de maior concentração de triglicerídeos (23,4%) e de baixo HDL-colesterol (23,3%)(5). Em se tratando do estado do Piauí, a busca à literatura revelou que até o presente momento, existe uma pesquisa em conclusão com foco na SM entre universitários e outras que iniciaram em 2014 com escolares, incluindo crianças e adolescentes de escolas públicas e privadas. Consequentemente, ainda não se conhece a sua prevalência nesses locais, assim como, não se conhece a prevalência da SM em populações específicas, como em adolescentes escolares. Levando em consideração as informações descritas anteriormente sobre os possíveis agravos que a SM pode causar, a associação às doenças cardiovasculares e ao DM2, acredita-se que a pesquisa sobre os fatores de risco para SM seja de extrema importância ao trazer dados iniciais sobre a SM, o que deverá suscitar o planejamento e a implementação de ações que tenham impacto na promoção da saúde dos estudantes.

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Predictors of Developing Hepatocellular Carcinoma in Treated HCV-Carriers in Morocco according to University Hospital Experience

ISRN Hepatology ◽

10.1155/2013/438306 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Younès Cherradi ◽

Rajaa Afifi ◽

Hanaa Benbrahim ◽

Wafaa Essamri ◽

Imane Benelbarhdadi ◽

...

Keyword(s):

Risk Factors ◽

Hepatocellular Carcinoma ◽

Predictive Factors ◽

Antiviral Treatment ◽

Significant Risk ◽

University Hospital ◽

Advanced Age ◽

Previously Treated Patients ◽

Previously Treated ◽

Severe Fibrosis

Introduction. Hepatitis C is the first major cause for HCC in Morocco. Antiviral treatment reduces the risk of developing HCC but few cases of HCC in HCV-treated patients were reported. We aimed to define this population’s features and to identify predictive factors of developing HCC. Patients and Methods. We included all HCV carriers who developed HCC after antiviral treatment from January 2002 to April 2010. We compare HCV-treated patients with no developed HCC to HCC population using khi-2 and Fisher Exact analysis. Results. 369 HVC-treated patients were considered, and 20 HCC were reported. The risk of HCC was not significant according to gender and genotypes (resp., P=0.63 and P=0.87). Advanced age and severe fibrosis were significant risk factors (resp., P=0.003 and P=0.0001). HCC was reported in 2.6% of sustained virological responders versus 12.5% of nonresponders (P=0.004). Conclusion. In our series, 5% of previously treated patients developed an HCC. Advanced age and severe fibrosis at HCV diagnosis are predictive factors of HCC occurrence. Sustained virological response reduces considerably the risk of HCC occurrence but screening is indicated even after SVR.

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