scholarly journals Ethnic characteristics of bone remodeling in female patients with type 2 diabetes mellitus

2022 ◽  
Vol 24 (5) ◽  
pp. 427-432
Author(s):  
T. P. Bardymova ◽  
M. V. Shestakova ◽  
Ya. P. Sandakov ◽  
M. V. Mistiakov ◽  
M. V. Berezina
Keyword(s):  
Postmenopausal Women ◽  
Bone Remodeling ◽  
Functional State ◽  
Reproductive Period ◽  
Russian Population ◽  
Controlled Study ◽  
Type I ◽  
Total Hip ◽  
Female Patients ◽  
Postmenopausal Period

Background: Structural and metabolic disorders of bone tissue in women with T2DM have no clinical manifestations, but they are accompanied by the risk of fractures.Aim: To study the parameters of bone metabolism, BMD and microarchitectonics in female patients with T2DM in the Buryat population.Materials and methods: The observational single-center one-stage controlled study included 73 women with T2DM, which were divided into 2 groups depending on the functional state of the ovaries (reproductive and postmenopausal periods). In each group, subgroups of the Buryat and Russian populations were identified. The first group included 34 patients with T2DM of the reproductive period: 16 from the Buryat population and 18 from the Russian population. The second group consisted of 39 postmenopausal patients with T2DM: 17 from the Buryat population and 22 from the Russian population. The study of BMD in the lumbar spine (L1-L4), femoral neck (Neck), in the proximal femur (Total hip), trabecular bone score (TBS), serum osteocalcin (OC), N-terminal propeptide type 1 procollagen was carried out (P1NP), vitamin D 25 (OH), blood plasma type I collagen C-terminal telopeptide (β-Cross laps) and ionized calcium (iCa).Results: In female patients with T2DM of the reproductive age of the Buryat population, an increase in both markers of osteosynthesis P1NP (p=0.035), OC (p=0.047), and bone resorption β-Cross laps (p=0.040) was found relative to the similar group of the Russian population. In women with T2DM in the postmenopausal period of the Buryat population, there was also an increase in P1NP (p = 0.016), OC (p = 0.048), β-Cross laps (p = 0.020) compared with the group of postmenopausal women in the Russian population. Structural disorders, characterized by a decrease in TBS, were detected only in the postmenopausal period in female patients of the Buryat population compared to women in the Russian population (p = 0.029).Comparative analysis among women with T2DM of the Buryat population, depending on the functional state of the ovaries, showed that activation of bone remodeling with an increase in P1NP (p = 0.019), OC (p = 0.004) and β-Cross laps (p = 0.004) is characteristic of postmenopausal women accompanied by a decrease in BMD Neck (p = 0.006), BMD Total hip (p = 0.003), BMD L1-L4 (p = 0.049) and TBS (p = 0.020) relative to female patients with T2DM in the reproductive period.Conclusion: In women with T2DM in the Buryat population, both in the reproductive and postmenopausal periods, an increase in bone remodeling markers and BMD stability was found when compared with the corresponding groups of patients in the Russian population. The postmenopausal period was characterized by an additional decrease in TBS in patients with T2DM in the Buryat population relative to women in the Russian population.

scholarly journals Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population

2020 ◽  
Vol 22 (5) ◽  
pp. 436-443
Author(s):  
Tatiana P. Bardymova ◽  
Maksim V. Mistiakov ◽  
Galina P. Yagelskaya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Comparison Group ◽  
Russian Population ◽  
Type 2 Dm

BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid pathology in different ethnic groups is continuing. AIMS: To study the concentration of markers of bone remodeling and indicators of BMD in postmenopausal women with type 2 DM of the Buryat population. MATERIALS AND METHODS: Thirty-nine postmenopausal women with type 2 DM (22 Russian population and 17 Buryat population) were examined. The comparison group consisted of 42 postmenopausal women (21 Russian population and 21 - Buryat population). The study of BMD in the lumbar spine (L1-L4), the femoral neck (Neck), and the proximal femur (Total hip) was performed using dual-energy X-ray absorptiometry. Parameters of osteocalcin (OC), type 1 N-terminal procollagen propeptide (P1NP), C-terminal telopeptides of type I collagen (-Cross laps), 25(OH) vitamin D and ionized calcium were evaluated. RESULTS: The presented study revealed a simultaneous increase in osteosynthesis: ОС (p=0.048) and P1NP (p=0.016) and in the bone resorption marker -Cross laps (p=0.020) accompanied by the absence of changes in BMD in women with type 2 DM in the postmenopausal period of the Buryat population relative to women with type 2 DM in the postmenopausal state of the Russian population. A decrease in osteosynthesis parameters (ОC, p=0.021; P1NP, p=0.029) with an increase in BMD L1-L4 (p=0.024) and BMD Total hip (p=0.039) in postmenopausal women with type 2 DM of the Buryat population was found relative to the women of the Buryat population in comparison group. CONCLUSIONS: The state of bone tissue in postmenopausal women with type 2 DM of the Buryat population is characterized by the activation of bone remodeling processes.

scholarly journals Temporal Change in Biomarkers of Bone Turnover Following Late Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix in Postmenopausal Women with Osteopenia

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1413
Author(s):  
Manjula Hettiarachchi ◽  
Rachel Cooke ◽  
Catherine Norton ◽  
Phil Jakeman
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Remodeling ◽  
Type I Collagen ◽  
Dietary Intervention ◽  
Type I ◽  
Protein Matrix ◽  
Procollagen Type ◽  
Amino Terminal ◽  
Fortified Milk

The diurnal rhythm of bone remodeling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of bedtime ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or maltodextrin (CON) on acute (0–4 h) blood and 24-h urinary change in biomarkers of bone remodeling in postmenopausal women with osteopenia. In CON, participants received 804 ± 52 mg calcium, 8.2 ± 3.2 µg vitamin D and 1.3 ± 0.2 g/kg BM protein per day. MBPM increased calcium intake to 1679 ± 196 mg, vitamin D to 9.2 ± 3.1 µg and protein to 1.6 ± 0.2 g/kg BM. Serum C-terminal cross-linked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP), and urinary N-telopeptide cross-links of type I collagen (NTX), pyridinoline (PYD) and deoxypyridinoline (DPD) was measured. Analyzed by AUC and compared to CON, a −32% lower CTX (p = 0.011, d = 0.83) and 24% (p = 0.52, d = 0.2) increase in P1NP was observed for MBPM. Mean total 24 h NTX excreted in MBPM was −10% (p = 0.035) lower than CON. Urinary PYD and DPD were unaffected by treatment. This study demonstrates the acute effects of bedtime ingestion of a calcium-fortified, milk-based protein matrix on bone remodeling.

Low Aromatase Activity and Estradiol/Sex Hormone Binding Globulin Ratio are Associated with Total Hip Bone Mineral Density and the Presence of Osteoporosis: A Study in Chinese Postmenopausal Women

2018 ◽  
Vol 50 (01) ◽  
pp. 65-72 ◽  
Author(s):  
Hai-Juan Liu ◽  
Jun Yan ◽  
Yan Li ◽  
Fang-Yuan Zhou ◽  
Xu-Dong Su ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Aromatase Activity ◽  
Type I ◽  
Hormone Binding ◽  
Mineral Density ◽  
Total Hip

AbstractSeveral groups have reported the important role of estradiol (E2) and testosterone (T) in postmenopausal osteoporosis (PMOP). Because aromatase catalyzes the conversion of T to E2, the purpose of this study was to determine the influence of aromatase activity on the bone mineral density (BMD) in postmenopausal women. A total of 344 postmenopausal women were selected for this study. Serum E2, T, sex hormone-binding globulin (SHBG), calcium (Ca), alkaline phosphatase (ALP), C-terminal telopeptide of type I collagen (CTX), and procollagen type I amino-terminal propeptide (PINP) were examined. The E2/T was positively associated with total hip BMD and PINP (p<0.05). When E2/T was divided into quartiles, participants in lower quartiles of E2/T were likely to have higher PINP and lower BMD (p<0.05). The prevalence of osteoporosis significantly increased as E2/T ratio decreased. The receiver operating characteristic (ROC) curves were constructed for serum E2, free E2 index (FEI), and E2/T, to assess their diagnostic accuracy in PMOP. The overall area under the curve (AUC) were 0.83 (95% CI=0.77–0.88) for E2, 0.87 (95% CI=0.82–0.92) for FEI, and 0.89 (95% CI=0.85–0.94), respectively. In conclusion, the study suggests that in postmenopausal women, aromatase activity could be an important determinant of skeletal health. The women with lower aromatase activity may have greater likelihood of PMOP and the E2/T was expected to be a valuable indicator for the prediction of PMOP and to monitor the process of osteoporosis.

scholarly journals Traditional and Novel Bone Remodeling Markers in Premenopausal and Postmenopausal Women

2013 ◽  
Vol 98 (11) ◽  
pp. E1740-E1748 ◽  
Author(s):  
Sonsoles Botella ◽  
Patricia Restituto ◽  
Ignacio Monreal ◽  
Inmaculada Colina ◽  
Amparo Calleja ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Acid Phosphatase ◽  
Postmenopausal Women ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Analytical Performance ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Mineral Density ◽  
Bone Remodeling Markers

Context: Bone turnover markers (BTMs) may identify changes in bone remodeling within a relatively short time interval before changes in bone mineral density can be detected. New markers such as osteoprotegerin, receptor activator of nuclear factor-κB ligand, and sclerostin have emerged, but there is little information about their potential use in clinical practice. Objectives: The aim of this study was to analyze the ability of several BTMs to predict bone loss in pre- and postmenopausal women and to monitor the efficacy of treatment in osteoporotic women. Design, Patients, and Setting: We performed an observational prospective study in pre- and postmenopausal ambulatory women (n = 72 and n = 152, respectively). Intervention: Postmenopausal women with osteoporosis (n = 18) were treated with risedronate and calcium. Women filled out a questionnaire and underwent bone mineral density measurement using dual-energy x-ray absorptiometry at the time of enrollment and after 1 year of follow-up. BTMs were measured at baseline, at 6 months, and after 1 year. Results: Increased levels of N-terminal propeptide of type 1 procollagen (P1NP) and β-type I collagen telopeptides (CTXs) were associated with low bone mineral density in the premenopausal (P = .02 and P = .04, respectively) and postmenopausal (P = .03 and P = .02) groups. The best analytical performance to diagnose osteoporosis was for β-CTX, osteocalcin, and P1NP, with areas under the curve of 0.70 (P = .005), 0.64 (P = .048), and 0.71 (P = .003). A significant decrease was found in P1NP, osteocalcin, tartrate-resistant acid phosphatase-5b, β-CTX, and bone alkaline phosphatase after 1 year of treatment (all P &lt; .05). Conclusions: Our data suggest that measurement of β-CTX and P1NP shows adequate analytical performance and could potentially be included in algorithms for the screening of osteoporosis. Furthermore, these two markers, along with osteocalcin and tartrate-resistant acid phosphatase-5b, are useful to monitor the response to risedronate.

scholarly journals Effect of Whey Protein Supplementation on Plasma Bone-Resorption Biomarker in Post-Menopausal Women Submitted to Physical Exercise Training

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1748-1748
Author(s):  
Roberto Burini ◽  
Loraine Gollino ◽  
Rafael Lima ◽  
Hugo Kano ◽  
Adriana Mendes ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Exercise Training ◽  
Physical Exercise ◽  
Postmenopausal Women ◽  
Whey Protein ◽  
Protein Supplementation ◽  
Controlled Study ◽  
Bone Resorption Marker ◽  
Type I ◽  
Physical Exercise Training

Abstract Objectives To evaluate the additional effect of whey protein supplementation (WPS) to the physical-exercise training on bone resorption in postmenopausal women. Methods In a prospective, controlled study, 38 postmenopausal women aged 50 to 70 years, were randomized into two groups: with WPS (n = 19) and without WPS (n = 19, control) intervention. The study included amenorrheic women (above 12 months) with normal bone mineral density (T-score ≥ −1.0 SD) not taken bone-related medicines, and practitioners of a physical exercise protocol involving combined walking/jogging and academy/resistance exercises performed under professional supervising, three times a week. Together, there was a weekly dietary counseling along with a daily supplementation of either 25 g of protein (WPS) or placebo. Food intake (24-hour recall), anthropometric, general biochemistry, plasma hormones and bone resorption marker: serum C-terminal cross-linked N-telopeptides of type-I collagen (s-CTX) assessments were undertaken at baseline and after 20-wk intervention. Statistical analysis of the data (P &lt; 0.05) was performed by using a time-repeated measures (ANOVA) followed by the Tukey multiple comparison test adjusted for group x moment interaction, or by gamma distribution (asymmetric variables). Results The groups were anthropometric and biochemical homogeneous, at baseline and after the intervention. Both groups increased similarly the intake of energy and lipids. However, only WPS significantly increased the intake of protein, calcium, phosphates and magnesium, as well as leucine, isoleucine and valine. From a similar baseline plasma values of s-CTX, calcium, phosphorus, alkaline phosphatase and parathormone, only s-CTX responded significantly to the intervention, being reduced in both groups (-34% and −15.2%), statistically significant in the control(non-WPS) group (P = 0.016). Conclusions The reduced plasma marker of bone resorption marker was observed in post-menopause women submitted to a 20-wk lifestyle-modification protocol with physical exercises, independently to the whey protein supplementation. Clinical trial (REBEC): RBR-7KD97. Funding Sources Brazilian foundations CNPq and CAPES.

Periodontal status and bone metabolism in women in reproductive and postmenopausal periods

2020 ◽  
Vol 41 (3) ◽  
Author(s):  
Iryna Mazur ◽  
Bassymbek Dilbarkhanov ◽  
Xeniya Kuracha ◽  
Volodymyr Novoshytskyy ◽  
Iryna Suprunovych ◽  
...  
Keyword(s):  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Postmenopausal Period ◽  
Group I ◽  
Group Ii

AbstractObjectivesChronic periodontitis is one of the most common diseases in the world. Periodontitis occurs more frequently in postmenopausal women due to hormonal changes and in patients with osteoporosis. Thus, the aim of our study was to compare levels of alveolar bone loss of mandible and maxilla and bone tissue remodeling markers in women of reproductive and postmenopausal periods.MethodsFifty-nine women aged 25–68 years were enrolled in a cross-sectional study and divided into two groups. Group I consisted of 42 women of reproductive age and Group II included 17 women in their postmenopausal period. The level of alveolar bone loss of mandible and maxilla was assessed using dental panoramic radiography, and the level of bone remodeling markers (Beta C-terminal telopeptide of type I collagen [β-CTx] and osteocalcin) was obtained in both groups.ResultsWomen in the postmenopausal period have higher level of alveolar bone loss in mandible and maxilla than women of reproductive age. The level of ß-CTx and osteocalcin was significantly higher in Group II, compared to Group I (p=0.002 and p=0.005, respectively).ConclusionsIn postmenopausal women, on the background of significantly higher bone remodeling, an increase of alveolar bone loss of mandible and maxilla was observed.

scholarly journals Effect of Stopping Risedronate after Long-Term Treatment on Bone Turnover

2011 ◽  
Vol 96 (11) ◽  
pp. 3367-3373 ◽  
Author(s):  
Richard Eastell ◽  
Rosemary A. Hannon ◽  
Dietrich Wenderoth ◽  
Jesus Rodriguez-Moreno ◽  
Andrzej Sawicki
Keyword(s):  
Postmenopausal Women ◽  
Type I Collagen ◽  
Term Treatment ◽  
Type I ◽  
Mineral Density ◽  
Open Label ◽  
Treatment Groups ◽  
Total Hip ◽  
Long Term Treatment ◽  
Hip Bmd

Abstract Context: Determining how quickly bisphosphonate treatment effects begin to regress is crucial when considering termination of treatment. Objective: Our objective was to assess the effects of 1 yr discontinuation of risedronate use in postmenopausal women with osteoporosis who had previously received risedronate for 2 or 7 yr. Design and Setting: Before initiation of the current study, placebo/5-mg-risedronate patients had received placebo for 5 yr and risedronate for 2 yr, whereas 5-mg-risedronate patients had received risedronate for a total of 7 yr. Risedronate was then discontinued for 1 yr (yr 8). Patients: Postmenopausal women with osteoporosis who had previously completed the 3-yr Vertebral Efficacy with Risedronate Therapy MultiNational (VERT-MN) pivotal trial, plus a 2-yr extension comparing risedronate or placebo for a total of 5 yr, followed by 2 yr of open-label risedronate treatment were enrolled in these trial extensions. Main Outcome Measures: Evaluations included changes in type I collagen cross-linked N-telopeptide (NTX)/creatinine (Cr) and bone mineral density (BMD) values, fracture incidence, and adverse events. Results: After 1 yr of risedronate discontinuation, NTX/Cr levels increased toward baseline in both patient groups vs. the values at the end of yr 7. In both treatment groups, off-treatment total hip and femoral trochanter BMD values decreased, whereas lumbar spine and femoral neck BMD were maintained or slightly increased. The adverse event profiles were similar between the two treatment groups during yr 8. Conclusions: One year of discontinuation of risedronate treatment in patients who had received 2 or 7 yr of risedronate therapy led to increases in NTX/Cr levels toward baseline and decreases in femoral trochanter and total hip BMD.

scholarly journals Nutrition in Menopausal Women: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2149
Author(s):  
Thais R. Silva ◽  
Karen Oppermann ◽  
Fernando M. Reis ◽  
Poli Mara Spritzer
Keyword(s):  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Fractures ◽  
Blood Pressure Reduction ◽  
Antioxidant Properties ◽  
Narrative Review ◽  
Current Evidence ◽  
Beneficial Effects ◽  
Clinical Endpoints ◽  
Postmenopausal Period

Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pressure, reduction of fat mass, and improvement in cholesterol levels. These effects remain to be evaluated over a longer period of time, with the assessment of hard outcomes such as bone fractures, diabetes, and coronary ischemia.

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