scholarly journals Ficus septica Burm. f. Leaves Ethanolic Extract Triggered Apoptosis on 7,12-Dimethylbenz[a]anthracene-Induced Rat Mammary Carcinogenesis Qualitatively

2012 ◽  
Vol 3 (1) ◽  
pp. 334
Author(s):  
Anindyajati Anindyajati ◽  
Andita Pra Darma ◽  
Ika Nurjizah ◽  
Dita Brenna Septhea ◽  
Agung Endro Nugroho
Keyword(s):  
Breast Cancer ◽  
Ethanolic Extract ◽  
Apoptosis Induction ◽  
Double Staining ◽  
Control Groups ◽  
Carcinogenic Activity ◽  
P53 Expression ◽  
Significant Difference ◽  
Double Staining Method ◽  
And Control

Ficus septica Burm. f. ethanolic extract (FEE) shows cytotoxic effects on several cancer cell lines. Our research aimed to investigate the effect of FEE on apoptosis induction and p53 expression against carcinogenesis of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced rat mammary.The research was conducted by comparing both apoptosis induction and p53 expression in DMBA-induced rats that were treated with FEE against control groups. Cells that undergo apoptosis were visualized by Double Staining method with acridine orange and ethidium bromide, while p53 expression was detected by IHC staining. Double staining results showed increased occurrence of apoptotic cells compared to the control groups. IHC staining of p53 did not show significant difference between treatment and control groups. However, FEE was able to repair morphology of cells undergoing carcinogenesis. Thus, we conclude that FEE has an anti-carcinogenic activity on DMBA-induced rat mammary through apoptosis induction without affecting p53 expression. Therefore, the ethanolic extract of Ficus Septica leaves is a potential chemo-preventive agent on breast cancer. Further study on its molecular mechanism needs to be explored.Keywords: Ficus septica, breast cancer, 7,12-Dimethylbenz[a]anthracene, carcinogenesis, apoptosis, p53

scholarly journals Effects of acupuncture on breast cancer-related lymphoedema: a systematic review and meta-analysis of randomised controlled trials

2019 ◽  
Vol 37 (1) ◽  
pp. 16-24
Author(s):  
Xinyan Zhang ◽  
Xiuli Wang ◽  
Bingyan Zhang ◽  
Sa Yang ◽  
Dongling Liu
Keyword(s):  
Breast Cancer ◽  
Elbow Joint ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Breast Cancer Treatment ◽  
Control Groups ◽  
Significant Difference ◽  
Effectiveness Index ◽  
Randomised Controlled ◽  
And Control

Objective: Breast cancer-related lymphoedema (BCRL) is a common complication after breast cancer treatment. We investigated whether acupuncture could be used to manage limb oedema in women after breast cancer surgery. Methods: The Cochrane Library, PubMed, Embase, Web of Science, CINAHL, and four Chinese databases were electronically searched for papers published through November 2017. Randomised controlled trials (RCTs) of acupuncture for BCRL were included. Results: In total, six RCTs with 318 patients were identified. The main analysis revealed a positive overall effect of acupuncture intervention on pre/post-treatment differences in the diameter of the elbow joint, reductions in upper limb lymphoedema and effectiveness index based on arm measurement data in patients with breast cancer. Two studies evaluating the outcome of acupuncture on the diameter of the elbow joint found a significant reduction in diameter between the acupuncture and control groups (weighted mean difference (WMD) 6 cm, 95% CI 5.11 to 6.89 cm; P<0.001). The same two studies investigated the effect of acupuncture on upper limb lymphoedema reduction and found a significant difference between the acupuncture and control groups (risk ratio 1.4, 95% CI 1.17 to 1.67; P<0.001). Two other studies used the effectiveness index to assess the arm and found a significant difference between the acupuncture and control groups (WMD 23.34, 95% CI 10.74 to 35.94; P<0.001). The fifth study used bioelectrical impedance spectroscopy to assess lymphoedema at several points on the arm before and after acupuncture; this study also reported a significant reduction in lymphoedema. The sixth study reported no significant difference in bioimpedance between the groups. Conclusions: The present meta-analysis and systematic review suggests that acupuncture is effective at reducing BCRL in patients after breast cancer treatment.

The effect of reflexology on quality of life in Iranian patients with breast cancer.

2016 ◽  
Vol 34 (26_suppl) ◽  
pp. 90-90
Author(s):  
Shadan Pedramrazi
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Placebo Group ◽  
Test Group ◽  
Control Group ◽  
Relaxation Techniques ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

90 Background: Breast cancer is one the most prevalent cancers among Iranian women. One of the complementary therapies is reflexology. The extant paper has been provided with the objective of determining the effect of reflexology on quality of life of patients with breast cancer undergoing chemotherapy in the breast disease center. Methods: This study is a randomized clinical trial which has been applied to 60 patients suffering from breast cancer under chemotherapy in breast diseases center, in 2012. The patients were selected randomly in three test, control and placebo groups. In test group, reflexology was implemented for 3 weeks and each session lasted half an hour. In placebo group, only relaxation techniques were implemented for 3 weeks, each session lasted 20-30 minutes. Control group received the routine therapies of breast cancer center. Results: Data were collected by standard questionnaires of EORTIC QLQ-C30.V.3 and EORTIC QLQ-BR23.V.3. The questionnaires were filled before intervention and two weeks after applying study. There was no significant difference in demographic characteristics or quality of life score of three groups, before intervention. Total score of quality of life was higher in interventional group compared to placebo group before and two weeks after intervention (p < 0.001) Results also indicated a significant difference in total score of quality of life between three test, placebo, and control groups after intervention (p < 0.001). A considerable improvement was noticed in the different aspects of quality of life in the test group compared to two other placebo and control groups. Conclusions: Reduction of pain, anxiety, nausea, and other symptoms related to cancer in patients suffering from cancer are assumed as the important cases of nursing cares focus, and precise nursing may diminish these symptoms considerably. Using reflexology in patients suffering from breast cancer may improve the quality of life as an effective method, and can be recommended for use in patients with breast cancer if it is supervised by health system personnel.

scholarly journals Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

2021 ◽  
Author(s):  
Pegah Mohammadzadeh ◽  
Elnaz Shaseb ◽  
Zohreh Sanaat ◽  
Parvin Sarbakhsh ◽  
Nasrin Gholami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peripheral Neuropathy ◽  
Intervention Group ◽  
Metastatic Breast ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

scholarly journals High Serum Estradiol Reduces Acute Hepatotoxicity Risk Induced by Epirubicin Plus Cyclophosphamide Chemotherapy in Premenopausal Women with Breast Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Shunmin Huang ◽  
Maobai Liu ◽  
Fangmeng Fu ◽  
Hangmin Liu ◽  
Baochang He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Linear Trend ◽  
Menopausal Status ◽  
High Serum ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Premenopausal Patients ◽  
And Control

Aim: We evaluated whether acute drug-induced liver injury (DILI) caused by adjuvant chemotherapy with epirubicin plus cyclophosphamide for early breast cancer was associated with estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH).Methods: Reproductive hormone test results of breast cancer patients were collected in the first chemotherapy cycle. E2, LH, and FSH levels were loge-transformed to normally distributed variables and were assessed using Student’s t-test to determine significant differences between the case and control groups. Hormone levels were classified according to the interquartile range and analyzed by logistic regression to determine their association with DILI caused by chemotherapy.Results: Among the 915 enrolled patients (DILI group: 204; control group: 711), menopausal status, along with serum E2, LH, and FSH levels, did not substantially differ between case and control groups. However, in the premenopause subgroup (n = 483), we found a significant difference in the E2 level between the case and control groups (p = 0.001). After adjusting for age and body mass index, premenopausal patients with 152–2,813 pg/mL E2 showed a lower risk of chemotherapy-induced DILI than patients with ≤20 pg/mL E2 (odds ratio: 0.394; 95% confidence interval: 0.207–0.748). The linear trend χ2 test revealed that E2 levels in premenopausal patients with breast cancer were inversely associated with the development of DILI.Conclusion: High serum E2 levels are associated with a reduced DILI risk in premenopausal patients with breast cancer undergoing epirubicin plus cyclophosphamide adjuvant chemotherapy.

scholarly journals Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan

2018 ◽  
Author(s):  
Mona Bustami ◽  
Abdel-Ellah Al-Shudifat ◽  
Nagham Hussein ◽  
Mohannad Yacoub ◽  
Eiad Atwa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sanger Sequencing ◽  
Breast Cancer Incidence ◽  
Control Groups ◽  
Allele Distribution ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Endogenous Compounds ◽  
And Control ◽  
The Impact

Sulfotransferases (SULTs) family plays a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds by which carcinogenesis and mutagenicity of different malignancies are increasingly affected. Recent data identified various genetically polymorphic SULTs enzymes with significant variations in the enzyme activity. This study aimed to investigate the impact of SULT1A1 gene polymorphism and and its potential risk on females with breast cancer in Jordan using a PCR-RFLP and Sanger Sequencing methods. The analysis showed that 24.7% of the patients and 25.3% of the controls were homozygous for the SULT1A1*1 allele (SULT1A1*1/SULT1A1*1) compared to 8.8% and 5.7% homozygous for the SULT1A1*2 allele (SULT1A1*2/SULT1A1*2) for patients and controls respectively. Most of the patients and controls were heterozygous for SULT1A1*1 allele (SULT1A1*1/SULT1A1*2) with rates of 66.5% and 69.0% in patients and controls respectively. In addition, the frequencies of the mutant SULT1A1*2 allele were 0.42 and 0.4 in the patient and control groups respectively. No significant difference in genotype and allele distribution was noted between the breast cancer and control groups. The risk of breast cancer in individuals carrying the SULT1A1*2 allele was determined by combining the SULT1A1*1/SULT1A1*2 and ULT1A1*2/SULT1A1*2 genotypes. No association was observed between SULT1A1 polymorphism and breast cancer incidence (P = 0.63; OR, 0.93; 95% CI, 0.68&ndash;1.26). However, SULT1A1*2 allele was found to increase the risk of breast cancer by 1.26-fold.

scholarly journals Evaluation of Cyclooxygenase-2 and p53 Expression in Pterygium Tissue Following Preoperative Intralesional Ranibizumab Injection

2021 ◽  
Vol 8 ◽  
Author(s):  
Ahmad Razif Omar ◽  
Mohtar Ibrahim ◽  
Hasnan Jaafar ◽  
Ab Hamid Siti-Azrin ◽  
Embong Zunaina
Keyword(s):  
Cyclooxygenase 2 ◽  
Control Group ◽  
Control Groups ◽  
P53 Expression ◽  
Anti Vegf ◽  
Significant Difference ◽  
Pterygium Surgery ◽  
Pterygium Excision ◽  
Cox 2 ◽  
And Control

Introduction: Overexpression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and p53 are the postulated aetiopathogenesis in pterygium. VEGF is responsible for the induction of COX-2 expression, whereas p53 plays an important role in the regulation of VEGF. This study aimed to evaluate the immunohistochemistry of COX-2 and p53 expressions from excised pterygium tissue from patients who received intralesional ranibizumab (anti-VEGF) injection 2 weeks prior to pterygium surgery.Materials and Methods: An interventional comparative study involving patients presenting with primary pterygium was conducted between September 2015 and November 2017. The patients were randomized into either the intervention or control group. Patients in the intervention group were injected with intralesional ranibizumab (0.5 mg/0.05 ml) 2 weeks prior to surgery. Both groups underwent pterygium excision followed by conjunctival autograft. Immunohistochemistry staining was performed to evaluate COX-2 and p53 expressions in the excised pterygium tissue.Results: A total of 50 patients (25 in both the intervention and control groups) were recruited. There were 34 (68%) patients with grade III pterygium and 16 (32%) patients with grade IV pterygium. There was statistically significant difference in reduction of COX-2 expression in the epithelial layer [84.0% (95% CI: 63.9, 95.5)] (p = 0.007) and stromal layer [84.0% (95% CI: 63.9, 95.5)] (p &lt; 0.001) between intervention and control groups. There was no significant difference in the reduction of p53 expression between the two groups.Conclusion: This study demonstrated the possible use of intralesional anti-VEGF treatment prior to pterygium excision as a potential future modality of adjunctive therapy for pterygium surgery.

scholarly journals Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan

2017 ◽  
Author(s):  
Mona Bustami ◽  
Abdel-Ellah Al-Shudifat ◽  
Nagham Hussein ◽  
Mohannad Yacoub ◽  
Eiad Atwa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sanger Sequencing ◽  
Breast Cancer Incidence ◽  
Control Groups ◽  
Allele Distribution ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Endogenous Compounds ◽  
And Control ◽  
The Impact

Sulfotransferases (SULTs) family plays a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds by which carcinogenesis and mutagenicity of different malignancies are increasingly affected. Recent data identified various genetically polymorphic SULTs enzymes with significant variations in the enzyme activity. This study aimed to investigate the impact of SULT1A1 gene polymorphism and and its potential risk on females with breast cancer in Jordan using a PCR-RFLP and Sanger Sequencing methods. The analysis showed that 24.7% of the patients and 25.3% of the controls were homozygous for the SULT1A1*1 allele (SULT1A1*1/SULT1A1*1) compared to 8.8% and 5.7% homozygous for the SULT1A1*2 allele (SULT1A1*2/SULT1A1*2) for patients and controls respectively. Most of the patients and controls were heterozygous for SULT1A1*1 allele (SULT1A1*1/SULT1A1*2) with rates of 66.5% and 69.0% in patients and controls respectively. In addition, the frequencies of the mutant SULT1A1*2 allele were 0.42 and 0.4 in the patient and control groups respectively. No significant difference in genotype and allele distribution was noted between the breast cancer and control groups. The risk of breast cancer in individuals carrying the SULT1A1*2 allele was determined by combining the SULT1A1*1/SULT1A1*2 and SULT1A1*2/SULT1A1*2 genotypes. No association was observed between SULT1A1 polymorphism and breast cancer incidence (P = 0.63; OR, 0.93; 95% CI, 0.68-1.26). However, SULT1A1*2 allele was found to increase the risk of breast cancer by 1.26-fold.

scholarly journals Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis

2011 ◽  
Vol 2 (2) ◽  
pp. 228
Author(s):  
Ameilinda Monikawati ◽  
Sofa Farida ◽  
Laras Widawaty Putri ◽  
Yurista Gilang Ikhtiarsyah ◽  
Edy Meiyanto
Keyword(s):  
Breast Cancer ◽  
Antiproliferative Activity ◽  
Ethanolic Extract ◽  
Control Groups ◽  
Treatment Groups ◽  
Popular Medicine ◽  
Chemopreventive Agent ◽  
Cycle Arrest ◽  
Physalis Angulata ◽  
And Control

Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.Keywords: Physalis angulata, breast cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Stick Figure and Think, Talk And Write: Integrating Media With Teaching Strategy For A Better Writing Competence

2017 ◽  
Vol 2 (1) ◽  
pp. 46
Author(s):  
Eva Sudarwati ◽  
Shynta Amalia
Keyword(s):  
Teaching Strategy ◽  
T Test ◽  
Narrative Writing ◽  
Control Groups ◽  
Stick Figure ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Mean Differences ◽  
And Control ◽  
Writing Competence

Abstract This study attempts to see the effect of Think, Talk, and Write strategy on the students’ narrative writing competence. Considering the importance of the use of teaching media, this study tries to integrate Stick Figure as a teaching media in Think, Talk, and Write Strategy. A quasi experimental study was conducted to see the improvement of the students’ narrative writing competence. It involved 42 students who were selected on the basis of convenience sampling and assigned into two groups; experimental and control groups. The statistical analyses of paired sample t-test in experimental group showed that there was significant improvement on the students’ writing competence before (M=5.77, SD= 2.342) and after (M= 11.79, SD= 2.342), t(21)=12.059, p<0.05.Moreover, the result of independent t-test between experimental and control groups showed a significant difference. It can be seen that the mean differences was 3.79545 and the significance value is lower than 0.05, 0.000<0.05.

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