Principles of radiation therapy

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Janusz Winiecki

AbstractIntroductionRadiotherapy is one of the basic methods of cancer treatment. Tens of millions of people around the world are exposed to ionizing radiation each year in the hope that it will help fight the disease or slow down its progress. Radiotherapy owes its success mainly to important discoveries in the field of physics, which allowed to understand the essence of the interaction of ionizing radiation with matter, in particular living matter.MaterialsThe following study explains which types of radiation have the ability to ionize matter. The difference between the interaction of electrically charged particles and neutral particles was explained. The author briefly described methods of delivering radiation to diseased tissues and how adjacent tissues are protected. The most important physical quantities describing the quality and dose of the delivered radiation were introduced.ConclusionsSafe use of radiotherapy as one of the methods of oncological treatment requires proficient knowledge of the basics of radiobiology and the physics of nuclear interactions. The study describes the most important steps in the preparation and implementation of radiotherapy, but it is not sufficient to fully understand this method. However, it provides an opportunity to be familiar with the issue in general.

Author(s):  
M. F. Atiyah ◽  
N. S. Manton ◽  
B. J. Schroers

Inspired by soliton models, we propose a description of static particles in terms of Riemannian 4-manifolds with self-dual Weyl tensor. For electrically charged particles, the 4-manifolds are non-compact and asymptotically fibred by circles over physical 3-space. This is akin to the Kaluza–Klein description of electromagnetism, except that we exchange the roles of magnetic and electric fields, and only assume the bundle structure asymptotically, away from the core of the particle in question. We identify the Chern class of the circle bundle at infinity with minus the electric charge and, at least provisionally, the signature of the 4-manifold with the baryon number. Electrically neutral particles are described by compact 4-manifolds. We illustrate our approach by studying the Taub–Newman, Unti, Tamburino (Taub–NUT) manifold as a model for the electron, the Atiyah–Hitchin manifold as a model for the proton, with the Fubini–Study metric as a model for the neutron and S 4 with its standard metric as a model for the neutrino.


2018 ◽  
pp. 5-29 ◽  
Author(s):  
L. M. Grigoryev ◽  
V. A. Pavlyushina

The phenomenon of economic growth is studied by economists and statisticians in various aspects for a long time. Economic theory is devoted to assessing factors of growth in the tradition of R. Solow, R. Barrow, W. Easterly and others. During the last quarter of the century, however, the institutionalists, namely D. North, D. Wallis, B. Weingast as well as D. Acemoglu and J. Robinson, have shown the complexity of the problem of development on the part of socioeconomic and political institutions. As a result, solving the problem of how economic growth affects inequality between countries has proved extremely difficult. The modern world is very diverse in terms of development level, and the article offers a new approach to the formation of the idea of stylized facts using cluster analysis. The existing statistics allows to estimate on a unified basis the level of GDP production by 174 countries of the world for 1992—2016. The article presents a structured picture of the world: the distribution of countries in seven clusters, different in levels of development. During the period under review, there was a strong per capita GDP growth in PPP in the middle of the distribution, poverty in various countries declined markedly. At the same time, in 1992—2016, the difference increased not only between rich and poor groups of countries, but also between clusters.


Author(s):  
Brian Willems

A human-centred approach to the environment is leading to ecological collapse. One of the ways that speculative realism challenges anthropomorphism is by taking non-human things to be as valid objects of investivation as humans, allowing a more responsible and truthful view of the world to take place. Brian Willems uses a range of science fiction literature that questions anthropomorphism both to develop and challenge this philosophical position. He looks at how nonsense and sense exist together in science fiction, the way in which language is not a guarantee of personhood, the role of vision in relation to identity formation, the difference between metamorphosis and modulation, representations of non-human deaths and the function of plasticity within the Anthropocene. Willems considers the works of Cormac McCarthy, Paolo Bacigalupi, Neil Gaiman, China Miéville, Doris Lessing and Kim Stanley Robinson are considered alongside some of the main figures of speculative materialism including Graham Harman, Quentin Meillassoux and Jane Bennett.


2019 ◽  
Vol 7 (8) ◽  
pp. 12
Author(s):  
Kunal Debnath

High culture is a collection of ideologies, beliefs, thoughts, trends, practices and works-- intellectual or creative-- that is intended for refined, cultured and educated elite people. Low culture is the culture of the common people and the mass. Popular culture is something that is always, most importantly, related to everyday average people and their experiences of the world; it is urban, changing and consumeristic in nature. Folk culture is the culture of preindustrial (premarket, precommodity) communities.


2019 ◽  
Vol 3 ◽  
pp. 00013
Author(s):  
Danny Susanto

<p class="Abstract">The purpose of this study is to analyze the phenomenon known as&nbsp;<span style="font-size: 1rem;">“anglicism”: a loan made to the English language by another language.&nbsp;</span><span style="font-size: 1rem;">Anglicism arose either from the adoption of an English word as a&nbsp;</span><span style="font-size: 1rem;">result of a translation defect despite the existence of an equivalent&nbsp;</span><span style="font-size: 1rem;">term in the language of the speaker, or from a wrong translation, as a&nbsp;</span><span style="font-size: 1rem;">word-by-word translation. Said phenomenon is very common&nbsp;</span><span style="font-size: 1rem;">nowadays and most languages of the world including making use of&nbsp;</span><span style="font-size: 1rem;">some linguistic concepts such as anglicism, neologism, syntax,&nbsp;</span><span style="font-size: 1rem;">morphology etc, this article addresses various aspects related to&nbsp;</span><span style="font-size: 1rem;">Anglicisms in French through a bibliographic study: the definition of&nbsp;</span><span style="font-size: 1rem;">Anglicism, the origin of Anglicisms in French and the current situation,&nbsp;</span><span style="font-size: 1rem;">the areas most affected by Anglicism, the different categories of&nbsp;</span><span style="font-size: 1rem;">Anglicism, the difference between French Anglicism in France and&nbsp;</span><span style="font-size: 1rem;">French-speaking Canada, the attitude of French-speaking society&nbsp;</span><span style="font-size: 1rem;">towards to the Anglicisms and their efforts to stop this phenomenon.&nbsp;</span><span style="font-size: 1rem;">The study shows that the areas affected are, among others, trade,&nbsp;</span><span style="font-size: 1rem;">travel, parliamentary and judicial institutions, sports, rail, industrial&nbsp;</span><span style="font-size: 1rem;">production and most recently film, industrial production, sport, oil industry, information technology,&nbsp;</span><span style="font-size: 1rem;">science and technology. Various initiatives have been implemented either by public institutions or by&nbsp;</span><span style="font-size: 1rem;">individuals who share concerns about the increasingly felt threat of the omnipresence of Anglicism in&nbsp;</span><span style="font-size: 1rem;">everyday life.</span></p>


Dreyfus argues that there is a basic methodological difference between the natural sciences and the social sciences, a difference that derives from the different goals and practices of each. He goes on to argue that being a realist about natural entities is compatible with pluralism or, as he calls it, “plural realism.” If intelligibility is always grounded in our practices, Dreyfus points out, then there is no point of view from which one can ask about or provide an answer to the one true nature of ultimate reality. But that is consistent with believing that the natural sciences can still reveal the way the world is independent of our theories and practices.


Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 597
Author(s):  
Daniela Luvero ◽  
Salvatore Lopez ◽  
Giorgio Bogani ◽  
Francesco Raspagliesi ◽  
Roberto Angioli

Cervical cancer (CC) is the second leading cause of cancer death in women aged 20–39 years. Persistent infection with oncogenic types of human papillomavirus (HPV) represents the most important risk factor for the development of cervical cancer. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent, and nonavalent. The nonavalent vaccine provides protection against almost 90% of HPV-related CC. Despite availability of primary and secondary prevention measures, CC persists as one of the most common cancers among women around the world. Although CC is a largely preventable disease, management of persistent or recurrent CC no longer amenable to control with surgery or radiation therapy has not improved significantly with the progress of modern chemotherapy and disseminated carcinoma of the cervix remains a discouraging clinical entity with a 1-year survival rate between 10% and 15%. Over the last few years, there has been increasing interest in immunotherapy as a strategy to fight tumors. This article focuses on recent discoveries about the HPV vaccine and immunotherapies in the prevention and treatment of CC, highlighting the future view.


Author(s):  
Rachel J. Crellin ◽  
Oliver J.T. Harris

In this paper we argue that to understand the difference Posthumanism makes to the relationship between archaeology, agency and ontology, several misconceptions need to be corrected. First, we emphasize that Posthumanism is multiple, with different elements, meaning any critique needs to be carefully targeted. The approach we advocate is a specifically Deleuzian and explicitly feminist approach to Posthumanism. Second, we examine the status of agency within Posthumanism and suggest that we may be better off thinking about affect. Third, we explore how the approach we advocate treats difference in new ways, not as a question of lack, or as difference ‘from’, but rather as a productive force in the world. Finally, we explore how Posthumanism allows us to re-position the role of the human in archaeology,


2021 ◽  
Vol 10 (11) ◽  
pp. 2519
Author(s):  
Pierpaolo Di Micco ◽  
Giuseppe Camporese ◽  
Vincenzo Russo ◽  
Giuseppe Cardillo ◽  
Egidio Imbalzano ◽  
...  

COVID-19 is an infection due to SARS-CoV-2; this virus has been identified as the cause of the present pandemic. Several typical characteristics are present in this infection, in particular pneumonia with possible lung failure, but atypical clinical presentations are being described daily by physicians around the world. Ground-glass opacities with pneumonia are the most common and dangerous presentations of the COVID-19 disease, and they are usually associated with positive nasopharyngeal swab (NPS) tests with detectable SARS-CoV-2 viral RNA. Compared to the general population, hospital workers have been at a greater risk of infection ever since the first patients were hospitalized. However, hospital workers have also been reported as having COVID-like symptoms despite repeated negative swab tests but having tested positive for SARS-CoV-2 antibodies with serological tests. We can postulate that a COVID-like syndrome is possible, in particular in hospital workers, that is characterized by symptoms similar to those of COVID-19, but with repeated negative nasopharyngeal swabs. These repeated negative NSPs make the difference in daily clinical management with people that experienced a single false negative nasopharyngeal swab; furthermore, a clear clinical differentiation of these situations is still lacking in the literature. For this reason, here, we report our main findings from a cohort of patients with a COVID-like syndrome compared to a similar group affected by typical COVID-19.


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