scholarly journals Seasonality of blood neopterin levels in the Old Order Amish

Pteridines ◽  
2017 ◽  
Vol 28 (3-4) ◽  
pp. 163-176 ◽  
Author(s):  
Hira Mohyuddin ◽  
Polymnia Georgiou ◽  
Abhishek Wadhawan ◽  
Melanie L. Daue ◽  
Lisa A. Brenner ◽  
...  
Keyword(s):  
Seasonal Affective Disorder ◽  
Seasonal Pattern ◽  
Analysis Of Covariance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Old Order Amish ◽  
Old Order ◽  
Neopterin Level ◽  
Cross Sectional Design ◽  
Assessment Questionnaire

AbstractSeasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer. We intended to measure seasonal variation in neopterin, a marker of cellular immunity, and its interactions with gender and seasonality of mood. We studied 320 Amish from Lancaster, PA, USA (men=128; 40%) with an average age [Standard deviation (SD)] of 56.7 (13.9) years. Blood neopterin level was measured with enzyme-linked immunosorbent assay (ELISA). Seasonality was measured with Seasonal Pattern Assessment Questionnaire (SPAQ). Statistical analysis included analysis of covariance (ANCOVAs) and multivariate linear regression. We also investigated interactions of seasonal differences in neopterin with gender, seasonality scores and estimation of SAD diagnosis. We found a significantly higher neopterin level in winter than in summer (p=0.006). There were no significant gender or seasonality interactions. Our study confirmed the hypothesized higher neopterin level in winter. A cross sectional design was our major limitation. If this finding will be replicated by longitudinal studies in multiple groups, neopterin could be used to monitor immune status across seasons in demographically diverse samples, even if heterogeneous in gender distribution, and degree of seasonality of mood.

scholarly journals Test-retest reliability of the Seasonal Pattern Assessment Questionnaire in Old Order Amish

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Ryan M. Kuehner ◽  
Dipika Vaswani ◽  
Uttam K. Raheja ◽  
Aamar Sleemi ◽  
Hassaan Yousufi ◽  
...  
Keyword(s):  
Seasonal Pattern ◽  
Old Order Amish ◽  
Retest Reliability ◽  
Old Order ◽  
Test Retest Reliability ◽  
Assessment Questionnaire

scholarly journals High prevalence of seasonal affective disorder among persons with severe visual impairment

2016 ◽  
Vol 208 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Helle ⊘stergaard Madsen ◽  
Henrik Dam ◽  
Ida Hageman
Keyword(s):  
Visual Impairment ◽  
Affective Disorder ◽  
Seasonal Affective Disorder ◽  
Seasonal Pattern ◽  
Cross Sectional Study ◽  
Light Perception ◽  
Cross Sectional ◽  
High Prevalence ◽  
Assessment Questionnaire ◽  
Light Input

BackgroundLight severely affects the occurrence of seasonal affective disorder (SAD).AimsTo compare the prevalence of SAD in persons with severe visual impairment and persons with full sight, and in persons with severe visual impairment with or without light perception.MethodThis cross-sectional study assessed the Global Seasonality Score (GSS) and the prevalence of SAD among 2781 persons with visual impairment and 4099 persons with full sight using the Seasonal Pattern Assessment Questionnaire (SPAQ).ResultsRespondents with visual impairment had significantly higher GSS and prevalence of SAD compared with full sight controls, P<0.001. Light perception respondents were more vulnerable to seasonal change than both full sight and no light perception respondents.ConclusionsThe study showed a highly significant association between visual impairment and SPAQ-defined SAD parameters, supporting the hypothesis that decreased retinal light input plays a role in the pathogenesis of SAD.

scholarly journals Seasonal sensitivity and psychiatric morbidity: study about seasonal affective disorder

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Aníbal Fonte ◽  
Bruno Coutinho
Keyword(s):  
Affective Disorder ◽  
Seasonal Affective Disorder ◽  
Seasonal Pattern ◽  
Psychiatric Morbidity ◽  
Cross Sectional Study ◽  
Psychiatric Disturbance ◽  
Cross Sectional ◽  
Vocational Courses ◽  
And Behavior ◽  
Assessment Questionnaire

Abstract Background Seasonal Affective Disorder is a recurrent depressive disorder which usually begins in the fall/winter and enters into remission in the spring/summer, although in some cases may occur in the summer with remission in the autumn-winter. In this study the authors evaluated the association between seasonal changes in mood and behavior with psychiatric disturbance. Method Descriptive, cross-sectional study. Participants, students attending higher education and vocational courses (N = 324), were evaluated with the Seasonal Pattern Assessment Questionnaire (SPAQ) and the Screening Scale for Mental Health (ER80). Results Among the respondents, 12.7% showed seasonal affective disorder (SAD), 29.0% showed subsyndromal seasonal affective disorder (s-SAD) and 58.3% did not show significant seasonal affective symptomatology. As for psychiatric morbidity, 36.6% of subjects with SAD and 13.8% of those with s-SAD were considered “psychiatric cases” whereas for subjects without SAD this value was only 3.2%. Conclusions There is a statistically significant association between psychiatric morbidity and seasonal affective disorder. This association corroborates the importance of the Seasonal Pattern Assessment Questionnaire in screening for seasonal fluctuations in mood and behavior related disorders, and the clinical need for recognition of these conditions, particularly associated suffering and disabilities.

scholarly journals A cross-sectional study of factors affecting seasonality in bipolar disorder

2014 ◽  
Vol 20 (2) ◽  
pp. 2 ◽  
Author(s):  
Pankaj Kumar Mittal ◽  
Shubham Mehta ◽  
Ram Kumar Solanki ◽  
Mukesh Kumar Swami ◽  
Parth Singh Meena
Keyword(s):  
Bipolar Disorder ◽  
Seasonal Variations ◽  
Affective Disorders ◽  
Seasonal Pattern ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Behavioural Patterns ◽  
Assessment Questionnaire

<p><strong>Background.</strong> Researchers have evinced interest in the effect of seasonal variations on mood and behavioural patterns in affective disorders. </p><p><strong>Objective. </strong>To study seasonality in bipolar disorder (BD) patients and also the factors affecting this seasonality. </p><p><strong>Method. </strong>Forty-nine patients with BD in euthymic phase were recruited and analysed using<strong> </strong>the<strong> </strong>Seasonal Pattern Assessment Questionnaire and Morningness-Eveningness Questionnaire. </p><p><strong>Results. </strong>Most of the patients were morning types but chronotype had no influence on seasonality. Age of patient and number of episodes were the most important factors affecting seasonality in BD. </p><p><strong>Conclusion. </strong>Seasonality and its influencing factors must be considered while managing bipolar disorder.</p>

scholarly journals Seasonal affective disorder among general practice attenders

2002 ◽  
Vol 180 (5) ◽  
pp. 394-395 ◽  
Author(s):  
Tony Kendrick
Keyword(s):  
Affective Disorder ◽  
Health Care Services ◽  
American Psychiatric Association ◽  
Seasonal Affective Disorder ◽  
Seasonal Pattern ◽  
Care Services ◽  
Primary Health ◽  
Primary Health Care Services ◽  
Dsm Iv ◽  
Assessment Questionnaire

In this issue, Eagles et al report that people suffering from seasonal affective disorder (SAD) are heavy users of primary health care services (Eagles et al, 2002, this issue). Nearly 10% of patients attending practices in Aberdeen screened positive for SAD using the Seasonal Pattern Assessment Questionnaire (SPAQ; Rosenthal et al, 1987), among whom around half of those attending for interview fulfilled DSM–IV (American Psychiatric Association, 1994) criteria for recurrent major depression with seasonal pattern. The patients with SAD had consulted significantly more frequently over a 5-year period, with a variety of symptoms both related and unrelated to SAD, and had received significantly more prescriptions, investigations and referrals than patients found not to fulfil the criteria for SAD.

scholarly journals Positive association between Toxoplasma gondii IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study

Pteridines ◽  
2017 ◽  
Vol 28 (3-4) ◽  
pp. 185-194 ◽  
Author(s):  
Abhishek Wadhawan ◽  
Aline Dagdag ◽  
Allyson Duffy ◽  
Melanie L. Daue ◽  
Kathy A. Ryan ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Behavioral Therapy ◽  
Positive Association ◽  
Unipolar Depression ◽  
Depression Screening ◽  
Enzyme Linked Immunosorbent Assay ◽  
Homogeneous Population ◽  
Old Order Amish ◽  
Old Order ◽  
Screening Questionnaires

AbstractToxoplasma gondii (T. gondii) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have been inconsistent, possibly as a consequence of high heterogeneity. We have now studied this association in a more homogeneous population, [that is (i.e.) Old Order Amish (OOA)] with previously reported high T. gondii seroprevalence. In 306 OOA with a mean age of 46.1±16.7 years, including 191 (62.4%) women in the Amish Wellness Study, we obtained both T. gondii IgG titers (by enzyme-linked immunosorbent assay [ELISA]), and depression screening questionnaires (Patient Health Questionnaire [PHQ-9] [n=280] and PHQ-2 [n=26]). Associations between T. gondii IgG and dysphoria/hopelessness and anhedonia scores on depression screening questionnaires were analyzed using multivariable linear methods with adjustment for age and sex. Serointensity was associated with both current dysphoria/hopelessness (p=0.045) and current combined anhedonia and dysphoria/hopelessness (p=0.043), while associations with simple anhedonia and past/lifelong (rather than current) phenotypes were not significant. These results indicate the need for larger longitudinal studies to corroborate the association between dysphoria/hopelessness and T. gondii IgG-titers. Current hopelessness is a known risk factor for SSDV which responds particularly well to cognitive behavioral therapy, and may be a focused treatment target for T. gondii-positive individuals at high-risk for SSDV.

scholarly journals Seasonal Affective Disorder: An Overview of Assessment and Treatment Approaches

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Sherri Melrose
Keyword(s):  
Affective Disorder ◽  
Seasonal Affective Disorder ◽  
Seasonal Pattern ◽  
Light Therapy ◽  
Early Summer ◽  
Major Depressive ◽  
Assessment And Treatment ◽  
Typical Treatment ◽  
Recurrent Major Depressive Disorder ◽  
Assessment Questionnaire

Seasonal affective disorder or SAD is a recurrent major depressive disorder with a seasonal pattern usually beginning in fall and continuing into winter months. A subsyndromal type of SAD, or S-SAD, is commonly known as “winter blues.” Less often, SAD causes depression in the spring or early summer. Symptoms center on sad mood and low energy. Those most at risk are female, are younger, live far from the equator, and have family histories of depression, bipolar disorder, or SAD. Screening instruments include the Seasonal Pattern Assessment Questionnaire (SPAQ). Typical treatment includes antidepressant medications, light therapy, Vitamin D, and counselling. This paper provides an overview of SAD.

scholarly journals S100A8 and S100A9 in saliva, blood and gingival crevicular fluid for screening periodontitis: a cross-sectional study

2020 ◽  
Author(s):  
Hyun-Duck Kim ◽  
Sandeep Karna ◽  
YooJin Shin ◽  
Huong Vu ◽  
Hyun-Jae Cho ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Characteristic Curve ◽  
Analysis Of Covariance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oral Diseases ◽  
Early Screening ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Crevicular Fluid ◽  
Healthy Participants

Abstract Background: Periodontitis is one of major oral diseases, which has no consensus on early screening tool. This study aimed to compare the association and screening ability of S100A8 and S100A9 in saliva, blood and gingival crevicular fluid (GCF) for periodontitis.Methods: We recruited 149 community Koreans, 50 healthy and 99 periodontitis. Using clinical attachment loss and a panoramic radiograph, stage II-IV of new classification of periodontitis proposed at 2018 was considered as periodontitis. Enzyme linked immunosorbent assay kit was used to quantify S100A8 and S100A9. T-test, analysis of covariance (ANCOVA), Mann-Whitney test and correlation analysis were applied to compare the relationship of S100A8 and S100A9 in saliva, blood, and GCF for periodontitis. Receiver operating characteristic curve was applied for screening ability.Results: Among S100A8 and S100A9 in saliva, blood and GCF, S100A8 in saliva was significantly higher in periodontitis participants than in healthy participants (p<0.05) and showed highest screening ability of 0.73 for periodontitis. However, S100A8 and S100A9 in GCF were significantly higher in healthy participants (p<0.05). Salivary S100A8 was positively correlated to blood S100A8 (r=0.21, p <0.05).Conclusion: Salivary S100A8 could be a potential diagnostic marker for periodontitis. Thus, S100A8 salivary kit will be useful for screening periodontitis.

scholarly journals Differences in levelFms-Like Tyrosine Kinase-1 (sFlt-1), soluble Endoglin (s-Eng), and Placental Growth Factor (PIGF) between Early Onset Preeclampsia and Late Onset Preeclampsia

2018 ◽  
Vol 3 (2) ◽  
pp. 11
Author(s):  
Lita Nafratilova ◽  
Yusrawati Yusrawati ◽  
Irza Wahi
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Intrinsic Factors ◽  
Significant Difference ◽  
The Difference ◽  
Cross Sectional Design ◽  
Early Onset Preeclampsia

Early Onset Preeclampsia (EO-PE) is preeclampsia that develops before 34 weeks 'gestation, caused by intrinsic factors, while Late Onset Preeclampsia (LO-PE) is preeclampsia that develops after 34 weeks' gestation due to extrinsic and maternal factors. There is an increased production of antiangiogenic factors (sFlt-1, s-Eng and PIGF) contribute to pathophysiology of preeclampsia.This study aims to measure the difference of sFlt-1, sEng, PIGF levels between EO-PE and LO-PE. This was an observational study with cross sectional design conducted at Dr. M. Djamil, TK Hospital. III dr. Reksodiwiryo and Biomedical Laboratory FK Unand Padang from August 2017 to August 2018. The sample of this study were 26 severe preeclampsia women : 13 (EO-PE)  and 13 (LO-PE), selected using consecutive sampling. Levels of sFlt-1, sEng, PIGF were examined using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using unpaired t test and Mann-Whitney Test. Results shown that serum levels of sFlt-1 and sEng in (EO-PE)  were 9.51 ± 0.71 ng / L, 1.44 ± 0.06 ng / mL, 5.79 ± 0.42 ng / mL while in PEAL it was 8, 89 ± 0.78 ng / mL, 1.35 ± 0.14 ng / mL, 6.72 ± 0.76. There were a significant difference with a value of p <0.05. The conclusion of this study is that the levels of sFlt-1 and sEng are higher in (EO-PE)  than(LO-PE)and PIGF levels was lower in (EO-PE) compared to (LO-PE)

scholarly journals EFFECT OF PRECONDITIONS AND UNSAFE ACTS ON EVACUATION DURATION IN FIRE DISASTER CONDITIONS (STUDY AT THE INPATIENT BUILDING OF GENERAL HOSPITAL R. KOESMA TUBAN

2021 ◽  
Vol 16 (2) ◽  
pp. 196
Author(s):  
Erwin Era Prasetya ◽  
Denny Ardyanto W ◽  
Hari Basuki Notobroto ◽  
Tjipto Suwandi
Keyword(s):  
General Hospital ◽  
Quantitative Method ◽  
Analysis Of Covariance ◽  
Test Results ◽  
Cross Sectional ◽  
Exercise Habits ◽  
Inpatient Ward ◽  
Fire Disaster ◽  
Cross Sectional Design ◽  
In Fire

ABSTRACTHospital fires have the potential to cause fatalities and huge material losses,  there were 22 hospital fires covered by newspapers in India in 2011-2012 with 102 dead. Buildings are considered safe if all occupants building threatened by fire must be able to exit and assembly point before available safe egress time. This study aimed to analyze the effect of preconditions and unsafe acts (violations of evacuation procedures) on evacuation duration in fire disaster conditions in the inpatient building of general hospital R. Koesma Tuban. This study was an observational study, a quantitative method and cross sectional design, which were carried out in April-July 2019. Analysis of Covariance test results stated preconditions (age, sex, exercise habits, location of inpatient ward, distance traveled) affect the duration of evacuation (p <0.05) while preconditions (interaction between workers and readiness of workers) don’t affect the duration evacuation (p> 0.05). Violation of evacuation procedures has the potential to influence the duration of evacuation (p = 0.054). The conclusions this study are age, gender, exercise habits, location of the inpatient ward, and distance traveled affect the duration of the evacuation. Keywords: Duration of evacuation, preconditions, violations of evacuation procedures, hospital

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