scholarly journals Severe hypovitaminosis D in pregnant refugees arriving in Europe: neonatal outcomes and importance of prenatal intervention

2021 ◽  
Author(s):  
Anna Liori ◽  
Damaskini Polychroni ◽  
Georgios K Markantes ◽  
Maria Stamou ◽  
Sarantis Livadas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Neonatal Health ◽  
Host Countries ◽  
Effective Interventions ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
Prenatal Intervention

Adequate vitamin D levels are particularly important in pregnant women for both the maternal and neonatal health. Prior studies have shown a significantly high prevalence of vitamin D deficiency (VDD) among refugees. However, no study has addressed the prevalence of VDD in pregnant refugees and its effects on neonatal health. In this study, we examined the prevalence of VDD in refugee pregnant women living in Greece and compared our results with Greek pregnant inhabitants. Vitamin D deficiency was frequent in both groups but was significantly more common in refugees (92.2% vs 67.3% of Greek women, p=0.003) with 70.6% of refugees having severe hypovitaminosis D (<10 ng/ml). As a result, most newborns had Vitamin D deficiency, which affected refugee newborns to a greater extent. Our results suggest a need to screen newcomer children and pregnant women for vitamin D deficiency in all host countries around the world. Such a screen will appropriately guide early and effective interventions with the goal to prevent adverse neonatal and maternal outcomes.

scholarly journals A study on vitamin D status among orthopaedic patients

2020 ◽  
Vol 6 (2) ◽  
pp. 286
Author(s):  
Srinivasalu Santhanagopal ◽  
Matthew Sebastian ◽  
Madan Mohan Muniswamy ◽  
Anoop Pilar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Indian Population ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Vitamin D Status ◽  
Orthopaedic Patients ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
Calcium Phosphorus

<p class="abstract"><strong>Background:</strong> There is an alarmingly high prevalence of hypovitaminosis D in orthopaedic patients, regardless of whether or not, they require surgical intervention. Vitamin D plays an essential role in bone formation, maintenance, and remodelling, as well as muscle function and deficiency could affect adversely in multiple ways. Many reports recently demonstrated high rates of vitamin D deficiency, in numerous segments of Indian population, but there is no study reported so far from India, which focuses specifically on vitamin D status in orthopaedic patients.</p><p class="abstract"><strong>Methods:</strong> It is a descriptive study to<strong> </strong>estimate vitamin D levels in patients scheduled to undergo orthopaedic surgery. Vitamin D, calcium, phosphorus and alkaline phosphatase (ALP) levels in 310 patients, who were admitted at our institution, from December 2015 to August 2017 were measured.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 310 patients included in our study, 189 (61%) were males and 121 (39%) females. Vitamin D deficiency (&lt;20 ng/ml) was present in 232 patients, insufficiency (&lt;30 ng/ml) was present in 63 patients and only 15 patients had desirable levels (&gt;30 ng/ml). Patients younger than 60 years and males had more prevalence of Vitamin D abnormality. 168 (72.4%) of the patients, with deficiency presented in winter, compared to 64 (27.6%) in summer.</p><p class="abstract"><strong>Conclusions:</strong> Statistically significant vitamin D deficiency was seen during winter months, in patients undergoing hip hemiarthroplasty, and in patients admitted for degenerative disease of the spine, hip and knee. Screening and treating hypovitaminosis D appears to be important in orthopaedic patients as vitamin D deficiency is prevalent across all age groups in the population studied.</p>

scholarly journals Comparison of Vitamin D Status Between Urban and Rural South Indian Mothers and Their Newborns

2017 ◽  
Vol 36 (3) ◽  
pp. 243-249 ◽  
Author(s):  
K. Jagadish Kumar ◽  
Abhishek Chavan ◽  
K. Shushma ◽  
Srinivasa Murthy
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Rural Population ◽  
Hypovitaminosis D ◽  
Dietary Calcium Intake ◽  
Vitamin D Status ◽  
Urban Mothers ◽  
Vitamin D Levels ◽  
Rural Mothers

Introduction: Though pregnant mothers are at risk of developing Vitamin D deficiency, their level differs among the urban and rural population and has various implications on newborns. This study was undertaken to compare the vitamin D status in urban and rural population of South India among pregnant women and their newborns.Material and Methods: Ninety one pregnant women and their newborns (46 urban and 45 rural) were recruited. Maternal Vitamin D levels and serum concentrations of calcium, phosphorus, alkaline phosphatase and Vitamin D were measured in the cord blood.Results: Eighty two (90%) of the pregnant women, 38 from rural and 44 from urban, had vitamin D deficiency. However, the mean vitamin D levels were low in urban (9.42 ± 12.2) compared to rural women (35.86 ± 16.3,p=0.037).Hypovitaminosis D was noted in 88% of the newborns, deficiency being more in neonates born to urban women. Though the dietary calcium intake was uniformly low, it was lower in rural (960.1 ± 139.9 mg/d) Vs urban mothers (1060.1 ± 150.6 mg/d, p< 0.001). Urban mothers were found to be exposed to sun for lower duration of 0.3 hours compared to rural mothers 0.5 hours. Similarly the surface area of body exposed to sun was lower in urban mothers (7.5%) compared to rural mothers (15%, p=0.0001). A moderate positive correlation between mother-neonate pair was noted.Conclusions: The magnitude of Hypovitaminosis D observed among pregnant women and their newborn warrants public health intervention in terms of vitamin D supplementations during pregnancy.J Nepal Paediatr Soc 2016;36(3):243-249

scholarly journals High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

2021 ◽  
Author(s):  
Linda Ahenkorah Fondjo ◽  
Worlanyo Tashie ◽  
William K. B. A. Owiredu ◽  
Enoch Appiah Adu-Gyamfi ◽  
Laila Seidu
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Sub Saharan Africa ◽  
Enzyme Linked Immunosorbent Assay ◽  
Vitamin D Levels ◽  
In Pregnancy

Abstract Background: Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and pregnancies complicated by preeclampsia, and evaluated the association between vitamin D deficiency and foeto-maternal outcome. Methods: This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25(OH)D using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) and were also estimated. Results: A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels was significantly reduced in the PE women compared to the normotensive pregnant women (p=0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidaemia, evidenced by significantly elevated TC (p=0.008), LDL (p<0.0001), triglycerides (p=0.017) and a significantly reduced HDL (p=0.001) as compared to NP. In the preeclamptic women, serum 25(OH)D showed an inverse, but not significant association with TC (β= -0.087, p=0.464), TG (β= -0.143, p=0.233) and LDL (β= -0.101, p=0.388) and a positive, but not significant association with HDL (β= 0.166, p=0.154). Conclusion: The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy especially in sub-Saharan Africa.

Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

2016 ◽  
Vol 9 (6) ◽  
pp. 3544-3548
Author(s):  
Aya Hallak ◽  
Malhis Mahmoud ◽  
Yaser Abajy Mohammad
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Coronary Syndrome ◽  
Normal Individuals ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

The Prevalence of Vitamin D Deficiency in Iran: A Literature Review

2020 ◽  
Vol 16 (7) ◽  
pp. 1015-1027
Author(s):  
Mohammad Bagherniya ◽  
Zahra Khorasanchi ◽  
Mina S. Bidokhti ◽  
Gordon A. Ferns ◽  
Mitra Rezaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Literature Review ◽  
Vitamin D Deficiency ◽  
Medical Condition ◽  
Scientific Information ◽  
Age Groups ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Vitamin D Levels ◽  
High Prevalence

Background: Vitamin D deficiency is a common medical condition worldwide. In Iran, it has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution in different parts of the country and among different age and regional groups is unclear. Therefore, the aim of this study was to review the recent literature on vitamin D deficiency in Iran. Methods: The literature review was performed using Web of Science, PubMed-Medline, Scopus and Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported vitamin D levels in male and female subjects of all age groups and in healthy populations were included. Results: From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90% and was found in all age groups and in all regions of Iran. Conclusion: This review highlights the very high prevalence of vitamin D deficiency in Iran. It will be important to recognize the importance of vitamin D deficiency as a major public health problem in Iran.

scholarly journals Vitamin D status in pregnant women and their newborns in a tertiary care hospital

2018 ◽  
Vol 7 (12) ◽  
pp. 5071
Author(s):  
Harleen Kour ◽  
Shashi Gupta ◽  
Swarn K. Gupta ◽  
Bawa Ram Bhagat ◽  
Gagan Singh
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Vitamin D Status ◽  
Pregnant Females ◽  
Vitamin D Levels ◽  
Maternal And Newborn

Background: In the recent years there has been an increased understanding of the role that vitamin D plays in regulation of cell growth, calcium absorption and immunity and its impact on the developing fetus and maternal health is of significant concern. This study aims at evaluating the Vitamin D status in pregnant women and their newborns.Methods: A cross sectional study was done on 100 pregnant females according to inclusion and exclusion criteria. At the time of delivery, maternal blood was collected, and newborn samples were taken from newborn side of umbilical cord and sent for analysis.Results: The prevalence of Vitamin D deficiency has been found to be 85% of pregnant females and 91% of the newborns. Only 5% of pregnant females and 1% of the newborns showed Vitamin D sufficiency. Maternal and newborn vitamin D levels show a positive correlation. Mean maternal and newborn Vitamin D levels were found to be 16.78±7.04 ng/mL and 11.29±5.75 ng/ml.Conclusions: Vitamin D deficiency is highly prevalent among pregnant women in north India. Low maternal vitamin D levels lead to vitamin D deficiency in the newborns also.

scholarly journals Vitamin D status and 3-month Glasgow Outcome Scale scores in patients in neurocritical care: prospective analysis of 497 patients

2018 ◽  
Vol 128 (6) ◽  
pp. 1635-1641 ◽  
Author(s):  
Jian Guan ◽  
Michael Karsy ◽  
Andrea A. Brock ◽  
Ilyas M. Eli ◽  
Gabrielle M. Manton ◽  
...  
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Vitamin D Deficiency ◽  
Glasgow Outcome Scale ◽  
Neurocritical Care ◽  
Care Center ◽  
Hypovitaminosis D ◽  
Simplified Acute Physiology Score ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels

OBJECTIVEVitamin D deficiency has been associated with a variety of negative outcomes in critically ill patients, but little focused study on the effects of hypovitaminosis D has been performed in the neurocritical care population. In this study, the authors examined the effect of vitamin D deficiency on 3-month outcomes after discharge from a neurocritical care unit (NCCU).METHODSThe authors prospectively analyzed 25-hydroxy vitamin D levels in patients admitted to the NCCU of a quaternary care center over a 6-month period. Glasgow Outcome Scale (GOS) scores were used to evaluate their 3-month outcome, and univariate and multivariate logistic regression was used to evaluate the effects of vitamin D deficiency.RESULTSFour hundred ninety-seven patients met the inclusion criteria. In the binomial logistic regression model, patients without vitamin D deficiency (> 20 ng/dl) were significantly more likely to have a 3-month GOS score of 4 or 5 than those who were vitamin D deficient (OR 1.768 [95% CI 1.095–2.852]). Patients with a higher Simplified Acute Physiology Score (SAPS II) (OR 0.925 [95% CI 0.910–0.940]) and those admitted for stroke (OR 0.409 [95% CI 0.209–0.803]) or those with an “other” diagnosis (OR 0.409 [95% CI 0.217–0.772]) were significantly more likely to have a 3-month GOS score of 3 or less.CONCLUSIONSVitamin D deficiency is associated with worse 3-month postdischarge GOS scores in patients admitted to an NCCU. Additional study is needed to determine the role of vitamin D supplementation in the NCCU population.

scholarly journals High Prevalence of Vitamin D Deficiency in Pregnant Women: A National Cross-Sectional Survey

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43868 ◽  
Author(s):  
Stefanie Vandevijvere ◽  
Sihame Amsalkhir ◽  
Herman Van Oyen ◽  
Rodrigo Moreno-Reyes
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
High Prevalence

scholarly journals Evaluation of the prevalence of vitamin d deficiency in pregnant women and its correlation with neonatal vitamin D levels

2021 ◽  
Vol 36 ◽  
pp. 91-97
Author(s):  
Masoumeh Ghafarzadeh ◽  
Amir Shakarami ◽  
Fariba Tarhani ◽  
Fatemeh Yari
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D Levels

A prospective analysis of hypovitaminosis D and mortality in 400 patients in the neurocritical care setting

2017 ◽  
Vol 127 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jian Guan ◽  
Michael Karsy ◽  
Andrea A. Brock ◽  
Ilyas M. Eli ◽  
Holly K. Ledyard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critical Care ◽  
Hospital Mortality ◽  
Vitamin D Deficiency ◽  
Neurocritical Care ◽  
Care Center ◽  
Demographic Data ◽  
Hypovitaminosis D ◽  
Vitamin D Levels ◽  
The Impact

OBJECTIVEHypovitaminosis D is highly prevalent among the general population. Studies have shown an association between hypovitaminosis D and multiple negative outcomes in critical care patients, but there has been no prospective evaluation of vitamin D in the neurological critical care population. The authors examined the impact of vitamin D deficiency on in-hospital mortality and a variety of secondary outcomes.METHODSThe authors prospectively collected 25-hydroxy vitamin D levels of all patients admitted to the neurocritical care unit (NCCU) of a quaternary-care center over a 3-month period. Demographic data, illness acuity, in-hospital mortality, infection, and length of hospitalization were collected. Univariate and multivariable logistic regression were used to examine the effects of vitamin D deficiency.RESULTSFour hundred fifteen patients met the inclusion criteria. In-hospital mortality was slightly worse (9.3% vs 4.5%; p = 0.059) among patients with deficient vitamin D (≤ 20 ng/dl). There was also a higher rate of urinary tract infection in patients with vitamin D deficiency (12.4% vs 4.2%; p = 0.002). For patients admitted to the NCCU on an emergency basis (n = 285), higher Simplified Acute Physiology Score II (OR 13.8, 95% CI 1.7–110.8; p = 0.014), and vitamin D deficiency (OR 3.0, 95% CI 1.0–8.6; p = 0.042) were significantly associated with increased in-hospital mortality after adjusting for other factors.CONCLUSIONSIn the subset of patients admitted to the NCCU on an emergency basis, vitamin D deficiency is significantly associated with higher in-hospital mortality. Larger studies are needed to confirm these findings and to investigate the role of vitamin D supplementation in these patients.

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