scholarly journals Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation

Reproduction ◽  
2009 ◽  
Vol 137 (4) ◽  
pp. 749-757 ◽  
Author(s):  
Dale A Redmer ◽  
Justin S Luther ◽  
John S Milne ◽  
Raymond P Aitken ◽  
Mary Lynn Johnson ◽  
...  
Keyword(s):  
Vascular Development ◽  
Nutrient Supply ◽  
Late Gestation ◽  
Fetal Weight ◽  
Dietary Intakes ◽  
Subsequent Reduction ◽  
Placental Development ◽  
Three Stages ◽  
And Function ◽  
Singleton Pregnancies

To establish the basis for altered placental development and function previously observed at late gestation, fetoplacental growth and placental vascular development were measured at three stages of gestation in a nutritional paradigm of compromised pregnancy. Singleton pregnancies to a single sire were established and thereafter adolescent ewes were offered an optimal control (C) or a high (H) dietary intake. At day 50, the H group had elevated maternal insulin and amniotic glucose, whereas mass of the fetus and placenta were unaltered. At day 90, the H group exhibited elevated maternal insulin, IGF1 and glucose; fetal weight and glucose concentrations in H were increased relative to C, but placental weight was independent of nutrition. By day 130, total placentome weight in the H group was reduced by 46% and was associated with lower fetal glucose and a 20% reduction in fetal weight. As pregnancy progressed from day 50 to 130, the parameters of vascular development in the maternal and fetal components of the placenta increased. In the fetal cotyledon, high dietary intakes were associated with impaired vascular development at day 50 and an increase in capillary number at day 90. At day 130, all vascular indices were independent of nutrition. Thus, high dietary intakes to promote rapid maternal growth influence capillary development in the fetal portion of the placenta during early to mid-pregnancy and may underlie the subsequent reduction in placental mass and hence fetal nutrient supply observed during the final third of gestation.

scholarly journals Assisted reproduction causes placental maldevelopment and dysfunction linked to reduced fetal weight in mice

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shuqiang Chen ◽  
Fang-zhen Sun ◽  
Xiuying Huang ◽  
Xiaohong Wang ◽  
Na Tang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Profile ◽  
Reproductive Technology ◽  
Fetal Weight ◽  
Imprinted Genes ◽  
Compelling Evidence ◽  
Placental Development ◽  
Placental Efficiency ◽  
Art Display ◽  
And Function

Abstract Compelling evidence indicates that stress in utero, as manifested by low birth weight (LBW), increases the risk of metabolic syndrome in adulthood. Singletons conceived by assisted reproductive technology (ART) display a significant increase in LBW risk and ART offspring have a different metabolic profile starting at birth. Here, used mouse as a model, we found that ART resulted in reduced fetal weight and placental overgrowth at embryonic day 18.5 (E18.5). The ART placentae exhibited histomorphological alterations with defects in placental layer segregation and glycogen cells migration at E18.5. Further, ART treatments resulted in downregulation of a majority of placental nutrient transporters and reduction in placental efficiency. Moreover, the ART placentae were associated with increased methylation levels at imprinting control regions of H19, KvDMR1 and disrupted expression of a majority of imprinted genes important for placental development and function at E18.5. Our results from the mouse model show the first piece of evidence that ART treatment could affect fetal growth by disrupting placental development and function, suggests that perturbation of genomic imprinting resulted from embryo manipulation may contribute to these problems.

Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions

2020 ◽  
Vol 19 (2) ◽  
pp. 176-192
Author(s):  
Samantha Bedell ◽  
Janine Hutson ◽  
Barbra de Vrijer ◽  
Genevieve Eastabrook
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Obesity ◽  
Environmental Changes ◽  
Current Knowledge ◽  
Therapeutic Interventions ◽  
Placental Development ◽  
Exchange Site ◽  
And Function

: Obesity and gestational diabetes mellitus (GDM) are becoming more common among pregnant women worldwide and are individually associated with a number of placenta-mediated obstetric complications, including preeclampsia, macrosomia, intrauterine growth restriction and stillbirth. The placenta serves several functions throughout pregnancy and is the main exchange site for the transfer of nutrients and gas from mother to fetus. In pregnancies complicated by maternal obesity or GDM, the placenta is exposed to environmental changes, such as increased inflammation and oxidative stress, dyslipidemia, and altered hormone levels. These changes can affect placental development and function and lead to abnormal fetal growth and development as well as metabolic and cardiovascular abnormalities in the offspring. This review aims to summarize current knowledge on the effects of obesity and GDM on placental development and function. Understanding these processes is key in developing therapeutic interventions with the goal of mitigating these effects and preventing future cardiovascular and metabolic pathology in subsequent generations.

scholarly journals A Potential Role and Contribution of Androgens in Placental Development and Pregnancy

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 644
Author(s):  
Agata M. Parsons ◽  
Gerrit J. Bouma
Keyword(s):  
Fetal Development ◽  
Fetal Loss ◽  
Membrane Receptors ◽  
Placental Development ◽  
Placental Function ◽  
Fetal Physiology ◽  
Estrogen Synthesis ◽  
And Function ◽  
Pregnancy Disorders

Successful pregnancy requires the establishment of a highly regulated maternal–fetal environment. This is achieved through the harmonious regulation of steroid hormones, which modulate both maternal and fetal physiology, and are critical for pregnancy maintenance. Defects in steroidogenesis and steroid signaling can lead to pregnancy disorders or even fetal loss. The placenta is a multifunctional, transitory organ which develops at the maternal–fetal interface, and supports fetal development through endocrine signaling, the transport of nutrients and gas exchange. The placenta has the ability to adapt to adverse environments, including hormonal variations, trying to support fetal development. However, if placental function is impaired, or its capacity to adapt is exceeded, fetal development will be compromised. The goal of this review is to explore the relevance of androgens and androgen signaling during pregnancy, specifically in placental development and function. Often considered a mere precursor to placental estrogen synthesis, the placenta in fact secretes androgens throughout pregnancy, and not only contains the androgen steroid nuclear receptor, but also non-genomic membrane receptors for androgens, suggesting a role of androgen signaling in placental function. Moreover, a number of pregnancy disorders, including pre-eclampsia, gestational diabetes, intrauterine growth restriction, and polycystic ovarian syndrome, are associated with abnormal androgen levels and androgen signaling. Understanding the role of androgens in the placenta will provide a greater understanding of the pathophysiology of pregnancy disorders associated with androgen elevation and its consequences.

scholarly journals Modelling the Human Placental Interface In Vitro—A Review

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 884
Author(s):  
Marta Cherubini ◽  
Scott Erickson ◽  
Kristina Haase
Keyword(s):  
Drug Testing ◽  
Cell Types ◽  
In Vitro Models ◽  
Placental Development ◽  
Scientific Challenge ◽  
Induced Pluripotent ◽  
And Function ◽  
And Control

Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fetus, the placenta evolves throughout pregnancy, making it a particularly difficult organ to study. Research into placental development and dysfunction poses a unique scientific challenge due to ethical constraints and the differences in morphology and function that exist between species. Recently, there have been increased efforts towards generating in vitro models of the human placenta. Advancements in the differentiation of human induced pluripotent stem cells (hiPSCs), microfluidics, and bioprinting have each contributed to the development of new models, which can be designed to closely match physiological in vivo conditions. By including relevant placental cell types and control over the microenvironment, these new in vitro models promise to reveal clues to the pathogenesis of placental dysfunction and facilitate drug testing across the maternal–fetal interface. In this minireview, we aim to highlight current in vitro placental models and their applications in the study of disease and discuss future avenues for these in vitro models.

scholarly journals Paternal High Fat Diet and Exercise Differentially Regulate Placental Development and Inflammation in a Sex-Specific Manner in C57BL6/J Mice (P19-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Kate Larson ◽  
Amy Bundy ◽  
Travis Alvine ◽  
James Roemmich
Keyword(s):  
Skeletal Muscle ◽  
Agricultural Research ◽  
Wheel Running ◽  
Fetal Weight ◽  
High Fat ◽  
Placental Development ◽  
Funding Sources ◽  
Service Project ◽  
Diet And Exercise ◽  
Placental Inflammation

Abstract Objectives We have shown that increases in T2D risk in male offspring when the father consumes a high-fat (HF) diet can be normalized when the father also exercises during preconception, and that this protection may occur by epigenetic increases in insulin signaling within offspring skeletal muscle. In our current study, we investigated to determine how paternal HF diet and exercise conditions alter sperm miRNA, fetal weight and placental inflammation. Methods Three-week old male C57BL/6 mice were fed a normal-fat (NF) diet (16% fat) or a HF diet (45% fat) and assigned to either voluntary wheel running exercise or cage activity for 3 months prior to mating with NF diet fed dams. Sperm samples were collected to determine changes in miRNA that may account for the enhanced offspring skeletal muscle responses that helped normalize paternal HF-induced glucose intolerance. Placentae were collected to determine whether changes in sperm miRNA expression differed by amount of placental inflammation. Results Sperm expression of miRNA 193b increased with paternal HF and exercise. In F1 males, placental and fetal weight decreased with HF diet while, in F1 female, paternal HF and exercise had no effect on placental and fetal weights. Paternal HF diet decreased placental IL-6 and TNF-alpha mRNA expression in F1 females, while no effects were observed in F1 male placenta. Conclusions Taken together these data suggest that paternal HF diet has a greater impact on placental development of male fetuses while paternal exercise has greater impact on placental inflammation of female fetuses. For both female and male fetuses, these paternal influences are mediated via sperm miRNA 193b. miR-193b is involved in regulation of the cell cycle and adipogenesis but may have additional functions. Thus, the exact role of sperm miRNA 193b in sex-specific epigenetic transmission of paternal HF diet and exercise on placental and fetal development needs further evaluation. Funding Sources USDA Agricultural Research Service Project #3062-51000-052-00D.

Epigenetics of Placental Development and Function

2014 ◽  
pp. 285-295
Author(s):  
Shuhei Ito ◽  
Mitsuko Hirosawa ◽  
Koji Hayakawa ◽  
Shintaro Yagi ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Placental Development ◽  
And Function

Maturation of cytokine receptors in preparation for birth

2001 ◽  
Vol 29 (2) ◽  
pp. 63-68 ◽  
Author(s):  
I. C. McMillen ◽  
D. C. Houghton ◽  
I. D. Phillips
Keyword(s):  
Cellular Proliferation ◽  
Functional Differentiation ◽  
Nutrient Supply ◽  
Late Gestation ◽  
Specific Expression ◽  
Tissue Specific ◽  
Embryonic And Fetal Development ◽  
Dominant Influence ◽  
Gh Receptors ◽  
Specific Profile

The elucidation of the tissue-specific profile of expression of the prolactin (PRL) and growth hormone (GH) receptors during embryonic and fetal development in a range of species has provided a new impetus for the delineation of the specific roles of the hormone ligands for these receptors in development. During late gestation, there is a requirement to shift from a phase of predominant cellular proliferation, where placental nutrient supply is a dominant influence on organ and body growth, to one of functional differentiation, which is required for independent homoeostasis after birth. In this review we discuss the interactions between the pre-partum increases in cortisol and thyroid hormones and the synthesis, secretion and actions of fetal PRL and GH. We also review the changes that occur in the tissue-specific expression of the PRL and GH receptors before birth which may play an important role in precocial species in the successful transition of the fetus to extra-uterine life.

scholarly journals P32.13: Ultrasound fetal weight estimation in term singleton pregnancies

2010 ◽  
Vol 36 (S1) ◽  
pp. 293-293
Author(s):  
M. Echevarria ◽  
S. Weil ◽  
I. Rodríguez ◽  
C. Comas ◽  
B. Serra
Keyword(s):  
Fetal Weight ◽  
Weight Estimation ◽  
Fetal Weight Estimation ◽  
Singleton Pregnancies

scholarly journals The Ontogeny and Function of Placental Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Jake R. Thomas ◽  
Praveena Naidu ◽  
Anna Appios ◽  
Naomi McGovern
Keyword(s):  
Human Placenta ◽  
Outer Layer ◽  
New Technologies ◽  
Placental Development ◽  
Fetal Health ◽  
Hofbauer Cells ◽  
Recent Developments ◽  
Placental Macrophages ◽  
And Function ◽  
Insight Into

The placenta is a fetal-derived organ whose function is crucial for both maternal and fetal health. The human placenta contains a population of fetal macrophages termed Hofbauer cells. These macrophages play diverse roles, aiding in placental development, function and defence. The outer layer of the human placenta is formed by syncytiotrophoblast cells, that fuse to form the syncytium. Adhered to the syncytium at sites of damage, on the maternal side of the placenta, is a population of macrophages termed placenta associated maternal macrophages (PAMM1a). Here we discuss recent developments that have led to renewed insight into our understanding of the ontogeny, phenotype and function of placental macrophages. Finally, we discuss how the application of new technologies within placental research are helping us to further understand these cells.

scholarly journals STRUKTUR, KATEGORI DAN FUNGSI SOSIAL UNGKAPAN LARANGAN MENGENAI CINTA, PACARAN, DAN MENIKAH DI KENAGARIAN TOBOH SIKALADI KECAMATAN SINTUK TOBOH GADANG KABUPATEN PADANG PARIAMAN

2018 ◽  
Vol 6 (2) ◽  
pp. 181
Author(s):  
Desy Murni MS ◽  
Yenni Hayati ◽  
Zulfadhli Zulfadhli
Keyword(s):  
Social Function ◽  
Human Environment ◽  
Projection System ◽  
Folk Beliefs ◽  
The Public ◽  
The Social ◽  
Social Expression ◽  
Three Stages ◽  
And Function ◽  
Phase Phase

This study aimed to describe the structure and function of social expression of a ban on love, dating, and married in Kenagarian Toboh Sikaladi Kecamatan Sintuk Toboh Gadang Kabupaten Padang Pariaman. The research is a qualitative study using descriptive methods. Background or where the study was conducted in Kenagarian Toboh Sikaladi Sintuk Toboh Tower District of Padang Pariaman district. The informants consist of one main informant and two supportive informants. Data were collected through three stages, namely observation, interview and recording techniques. After that, the data is analyzed by a data inventory phase, phase description of the structure and a social function, stage identifies the data, and reporting stage. Based on the results, it can be concluded that data about people's trust ban expression of love, dating, and married in Kenagarian Toboh Sikaladi Kecamatan Sintuk Toboh Gadang Kabupaten Padang Pariaman found as many as 53 expression. The structure of the people's trust in the public ban Kenagarian Toboh Sikaladi Kecamatan Sintuk Toboh Gadang Kabupaten Padang Pariaman is divided into two forms,ie expression of belief and expression structured two-part folk beliefs structured three parts.The phrase structured ban two parts are found as many as 45 expression, whereas expression of a structured three parts found eight expression. This study included into the category of folk beliefs surrounding human environment of love, courtship, and marriage. The social function of the people's trust ban expression in this research, strengthen religious emotion and conviction found as many as five expressions, fantasy projection system found 31 expression, educate found three expressions, prohibit found 13 expression, and had found a phrase.Keywords: social expression, local beliefs, prohibition

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