On the Miscibility of Nematic Liquid Crystals with Ionic Liquids and Joint Reaction for High Helical Twisting Power Product(s)

Mixtures of nematic liquid crystals (LCs) with chiral ionic liquids (CILs) may find application as active materials for electrically driven broadband mirrors. Five nematic liquid crystal hosts were mixed with twenty three ionic liquids, including chiral ones, and studied in terms of their miscibility within the nematic phase. Phase diagrams of the mixtures with CILs which exhibited twisted nematic phase were determined. Miscibility, at levels between 2 and 5 wt%, was found in six mixtures with cyanobiphenyl-based liquid crystal host—E7. On the other hand, the highest changes in the isotropization temperature was found in the mixtures with isothiocyanate-based liquid crystal host—1825. Occurrence of chemical reactions was found. A novel chiral binaphtyl-based organic salt [N11116][BNDP] was synthesized and, in reaction to the 1825 host, resulted in high helical twisting power product(s). Selectivity of the reaction with the isothiocyanate-based liquid crystal was found.

regCOVID: Tracking publications of registered COVID-19 studies

In response to the COVID-19 pandemic many clinical studies have been initiated leading to the need for efficient ways to track and analyze study results. We expanded our previous project that tracked registered COVID-19 clinical studies to also track result articles generated from these studies. We conducted searches of ClinicalTrials.gov and PubMed to identify articles linked to COVID-19 studies, and developed criteria based on the trial phase, intervention, location, and record recency to develop a prioritized list of result publications. We found 760 articles linked to 419 interventional trials (15.7% of all 2 669 COVID-19 interventional trials as of 15 August 2021), with 418 identified via abstract-link in PubMed and 342 via registry-link in ClinicalTrials.gov. Of the 419 trials publishing at least one article, 123 (29.4%) have multiple linked publications. We used an attention score to develop a prioritized list of all publications linked to COVID-19 trials and identified 58 publications that are result articles from late phase (Phase 3) trials with at least one US site and multiple study record updates. For COVID-19 vaccine trials, we found 69 linked result articles for 40 trials (13.9% of 290 total COVID-19 vaccine trials). Our method allows for the efficient identification of important COVID-19 articles that report results of registered clinical trials and are connected via a structured article-trial link.

Lattice Model of Multilayer Adsorption of Particles with Orientation Dependent Interactions at Solid Surfaces

A simple lattice model has been used to study the formation of multilayer films by fluids with orientation-dependent interactions on solid surfaces. The particles, composed of two halves (A and B) were allowed to take on one of six different orientations. The interaction between a pair of differently oriented neighboring particles was assumed to depend on the degrees to which their A and B parts overlap. Here, we have assumed that the AA interaction was strongly attractive, the AB interaction was set to zero, while the BB interaction was varied between 0 and −1.0. The ground state properties of the model have been determined for the systems being in contact with non-selective and selective walls over the entire range of BB interaction energies between 0 and −1.0. It has been demonstrated that the structure of multilayer films depends on the strengths of surface potential felt by differently oriented particles and the interaction between the B halves of fluid particles. Finite temperature behavior has been studied by Monte Carlo simulation methods. It has been shown that the bulk phase phase diagram is qualitatively independent of the BB interaction energy, and has the swan neck shape, since the high stability of the dense ordered phase suppresses the possibility of the formation of disordered liquid-like phase. Only one class of non-uniform systems with the BB interaction set to zero has been considered. The results have been found to be consistent with the predictions stemming form the ground state considerations. In particular, we have found that a complete wetting occurs at any temperature, down to zero. Furthermore, the sequences of layering transitions, and the structure of multilayer films, have been found to be the same as observed in the ground state.

The Pivot Roadmap: From Dreams to Reality

The objective of this report is to present an actionable programme to bring initial moonshot ideas into fully accomplishable projects, ready to be deployed. It comprises three parts. The first part, namely Section 2, provides a background and development avenues for three broad domains of Caribbean economies, namely electric vehicles, digital transformation, and tourism. The second part breaks down the realisation of moonshot ideas into steps using a comprehensive roadmap, which lays out, in sequential point-by-point form, how to steer the coherent long-term deployment of moonshot ideas into concrete actionable projects. Sections 3.1 (From Dreams to Deployment) and 3.2 (Overview of Sequential Tasks by Stakeholder Category) present this in detail. Finally, in the third part, Sections 3.3 and 3.4 define and illustrate the roadmap of moonshot ideas identified during the PIVOT Event. In elaborating these two sections, key emphasis was put on the tasks to be conducted during the preparedness phase (Phase 2 of the roadmap). The conclusion summarizes all dimensions of the roadmap into three illustrations, one for each domain, depicting all nine moonshots from the PIVOT Event.

Environmental Assessment of Furrow vs. Drip Irrigated Pear (Pyrus bretschneideri Rehd.) Production Systems in Loess Plateau (China)

Irrigation systems increase fruit yield of water shortage orchards in semiarid and arid lands, but their environmental impacts remain unclear. This study carries out a comparative cradle-to-gate life cycle assessment (LCA) of the furrow and drip irrigated pear production systems in the Loess Plateau of China based on 2009–2018 inventory data from integrated experimental stations. The water depletion (WD), water footprint (WF), global warming (GWP), acidification (AP), and eutrophication (EP) potentials of the furrow and drip irrigated pear production systems were calculated and compared, including the orchard installation phase (phase I), primary growing phase (phase II), low production phase (phase III), and full production phase (phase IV). Results indicated that the cumulative WD, GWP, AP, and EP of the drip irrigated system were 148.3 m3, 130.1 kg CO2-eq, 0.9 kg SO2-eq, and 0.6 kg PO4-eq per ton of pear fruit harvest, respectively, which were 37.3–73.5% lower than those of the furrow irrigated system. The GWP, AP, EP, and WD of phase I to III contributed 39.3–46.1% in the drip irrigated system vs. 27.8–38.6% in the furrow irrigated system of the total amount, which should not be neglected in perennial orchard systems. The annual WFs were 0.9, 0.2, and 0.2 m3 kg−1 year−1 in phases II, III, and IV of the drip system, respectively, which were 50–71.4% lower than that of the furrow system. Green WF of furrow and drip irrigated systems were approximately the same, but the blue WF and grey WF of drip irrigation systems were 35.7–62.1% and 66.0–73.2% lower than those of the furrow irrigated system. The drip irrigated pear production system significantly mitigated environmental impacts and WFs, mainly due to reduced fertilizer application, water consumption, electricity, and diesel demand. Irrigation that changed from a furrow to a drip system was responsible for most environmental reductions, but 8% decreases of yields in phase IV. The outcomes from assessing the furrow and drip irrigated pear production systems could provide useful information for decision-making by the pear orchardists in the Loess Plateau.

Design and analysis 5G mobile network model to enhancement high-density subscribers

To obtain a high data rate that is commensurate with the growing demand for internet services, the fifth generation (5G) cellular networks will use the bandwidth beyond 6 GHz, called millimeters waves (mm-waves), to obtain a higher. The first phase (phase I) of the 5G network design for high user density, where the optimized microcells are deployed at carrier frequency 700 MHz with 20 MHz bandwidth. The second phase (phase II) of the design consists of the deployment of microcells which are operating at 3.6 GHz with 100 MHz bandwidth; this phase is planned to cover 200000 users within the province. The third phase (phase III) of the design is represented by the deployment of picocells, which are planned to operate at 26 GHz frequency and bandwidth 500 MHz; this phase is planned to cover 3,500,000 users within the province. Two types of modulation are adopted for the network (orthogonal frequency division multiplexing (OFDM) and 256 quadrature amplitude modulation (QAM)); the overall performance of the network is studied with regards to the percentage of coverage, power overlapping ratio, frequency interference, and quality of service (QoS).

Linear causal filtering: definition and theory

This work provides a framework based on multivariate autoregressive modeling for linear causal filtering in the sense of Granger. In its bivariate form, the linear causal filter defined here takes as input signals A and B, and it filters out the causal effect of B on A, thus yielding two new signals only containing the Granger-causal effect of A on B. In its general multivariate form for more than two signals, the effect of all indirect causal connections between A and B, mediated by all other signals, are accounted for, partialled out, and filtered out also. The importance of this filter is that it enables the estimation of directional measures of causal information flow from any non-causal, non-directional measure of association. For instance, based on the classic coherence, a directional measure of strength of information flow from A to B is obtained when applied to the linear causal filtered pair containing only A to B connectivity information. This particular case is equivalent to the isolated effective coherence (doi.org/10.3389/fnhum.2014.00448). Of more recent interest are the large family of phase-phase, phase-amplitude, and amplitude-amplitude cross-frequency coupling measures which are non-directional. The linear causal filter makes it now possible to estimate the directional causal versions these measures of association. One important field of application is in brain connectivity analysis based on cortical signals of electric neuronal activity (e.g. estimated sources of EEG and MEG, and invasive intracranial ECoG recordings). The linear causal filter introduced here provides a novel solution to the problem of estimating the direction of information flow from any non-directional measure of association. This work provides definitions, non-ambiguous equations, and clear prescriptions for implementing the linear causal filter in diverse settings.

The metastable brain associated with autistic-like traits of typically developing individuals

Metastability in the brain is thought to be a mechanism involved in dynamic organization of cognitive and behavioral functions across multiple spatiotemporal scales. However, it is not clear how such organization is realized in underlying neural oscillations in a high-dimensional state space. It was shown that macroscopic oscillations often form phase-phase coupling (PPC) and phase-amplitude coupling (PAC) which result in synchronization and amplitude modulation, respectively, even without external stimuli. These oscillations can also make spontaneous transitions across synchronous states at rest. Using resting-state electroencephalographic signals and the autism-spectrum quotient scores acquired from healthy humans, we show experimental evidence that the PAC combined with PPC allows amplitude modulation to be transient, and that the metastable dynamics with this transient modulation is associated with autistic-like traits. In individuals with a longer attention span, such dynamics tended to show fewer transitions between states by forming delta-alpha PAC. We identified these states as two-dimensional metastable states that could share consistent patterns across individuals. Our findings suggest that the human brain dynamically organizes inter-individual differences in a hierarchy of macroscopic oscillations with multiple timescales by utilizing metastability.

Phase-based cortical synchrony is affected by prematurity

Inter-areal synchronization by phase-phase correlations (PPC) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography (EEG) to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner suggesting early functional biomarkers of later neurodevelopmental compromise to be used in clinical and translational studies after early neonatal adversity.