scholarly journals Comparative analysis of anti-cellulite market products containing vegetal cosmetic assets

2019 ◽  
Vol 3 (1) ◽  
pp. 26-30
Author(s):  
Carla Aparecida Pedriali Moraes
Keyword(s):  
Scientific Literature ◽  
Raw Materials ◽  
Centella Asiatica ◽  
Horse Chestnut ◽  
Active Ingredients ◽  
Hedera Helix ◽  
Lipolytic Action ◽  
Cosmetic Formulations ◽  
Poor Nutrition ◽  
Inflammatory Action

Introduction: Cellulite is characterized by a weakness of the fascia which accumulates fat lobules alongside irregular lobular hypertrophy that causes skin dimpling and occurs mostly in women after puberty. Cellulite may arise from a sum of different conditions, such as emotional alterations, genetics, sedentary lifestyle, hormones, weight gain and poor nutrition. There are several techniques designed to prevent and treat cellulite, but consumers prefer topical lotions and creams due to them being more affordable. This work aimed to review studies published in scientific literature on major plant-based active ingredients used in anti-cellulite formulations commonly available to consumers. Methodology: Nine formulations available to consumers were reviewed: 3 from Brazilian companies, 3 from US companies and 3 from European companies. Results and discussion: The main active ingredients found in products claiming to reduce cellulite damage are: asiaticoside (obtained from Centella asiatica), Saponin (found in horse chestnut), Hedera helix (found in ivy), and caffeine. Conclusion: There is a great diversity and vegetal assets; however, the most used are caffeine, for its lipolytic action, centella asiatica for presenting its anti-inflammatory action, ivy for improving circulation due to its action of vasoconstrictor and chestnut India that helps in strengthening vessels. Cosmetics are often used as a co-adjuvant of other techniques, such as modeling massage and ultrasound, which makes the active more easily penetrate the skin. Similar raw materials are incorporated into the cosmetic formulations with the skin, which will hydrate it, thus facilitating the penetration of the active substance into the skin.

Fruit and berry raw materials is a promising source of food ingredients for flour confectionery.

2020 ◽  
Vol 29 (11) ◽  
pp. 45-49
Author(s):  
L.N. Fedyanina ◽  
◽  
E.S. Smertina ◽  
V.A. Lyakh ◽  
A.E. Elizarova ◽  
...  
Keyword(s):  
Dietary Fiber ◽  
Scientific Literature ◽  
Consumer Demand ◽  
Raw Materials ◽  
Plant Materials ◽  
Food Ingredients ◽  
Promising Source

The article considers the problem of improving the range of confectionery from the standpoint of use plant materials of satisfaction by consumer demand in dieteticpreventive foods. The analysis of domestic and foreign scientific literature on promising directions of improving the range of dietetic-preventive confectionery is given. It is noted that in the recipes for flour confectionery introduced from non-traditional raw materials containing dietary fiber.

scholarly journals Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis

2010 ◽  
Vol 46 (1) ◽  
pp. 129-134 ◽  
Author(s):  
Mariana Mandelli de Almeida ◽  
Cibele Rosana Ribeiro de Castro Lima ◽  
Joyce Santos Quenca-Guillen ◽  
Elder Moscardini Filho ◽  
Lucildes Pita Mercuri ◽  
...  
Keyword(s):  
Thermal Analysis ◽  
Raw Materials ◽  
Skin Aging ◽  
Tocopheryl Acetate ◽  
Stability Evaluation ◽  
Scanning Calorimetry ◽  
Cosmetic Formulations ◽  
Cosmetic Formulation ◽  
Excellent Tool

In view of the increase in the number of cosmetic preparations containing antioxidant vitamins, chiefly, due to their action in preventing the process of skin aging, there is a need to develop pre-formulation studies and to validate analytical methods in order to obtain high quality products. Thus, the objective of this research was to evaluate and compare the thermal behavior of tocopheryl acetate and ascorbyl tetraisopalmitate as raw materials, and incorporated into a base cream. Thermogravimetry (TG / DTG) and differential scanning calorimetry (DSC) were used for this purpose. Both vitamins were found to be stable up to 250ºC. The base cream (placebo) and the sample (base cream containing the vitamins) presented different weight loss. Thermal analysis has shown itself to be an excellent tool for the characterization of these vitamins and can be used in routine analysis for quality control of this type of cosmetic formulation.

scholarly journals Cryogenic technologies in biology and medicine

2020 ◽  
Vol 2020 (2b) ◽  
pp. 129-134
Author(s):  
O.I. Ossetsky ◽  
◽  
O.S. Snurnikov ◽  
Keyword(s):  
Public Health ◽  
Food Industry ◽  
Raw Materials ◽  
Biologically Active ◽  
Whole Body ◽  
Active Ingredients ◽  
Lipid Fractions ◽  
The World ◽  
New Generation

Cryogenic technologies in biology and medicine Current tendencies of the development of cryogenic technologies in the world practice and in Ukraine have been comparatively analyzed. A special attention has been paid to cryotechnologies in biology and medicine. The features of deriving the biologically active ingredients of natural raw materials by means of cryosublimation fractionation and extraction of lipid fractions with liquefied refrigerants, as well as perspectives of their application when obtaining the products of new generation in pharmacy, cosmetics, food industry have been considered. There were discussed the possibilities of human whole body extreme cryotherapy. Main aspects of its usage in practical public health have been considered.

scholarly journals Φαρμακοκινητικές αλληλεπιδράσεις φαρμάκων με φυτοθεραπευτικά σκευάσματα

2012 ◽  
Author(s):  
Μάριος Σπανάκης
Keyword(s):  
Aloe Vera ◽  
Rhodiola Rosea ◽  
Crocus Sativus ◽  
Horse Chestnut ◽  
Evening Primrose Oil ◽  
Hedera Helix ◽  
Evening Primrose ◽  
Agnus Castus

Τα φυτοθεραπευτικά σκευάσματα (φυτικά φαρμακευτικά προϊόντα) αποτελούν σκευάσματα τα οποία περιέχουν ως συστατικά ενώσεις φυτικής προέλευσης ή τμήματα φυτικού υλικού. Τα φυτοθεραπευτικά σκευάσματα χαρακτηρίζονται και διατίθενται ως συμπληρώματα διατροφής ή σκευάσματα συμπληρωματικών - εναλλακτικών θεραπειών. Τα τυποποιημένα φυτικά φαρμακευτικά προϊόντα γενικά χαρακτηρίζονται ως ασφαλή σκευάσματα, παρόλα αυτά, η ταυτόχρονη χρήση τους κατά τη λήψη συμβατικής θεραπευτικής αγωγής από ασθενείς πρέπει να λαμβάνεται υπόψη για την αποφυγή πιθανών προβλημάτων όσον αφορά την αποτελεσματικότητα και την ασφάλεια των λαμβανόμενων συμβατικών φαρμάκων. Σκοπός της παρούσας διατριβής ήταν να μελετήσει τo ενδεχόμενο πρόκλησης φαρμακοκινητικών αλληλεπιδράσεων μεταξύ φαρμάκων και τυποποιημένων φυτοθεραπευτικών σκευασμάτων καθώς και να εκτιμήσει την κλινική σημασία τους. Η μελέτη επικεντρώθηκε στην εκκριτική λειτουργία της Ρ-γλυκοπρωτεΐνης (P-gp), η οποία διαδραματίζει σημαντικό ρόλο στην απορρόφηση φαρμάκων από το έντερο καθώς και στο μεταβολισμό από τα κυτοχρώματα Ρ-450 (CYPs) τα οποία παίζουν σημαντικό ρόλο στο μεταβολισμό των φαρμάκων. Η επίδραση των φυτοθεραπευτικών εκχυλισμάτων μελετήθηκε όσον αφορά την εκκριτική λειτουργία της Ρ-γλυκοπρωτεΐνης στα Caco-2 κύτταρα εκτιμώντας το φαινόμενο συντελεστή διαπερατότητας της ροδαμίνης-123. Η μεταβολική δραστηριότητα των ανασυνδυασμένων CYPs μελετήθηκε με τη χρήση προτύπων φαρμάκων όπως της φαινακετίνης από το CYP1A2, της S-βαρφαρίνης από το CYP2C9 και της δεξτρομεθορφάνης από το CYP2D6 και CYP3A4. Για την ποσοτικοποίηση των προτύπων ενώσεων και των μεταβολιτών τους αναπτύχθηκαν και επικυρώθηκαν αξιόπιστες SIM GC/MS και HPLC/UV βιοαναλυτικές μέθοδοι. Τα αποτελέσματα των in vitro πειραμάτων αναλύθηκαν περαιτέρω με την εφαρμογή της πλατφόρμας πληθυσμιακής φαρμακοκινητικής Simcyp® για να εκτιμηθεί η πιθανή κλινική σημασία των αποτελεσμάτων τα οποία θα αιτιολογούσαν τη διενέργεια μιας in vivo μελέτης φαρμακοκινητικής αλληλεπίδρασης μεταξύ ενός φυτοθεραπευτικού σκευάσματος και της λοσαρτάνης που αποτελεί υπόστρωμα της P-gp και μεταβολίζεται από τα CYP2C9 και CYP3A4. Τα τυποποιημένα φυτοθεραπευτικά σκευάσματα που επιλέχθηκαν να μελετηθούν στην παρούσα εργασία ήταν τα: Agnus castus, Aloe vera, Artichoke, Crocus sativus, Evening primrose oil, Ginseng, Guarana, Hawthorn, Hedera helix, Horse chestnut, Lobelia, Rhodiolarosea and Senna. Τα αποτελέσματα των επωάσεων με τα Caco-2 κύτταρα και τα ανασυνδυασμένα CYPs έδειξαν ότι τα φυτοθεραπευτικά σκευάσματα Rhodiola rosea, Artichoke, Agnus castus, Ginseng και Senna επηρέασαν περισσότερο από όλα την εκκριτική λειτουργία της P-gp και το μεταβολισμό μέσω των CYPs. Τα αποτελέσματα από το Simcyp® έδειξαν ότι τα σκευάσματα της Rhodiola rosea και του Artichoke παρουσίασαν το μεγαλύτερο ενδιαφέρον για περαιτέρω διερεύνηση σε επίπεδο κλινικών μελετών για πιθανές φαρμακοκινητικές αλληλεπιδράσεις με φάρμακα που αποτελούν υποστρώματα της P-gp και των CYPs. Η in vivo φαρμακοκινητική μελέτη που διερεύνησε την αλληλεπίδραση της λοσαρτάνης με το σκεύασμα της Rhodiola rosea επιβεβαίωσε σε ένα βαθμό τα in vitro αποτελέσματα και τις εκτιμήσεις από το Simcyp®.

scholarly journals An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

2020 ◽  
Vol 21 (7) ◽  
pp. 2285 ◽  
Author(s):  
Alessandra Durazzo ◽  
Amirhossein Nazhand ◽  
Massimo Lucarini ◽  
Atanas G. Atanasov ◽  
Eliana B. Souto ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Scientific Literature ◽  
Experimental Studies ◽  
Active Ingredients ◽  
Research Strategies ◽  
Absorption Enhancers ◽  
Literature Research ◽  
Safety Aspects ◽  
Area Of Interest

Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved therapeutic/nutraceutical outcomes. The focus of this work is nanoprebiotics and nanoprobiotics, terms which stand for the loading of a set of compounds (e.g., prebiotics, probiotics, and synbiotics) in nanoparticles that work as absorption enhancers in the gastrointestinal tract. In this manuscript, the main features of prebiotics and probiotics are highlighted, together with the discussion of emerging applications of nanotechnologies in their formulation. Current research strategies are also discussed, in particular the promising use of nanofibers for the delivery of probiotics. Synbiotic-based nanoparticles represent an innovative trend within this area of interest. As only few experimental studies on nanoprebiotics and nanoprobiotics are available in the scientific literature, research on this prominent field is needed, covering effectiveness, bioavailability, and safety aspects.

scholarly journals Alkaloids in the pharmaceutical industry: Structure, isolation and application

2003 ◽  
Vol 57 (10) ◽  
pp. 471-478
Author(s):  
Milan Nikolic ◽  
Sinisa Djordjevic
Keyword(s):  
Pharmaceutical Industry ◽  
Raw Materials ◽  
Ergot Alkaloids ◽  
New Drugs ◽  
Practical Reasons ◽  
Active Ingredients ◽  
Active Components ◽  
Partial Synthesis ◽  
Purine Derivative

By the end of the 18th and the beginning of the 19th century a new era began in medicine, pharmaceutics and chemistry that was strongly connected with alkaloids and alkaloid drugs. Even before that it was known that certain drugs administered in limited doses were medicines, and toxic if taken in larger doses (opium, coke leaves, belladonna roots, monkshood tubers crocus or hemlock seeds). However, the identification, isolation and structural characterization of the active ingredients of the alkaloid drugs was only possible in the mid 20th century by the use of modern extraction equipment and instrumental methods (NMR, X-ray diffraction and others).In spite of continuing use over a long time, there is still great interest in investigating new drugs, potential raw materials for the pharmaceutical industry, as well as the more detailed investigation and definition of bio-active components and the indication of their activity range, and the partial synthesis of new alkaloid molecules based on natural alkaloids. The scope of these investigations, especially in the field of semi-synthesis is to make better use of the bio-active ingredients of alkaloid drugs, i.e. to improve the pharmacological effect (stronger and prolonged effect of the medicine, decreased toxicity and side effects), or to extend or change the applications. A combined classification of alkaloids was used, based on the chemical structure and origin, i.e. the source of their isolation to study alkaloid structure. For practical reasons, the following classification of alkaloids was used: ergot alkaloids, poppy alkaloids, tropanic alkaloids purine derivative alkaloids, carbon-cyclic alkaloids, and other alkaloids. The second part of this report presents a table of general procedures for alkaloid isolation from plant drugs (extraction by water non-miscible solvents, extraction by water-miscible solvents and extraction by diluted acid solutions). Also, methods for obtaining chelidonine and glaucine as hydrochloride bases and salts were presented in more details. Data from leading world pharmacopoeias (Ph. Eur. Ill/s 2000, DAB 1996, USP 23, JP XIII, BP 1993, Ph. Jug. IV) were used in the study of application of the pure alkaloids in pharmaceutical forms with predetermined doses. A comparative study of these data shows that a great number of preparations are produced worldwide based on alkaloids and alkaloids with modified structure. These medicines have found use in modern therapeutic practice in many countries. Most products are produced on the basis of caffeine, theophylline, ephedrine, atropine, scopolamine, reserpine and pilocarpine.

scholarly journals Innovative approaches in the technology of preparations on a basis of cholagogae species

2011 ◽  
Vol 10 (5) ◽  
pp. 167-173
Author(s):  
V. S. Chuchalin ◽  
Ya. I. Abramova ◽  
V. V. Sheykin ◽  
Ye. M. Teplyakova
Keyword(s):  
Herbal Medicine ◽  
Plant Species ◽  
Intermediate Product ◽  
Control Method ◽  
Raw Materials ◽  
Innovative Product ◽  
Bioactive Substances ◽  
Tablet Form ◽  
Effective Technology ◽  
Inflammatory Action

The technology of a tablet form of herbal medicine on the base of a standardized extractive complex is developed. It is possessed of well-defined cholagogae, antispasmodic and anti-inflammatory action. This development is an innovative product, which represent an alternative of officinal plant species (traditional and imperfect form) and constitutes an effective technology of bioactive substances extraction from the plant species. It is a rational mixture and technology of tablet form as well as a control method of raw materials, an intermediate product and a standardization of a final product too.

scholarly journals Members of the family Lamiaceae Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugs

2020 ◽  
Vol 8 (1) ◽  
pp. 4-28
Author(s):  
Е. V. Zvezdina ◽  
J. V. Dayronas ◽  
I. I. Bochkareva ◽  
I. N. Zilfikarov ◽  
E. Yu. Babaeva ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Scientific Literature ◽  
Raw Materials ◽  
Neurotropic Activity ◽  
Biologically Active ◽  
Plant Materials ◽  
Plant Raw Materials ◽  
Pharmaceutical Substances ◽  
The Family ◽  
Active Substances

The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family Lamiaceae L., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.Materials and methods. For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the family Lamiaceae (Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.Results. When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of the Lamiaceae family, remains unrealized despite the close attention of various researchers.Conclusion. This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.

Historical experience and prospects of using quince fruit in medicine

2021 ◽  
pp. 9-15
Author(s):  
Darya Aleksandrovna Koshman ◽  
Anastasiya Evgenievna Sayapina ◽  
Nadezhda Viktorovna Nesterova
Keyword(s):  
Medical Practice ◽  
Food Industry ◽  
Scientific Literature ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Historical Experience ◽  
Active Substances

In this article, a study of the scientific literature was conducted, proving the prospects of using in medical practice a plant widely used in the food industry — common quince. Despite its popularity and a large number of studies proving the presence of valuable biologically active substances in the raw materials of this plant, today, it is not medicinal and is not used in medicine and pharmacy, due to the lack of necessary regulatory documentation.

Evaluation of the EYTEX™ System as a Screening Method for Ocular Tolerance: Application to Raw Materials and Finished Products

1992 ◽  
Vol 20 (3) ◽  
pp. 466-470
Author(s):  
Pascal Courtellemont ◽  
Patrice Hebert ◽  
Gerard Redziniak
Keyword(s):  
Raw Materials ◽  
Screening Method ◽  
Alternative Methods ◽  
Clinical Tests ◽  
Excellent Correlation ◽  
Internal Validation ◽  
Ocular Irritation ◽  
Cosmetic Formulations

In vitro evaluation of ocular irritation requires the use of a battery of tests, for example cell culture assays and the HET-CAM test. In order to check the field applications of the different methods and their complementation, we have studied the EYTEX™ physicochemical model in an internal validation study. In this study, we compared the EYTEX™ results with the in vitro ocular irritation potencies of 52 formulations and 49 chemicals. The in vivo/in vitro correlation was highly significant, p < 0.01%, K = 0.8 (Kappa method). On the other hand, the concordance, sensitivity and specificity of this method were, 85%, 89% and 83% respectively. The compatability of 98% obtained showed the kit to be applicable to cosmetic formulations. The EYTEX™ system has also been evaluated during a comparative study of EYTEX™ human clinical tests, performed on 12 finished products; we have observed a concordance equal to 92%, indicating an excellent correlation between the two methodologies. These results suggest that the EYTEX™ test could be a reliable in vitro prescreening system for determining the eye irritation potential of cosmetic formulations, and that it should be accepted as a component of our battery of alternative methods.

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