scholarly journals THE INFLUENCE OF METISEVIT AND METIFEN ON THE INTENSITY OF LIPID PER OXIDATION IN THE BLOOD OF BULLS ON NITRATE LOAD

2016 ◽  
Vol 18 (3(70)) ◽  
pp. 67-71 ◽  
Author(s):  
B.V. Gutyj ◽  
D.F. Hufriy ◽  
V.M. Hunchak ◽  
I.I. Khariv ◽  
N.D. Levkivska ◽  
...  
Keyword(s):  
The Body ◽  
Oxidation Products ◽  
Depressing Effect ◽  
Chain Reaction ◽  
Diene Conjugates ◽  
Inactive Compound ◽  
Nitrite Toxicity ◽  
Nitrate Load ◽  
Young Cattle ◽  
A Chain

The level of primary and secondary lipid per oxidation products were investigated: diene conjugates and malondialdehyde in conditions of nitrate loading. It was established that at bulls feeding with sodium nitrite at a dose of 0.2 hNO3ˉ/kg of body weight, the level of diene conjugates and malondialdehyde in their was increased during the entire the experiment. On the 30thday of the experiment the level of diene conjugates in blood of bull, which were conducted with nitrate load was 7.44 ± 0.15 mmol/l, and the level of malondialdehyde – 0.305 ± 0.014 mmol/l.Under conditions of nitrate load , young cattle was used a new integrated drug «Metisevit», which consists of sodium selenite, vitamin E and metifen. It was found the stimulating effect of metifen and metisevit on antioxidant system of the body of young cattle. Depressing effect of metifen and metisevit on the processes and lipid per oxidation in the blood of bulls under conditions of chronic nitrate–nitrite toxicity. Metifen and metisevit interact with radicals of fatty acids and delay the development of a chain reaction of oxidative stress, reduce the oxidation of phospholipids and form a biologically inactive compound with products of per oxidation of fats. Obtained results of the research indicate antioxidant drugs «Metisevit» and «Metifen» in the application of their young cattle.The mentioned changes are occurring through the comprehensive action of the drug components «Medisvit», that leads to the normalization of metabolic processes and free radical in the body of bulls. Obtained results of the research indicate the antioxidant action of the drugs «Metisevit» and «Metifen» in the application of their young cattle and the reasonableness of their administration to improve the antioxidant status of the organism according to nitrate loading.

scholarly journals Способи корекції біохімічних змін в організмі тварин за умов розвитку хронічного нітратно-нітритного токсикозу

2013 ◽  
pp. 180-184
Author(s):  
Х. Я. Леськів
Keyword(s):  
Biochemical Parameters ◽  
The Body ◽  
Nitrite Toxicity ◽  
Nitrate Load ◽  
Experimental Pigs

Розкритий вплив нітратного навантаження на біохімічні показники крові поросят, а також за-пропоновані способи корекції патогенезу токсико-зу наступними антиоксидантами: «Фенароном», «Метіфеном» та «Метіоніном». Застосування поросятам в умовах розвитку нітратно-нітратного токсикозу «Метіоніну», «Фенарону» та «Метіфену» сприяло нормалізації морфологіч-них і біохімічних показників крові піддослідних поросят. Кращу нормалізуючу дію на організм поросят, яким здійснювали нітратне наванта-ження, проявляв «Метіфен» у дозі 0,9 мг/кг. The effects of nitrate load on the biochemical blood of pigs were disclosed, as well as methods of correction of the pathogenesis of toxicity in antioxidants were proposed. The use of methionine, fenaron and metifen at pigs in the development of nitrate-nitrite toxicity contributed to the normalization of morphological and biochemical parameters of blood of experimental pigs. Best normalizing effect on the body of pigs, which carried nitrate load metifen showed a dose of 0.9 mg/kg.

scholarly journals SOME FEATURES OF DIFFERENTIATION OF CONCENTRATION OF DIENE CONJUGATES IN BLOOD SERUM AND TISSUE OF RATS

2021 ◽  
pp. 12-15
Author(s):  
Ol'ga Nikolaevna Gulenko ◽  
Viktor Valerievich Leonov ◽  
Anna Aleksandrovna Fedotova ◽  
Elena Vladimirovna Dvoriankina ◽  
Olga Nikolaevna Pavlova
Keyword(s):  
Blood Serum ◽  
The Body ◽  
Oxidation Products ◽  
Diene Conjugates ◽  
Internal Factors ◽  
Factors Affecting ◽  
Organ Systems ◽  
Intermediate Oxidation ◽  
Relationship Of ◽  
Nonparametric Correlation

One of the mechanisms for maintaining homeostasis in the body is lipid peroxidation (LPO). The influence of external and internal factors affecting the body can change the dynamics of LPO processes, causing numerous disorders in the functioning of organ systems. The dynamics of LPO processes in the early stages can be estimated from the change in the concentration of intermediate oxidation products - diene conjugates (DC). The purpose of our study was to identify the features of the differentiation of the distribution of the concentration of diene conjugates in the blood serum and tissues of white outbred rats. New results of nonparametric correlation analysis are presented to assess the relationship of the distribution of the concentration of diene conjugates in the blood serum and tissues of white outbred rats.

Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen

1963 ◽  
Vol 10 (02) ◽  
pp. 400-405 ◽  
Author(s):  
B. A Amundson ◽  
L. O Pilgeram
Keyword(s):  
Blood Coagulation ◽  
Methyl Ether ◽  
Broad Spectrum ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Steroid Metabolism ◽  
Specific Site ◽  
Chain Reaction ◽  
Normal Human ◽  
A Chain

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

scholarly journals Pathogenesis and Management of COVID-19

2021 ◽  
Vol 11 (2) ◽  
pp. 77-93
Author(s):  
Khalid O. Alfarouk ◽  
Sari T. S. AlHoufie ◽  
Samrein B. M. Ahmed ◽  
Mona Shabana ◽  
Ahmed Ahmed ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Human Body ◽  
Inflammatory Mediators ◽  
Expression Patterns ◽  
Multiple Organ ◽  
Cytokine Storm ◽  
Chain Reaction ◽  
Road Map ◽  
A Chain ◽  
Global War

COVID-19, occurring due to SARS-COV-2 infection, is the most recent pandemic disease that has led to three million deaths at the time of writing. A great deal of effort has been directed towards altering the virus trajectory and/or managing the interactions of the virus with its subsequent targets in the human body; these interactions can lead to a chain reaction-like state manifested by a cytokine storm and progress to multiple organ failure. During cytokine storms the ratio of pro-inflammatory to anti-inflammatory mediators is generally increased, which contributes to the instigation of hyper-inflammation and confers advantages to the virus. Because cytokine expression patterns fluctuate from one person to another and even within the same person from one time to another, we suggest a road map of COVID-19 management using an individual approach instead of focusing on the blockbuster process (one treatment for most people, if not all). Here, we highlight the biology of the virus, study the interaction between the virus and humans, and present potential pharmacological and non-pharmacological modulators that might contribute to the global war against SARS-COV-2. We suggest an algorithmic roadmap to manage COVID-19.

Influence of initiation mode on stability and control of a chain reaction

1980 ◽  
Vol 20 (18) ◽  
pp. 1197-1204 ◽  
Author(s):  
H. T. Chen ◽  
P. A. Chartier ◽  
S. Setthachayanon
Keyword(s):  
Chain Reaction ◽  
Stability And Control ◽  
A Chain ◽  
And Control

Residual Deformation of a Hard-Coated Valve Seat Subjected to Thermal Shocks

2010 ◽  
Author(s):  
Jean-Philippe Mathieu ◽  
Jean-Franc¸ois Rit ◽  
Je`roˆme Ferrari ◽  
David Hersant
Keyword(s):  
Welding Process ◽  
Residual Deformation ◽  
The Body ◽  
Dominant Effect ◽  
Welding Temperature ◽  
Physical Test ◽  
Physical Testing ◽  
A Chain ◽  
Globe Valve ◽  
Thermal Shocks

Most safety related valves in EDF’s nuclear plant must prove their ability to sustain thermal shocks of approximately 240K amplitude. This paper evaluates the simulation of a globe valve tested for thermal shocks. Since the physical test campaign showed inadequate internal sealing, the simulation focuses on the residual deformation of the hard alloy, planar seat, welded on successive body designs. This deformation is the result of the thermal loadings first induced by the welding process, then by fluid flow inside the valve. A chain of 3D simulations successively computes: a welding temperature transient in the body, the resulting strain hardening — especially in the seat vicinity —; temperature transients in the flow and the valve parts, and the resulting strains in the body causing a bump deformation of the seat surface. This end result agrees with measurements on the tested valve specimen. We show that inaccurate results are obtained on simpler assumptions, such as no welding, and we give insights on the dominant effect of the first hot, cold, hot transient over other profiles. Finally, the agreement we obtain on deformation predictions is toned down by an unsatisfactory sealing prediction, as well as the complexity and duration of the simulation chain compared with physical testing.

Exposure of squalene hydroperoxides to photons causes the formation of unique squalene cyclic peroxides via a chain reaction mechanism detected on the human skin and causing harm to skin cells (HaCaT)

2021 ◽  
Author(s):  
Saoussane Khalifa ◽  
Masaru Enomoto ◽  
Takahiro Eitsuka ◽  
Kiyotaka Nakagawa ◽  
Yurika Otoki ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Human Skin ◽  
Chain Reaction ◽  
Skin Cells ◽  
A Chain

scholarly journals On the explosion of chain-thermal reactions

1982 ◽  
Vol 24 (2) ◽  
pp. 194-202 ◽  
Author(s):  
R. O. Ayeni
Keyword(s):  
Activation Energy ◽  
Asymptotic Analysis ◽  
Upper Bound ◽  
Homogeneous Model ◽  
Chain Reaction ◽  
Isothermal Reaction ◽  
Thermal Reactions ◽  
Spatially Homogeneous ◽  
Branched Chain ◽  
A Chain

AbstractA chain reaction of oxygen (reactant) and hydrogen (active intermediary) with mtrosyl chloride (sensitizer) as a catalyst may be modelled mathematically as a non-isothermal reaction. In this paper we present an asymptotic analysis of a spatially homogeneous model of a non-isothermal branched-chain reaction. Of particular interest is the so-called explosion time and we provide an upper bound for it as a function of the activation energy which can vary over all positive values. We also establish a bound on the temperature when the activation energy is finite.

Leptospirosis: a diagnostic conundrum

2018 ◽  
Vol 48 (4) ◽  
pp. 306-309
Author(s):  
Keerthivasan Gurumurthy ◽  
Harish Belgode Narasimha ◽  
Mukta Wyawahare ◽  
Niranjan Biswal
Keyword(s):  
The Body ◽  
Health Concern ◽  
Andaman Islands ◽  
Public Health Concern ◽  
Chain Reaction ◽  
Pathogenic Leptospira ◽  
Indian States ◽  
Polymerase Chain Reaction Testing ◽  
Laboratory Confirmation ◽  
Polymerase Chain

Leptospirosis is a serious public health concern worldwide. It is highly endemic in the Andaman Islands and its prevalence is increasing in other Indian states. Clinical features are non-specific and diagnosis relies on laboratory confirmation. The gold standard is microscopic agglutination testing, but this is not widely available. Real-time polymerase chain reaction testing of LipL32 antigen provides the earliest detection of pathogenic Leptospira in the body. We found it to be 100% specific, but it should be used in the first 10 days of illness for reliable results.

THE KINETICS OF THE OXIDATION OF GASEOUS ACETALDEHYDE

1932 ◽  
Vol 7 (2) ◽  
pp. 149-161 ◽  
Author(s):  
W. H. Hatcher ◽  
E. W. R. Steacie ◽  
Frances Howland
Keyword(s):  
Carbon Dioxide ◽  
Formic Acid ◽  
Induction Period ◽  
Reaction Vessel ◽  
Oxidation Products ◽  
Main Reaction ◽  
Chain Mechanism ◽  
Subsequent Reaction ◽  
A Chain ◽  
Kinetics Of

The kinetics of the oxidation of gaseous acetaldehyde have been investigated from 60° to 120 °C. by observing the rate of pressure decrease in a system at constant volume. A considerable induction period exists, during which the main products of the reaction are carbon dioxide, water, and formic acid. The main reaction in the subsequent stages involves the formation of peroxides and their oxidation products. The heat of activation of the reaction is 8700 calories per gram molecule. The indications are that the reactions occurring during the induction period are heterogeneous. The subsequent reaction occurs by a chain mechanism. The chains are initiated at the walls of the reaction vessel, and are also largely broken at the walls.

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