scholarly journals Biotechnological valorization of agro industrial and household wastes for lactic acid production

2019 ◽  
Vol 21 (1) ◽  
pp. 113-127 ◽  
Author(s):  
Juliana Romo-Buchelly ◽  
María Rodríguez-Torres ◽  
Fernando Orozco-Sánchez
Keyword(s):  
Lactic Acid ◽  
Large Scale ◽  
Lactic Acid Production ◽  
Scale Production ◽  
Advantages And Disadvantages ◽  
Large Scale Production ◽  
Different Types ◽  
High Transformation ◽  
Transformation Potential ◽  
The Cost

Lactic acid (LA) is an organic compound used in several industries, such as food, textile, chemical, and pharmaceutical. The global interest  in  this  product  is  due  to  its  use  for  the  synthesis  of  numerous  chemical  compounds,  including  polylactic  acid,  a  biode-gradable thermoplastic and substitute for petroleum-derived plastics. An in-depth overview of the use of industrial and household wastes as inexpensive substrates in order to reduce the cost of LA production is presented. A review is carried out of the biotech-nological aspects that must be taken into account when using some wastes with high transformation potential to produce LA in a submerged  culture,  as  well  recommendations  for  their  use.  The  advantages  and  disadvantages  of  different  types  of  treatments used for the transformation of waste into suitable substrates are considered. Several methods of fermentation, as well as genetic strategies for increasing the production, are summarized and compared. It is expected that in a few years there will be many ad-vances in these areas that will allow greater large-scale production of LA using agroindustrial or household wastes, with potential positive economic and environmental impact in some regions of the planet.

scholarly journals Replacement of a Metabolic Pathway for Large-Scale Production of Lactic Acid from Engineered Yeasts

1999 ◽  
Vol 65 (9) ◽  
pp. 4211-4215 ◽  
Author(s):  
Danilo Porro ◽  
Michele M. Bianchi ◽  
Luca Brambilla ◽  
Rossella Menghini ◽  
Davide Bolzani ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Large Scale ◽  
Kluyveromyces Lactis ◽  
Lactic Acid Production ◽  
Pyruvate Decarboxylase ◽  
Polymer Materials ◽  
Efficient Production ◽  
Scale Production ◽  
High Productivity ◽  
Large Scale Production

ABSTRACT Interest in the production of l-(+)-lactic acid is presently growing in relation to its applications in the synthesis of biodegradable polymer materials. With the aim of obtaining efficient production and high productivity, we introduced the bovinel-lactate dehydrogenase gene (LDH) into a wild-type Kluyveromyces lactis yeast strain. The observed lactic acid production was not satisfactory due to the continued coproduction of ethanol. A further restructuring of the cellular metabolism was obtained by introducing the LDH gene into aK. lactis strain in which the unique pyruvate decarboxylase gene had been deleted. With this modified strain, in which lactic fermentation substituted completely for the pathway leading to the production of ethanol, we obtained concentrations, productivities, and yields of lactic acid as high as 109 g liter−1, 0.91 g liter−1 h−1, and 1.19 mol per mole of glucose consumed, respectively. The organic acid was also produced at pH levels lower than those usual for bacterial processes.

Solar Concentrators

2019 ◽  
pp. 1-38
Author(s):  
Bekhruzi Talbi Shokhzoda ◽  
Mikhail Georgievich Tyagunov
Keyword(s):  
Renewable Energy ◽  
Solar Energy ◽  
Large Scale ◽  
Scale Production ◽  
Cell Area ◽  
Solar Panels ◽  
Solar Concentrators ◽  
Large Scale Production ◽  
History Of ◽  
The Cost

Looking at the history of solar energy and renewable energy in general, the authorities and scientists have been paying much attention to the recent period, due to the depletion of fossil energy resources and the growing difficulties in solving environmental problems. The development of solar energy has led to the use of solar energy concentrators. Concentrators are used to concentrate sunlight onto PV cells. This allows for a reduction in the cell area required for producing a given amount of power. The goal is to significantly reduce the cost of electricity generated by replacing expensive PV converter area with less expensive optical material. In this chapter, the authors talk about concentrators in solar energy, especially about modules based on holographic films. Holographic solar panels (HSP) in recent decades have appeared in large-scale production and been actively used in solar energy. Evaluations of other types of existing concentrators are presented.

scholarly journals Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications

2019 ◽  
Vol 20 (23) ◽  
pp. 5862 ◽  
Author(s):  
Daniel Brady ◽  
Alessandro Grapputo ◽  
Ottavia Romoli ◽  
Federica Sandrelli
Keyword(s):  
Infectious Diseases ◽  
Antimicrobial Peptides ◽  
Mammalian Cells ◽  
Large Scale ◽  
Scale Production ◽  
Gram Negative ◽  
Social Burden ◽  
Large Scale Production ◽  
Conventional Antibiotics ◽  
The Cost

The alarming escalation of infectious diseases resistant to conventional antibiotics requires urgent global actions, including the development of new therapeutics. Antimicrobial peptides (AMPs) represent potential alternatives in the treatment of multi-drug resistant (MDR) infections. Here, we focus on Cecropins (Cecs), a group of naturally occurring AMPs in insects, and on synthetic Cec-analogs. We describe their action mechanisms and antimicrobial activity against MDR bacteria and other pathogens. We report several data suggesting that Cec and Cec-analog peptides are promising antibacterial therapeutic candidates, including their low toxicity against mammalian cells, and anti-inflammatory activity. We highlight limitations linked to the use of peptides as therapeutics and discuss methods overcoming these constraints, particularly regarding the introduction of nanotechnologies. New formulations based on natural Cecs would allow the development of drugs active against Gram-negative bacteria, and those based on Cec-analogs would give rise to therapeutics effective against both Gram-positive and Gram-negative pathogens. Cecs and Cec-analogs might be also employed to coat biomaterials for medical devices as an approach to prevent biomaterial-associated infections. The cost of large-scale production is discussed in comparison with the economic and social burden resulting from the progressive diffusion of MDR infectious diseases.

scholarly journals Optimizing Workflow Data Footprint

2007 ◽  
Vol 15 (4) ◽  
pp. 249-268 ◽  
Author(s):  
Gurmeet Singh ◽  
Karan Vahi ◽  
Arun Ramakrishnan ◽  
Gaurang Mehta ◽  
Ewa Deelman ◽  
...  
Keyword(s):  
Data Storage ◽  
Large Scale ◽  
Open Science ◽  
Scale Production ◽  
Distributed Resources ◽  
Data Intensive ◽  
Large Scale Production ◽  
Data Files ◽  
The Cost ◽  
Open Science Grid

In this paper we examine the issue of optimizing disk usage and scheduling large-scale scientific workflows onto distributed resources where the workflows are data-intensive, requiring large amounts of data storage, and the resources have limited storage resources. Our approach is two-fold: we minimize the amount of space a workflow requires during execution by removing data files at runtime when they are no longer needed and we demonstrate that workflows may have to be restructured to reduce the overall data footprint of the workflow. We show the results of our data management and workflow restructuring solutions using a Laser Interferometer Gravitational-Wave Observatory (LIGO) application and an astronomy application, Montage, running on a large-scale production grid-the Open Science Grid. We show that although reducing the data footprint of Montage by 48% can be achieved with dynamic data cleanup techniques, LIGO Scientific Collaboration workflows require additional restructuring to achieve a 56% reduction in data space usage. We also examine the cost of the workflow restructuring in terms of the application's runtime.

Assessment of Optimized Process Quality and Reliability for Wafer Level Applications

2016 ◽  
Vol 2016 (S2) ◽  
pp. S1-S52 ◽  
Author(s):  
Ennis Ogawa ◽  
Aimin Xing ◽  
David F.-S. Liao ◽  
Ten V. Y. Ten ◽  
Chong Wei Neo ◽  
...  
Keyword(s):  
System Integration ◽  
Large Scale ◽  
Low Cost ◽  
Scale Production ◽  
Wafer Level ◽  
Single Defect ◽  
Large Scale Production ◽  
Quality And Reliability ◽  
Edge Delamination ◽  
The Cost

Fanout Wafer Level Packaging (FoWLP) is a very attractive solution for microelectronics applications requiring optimized performance, smaller form factor, and low cost. By utilizing such an approach where system integration is done to multiple chips on a single package frame, the need to ensure much higher levels of process integrity, quality, and reliability becomes absolutely critical, especially if the total product volume lies in the range of tens of millions of units. A single defect type may negate the benefits of such an approach because the cost of losing one FoWLP unit results in the loss of multiple devices. Thus, yield, quality, and reliability optimization using such a package solution is critical for successful large scale manufacturing. In this talk, the issue of defectivity and its impact on quality and reliability on Wafer-Level (WL) devices with regards to the issue of Die Edge Delamination (DED) and Chip Mechanical Integrity (CMI) is discussed. Through this discussion and the resulting solutions found to improve WL quality and reliability, better understanding on how to assess the quality and reliability of a given FoWLP solution for large scale production will be demonstrated.

A Short Review on the Synthesis of Polylactic Acid by Reactive Extrusion and Static Mixing Reaction Techniques

2021 ◽  
Vol 13 (2) ◽  
pp. 181-187
Author(s):  
Rong Liu ◽  
Yue Zhao
Keyword(s):  
Polylactic Acid ◽  
Large Scale ◽  
Reactive Extrusion ◽  
Short Review ◽  
Synthetic Methods ◽  
Scale Production ◽  
Synthesis Mechanism ◽  
Advantages And Disadvantages ◽  
Large Scale Production ◽  
Twin Screw

Polylactic acid (PLA) is one of the most attractive biodegradable polymers, but the large-scale production of PLA in most countries is still in its infancy. This review begins with a brief introduction to PLA synthesis mechanism, followed by a summary of the techniques of twin-screw reactive extrusion and tubular static mixing reaction, which are two new methods for rapid synthesis of PLA with large-scale production potential. The structures, advantages and disadvantages of each technique are then reviewed in the paper. Finally, the rapid synthetic methods are prospected.

Amines via Hydroaminomethylation: An Updated Overview

2021 ◽  
Vol 25 ◽  
Author(s):  
Carmela G. Arena
Keyword(s):  
Large Scale ◽  
Synthetic Methods ◽  
Catalytic Process ◽  
Scale Production ◽  
Tertiary Amines ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Large Scale Production ◽  
The Cost

: Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals. Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials. In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom economy that starts from inexpensive reagents, such as alkenes. This review aims to provide an updated overview of hydroaminomethylation as a useful tool for synthesizing aliphatic secondary and tertiary amines. Therefore, the discussion will focus on both unsaturated starting compounds and the amines obtained by this one-pot reaction.

scholarly journals Toward high production of graphene flakes – a review on recent developments in their synthesis methods and scalability

2018 ◽  
Vol 6 (31) ◽  
pp. 15010-15026 ◽  
Author(s):  
Muhammad Izhar Kairi ◽  
Sebastian Dayou ◽  
Nurul Izni Kairi ◽  
Suriani Abu Bakar ◽  
Brigitte Vigolo ◽  
...  
Keyword(s):  
Large Scale ◽  
Synthesis Methods ◽  
Scale Production ◽  
Large Scale Production ◽  
Graphene Flakes ◽  
Recent Developments ◽  
High Production ◽  
Cost Of Production ◽  
The Cost

Graphene flakes, one of the most popular form of graphene, can be used for many applications. Their synthesis is in the path to reach the large-scale production if the cost of production is further improved.

Production of isomelezitose from sucrose by engineered glucansucrases

Amylase ◽  
2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Gregory L. Côté ◽  
Christopher A. Dunlap ◽  
Karl E. Vermillion ◽  
Christopher D. Skory
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Biomedical Applications ◽  
Large Scale ◽  
Single Point ◽  
Single Point Mutation ◽  
Scale Production ◽  
Acceptor Substrate ◽  
Large Scale Production ◽  
High Yields

AbstractCertain lactic acid bacteria produce glycosyltransferases known as glucansucrases, which synthesize α-D-glucans via glucosyl transfer from sucrose. We recently reported on the formation of the unusual trisaccharide isomelezitose in low yields by a variety of glucansucrases. Isomelezitose is a rare non-reducing trisaccharide, with the structure α-d-glucopyranosyl- (1→6)-β-d-fructofuranosyl-(2↔1)-α-d-glucopyranoside. In this work, we describe the synthesis of isomelezitose in high yields by variants of glucansucrases engineered to contain a single point mutation at a key leucine residue involved in acceptor substrate binding. Some variants produce isomelezitose in yields up to 57%. This method is amenable to large-scale production of isomelezitose for food, industrial and biomedical applications.

scholarly journals Crack engineering for the construction of arbitrary hierarchical architectures

2019 ◽  
Vol 116 (48) ◽  
pp. 23909-23914 ◽  
Author(s):  
Wanbo Li ◽  
Miao Yu ◽  
Jing Sun ◽  
Kentaro Mochizuki ◽  
Siyu Chen ◽  
...  
Keyword(s):  
Large Scale ◽  
Signal Transmission ◽  
Three Dimensional ◽  
Hierarchical Structures ◽  
Cost Effective ◽  
Scale Production ◽  
Biomimetic Materials ◽  
Large Scale Production ◽  
Elastic Crack ◽  
The Cost

Three-dimensional hierarchical morphologies widely exist in natural and biomimetic materials, which impart preferential functions including liquid and mass transport, energy conversion, and signal transmission for various applications. While notable progress has been made in the design and manufacturing of various hierarchical materials, the state-of-the-art approaches suffer from limited materials selection, high costs, as well as low processing throughput. Herein, by harnessing the configurable elastic crack engineering—controlled formation and configuration of cracks in elastic materials—an effect normally avoided in various industrial processes, we report the development of a facile and powerful technique that enables the faithful transfer of arbitrary hierarchical structures with broad material compatibility and structural and functional integrity. Our work paves the way for the cost-effective, large-scale production of a variety of flexible, inexpensive, and transparent 3D hierarchical and biomimetic materials.

Sign in / Sign up

Export Citation Format

Share Document