scholarly journals Menopause and its management: A review

2022 ◽  
Keyword(s):  
Clinical Symptoms ◽  
Healthy Lifestyle ◽  
Reproductive Stage ◽  
Menopausal Transition ◽  
Average Life ◽  
Average Life Expectancy ◽  
Urogenital Atrophy ◽  
Increased Risk ◽  
Perimenopausal Women ◽  
Genitourinary Syndrome

Abstract Menopausal transition (premenopause) is the phase in the ageing process of women representing the transition from the reproductive stage of life to the non-reproductive stage. With improvements in average life expectancy, women live an increased proportion of their lives in the postmenopause. The consequences of oestrogen loss are the early symptoms (psychological and vasomotor), the genitourinary syndrome (intermediate), as well as postmenopausal osteoporosis with increased risk of fractures and cardiovascular diseases (late). The diagnosis of climacteric syndrome is based on typical clinical symptoms. Perimenopausal women should understand physiological changes occurring in menopausal transition. They should be encouraged to live a healthy lifestyle. Menopausal hormone therapy is indicated for relief of the acute symptoms of menopause and for treatment of urogenital atrophy. It should be administered in the lowest effective dose for the shortest period of time. The treatment should be initiated before the age of 60 years or within 10 years after menopause in order to decrease its risks. The benefit/risk profile needs to be individually re-assessed every year.

scholarly journals Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 373
Author(s):  
Marisa Silva ◽  
Paula Seijas ◽  
Paz Otero
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Senile Plaques ◽  
Nmda Receptor Antagonists ◽  
Average Life ◽  
Average Life Expectancy ◽  
Large Reservoir ◽  
Drug Candidates ◽  
Neurodegenerative Process ◽  
Main Action

Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

2012 ◽  
Vol 167 (5) ◽  
pp. 609-618 ◽  
Author(s):  
Bernadette Biondi
Keyword(s):  
Heart Failure ◽  
Thyroid Dysfunction ◽  
Clinical Symptoms ◽  
Systolic Function ◽  
Evidence Synthesis ◽  
The United States ◽  
Antithyroid Drugs ◽  
Cardiac Symptoms ◽  
Appropriate Treatment ◽  
Increased Risk

ContextHeart failure (HF) is a major cause of morbidity and mortality in Europe and in the United States. The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction.Evidence AcquisitionReports published with the following search terms were searched:, thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, levothyroxine, triiodothyronine, antithyroid drugs, radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone and atrial fibrillation. The investigation was restricted to reports published in English.Evidence SynthesisThe outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH <0.1 or >10 mU/l.ConclusionsThe timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction.

ASSESSMENT OF THE DEPENDENCE OF THE AVERAGE LIFE EXPECTANCY OF THE POPULATION RESIDING IN THE TULA REGION IN THE AREAS WITH A HIGH CONTENT OF HEA VYMETALS IN THE SOIL

2021 ◽  
Vol 1 (1) ◽  
pp. 53-63
Author(s):  
KHROMUSHIN V.A. ◽  
◽  
VOLKOV A.V. ◽  
KHADARTSEV A.A. ◽  
◽  
...  
Keyword(s):  
Heavy Metals ◽  
Life Expectancy ◽  
Respiratory Diseases ◽  
Causes Of Death ◽  
Algebraic Model ◽  
Constructive Logic ◽  
Average Life ◽  
Average Life Expectancy ◽  
Lead Zinc ◽  
Regional Mortality

The article presents the relevance of the problem, defines the research purpose: to compare the average life expectancy of the population in the areas of the Tula region with different contents of heavy metals in the class of causes of death “Respiratory diseases ”. The authors used the data of the regional mortality register, the results of analyzes of the content of heavy metals (copper, lead, zinc, nickel) in the soil by atomic absorption spectroscopy, and the calculation of the average life expectancy by the algebraic model of constructive logic. The results indicate a decrease in average life expectancy due to the presence of heavy metals in the soil, but the average life expectancy in both contaminated and non-contaminated areas is gradually increasing.

FEATURES OF THE BIOLOGICAL DEVELOPMENT OF THE BIRD CHERRY-OAT APHID (RHOPALOSIPHUM PADI) IN THE LABORATORY

2021 ◽  
pp. 142-148
Author(s):  
YA.YU. GOLIVANOV ◽  
◽  
V.V. ZELENENKO ◽  
V.V. GRITSENKO
Keyword(s):  
Life Expectancy ◽  
Life Span ◽  
Average Duration ◽  
Rhopalosiphum Padi ◽  
Reproductive Period ◽  
Average Life ◽  
Average Life Expectancy ◽  
Entire Life ◽  
Biological Development

The article presents data on the assessment of some issues of the ontogenesis of the bird cherryoat aphid: the average life expectancy, the number of offspring over a lifetime, the beginning of the reproductive period, the end of the reproductive period, the duration of the reproductive period, the life span of aphids and the number of offspring. The author found that the average life expectancy of animals was 21.55 days. The beginning of the reproductive period, on average, was on days 7–8, the end – on day 19. The average duration of the reproductive period was 12.5 days. The average number of offspring over the entire life for individuals in the sample was 34 nymphs, in a separate litter – 2–3 nymphs.

MO765CENTRAL VEIN STENOSES IN HD PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Aleksei Zulkarnaev ◽  
Andrey Vatazin ◽  
Vadim Stepanov ◽  
Ekaterina Parshina ◽  
Mariya Novoseltseva
Keyword(s):  
Risk Factor ◽  
Vascular Access ◽  
Dwell Time ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Cox Proportional Hazards ◽  
Important Risk Factor ◽  
Central Vein ◽  
Increased Risk ◽  
The Mean

Abstract Background and Aims The prevalence of central vein stenosis (CVS) in patients on hemodialysis (HD) is difficult to be assessed directly. This is mainly caused by the variety of clinical signs and the high frequency of asymptomatic CVS. Aim: to assess the frequency of occurrence of various CVS forms in HD patients. Method The retrospective observational study is based on the results of treatment of 1865 HD patients who underwent diagnostic and therapeutic procedures on vascular access in our center. In case of vascular access dysfunction, patients were examined according to a local protocol: ultrasound of the peripheral (to exclude lesion of peripheral AVF segments) and central veins (over the available length), followed with CT-angiography or percutaneous angiography, if necessary. Results AVF/AVG dysfunction was observed in 29.4% of patients (549 of 1865). 211 patients were diagnosed with CVS. The prevalence of CVS was 11.3% (211 of 1865) among all HD patients and 38.4% (211 of 549) in patients with AVF dysfunction. Among patients with CVS, 37% (78 of 211) had vein lesions without clinical symptoms or with minimal manifestations (a tendency to decrease KT/V). The prevalence of asymptomatic CVS was 4.2% (78 of 1865) in the general population of HD patients and 14.2% (78 of 549) in patients with AVF dysfunction. In case of asymptomatic CVS it was detected by an ultrasound examination during CVC implantation (N=38), during unsuccessful attempts to implant CVC (N=29), in the case of recurrent AVF thrombosis without underlying peripheral segments lesion (N=9) or during echocardiography (N=2). The prevalence of asymptomatic CVS among patients without AVF dysfunction was 5.9% (78 of 1316). True prevalence of subclinical CVS among HD patients without obvious signs of AVF dysfunction may vary widely. A total of 48.8% (103 of 211) of all CVS cases were treated. At the same time, in 10.7% (11 of 103) of cases, patients did not present symptoms of CVS, and surgery was performed due to recurrent AVF thrombosis without damage of the peripheral parts of AVF. Patients with clinically manifest CVS who received endovascular interventions had a significantly higher risk of AVF loss compared to patients with asymptomatic CVS: HR=2.566 [95% CI 1.706; 3.86], log rank p&lt;0.0001. However, patients with an asymptomatic CVS had a higher risk of AVF function loss compared to the general HD population (HR=2,051 [95% CI 1,243; 3,384], log rank p= 0.0004) – fig. 1. The use of CVC is a known risk factor of CVS development. We analyzed the relationship of CVS risk with multiply CVC placements and catheter dwell time using the Cox proportional hazards regression model (fig. 2). In the univariate model, a greater No of CVCs as well as longer time in place increased the risk of CVS. In the multivariate model (χ2=105.516, df=2, p&lt;0.0001), catheter dwell time was no longer associated with an increased risk of CVC, while the mean number of inserted catheters remained an important risk factor. Conclusion The prevalence of both symptomatic and asymptomatic forms of CVS in HD patients is high. Patients with vascular access dysfunction should be carefully examined to identify the asymptomatic CVS. The mean No of catheterizations is a more important risk factor of CVS than longer catheter dwell time.

scholarly journals Actividad físico-deportiva extraescolar en alumnos de primaria: el caso de Torrevieja (Alicante) (Extracurricular physical and sports activities in elementary students: the case of Torrevieja (Alicante))

Retos ◽  
2015 ◽  
pp. 48-52
Author(s):  
Joaquín Reverter Masià ◽  
Dani Plaza Montero ◽  
María del Carmen Jové Deltell ◽  
Vicenç Hernández González
Keyword(s):  
Physical Activity ◽  
Primary Schools ◽  
Healthy Lifestyle ◽  
Intervention Programs ◽  
Accurate Information ◽  
Activity Levels ◽  
Cross Sectional ◽  
Increased Risk ◽  
Youth Counseling ◽  
The City

En los últimos años se está creando un importante problema de sedentarismo en la infancia. A la hora de diseñar programas de intervención para fomentar la práctica de actividad física es necesario obtener información precisa sobre los niveles de práctica de la población infantil así como de los posibles determinantes de la práctica. Para ello se ha diseñado un estudio donde se evalúan los niveles de práctica de niños y niñas de 6 a 12 años de actividad física. Las conclusiones que se desprenden del estudio realizado son: un alto porcentaje de sujetos no realizan ejercicio físico (34,4%), observándose diferencias entre niños y niñas; se puede afirmar que las niñas practican menos que los niños (35,4% versus 24,9%). Por otro lado, el porcentaje de sujetos físicamente activos es de un 31,2% cuando se considera la recomendación más extendida, de tres o más horas a la semana. Los resultados obtenidos confirman la necesidad de incentivar programas de intervención en niños y jóvenes, aconsejando la práctica de actividad física, prestando especial interés a las chicas.Palabras clave: Salud. Actividad física. Deportes. Niños y adolescentes.Abstract: In recent years, is creating a major problem of physical inactivity in childhood. To design intervention programs that promote physical activity is necessary to obtain accurate information about levels of practice of the child population as well as the possible determinants of the practice. This was carried out a cross-sectional and descriptive. The sample is representative of students attending school in the city of Torrevieja and was selected by a pro rata basis. Participants in the study were 1248 students from thirteen primary schools offering primary education in the city of Torrevieja. The study evaluated physical activity levels of children aged 6 to 12 years. The instrument used in this study is a questionnaire (Latorre, 2006). The version used shows adequate factorial structure (Latorre, 2006). It is an instrument designed to assess the variables of healthy lifestyle among young people and teenagers. The results confirm the need to provide adequate education about healthy lifestyles and enhance the development of intervention programs for children and youth, counseling on diet and physical activity with particular interest in the girls, who are less physically active group and increased risk of disorders.Keywords: Health. Physical activity. Sports. Children and adolescents.

scholarly journals Sclerosing cholangitis and inflammatory bowel disease: which comes first?

2021 ◽  
Vol 66 (1) ◽  
pp. 39-46
Author(s):  
A. V. Nikitin ◽  
G. V. Volynets
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Clinical Symptoms ◽  
Cross Reactivity ◽  
Formation Mechanisms ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Sclerosing cholangitis is one of the most common hepatologic extraintestinal manifestations of inflammatory bowel disease. The article discusses the phenotype of the combination of sclerosing cholangitis and inflammatory bowel disease. The authors present their theories of the etiopathogenesis of sclerosing cholangitis in patients with inflammatory bowel disease, as well as some features of the phenotype of both mixed and monogenic forms of diseases.Sclerosing cholangitis in combination with inflammatory bowel disease is commonly associated with pancolitis, but the endoscopically visualized activity of inflammatory bowel diseases is significantly lower and clinical symptoms are less pronounced. The authors have established that the patients with the combination of sclerosing cholangitis and inflammatory bowel disease are at the increased risk of developing malignant neoplasms. The formation mechanisms of a combination of inflammatory bowel disease and sclerosing cholangitis remain poorly understood, although this pathology is influenced by lymphocytic cross-reactivity, aberrant recognition of microbiotic epitopes and intestinal microbiota imbalance. New biological agents aimed at correcting the interaction between the immune system and target organs may provide new ways of treatment for sclerosing cholangitis associated with inflammatory bowel disease.

scholarly journals Postmenopausal women – comorbid patients

2020 ◽  
Vol 1 (3) ◽  
pp. 30-38
Author(s):  
Tatyana Yu. Pestrikova ◽  
◽  
Elena A. Yurasova ◽  
Olga G. Sherbakova ◽  
Marina А. Shveeva ◽  
...  
Keyword(s):  
Healthcare Professionals ◽  
Social Significance ◽  
Average Life ◽  
Average Life Expectancy ◽  
The Past ◽  
Age Related ◽  
Menopausal Women ◽  
Comorbid Diseases ◽  
Clinical Cases

Relevance. As the prevention and treatment of diseases improves, the average life expectancy of the population increases. For many of our contemporaries, a third of their lives are postmenopausal. Menopause-related health problems are increasingly common and require the attention of healthcare professionals. Aim. To raise awareness of gynecologists, urologists and other specialists about the medico-social significance of the problems of women in the menopausal period based on the analysis of literature sources and analysis of clinical cases. Materials and methods. To write this review, a search was carried out for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) over the past 20 years. The review included articles from the peer-reviewed literature. An analysis of 2 clinical cases with comorbid pathology in menopausal patients is presented. Results. The review presents data on age-related physiological changes and quality of life in menopausal women. The analysis of 2 clinical cases of the appointment of menopausal hormone therapy in patients with comorbid diseases was carried out. Conclusions. The importance of awareness of outpatient doctors in the diagnosis and management tactics of patients with comorbid diseases in menopause is emphasized.

scholarly journals Movember in a pandemic - it matters, more than ever

2021 ◽  
Vol 93 (1) ◽  
pp. 82-83
Author(s):  
João Vasco Barreira ◽  
Gil Falcão ◽  
Mariana Amaral ◽  
Pedro Barreira
Keyword(s):  
Life Expectancy ◽  
Diagnostic Techniques ◽  
Average Life ◽  
Average Life Expectancy ◽  
Screening Programs

Dear Editor, in recent years there has been an increase in the number of new cases of cancer. This increase, in part, is closely related to the increase in average life expectancy, as well as more accurate diagnostic techniques and well-defined screening programs. [...]

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