Testicular function and semen characteristics of Awassi rams treated with melatonin out of the breeding season

2009 ◽  
Vol 57 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Vera Faigl ◽  
Mónika Keresztes ◽  
Margit Kulcsár ◽  
Sándor Nagy ◽  
Zsuzsanna Keresztes ◽  
...  
Keyword(s):  
Breeding Season ◽  
Slow Release ◽  
Endocrine Function ◽  
Semen Parameters ◽  
Control Group ◽  
Melatonin Treatment ◽  
Semen Characteristics ◽  
Igf I ◽  
Semen Donor

The objective of this study was to evaluate the effect of long-term melatonin treatment applied during the non-breeding season on semen characteristics, endocrine function of testicles and baseline level of insulin-like growth factor-I (IGF-I) in Awassi rams kept in the temperate continental zone of Europe and used as semen donors in an artificial insemination (AI) programme. On 23 February (day 0), slow-release melatonin implants were inserted subcutaneously into rams (n = 8). Control animals (n = 8) received no treatment. In both groups, basic semen parameters (concentration, total motility, fast and slow forward motility, morphology), GnRH-induced testosterone response and basal IGF-I concentration were evaluated on days 0, 47 and 71. No differences were found in concentration of spermatozoa, total motility, and numbers of spermatozoa with fast and slow progressive motility and normal/abnormal morphology between the melatonin-treated and the control group. However, in melatonin-treated animals, basal and GnRH-induced testosterone levels were slightly elevated on day 47 and became significantly higher on day 71 (P < 0.05) as compared to controls. There was no difference in plasma IGF-I levels between the groups. In conclusion, slow-release melatonin applied during the non-breeding season improves testicular testosterone production but does not influence the semen characteristics and the IGF-I level of semen donor Awassi rams used in an AI programme and kept in the temperate continental zone of Europe.

Effect of melatonin treatment on semen parameters and endocrine function in Black Racka rams out of the breeding season

2014 ◽  
Vol 116 (2-3) ◽  
pp. 192-198 ◽  
Author(s):  
I. Egerszegi ◽  
P. Sarlós ◽  
J. Rátky ◽  
L. Solti ◽  
V. Faigl ◽  
...  
Keyword(s):  
Breeding Season ◽  
Endocrine Function ◽  
Semen Parameters ◽  
Melatonin Treatment

110 EFFECT OF MELATONIN TREATMENT ON LIBIDO AND ENDOCRINE FUNCTION OF DROMEDARY CAMEL BULLS OUT OF THE BREEDING SEASON

2017 ◽  
Vol 29 (1) ◽  
pp. 163 ◽  
Author(s):  
A. Swelum ◽  
I. Saadeldin ◽  
H. Ba-Awadh ◽  
A. Alowaimer
Keyword(s):  
Breeding Season ◽  
Reproductive Performance ◽  
Repeated Measures ◽  
Endocrine Function ◽  
Gland Secretion ◽  
Control Group ◽  
Dromedary Camel ◽  
Testosterone Levels ◽  
Significant Difference ◽  
Length Changes

The reproductive performance of camels is poor and has remained a major obstacle to the growth of dromedary populations. The limited breeding season is one of the most important causes of the poor reproductive performance. In seasonal animals, melatonin is the chemical messenger that allows the perception of daylight length changes. Commercial melatonin products have been developed for the manipulation of seasonal breeding in animals. The present study aimed to evaluate the influence of melatonin implantation on libido, serum melatonin, and testosterone concentrations in dromedary camels during the non-breeding season (June and July). Ten camel bulls were used in the 35-day-long trial; 5 of them were implanted with 30 Melovine® implant (Ceva, Libourne, France) subcutaneously on Day 0, whereas the other 5 camel bulls remained untreated as a control. Libido was evaluated weekly in response to oestrous-induced female camels treated with oestrogen (1 mL Oestrocon; oestradiol benzoate 5 mg mL−1) 2 days before assessment of libido. Libido was scored as follows: 0 = not interested: the male did not show any libido; 1 = low interested: the male went near the female and showed low frequency of sniffing and flehmen; 2 = interested: the male went near the female, it showed sniffing, flehmen, grinding of teeth/whistling, yawning; 3 = high interested: the male went near the female and was very agitated, it showed sniffing, flehmen, grinding of teeth/whistling, yawning, urination, and tail raising. It stood with open legs, and poll gland secretion and neck rubbing were observed; 4 = excited, like 3, but the male showed blatering and dulaa extrusion, was very excited, stood with open legs, high poll gland secretion and neck rubbing were observed. Blood samples were collected weekly. Serum melatonin and testosterone concentrations were evaluated using commercial ELISA kits. Comparisons among groups were evaluated using repeated-measures ANOVA, using SAS software (SAS Institute Inc., Cary, NC, USA). A difference was considered significant at the P < 0.05 level. The results revealed that at Day 0, all camel bulls in 2 groups had no libido and there was no significant difference in the melatonin or testosterone levels in the 2 groups. The libido increased gradually in the melatonin group and reached the maximum (3–5) at week 4 and week 5. The control group had low libido (0–1) along the trial. Statistically, the libido was significantly higher in the melatonin group than control group. Additionally, testosterone levels were significantly higher in melatonin group than control group, especially in the fourth week of the present trial (565.07 ± 33.04 pg mL−1 and 458.49 ± 25.36 pg mL−1, respectively). In conclusion, melatonin implantation in the non-breeding season significantly improved the libido and the reproductive performance of dromedary camel bulls. Therefore, it may be possible to improve the reproductive efficiency of camels by extending the breeding season through treatment with melatonin during the non-breeding season.

Effects of melatonin and a dopamine agonist and antagonist on seasonal changes in voluntary intake, reproductive activity and plasma concentrations of prolactin and tri-iodothyronine in red deer hinds

1990 ◽  
Vol 125 (2) ◽  
pp. 241-249 ◽  
Author(s):  
J. A. Milne ◽  
A. S. I. Loudon ◽  
A. M. Sibbald ◽  
J. D. Curlewis ◽  
A. S. McNeilly
Keyword(s):  
Dopamine Agonist ◽  
Breeding Season ◽  
Red Deer ◽  
Plasma Concentrations ◽  
Control Group ◽  
Rapid Decline ◽  
Dopamine Antagonist ◽  
Plasma Prolactin ◽  
Melatonin Treatment ◽  
The Mean

ABSTRACT Three experiments were conducted in the period between July and November with non-lactating red deer hinds to describe the effects of treatment with melatonin during this period on voluntary food intake (VFI), the onset of the breeding season, coat changes and plasma concentrations of prolactin and tri-iodothyronine (T3), and to examine whether prolactin mediated the observed effects. In experiment 1, eight animals were treated orally each day with either 10 mg melatonin at 16.00 h or 10 mg melatonin at 16.00 h plus 10 mg domperidone (a dopamine antagonist) given twice daily for 120 days from July; eight animals were maintained as controls. In experiment 2, the same numbers of animals per treatment were used to compare treatments in which 10 mg melatonin or 20 mg bromocriptine (a dopamine agonist) were given orally each day at 16.00 h for 119 days from late June and compared with an untreated control group. In experiment 3, six animals were treated daily for 105 days from mid August with 5 mg domperidone given i.m. and compared with six control animals. In experiments 1 and 2, the VFI of control animals reached a peak in late August and thereafter declined. Melatonin-treated animals showed a similar pattern but the peak in VFI was significantly (P<0·05) advanced by 2 weeks compared with controls, although the VFIs of both groups were similar in November. The mean date of onset of the breeding season of the melatonin-treated animals was advanced significantly (P < 0·05) by 23 days in both experiments and the coats of these animals had less undercoat and were pale coloured and patchy compared with the controls. The changes in VFI, coat and the onset of the breeding season were associated with the rapid decline in plasma prolactin concentration after the start of the melatonin treatment and significantly (P<0·01) lower plasma T3 concentrations than those of control animals. In experiments 1 and 3, plasma prolactin concentrations in animals treated with domperidone were higher than those of controls for periods of 2–3 weeks. These short-term increases in plasma prolactin concentration were not associated with changes in VFI, coat or onset of the breeding season compared with controls. In experiment 2, the pattern of decline in plasma prolactin concentrations was the same in bromocriptine-treated animals as in the melatonin-treated animals; plasma T3 concentrations were also similar in the two groups. The pattern of change in VFI over time in bromocriptine-treated animals was significantly (P<0·05) different from that of melatonin-treated animals and there was also a reduced amount and length of winter coat in the bromocriptine-treated animals. The mean date of onset of the breeding season in bromocriptine-treated animals was not significantly different from that of controls. It was concluded that a reduction in plasma prolactin concentration induced by bromocriptine produced different effects from that induced by melatonin treatment and that the effects of melatonin are unlikely to be induced through changes in contemporary plasma prolactin concentrations. Journal of Endocrinology (1990) 125, 241–249

scholarly journals Variable growth hormone profiles following withdrawal of long-term 30mg slow-release lanreotide treatment in acromegalic patients: clinical implications

2000 ◽  
pp. 565-571 ◽  
Author(s):  
P Caron ◽  
A Tabarin ◽  
M Cogne ◽  
P Chanson ◽  
P Jaquet
Keyword(s):  
Slow Release ◽  
High Sensitivity ◽  
Somatostatin Analogue ◽  
Intramuscular Injections ◽  
Igf I ◽  
Group 2 ◽  
New Formulation ◽  
Group 1

OBJECTIVE: Intramuscular injections of 30mg slow-release (SR) lanreotide (every 10 to 14 days) are an effective treatment in acromegalic patients. Because of an ongoing need to assess the efficacy and the tolerance of a new formulation of a depot preparation of lanreotide, we have evaluated prospectively GH profiles following withdrawal of 30mg slow-release lanreotide in a cohort of acromegalic patients. PATIENTS: Fifty-one acromegalic patients, controlled during long-term 30mg SR lanreotide treatment (GH: 1.44 +/- 0.64 microgram/l, IGF-I: 316 +/- 145ng/ml) (mean +/- s.d.), were studied following the withdrawal of the drug. MEASUREMENTS: Mean GH (half-hour samples, 0800-1200h), IGF-I and lanreotide levels were evaluated 14, 28, and 42 days following the last 30mg SR lanreotide injection. RESULTS: Mean GH levels remained below 2.5 microgram/l in 32 patients (group 1) twenty-eight days following SR lanreotide withdrawal. In these patients, mean GH and IGF-I levels had increased from 1.2 +/- 0.6 to 1.7 +/- 0.5 microgram/l (P < 0001), and from 283 +/- 138 to 359 +/- 168ng/ml (P < 0.001) respectively. In the 19 other patients (group 2), mean GH concentrations had risen above 2.5 microgram/l at 28 days following SR lanreotide withdrawal. Mean GH and IGF-I levels had increased from 1.9 +/- 0.4 to 5.1 +/- 2.8 microgram/l (P < 0.001), and from 371 +/- 143 to 568 +/- 206ng/ml (P < 0.001) respectively. Patients of groups 1 and 2 were comparable with regard to age, sex, tumoral status, mean GH levels before somatostatin analogue treatment, and previous treatments such as radiotherapy and duration of somatostatin analogue therapy, but 75% of group 1 patients underwent surgery compared with 37% of group 2 patients (P < 0.01). Twenty-eight days following SR lanreotide withdrawal, mean lanreotide levels in group 1 and group 2 had decreased from 1.6 +/- 0.7 to 0.6 +/- 0.3ng/ml (P < 0.001), and from 2.7 +/- 2.0 to 0.7 +/- 0.7ng/ml (P < 0.001) respectively. A negative correlation was observed between the lanreotide levels and GH and IGF-I concentrations in the two groups of patients, but the inhibition of GH/IGF-I concentrations by lanreotide levels was higher in group 1 patients than in those of group 2. Six patients of group 1 were treated with 30mg SR lanreotide injected at monthly intervals. During monthly follow-up, mean GH levels increased above 2.5 microgram/l in 2 patients. After 12 months follow-up, mean GH and IGF-I levels from 4 other patients were similar to those obtained with previous therapeutic sequence (i.e. intramuscular injections every 14 days). CONCLUSION: The degree of responsiveness to lanreotide and the duration of somatotroph suppression following lanreotide withdrawal are variable in acromegalic patients controlled during long-term 30mg SR lanreotide treatment. In patients displaying high sensitivity to lanreotide, the interval between i.m. 30mg SR lanreotide injections can be increased to one month, thus reducing the cost of the therapy, without altering its efficacy upon GH/IGF-I control.

Semen parameters, fertility and testosterone levels in male rats exposed prenatally to betamethasone

2009 ◽  
Vol 21 (5) ◽  
pp. 634 ◽  
Author(s):  
Renata C. Piffer ◽  
Patrícia C. Garcia ◽  
Daniela C. C. Gerardin ◽  
Wilma G. Kempinas ◽  
Oduvaldo C. M. Pereira
Keyword(s):  
Adult Male ◽  
Sperm Quality ◽  
Male Offspring ◽  
Male Rats ◽  
Semen Parameters ◽  
Plasma Testosterone ◽  
Control Group ◽  
Long Term Effects ◽  
Testosterone Levels

The present study investigated the long-term effects of prenatal betamethasone exposure on sperm quality and count, fertility and plasma testosterone levels in adult male rats. Pregnant rats received 0.1 mg kg–1 betamethasone on Days 12, 13, 18 and 19 of pregnancy. This treatment impaired sperm quality, sperm production, fertility and plasma testosterone levels in adult male offspring compared to the control group. Thus, the results of the present study indicate that the long-term effects of prenatal betamethasone exposure may be deleterious to offspring. The consequent decrease in testosterone production during adulthood, in association with damaged semen parameters, may explain for the observed decrease in the capacity of adult male offspring to themselves generate viable descendants.

scholarly journals The effect of hormonal treatment with kisspeptin, GnRH and hCG on semen characteristics in buck Cyprus goats during non-breeding season as compared with breeding season

2019 ◽  
Vol 12 (1) ◽  
pp. 74-88
Author(s):  
Maad AL-Ameri ◽  
Talal Abdulkareem ◽  
Ahmed Taha
Keyword(s):  
Body Weight ◽  
Breeding Season ◽  
Normal Saline ◽  
Hormonal Treatment ◽  
Post Treatment ◽  
Abu Ghraib ◽  
Plasma Testosterone ◽  
Control Group ◽  
Testosterone Concentration ◽  
Semen Characteristics

The current study aimed to determine the effect of hormonal treatment with kisspeptin, GnRH and hCG on plasma testosterone concentration and semen characteristics in buck Cyprus goats during non-breeding season as compared with breeding season. This study was executed at the Ruminant Researches Station pertaining to the Directorate of Agricultural Researches, Ministry of Agriculture, Abu-Ghraib, Baghdad (latitude 33˚20' N) for the period from November 15th, 2012 to December 〖31〗^st 2013. A total of 20 buck Cyprus goats 2 years old and averages 55 kg body weight. During non-breeding season bucks were randomly divided into five equal groups (4 bucks / group). The first group (A1) was regarded as a control group, i.m injected with normal saline, whereas, the second (A2) and third (A3) groups were i.v injected with 4 and 8 µg / kg body weight of Kisspeptin-10 respectively. The fourth (A4) and fifth (A5) groups were i.m injected with hCG (250 IU / buck) and GnRH (20 µg / buck) respectively. Plasma testosterone concentrations were significantly (P≤ 0.01 and P≤ 0.05) increased at 20, 30, 40 and 50 min post-treatment in A5, A2 and A3 groups as compared with control A1. Mass motility and individual motility were significantly (P≤ 0.01) in A5, A4, A2 and A3 as compared with control during non-breeding season. In conclusion, our results show that Kisspeptin-10, GnRH and hCG can stimulate the quiescent hypothalamic–pituitary–gonadal axis of bucks during non-breeding season by increasing plasma testosterone concentration post treatment that leads improving some semen characteristics during non-breeding season.

Can advance of first lambing induced by melatonin implants influence the next lambing time in Sarda breed sheep?

2012 ◽  
Vol 92 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Vincenzo Carcangiu ◽  
Maria Consuelo Mura ◽  
Pier Paolo Bini ◽  
Giuseppe Massimo Vacca ◽  
Cinzia Daga ◽  
...  
Keyword(s):  
Breeding Season ◽  
Slow Release ◽  
Reproductive Activity ◽  
First Year ◽  
Melatonin Treatment ◽  
Ewe Lambs ◽  
Second Year ◽  
Single Implant ◽  
Breed Sheep ◽  
Short Days

Carcangiu, V., Mura, M. C., Bini, P. P., Vacca, G. M., Daga, C. and Luridiana, S. 2012. Can advance of first lambing induced by melatonin implants influence the next lambing time in Sarda breed sheep? Can. J. Anim. Sci. 92: 67–71. In adult sheep, exogenously administered melatonin from continuous slow-release implants has been shown to advance the onset of the breeding season by mimicking the stimulatory effect of short days. The aim of this study was to verify if treatment with one or two melatonin implants was effective in advancing the first conception in Sarda ewe lambs, and if this advance would also be seen in the second lambing too. In the first year, 600 ewe lambs were randomly assigned to groups M, M+M and C, each with 200 animals. On Jun. 30, group M received a single implant while group M+M received two implants. Group C was untreated. On Aug. 04, 25 rams were introduced in the groups and removed after 70 d. From these 600 animals the 420 head that lambed prior to Mar. 12 were chosen for the second year. These ewes were subdivided into two groups T1 (ewes who lambed between 2007 Jan. 01 and Feb. 10) and T2 (ewes which lambed between 2007 Feb. 11 and Mar. 12). Both in T1 and T2 the distribution of the animals in M, M+M and C group was maintained. In the first year, the treated animals lambed earlier (P<0.05) and showed higher numbers of lambed ewes at Feb. 10 (P<0.01) and at March 12 (P<0.05) compared with untreated control animals. The animals that showed an advance in the period of their first conception, also showed, in the second breeding year, an advance in the lambing time (P<0.001). This study provides evidence that the advance of first conception, obtained with melatonin treatment also influenced the reproductive activity in the following breeding season.

P–124 The beneficial effects of novel quercetin delivery system (loaded on bigel) on male fertility parameters of Non-alcoholic fatty liver model: an in-vivo (rat model) study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
E Hosseini ◽  
S N Mousavi ◽  
M S Seye. Dorraj ◽  
S Sheik. Mohammadi ◽  
Z Pourmansoori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Delivery System ◽  
Rat Model ◽  
Male Fertility ◽  
Slow Release ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Semen Parameters ◽  
Control Group ◽  
Alcoholic Fatty Liver

Abstract Study question Dose quercetin encapsulated in a bigel slow- release delivery system improve male fertility parameters in Non-alcoholic fatty liver (NAFLD) model Summary answer Quercetin in a bigel slow- release delivery system can boost semen parameters in NAFLD rat model What is known already Recent molecular and physiological studies have shown that adverse effects of NAFLD extend far beyond the liver. NAFLD can impair male reproductive function by increasing Reactive Oxidative Stress (ROS) levels, reducing the expression of antioxidant genes and inducing damage in testes immune privilege. Antioxidant therapy and its effectiveness depend on whether the exogenous antioxidant will be readily absorbed to reach high enough that are required to decrease the pathological damages. Quercetin, as an antioxidant, is able to ameliorate oxidative stress. The design of new drug delivery systems using encapsulating antioxidant can boost its durability and effectiveness. Study design, size, duration Bigels were prepared using cottonseed oil/cannabis oil/alginate/ferula gum. Sprague-Dawley rats are housed for 2 weeks, then NAFLD was induced by 58% of dietary calorie as lard and 42 g/L fructose for 16 weeks. The experimental protocol was approved by the ethical committee of Zanjan University of Medical Sciences, Zanjan, Iran. Participants/materials, setting, methods After confirming the NAFLD induction, animals divided into five groups: Control, control NAFLD, received 2 mg/kg Quer loaded on bigels, free bigels, free Quer for 45 days as daily gavage. Semen parameters (count, motility, and morphology), viability (Eosin-nigrosine staining) and serum testosterone levels were analyzed. In addition, histological sections of testicular tissues were investigated by Hematoxylin-Eosin (H&E) staining method. In situ detection of apoptosis was performed using terminal deoxynucleotidyl-transferase dUTP nick end labeling (TUNEL) assay. Main results and the role of chance The sperm count, sperm motility, normal morphology and testosterone level were significantly lower in the NAFLD group than those the controls. Moreover, higher head and tail abnormality percentages were seen in the sperm of these groups. Bigel-Quer significantly improved the serum testosterone level, sperm count, motility, and morphology compared with the NAFLD group. Spermatogenic cells in all stages of differentiation (spermatogonia, primary spermatocytes, early spermatids, late spermatids) are observed and preserved normally in the testicular tubules and lumen filled with mature sperms in the control group. Interestingly, atrophic changes in the testicular tubule architecture with swelling in spermatogonia cells, detachment from tubule membrane, reduced number of mature sperm, and reduced lumen thickness were seen in the NAFLD. In the Quer, bigel and bigel-Quer-treated groups, swelling and vacuolation rate of germ cells decreased. The testicular morphology, and tubule structure were significantly normalized, especially in the bigel-Quer-treated group. Serum testosterone levels significantly increased and reached the healthy control group in the bigel-Quer group. TUNEL-positive cells in testes increased significantly after NAFLD induction. Quantitative analysis showed a significant decrease in testicular TUNEL-positive cells following bigel-Quer treatment, but not in other groups. Limitations, reasons for caution Keeping and daily handling of animals for long-time in animal house for diet-induced NAFLD. NAFLD requires long periods of treatment to get the desired outcome especially in the case of sperm parameters investigation. Wider implications of the findings: The bigel showed synergistic effects with Quer for treating infertility in male rats with NAFLD. Stability and bio-availability of Quer are important aspects that should be considered to justify its supplementation. Empowering antioxidant shield of NAFLD patients by Quer supplementation can improve various damage effects and clinical status of diseases. Trial registration number Not applicable

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

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