Digitalised Risk Analysis of Cardiovascular Diseases: New Possibility to Make Patients Motivated. Use of the Cardiovascular Prevention (CARMEN) Programme in the Practice

2008 ◽  
Vol 2 (3) ◽  
pp. 407-416 ◽  
Author(s):  
Csaba Arnold ◽  
Zoltán Englert ◽  
Csaba Szabadhegyi ◽  
Csaba Farsang
Keyword(s):  
Cardiovascular Diseases ◽  
Risk Analysis ◽  
Cardiovascular Prevention

Digital risk analysis of cardiovascular diseases: new opportunities for the patients

2008 ◽  
Vol 149 (15) ◽  
pp. 677-684 ◽  
Author(s):  
Csaba Arnold ◽  
Zoltán Englert ◽  
Csaba Szabadhegyi ◽  
Csaba Farsang
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Risk Analysis ◽  
Effective Treatment ◽  
Medical History ◽  
Vascular Diseases ◽  
Coronary Risk ◽  
Risk Status ◽  
Long Period ◽  
Graphic Presentation

Authors constructed a software helping the prevention programme of coronary and vascular diseases as the classical risk factors are used for graphic presentation of coronary risk as compared to “normal” risk. By repeated estimation alterations in coronary risk status can be compared to previous ones and thereby help evaluating the changes. This programme is highlighted by the presentation of changes in coronary risk of a patient during a 4-year-long period of her medical history. It is also shown how graphic presentation of risk can support the more effective treatment and patient care.

scholarly journals Aszimmetrikus dimetilarginin: a cardiovascularis betegségek prediktora?

2016 ◽  
Vol 157 (13) ◽  
pp. 483-487
Author(s):  
Balázs Németh ◽  
Péter Kustán ◽  
Ádám Németh ◽  
Zsófia Lenkey ◽  
Attila Cziráki ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Asymmetric Dimethylarginine ◽  
Disease Onset ◽  
Cardiovascular Prevention ◽  
Competitive Inhibitor ◽  
Diabetic Patients ◽  
Artery Disease

Cardiovascular diseases are the most common diseases worldwide. They are responsible for one third of global deaths and they are the leading cause of disability, too. The usage of different levels of prevention in combination with effective risk assessment improved these statistical data. Risk assessment based on classic risk factors has recently been supported with several new markers, such as asymmetric dimethylarginine, which is an endogenous competitive inhibitor of nitric oxide synthase. Elevated levels of asymmetric dimethylarginine have been reported in obese, smoker, hypercholesterolemic, hypertensive and diabetic patients. According to previous studies, asymmetric dimethylarginine is a suitable indicator of endothelial dysfunction, which is held to be the previous state of atherosclerosis. Several researches found positive correlation between higher levels of asymmetric dimethylarginine and coronary artery disease onset, or progression of existing coronary disease. According to a study involving 3000 patients, asymmetric dimethylarginine is an independent risk factor of cardiovascular mortality in patients with coronary artery disease. This article summarizes the role of asymmetric dimethylarginine in prediction of cardiovascular diseases, and underlines its importance in cardiovascular prevention. Orv. Hetil., 2016, 157(13), 483–487.

scholarly journals Prevention Considerations in Cardiovascular Diseases regarding the premature mortality reduction

2020 ◽  
pp. 55-59
Author(s):  
Elena RAEVSCHI
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Good Practice ◽  
Cardiovascular Prevention ◽  
Premature Mortality ◽  
Tertiary Prevention ◽  
Noncommunicable Disease ◽  
World Health ◽  
Republic Of Moldova ◽  
The Republic

Introduction. Cardiovascular diseases are recognized as worldwide (1) and national public health issue (2, 3). This is argued by having a leading position in the structure of general mortality and disability, the substantial loss of quality of life and the health system needs for increased costs. Prevention and control of cardiovascular disease has become one of the priority directions for global and national noncommunicable disease control strategies developed to reduce premature mortality (1, 5). The major cardiovascular diseases mortality was identified some aspects of premature mortality among the adult population in the Republic of Moldova. Overall decrease of mortality due to cardiovascular diseases among adults (-5.9%) has been accompanied by a relatively slower decrease in premature mortality (-2.4%) in the Republic of Moldova (6). Primary, secondary and tertiary prevention measures are essential in reducing the burden of cardiovascular disease and contribute to improving cardiovascular health at the population level. Nature is helping people to maintain their health through mechanisms much closer to them than pharmaceutical ones through the curative action of the various natural factors that form the climate of the respective territorial area. Material and method. There is a descriptive study based on statistical data of the World Health Organization and official vital statistics of the Republic of Moldova. Results and discussions. The climatic conditions of Moldova are favorable to cardiovascular prevention and rehabilitation. Moldova is located in the temperate continental climate influenced by the proximity of the Black Sea and the interference of warm-humid air from the Mediterranean. The annual air temperatures average in the country is 9,30C. In the Republic of Moldova the warm weather with a confortable temperature lasts 175 days and the relative humidity oscillates in the average from 66 to 87%. The country's thermal regime is the most important curative factor for treating chronic diseases and opportunity for the amplification of medical rehabilitation programs for patients with cardiovascular diseases. Application of methods based on the action of climatic factors in cardiovascular rehabilitation process contributes to its efficiency. Increasing the role of tertiary prevention is a good practice for the quality improvement of medical services for this category of patients. By making appropriate, timely and complex measures of primary, secondary and tertiary prevention cardiovascular disease can be substantially prevented. Conclusions. Strengthening cardiovascular prevention centered on a complex approach to all its primary, secondary, and tertiary components is an opportunity to reduce premature mortality in the population. Key words: Cardiovascular diseases, prevention, premature mortality,

scholarly journals Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ilaria Peluso ◽  
Anna Raguzzini ◽  
Giovina Catasta ◽  
Vittoria Cammisotto ◽  
Anna Perrone ◽  
...  
Keyword(s):  
At Risk ◽  
Cardiovascular Diseases ◽  
Immune Function ◽  
Antioxidant Status ◽  
Vegetable Consumption ◽  
Jerusalem Artichoke ◽  
Cardiovascular Prevention ◽  
High Consumption ◽  
Before And After ◽  
Antioxidant Markers

High intakes of vegetables have been associated with a lower incidence of cardiovascular diseases (CVD). However, the effect of vegetables on immune function and antioxidant status in human studies have provided contrasting results. In the present study, after a week of run-in period, 38 subjects at risk of CVD were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week). Vegetables included carrots, topinambur (Jerusalem artichoke, Helianthus tuberosus), tomatoes, red cabbage, and sweet peppers. Blood and salivary samples were collected before and after intervention periods. In addition to clinical, immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin was evaluated. No significant changes were detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group (p<0.05). The study provides additional evidence about the uncertainty of providing a clear evidence for vegetables in modulating markers of immune function and antioxidant status. Further studies are needed in order to unravel the mechanism of effect of vegetable consumption in cardiovascular prevention.

scholarly journals CONTROL OF CARDIOVASCULAR RISK FACTORS IN PATIENTS AFTER MYOCARDIAL INFARCTION

2019 ◽  
Vol 72 (3) ◽  
pp. 472-483
Author(s):  
Jan W. Pęksa ◽  
Piotr Jankowski ◽  
Danuta Czarnecka
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Antiplatelet Therapy ◽  
Cardiovascular Prevention ◽  
Pharmacological Therapy ◽  
Unhealthy Lifestyle ◽  
Individual Level ◽  
Coronary Syndrome

Despite significant improvements in the diagnosis and treatment of cardiovascular diseases that have occurred in recent years, they remain the main cause of morbidity and mortality in the population. In many European countries, the incidence of coronary heart disease is currently 50% lower than it was in the early 1980s, which is the result of cardiovascular prevention. A special group of patients are people after myocardial infarction with very high cardiovascular risk. They should definitely implement activities at the individual level e. g. work on improving the unhealthy lifestyle and pharmacologically control other risk factors. A diet low in saturated fats should be recommended, i.e. mainly containing whole grains, vegetables, fruits and fish, recommend regular physical exercise: 150 min / week of moderate, aerobic physical activity, reducing the supply of calories in order to get rid of overweight or obesity. Help in quitting tobacco addiction should take place through the minimal nicotine intervention and, if necessary, pharmacological therapy. Another thing is the control of other risk factors, i. e. the appropriate treatment of dyslipidemia (the primary target is LDL cholesterol <1.8 mmol/l or reduction by ≥ 50%, if the initial concentration is between 1.8 and 3.5 mmol/l, treatment hypertension (target arterial pressure for most people aged 18–65 is in the range: 120–130/70–79 mmHg, if it is well tolerated, while for older people it is in the range: 130–139/70–79mmHg, if it is well tolerated), optimal diabetes therapy (target glycated hemoglobin <7%) and appropriate antiplatelet therapy (in most patients double antiplatelet therapy is recommended for 12 months after acute coronary syndrome). These activities lead to a significant improvement in quality of life and a decrease in mortality due to cardiovascular diseases.

scholarly journals Statistical Investigation of Correlation between Cardiovascular Event ad Hypertension

2021 ◽  
Vol 292 ◽  
pp. 03077
Author(s):  
Linfei Dai ◽  
Mingyang Song ◽  
Danni Zhang
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Cardiovascular Mortality ◽  
Secondary Analysis ◽  
Cardiovascular Prevention ◽  
Statistical Investigation ◽  
Hazard Ratios ◽  
History Of

Cardiovascular disease is one of the most severe health killers in modern life. In this study, the association among the risk of cardiovascular diseases, patients’ blood pressure and treatment was analyzed. This study makes a secondary analysis on the data from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) database. Participants have recruited 39705 representative participants with diverse blood pressure. The results show that the treated participants have a higher proportion of diabetes mellitus, dyslipidemia, and history of cardiovascular diseases (P<0.0001), compared with untreated participants. During the 10-year follow-up period, there were 2032 cardiovascular deaths distributed among coronary heart disease(CHD), heart failure, and stroke. The treated participants showed an significantly risk for cardiovascular mortality (Hazard ratios (HR):1.5; 95% confidence intervals (CI):1.36-1.66), CHD (HR:1.53, 95%CI: 1.23-1.9), heart failure (HR:1.39; 95%CI: 1.09-1.76) and stroke (HR:1.48; 95%CI: 1.28-1.72). Especially for the participants under antihypertensive medication, their risk of cardiovascular mortality was 1.5 times higher than that of the untreated participants.

scholarly journals Long-term trends in adherence to prevention in female population aged 25-44 years in Russia/Siberia

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
V Gafarov ◽  
D Panov ◽  
E Gromova ◽  
I Gagulin ◽  
A Gafarova
Keyword(s):  
Cardiovascular Diseases ◽  
Representative Sample ◽  
Cardiovascular Prevention ◽  
Modern Medicine ◽  
Behavioral Characteristics ◽  
Positive Trend ◽  
Family Status ◽  
Cvd Risk ◽  
Female Population ◽  
Open Population

Abstract Objective To determine the 23-year trends 1994-2016 yy of adherence towards cardiovascular diseases prevention, behavioral characteristics and awareness about the health in general female population aged 25-44 years in Russia / Siberia. Methods Under the third screening of the WHO program MONICA and sub-program ’MONICA-psychosocial’ (MOPSY) random representative sample of women aged 25-64 years (n = 870) were surveyed in Novosibirsk in 1994; 284 persons in group 25-44y. In 2016 within the framework of the screening studies covered by state task reg.# 01201282292 a random representative sample of women aged 25-44 years was examined in the same district of Novosibirsk (n = 540). Questionnaire MOPSY ‘Awareness and attitude towards the health’ was used to estimate adherence towards cardiovascular diseases prevention, behavioral characteristics and awareness about the health. Results The analysis showed there is a positive trend in self-rated health in female population aged 25-44 years. Despite this 50% of women rate their health negatively and 96% consider the existence of high chance to be ill with serious disease within next 5-10 years. Majority of women believed in the possibilities of modern medicine for the prevention of heart disease but there is extremely low level of healthcare utilization as prevention measure and it doesn’t exceed 10% in those women (p &lt; 0.05). There is a growth of job stress levels and upward trends in family status changes over 23 years in an open population of women aged 25-44 years. Some changes in behavioral status were found over 1994-2016 yy: increased share of people quit smoking and doing regular physical exercises, improved diet behavior. Conclusions We showed a positive trend in CVD risk factors prevention in women 25-44y. In spite of this, half of the women negatively evaluate their health and using of healthcare resources is deficient. There are adverse changes in the social gradient over the follow-up period. Key messages The purpose of this survey was to study the trends in awareness and attitudes towards cardiovascular prevention over 28 years (from 1988 to 2016) in an open female population of 25-44 years old. The purpose of this survey was to study the trends in awareness and attitudes towards cardiovascular prevention over 28 years (from 1988 to 2016) in an open female population of 25-44 years old.

Trends and current questions of cardiovascular prevention in primary health care

2012 ◽  
Vol 153 (39) ◽  
pp. 1536-1546 ◽  
Author(s):  
István Ilyés ◽  
Zoltán Jancsó ◽  
Attila Simay
Keyword(s):  
Risk Factors ◽  
Primary Care ◽  
Health Care ◽  
Primary Health Care ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Risk Group ◽  
Cardiovascular Prevention ◽  
Continuous Care ◽  
Primary Health

Although an impressive progress has been achieved in the treatment of cardiovascular diseases, they are at the top of the mortality statistics in Hungary. Prevention of these diseases is an essential task of the primary health care. Cardiovascular prevention is carried out at primary, secondary and tertiary levels using risk group and population preventive strategies. The two main tasks of primary cardiovascular prevention are health promotion and cardiovascular disease prevention, and its main programs are ensuring healthy nutrition, improving physical training and accomplishing an anti-smoking program. The essential form of secondary prevention is the screening activity of the primary health care. The majority of cardiovascular risk factors can be discovered during the doctor–patient consultation, but laboratory screening is needed for assessing metabolic risks. The official screening rules of the cardiovascular risk factors and diseases are based on diagnostic criteria of the metabolic syndrome; however, nowadays revealing of global cardiometabolic risks is also necessary. In patients without cardiovascular diseases but with risk factors, a cardiovascular risk estimation has to be performed. In primary care, there is a possibility for long term follow-up and continuous care of patients with chronic diseases, which is the main form of the tertiary prevention. In patients with cardiovascular diseases, ranking to cardiovascular risk groups is a very important task since target values of continuous care depend on which risk group they belong to. The methods used during continuous care are lifestyle therapy, specific pharmacotherapy and organ protection with drugs. Combined health education and counselling is the next element of the primary health care prevention; it is a tool that helps primary, secondary and tertiary prevention. Changes needed for improving cardiovascular prevention in primary care are the following: appropriate evaluation of primary prevention, health education and counselling, renewal of the cardiovascular screening system based on the notion of global cardiometabolic risk, creating a unified cardiovascular prevention guideline, and operating primary care cardiovascular prevention within the framework of an integrated prevention system. Orv. Hetil., 2012, 153, 1536–1546.

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Nlrp3 Inflammasome ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Cardiovascular Research ◽  
Inflammatory Processes ◽  
Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

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