scholarly journals Levels of molecular angiogenic and antiangiogenic in pregnant women with risk of preeclampsia

Author(s):  
Diah Wulandari ◽  
Mohamad Sulchan ◽  
Syarief Thaufik Hidayat

Background: Angiogenic and antiangiogenic imbalances play a major role in the pathogenesis of preeclampsia. Increased production of sFlt-1 by the placenta causes free circulating PIGF and VEGF concentrations to lower because it is bound by sFlt-1. Measuring levels of angiogenic and antiangiogenic proteins as biomarkers indicates placental dysfunction and distinguishes preeclampsia from other disorders. This study aims to analyze the levels of angiogenic and antiangiogenic molecules in pregnant women at risk for preeclampsia.Methods: The study with a cross-sectional design was carried out in 11-15 weeks gestational age whom had a risk of preeclampsia with 30 samples in primary health care starting April-August 2018. Blood serum was measured by molecular levels of VEGF, PlGF, sFlt-1, and sFlt-1/PlGF ratio using the ELISA method. Data analysis used Pearson product moment test.Results: The mean of VEGF levels are 15.5±21.6, PlGF 89.7±55.5, sFlt-1 11519.4±5126.0 and the ratio sFlt-1/PlGF 166.7±102.1. Correlation value of risk factors for preeclampsia with molecular levels of VEGF r= -0.05; p = 0.76, PlGF r= -0.21; p = 0.26, sFlt r= 0.01; p =0.99 and ratio sFlt-1/PlGF r = 0.10; p = 0.58.Conclusions: The higher the total score of preeclampsia risk factor, the lower the molecular level of VEGF and PlGF is. Moreover, the higher the total score of preeclampsia risk factor, the higher the molecular level sFlt-1 and the sFlt-1/PlGF ratio is. There are no significant correlation between total score of preeclampsia risk factor and levels of molecule VEGF, PlGF, sFlt-1 and sFlt-1/PlGF ratio.

Author(s):  
Fatima Aslam ◽  
Karimah Hanim Abd Aziz ◽  
Nurjasmine Aida Jamani ◽  
Razman Mohd Rus

Introduction: Co-morbidities such as obesity, gestational diabetes and pregnancy induced hypertension during pregnancy can be dangerous to the mother and foetus. Regular physical activity during pregnancy not only maintains maternal and foetal wellbeing, but it also maintains physical fitness and brings various health benefits. However, many women reduce their physical activity levels during pregnancy.Objectives: Thus, this study aimed to identify the barriers that could prevent pregnant mothers from doing physical activities.Methods: This is a cross-sectional study involving 168 pregnant women aged 18 to 35 years between gestational age 12 to 35 weeks in a primary health clinic in Kuantan, Pahang. Their socio-demographic characteristics were recorded, and barriers for physical activity assessed through a set of pre-tested questionnaire.Descriptive statisticswere used to describe the sociodemographiccharacteristics and the barriers.Results: The mean (SD) age was 28.0 (3.6) and majority of them were of Malay ethnicity from B40 group. Two thirds (74.4%) had tertiary education and 66.7% were working mothers. More than half (53.0%) of the participants wereoverweight and obese.Moreover, 58% of the participants had leg cramp and 63.1% felt fatigue. Almost 80.4% had backache and 46.4% had epigastric discomfort.Conclusion: Barriers such as leg cramp, backache, fatigue and epigastric discomfort could prevent pregnant women from conducting physical activities. Opportunistic recommendation by physician and concerns on the physical activity should be addressed.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S23


2021 ◽  
Vol 49 (1) ◽  
pp. 57-62
Author(s):  
Nendyah Roestijawati ◽  
Yudhi Wibowo

Cadmium (Cd) is one of the environmental factors that can cause prostate cancer. Cadmium can induces metallothionein (MT) in several tissues that functions to carry out an intracellular detoxification procession by binding to Cd. Exposure of Cd can cause an increase in reactive oxygen species which will cause lipid peroxidation with the end product being malondialdehyde (MDA). The research aims to determine the correlation between MT, MDA and prostate specific antigen (PSA) among auto body repair workers. The study used a cross sectional design involving 32 auto body repair workers and their ages ranged from 18 to 66 years. Measurement of MT, MDA and PSA using the ELISA method. We performed a multiple regression analysis to evaluate the relationships between MT, MDA with PSA for age and other covariates. The mean age of subjects was 38.88 ± 12.82 years. The mean levels of MT was 2.84 ± 1.18 ng/dL, MDA was 8.22 ± 20.06 ng / dL and PSA was 0.86 ± 1.79 ng / dL. The study found that MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) and MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) significantly predicted PSA. MDA (β = 0.827) has stronger relationship with PSA compared to MT (β =0.232). This results confirmed the role of MT and MDA on PSA synthesis. Metallothionein induce the process of lipid peroxidation with the end product being malondialdehyde (MDA) and increase PSA. Keywords : auto body repair workers, metallothionein, malondialdehyde, prostate Abstrak Kadmium (Cd) merupakan salah satu faktor lingkungan yang dapat menyebabkan kanker porstat. Kadmium dapat menginduksi metalotionin (MT) di beberapa jaringan yang akan berikatan dengan Cd untuk proses detoksifikasi. Pajanan Cd dapat meningkatkan ROS yang akan meyebabkan terjadinya peroksidase lipid dengan hasil akhir malondialdehid (MDA). Penelitian bertujuan untuk mengetahui hubungan antara MT, MDA dan PSA pada pekerja bengkel mobil. Penelitian menggunakan disain kros seksional dengan subyek sebanyak 32 pekerja bengkel mobil yang berusia 18 hingga 66 tahun. Pengukuran MT, MDA dan PSA menggunakan metode ELISA. Analisis statistik menggunakan analisis regresi berganda. Rata-rata usia subyek adalah 38.88 ± 12.82 tahun. Rata-rata kadar MT 2.84 ± 1.18 ng/dL, MDA 8.22 ± 20.06 ng / dL dan PSA 0.86 ± 1.79 ng / dL. Hasil uji didapatkan MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) dan MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) berpengaruh terhadap PSA secara signifikan. MDA (β = 0.827) mempunyai hubungan dengan PSA yang lebih kuat dibanding MT (β =0.232). Hasil penelitian mengkonfirmasi adanya peran MT dan MDA pada sintesis PSA. MT menginduksi proses peroksidase lipid dengan produk akhir MDA dan meningkatkan kadar PSA. Kata kunci : pekerja bengkel mobil, metalotionin, malondialdehid, prostat


e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Florencia T. Paendong ◽  
Eddy Suparman ◽  
Hermie M. M. Tendean

Abstract: Anemia due to iron deficiency is one of the major causes of anemia among Indonesian pregnant women. In developed country, the deaths of mothers and infants are relate to anemia caused by iron deficiency. This study aimed to obtain the profile of maternal anemia at the primary health care Bahu Manado. This was a descriptive prospective study with a cross sectional design. Samples were sobtained by using total sampling method consisted of 40 pregnant women. Serum iron (SI) was examined among anemic pregnant women. The results showed that of the 40 pregnant women, 13 (32.5%) had anemia. Of the 13 anemic pregnant women, 8 (61.5%) had decreased SI. The analysis found that there was a relation between age, age of pregnancy, parity, education, and job with anemia and decreased SI. It is recommended to consume enough iron during pregnancy and have a regular check up, and treatment in case that the iron level is not optimal.Keywords: anemia, pregnant woman, iron deficiency Abstrak: Anemia defisiensi besi merupakan penyebab utama terjadinya anemia pada ibu hamil di Indonesia dengan prevalensi yang cukup tinggi sehingga masih menjadi masalah kesehatan masyarakat. Di negara berkembang kematian ibu dan janin berkaitan dengan anemia pada kehamilan dan kebanyakan anemia pada kehamilan disebabkan oleh defisiensi besi. Penelitian ini bertujuan untuk mengetahui profil zat besi (Fe) pada ibu hamil dengan anemia di Puskesmas Bahu Manado. Jenis penelitian deskriptif prospektif dengan desain potong lintang. Pemilihan sampel menggunakan metode total sampling yaitu dengan menggunakan seluruh populasi berjumlah 40 orang. Serum iron (SI) diperiksa pada ibu hamil dengan anemia. Hasil penelitian menunjukkan dari 40 ibu hamil yang berkunjung ke Puskesmas Bahu Manado, didapatkan 13 (32,5%) ibu hamil mengalami anemia. Dari 13 ibu hamil yang anemia, didapatkan 8 (61,5%) ibu hamil mengalami penurunan kadar SI . Hasil analisis mendapatkan hubungan antara usia, usia kehamilan, paritas, pendidikan dan pekerjaan dengan anemia dan penurunan kadar SI pada ibu hamil. Disarankan kepada ibu hamil untuk memenuhi asupan zat besi saat hamil dan melakukan kontrol pemeriksaan serta mendapatkan pengobatan bila kadar zat besi (Fe) tidak berada pada nilai optimal. Kata kunci: anemia, ibu hamil, defisiensi besi


2021 ◽  
Vol 10 (1) ◽  
pp. 11
Author(s):  
Vivian Ade Wilsye Maria Mongdong ◽  
Rivan Virlando Suryadinata ◽  
Sawitri Boengas ◽  
Siti Ariffatus Saroh

One of the complications of pregnancy which is quite dangerous is preeclampsia. Increased blood pressure is a major indicator for pregnant women from preeclampsia. Various complications lead to increased risk of mortality and morbidity in the mother and fetus. During the birth process, the fetus that is conceived by a mother with preeclampsia, have a higher risk of developing neonatal asphyxia. This study aims was to determine the risk of preeclampsia on the incidence of neonatal asphyxia in dr. Sayidiman Magetan Hospital in 2018. The method used was observational with a cross sectional design. Data were collected using patient medical records. The results showed there was a difference in the incidence of neonatal asphyxia in preeclampsia and non- preeclampsia pregnant women (p = 0.000). Pregnant women with preeclampsia had a higher risk of giving birth with neonatal asphyxia (OR=3,071). In this study, it can be concluded that the risk of incidence of neonatal asphyxia is 3 times higher in preeclampsia than in non-preeclampsia at dr. Sayidiman Magetan in 2018.


Author(s):  
Abraham Winarto ◽  
Eddy Suparman ◽  
John Wantania

Objective: Determining the cystatin C serum level among normotensive, mild preeclamptic, severe preeclamptic pregnant women and their relationship with the severity of preeclampsia. Method: The study was held using cross sectional design in Prof. Dr. RD Kandou Hospital in Manado and its network hospitals. We did on 51 samples at term pregnant women, consisting of 17 samples for each group in normotensive, mild preeclampsia, and severe preeclampsia. The data were analyzed using SPSS version 22.0 software through ANOVA and Kruskal Wallis statistical test. Result: The mean cystatin C serum concentration in normotensive pregnant women, mild preeclampsia, and severe preeclampsia were 0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical test showed the significant association between cystatin C level and severity of preeclampsia (p


2021 ◽  
Vol 49 (1) ◽  
pp. 57-62
Author(s):  
Nendyah Roestijawati ◽  
Yudhi Wibowo

Cadmium (Cd) is one of the environmental factors that can cause prostate cancer. Cadmium can induces metallothionein (MT) in several tissues that functions to carry out an intracellular detoxification procession by binding to Cd. Exposure of Cd can cause an increase in reactive oxygen species which will cause lipid peroxidation with the end product being malondialdehyde (MDA). The research aims to determine the correlation between MT, MDA and prostate specific antigen (PSA) among auto body repair workers. The study used a cross sectional design involving 32 auto body repair workers and their ages ranged from 18 to 66 years. Measurement of MT, MDA and PSA using the ELISA method. We performed a multiple regression analysis to evaluate the relationships between MT, MDA with PSA for age and other covariates. The mean age of subjects was 38.88 ± 12.82 years. The mean levels of MT was 2.84 ± 1.18 ng/dL, MDA was 8.22 ± 20.06 ng / dL and PSA was 0.86 ± 1.79 ng / dL. The study found that MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) and MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) significantly predicted PSA. MDA (β = 0.827) has stronger relationship with PSA compared to MT (β =0.232). This results confirmed the role of MT and MDA on PSA synthesis. Metallothionein induce the process of lipid peroxidation with the end product being malondialdehyde (MDA) and increase PSA. Keywords : auto body repair workers, metallothionein, malondialdehyde, prostate Abstrak Kadmium (Cd) merupakan salah satu faktor lingkungan yang dapat menyebabkan kanker porstat. Kadmium dapat menginduksi metalotionin (MT) di beberapa jaringan yang akan berikatan dengan Cd untuk proses detoksifikasi. Pajanan Cd dapat meningkatkan ROS yang akan meyebabkan terjadinya peroksidase lipid dengan hasil akhir malondialdehid (MDA). Penelitian bertujuan untuk mengetahui hubungan antara MT, MDA dan PSA pada pekerja bengkel mobil. Penelitian menggunakan disain kros seksional dengan subyek sebanyak 32 pekerja bengkel mobil yang berusia 18 hingga 66 tahun. Pengukuran MT, MDA dan PSA menggunakan metode ELISA. Analisis statistik menggunakan analisis regresi berganda. Rata-rata usia subyek adalah 38.88 ± 12.82 tahun. Rata-rata kadar MT 2.84 ± 1.18 ng/dL, MDA 8.22 ± 20.06 ng / dL dan PSA 0.86 ± 1.79 ng / dL. Hasil uji didapatkan MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) dan MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) berpengaruh terhadap PSA secara signifikan. MDA (β = 0.827) mempunyai hubungan dengan PSA yang lebih kuat dibanding MT (β =0.232). Hasil penelitian mengkonfirmasi adanya peran MT dan MDA pada sintesis PSA. MT menginduksi proses peroksidase lipid dengan produk akhir MDA dan meningkatkan kadar PSA. Kata kunci : pekerja bengkel mobil, metalotionin, malondialdehid, prostat


2018 ◽  
Vol 8 (6) ◽  
pp. 138-144
Author(s):  
Thien Nguyen Duc ◽  
Tai Tran Tan

Background: Periodontal disease is a prominent and important issue of public health, especially in pregnant women. The objective of this study is to describe the clinical characteristics; learn knowledge, attitudes, practice oral hygiene and assess the need for treatment of periodontal disease in pregnant women. Subjects and Methods: A cross-sectional study of 210 pregnant women who visited the Department of Obstetrics and Gynecology at the Hue University of Medicine and Pharmacy Hospital. Clinical examination and interview questions on knowledge, attitudes and practice of oral care for all subjects. Results: The incidence of gingivitis was 100%, with mild gingivitis of 4,3% and moderate gingivitis of 95.7%. There was a difference in incidence rates of gingivitis in the gestational period (p<0.001). The incidence of periodontitis is 17.6% and there is no difference in gestational age (p>0.05). The mean values of GI and BOP indices differed by gestation period (p<0.05) and PD, OHI-S, PlI have statistically significant relationship with gestation period (p>0.05). The incidence of periodontal disease is 80.5%; The percentage of pregnant women who abstain from brushing their teeth after birth is 61.4%. Prevalence of brushing once a day: 7.1%; Twice a day: 70.5% and 3 times daily: 22.4%; The mean values of GI, PD, BOP, OHI-S and PlI were inversely proportional to the number of brushing (p<0.001). The rate of dental hygiene is just 3.3%; The rate of oral hygiene, dental plaque and plaque removal was 94,3%; The proportion of subjects required for intensive treatment is 2.4%. Conclusion: Periodontal disease, especially for pregnant women, is high. It is necessary to educate the knowledge, attitudes and practice of proper oral hygiene and to better meet the demand for periodontal disease treatment for pregnant women. Key words: Periodontal disease, pregnant women, knowledge, attitude, practice for oral hygiene, treatment needs


2021 ◽  
Vol 9 ◽  
pp. 251513552110158
Author(s):  
Abdoulreza Esteghamati ◽  
Shirin Sayyahfar ◽  
Yousef Alimohamadi ◽  
Sarvenaz Salahi ◽  
Mahmood Faramarzi

Background: Whole-cell pertussis (wP) vaccine administration is still advocated for children under 7 years of age in Iran. However, there is no recommendation for the administration of a dose of tetanus, diphtheria, and acellular pertussis (Tdap) vaccine to childbearing age/pregnant women in the Iranian vaccination program and it has increased the risk of infection through waning immunity during women’s childbearing age life. The study aimed to assess the levels of anti- Bordetella pertussis antibodies in childbearing age women of different ages in Iran. Methods: A cross-sectional study was conducted on a total number of 360 childbearing age women divided into six age groups, with 5-year intervals from 15 to 45 years old, in 2018–2019. Then, the levels of immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) antibodies against B. pertussis were evaluated using enzyme-linked immunosorbent assay (ELISA). The IBM SPSS Statistics software (version 16.0) (SPSS Inc., Chicago, IL, USA) was used for data analysis. Results: The mean age of the participants was 30.01 ± 8.35 years (range 14–45 years). All the cases were IgM negative, but two IgA-positive individuals (in the age groups of 14–19 and 30–34 years) were reported. Overall, 239 (66.4%) cases were IgG positive. The mean age of IgG-positive cases was 30.37 ± 8.37 years. The IgG-positive cases were mostly in the age groups of 30–34 and 35–39 years [43 (71.1%)]. The odds of IgG positivity were 1.97. The highest odds of IgG positivity were seen in 30–34 and 35–39 years groups (2.52) and the lowest odds were seen in the 20–24 and 25–29 years groups (1.60). Using the Jonckheere–Terpstra test, the increasing trend of IgG changes in different age groups was not statistically significant (Tπ=5.78, p = 0.09). Conclusion: The infants of women of childbearing age might be prone to pertussis in countries using the wP vaccination schedule. It is suggested to administer a dose of Tdap to women before or during pregnancy to increase the immunity of their infants against this disease during early infancy.


Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 418
Author(s):  
Maria Maroudia Berikopoulou ◽  
Aikaterini Pana ◽  
Theodota Liakopoulou-Tsitsipi ◽  
Nikos F. Vlahos ◽  
Vasiliki Papaevangelou ◽  
...  

Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 36 0/7 and 37 6/7 weeks’ gestation. We sought to examine the level of adherence to the GBS screening guidelines and estimate the prevalence of GBS colonization among pregnant women. Although in Greece the screening-based strategy is followed, we also examined known EOD risk factors and linked them to GBS colonization. A cross-sectional study of 604 women postpartum in three hospitals and maternity clinics was conducted. Following written informed consent, data were collected via a short self-completed questionnaire and review of patients’ records. In 34.6% of the enrolled pregnant women, no culture had been taken. Of the remaining, 12.8% had proper vaginal-rectal sample collections. The overall maternal colonization rate was 9.6%. At least one risk factor for EOD was identified in 12.6% of participants. The presence of risk factors was associated with positive cultures (p = 0.014). The rate of culture collection did not differ between women with or without an EOD risk factor. Adherence to a universal screening of pregnant women with vaginal-rectal cultures was poor. Despite probable underestimation of GBS carrier status, almost 1 in 10 participants were GBS positive during pregnancy. Screening of women with risk factors for EOD should, at least, be prioritized to achieve prevention and prompt intervention of EOD.


2021 ◽  
Vol 29 (6) ◽  
pp. 316-322
Author(s):  
Nurul Nabilah Ahmad Fadzil ◽  
Azura Abdul Halain ◽  
Santhi A/P Yew Roan Nee ◽  
Soh Kim Lam ◽  
Salimah Japar

Background Prenatal supplementation has been introduced to pregnant women during early pregnancy to prevent complication to both mother and fetus. The complications include anaemia, postpartum haemorrhage, low birth weight and fetal defects. Aim To assess compliance with vitamin and mineral supplementation in pregnant women. Methods A cross-sectional design with simple random sampling was used in this study with 100 respondents who attended the maternal and child clinic in Selangor, Malaysia. Findings The findings showed that 86 respondents (86%) were compliance towards vitamin and mineral supplementation, whereas 35 respondents (35%) were non-compliance mainly due to forgetfulness. The result indicated a significant association between compliance with race (p=0.02), occupation (p<0.01), household income (p=0.02), education (p<0.01), parity (p<0.01) and trimester (p=0.02). Conclusion Majority of the respondents acknowledge that side effects and forgetfulness were the main influencing factors towards non-compliance.


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