Diode Laser Bonding of Planar MEMS, MOEMS, & Microfluidic Devices

2005 ◽  
Vol 872 ◽  
Author(s):  
Jie-Wei Chen ◽  
Jerry Zybko ◽  
James Clements
Keyword(s):  
Diode Laser ◽  
Low Cost ◽  
New Technology ◽  
Microfluidic Devices ◽  
High Volume ◽  
Process Characteristics ◽  
Alignment System ◽  
Laser Bonding ◽  
Plastic Parts ◽  
Automated Alignment

AbstractThe assembly of plastic microfluidic devices, MOEMS and microarrays requiring high positioning and welding accuracy in the micrometer range, has been successfully achieved using a new technology based on laser transmission welding combined with a photolithographic mask technique. This paper reviews a laser assembly platform for the joining of microfluidic plastic parts with its main related process characteristics and its potential for low-cost and high volume manufacturing. The system consists of a of diode laser with a mask and an automated alignment function to generate micro welding seams with freely definable geometries. A fully automated mask alignment system with a resolution of < 2 μm and a precise, non-contact energy input allows a fast welding of micro structured plastic parts with high reproducibility and excellent welding quality.

scholarly journals A Modular Toolkit to Fabricate Microfluidic Devices for 3D Cell Culture and Near Real-time Measurements

2020 ◽  
Author(s):  
Giraso Kabandana ◽  
Adam Michael Ratajczak ◽  
Chengpeng Chen
Keyword(s):  
Cell Culture ◽  
Real Time ◽  
Low Cost ◽  
New Technology ◽  
Microfluidic Channel ◽  
3D Cell Culture ◽  
Microfluidic Devices ◽  
In Vitro Cell Cultures ◽  
Scoring Tools

Microfluidic technology has tremendously facilitated the development of in vitro cell cultures and studies. Conventionally, microfluidic devices are fabricated with extensive facilities by well-trained researchers, which hinders the widespread adoption of the technology for broader applications. Enlightened by the fact that low-cost microbore tubing is a natural microfluidic channel, we developed a series of adaptors in a toolkit that can twine, connect, organize, and configure the tubing to produce functional microfluidic units. Three subsets of the toolkit were thoroughly developed: the tubing and scoring tools, the flow adaptors, and the 3D cell culture suite. To demonstrate the usefulness and versatility of the toolkit, we assembled a microfluidic device and successfully applied it for 3D macrophage cultures, flow-based stimulation, and automated near real-time quantitation with new knowledge generated. Overall, we present a new technology that allows simple, fast, and robust assembly of customizable and scalable microfluidic devices with minimal facilities, which is broadly applicable to research that needs or could be enhanced by microfluidics.

In-Situ Bonding of Multi-Layer Microfluidic Devices Assisted by an Automated Alignment System

2021 ◽  
Vol 6 (2) ◽  
pp. 2611-2617
Author(s):  
Pengyun Li ◽  
Xiaoming Liu ◽  
Dan Liu ◽  
Xiaoqing Tang ◽  
Masaru Kojima ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Alignment System ◽  
Automated Alignment

STELLA - STretchable ELectronics for Large Area Applications - A New Technology for Smart Textiles

2008 ◽  
Vol 60 ◽  
pp. 67-73 ◽  
Author(s):  
Benno Schmied ◽  
Jürgen Günther ◽  
Christopher Klatt ◽  
Horst Kober ◽  
Eugène Raemaekers
Keyword(s):  
Low Cost ◽  
New Technology ◽  
High Volume ◽  
The Body ◽  
Stretchable Electronics ◽  
Electronic Systems ◽  
Wearable Electronics ◽  
Large Area ◽  
Ambient Intelligent ◽  
Eu Project

As a consequence of the ambient intelligent vision where the citizen carries along more and more electronic systems near the body wearable electronics is needed. Typical applications are intelligent textiles and clothes, personnel healthcare or fitness monitoring. The electronic systems for these applications have to be stretchable with soft touch nature in order not to hamper the comfort of the user and to be ideally almost non-noticeable to him. They should be reliably withstanding all mechanical and chemical requirements of clothes, in which they are integrated. In the EU- project "STELLA" IST - 028260 the consortium has developed a platform technology of enabling interconnection, packaging and assembling technologies. For example a new generation of stretchable substrates based on non woven with stretchable conductor pattern for large area application has been developed. In order to realize low-cost high volume stretchable electronics printed circuit methods have been modified and applied so far.

scholarly journals A Modular Toolkit to Fabricate Microfluidic Devices for 3D Cell Culture and Near Real-time Measurements

2020 ◽  
Author(s):  
Giraso Kabandana ◽  
Adam Michael Ratajczak ◽  
Chengpeng Chen
Keyword(s):  
Cell Culture ◽  
Real Time ◽  
Low Cost ◽  
New Technology ◽  
Microfluidic Channel ◽  
3D Cell Culture ◽  
Microfluidic Devices ◽  
In Vitro Cell Cultures ◽  
Scoring Tools

Microfluidic technology has tremendously facilitated the development of in vitro cell cultures and studies. Conventionally, microfluidic devices are fabricated with extensive facilities by well-trained researchers, which hinders the widespread adoption of the technology for broader applications. Enlightened by the fact that low-cost microbore tubing is a natural microfluidic channel, we developed a series of adaptors in a toolkit that can twine, connect, organize, and configure the tubing to produce functional microfluidic units. Three subsets of the toolkit were thoroughly developed: the tubing and scoring tools, the flow adaptors, and the 3D cell culture suite. To demonstrate the usefulness and versatility of the toolkit, we assembled a microfluidic device and successfully applied it for 3D macrophage cultures, flow-based stimulation, and automated near real-time quantitation with new knowledge generated. Overall, we present a new technology that allows simple, fast, and robust assembly of customizable and scalable microfluidic devices with minimal facilities, which is broadly applicable to research that needs or could be enhanced by microfluidics.

scholarly journals A rapid, accurate, scalable, and portable testing system for COVID-19 diagnosis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guanhua Xun ◽  
Stephan Thomas Lane ◽  
Vassily Andrew Petrov ◽  
Brandon Elliott Pepa ◽  
Huimin Zhao
Keyword(s):  
Limit Of Detection ◽  
Low Cost ◽  
High Volume ◽  
N Gene ◽  
Testing System ◽  
Target Sequence ◽  
One Pot ◽  
Sequence Detection ◽  
Highly Sensitive ◽  
Speed Accuracy

AbstractThe need for rapid, accurate, and scalable testing systems for COVID-19 diagnosis is clear and urgent. Here, we report a rapid Scalable and Portable Testing (SPOT) system consisting of a rapid, highly sensitive, and accurate assay and a battery-powered portable device for COVID-19 diagnosis. The SPOT assay comprises a one-pot reverse transcriptase-loop-mediated isothermal amplification (RT-LAMP) followed by PfAgo-based target sequence detection. It is capable of detecting the N gene and E gene in a multiplexed reaction with the limit of detection (LoD) of 0.44 copies/μL and 1.09 copies/μL, respectively, in SARS-CoV-2 virus-spiked saliva samples within 30 min. Moreover, the SPOT system is used to analyze 104 clinical saliva samples and identified 28/30 (93.3% sensitivity) SARS-CoV-2 positive samples (100% sensitivity if LoD is considered) and 73/74 (98.6% specificity) SARS-CoV-2 negative samples. This combination of speed, accuracy, sensitivity, and portability will enable high-volume, low-cost access to areas in need of urgent COVID-19 testing capabilities.

scholarly journals Microfabrication with Very Low-Average Power of Green Light to Produce PDMS Microchips

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 607
Author(s):  
Lucero M. Hernandez-Cedillo ◽  
Francisco G. Vázquez-Cuevas ◽  
Rafael Quintero-Torres ◽  
Jose L. Aragón ◽  
Miguel Angel Ocampo Mortera ◽  
...  
Keyword(s):  
Low Cost ◽  
Average Power ◽  
Green Light ◽  
Microfluidic Devices ◽  
Processing Parameters ◽  
Coating Film ◽  
Two Dimensional ◽  
Dimethyl Siloxane ◽  
Visible Laser ◽  
High Absorption

In this article, we show an alternative low-cost fabrication method to obtain poly(dimethyl siloxane) (PDMS) microfluidic devices. The proposed method allows the inscription of micron resolution channels on polystyrene (PS) surfaces, used as a mold for the wanted microchip’s production, by applying a high absorption coating film on the PS surface to ablate it with a focused low-power visible laser. The method allows for obtaining micro-resolution channels at powers between 2 and 10 mW and can realize any two-dimensional polymeric devices. The effect of the main processing parameters on the channel’s geometry is presented.

A Study on the Birefringence Measurement in Injection Molded Parts Using Two Different Laser Sources and R-G-B Separation of White Light

2006 ◽  
Vol 326-328 ◽  
pp. 187-190
Author(s):  
Jong Sun Kim ◽  
Chul Jin Hwang ◽  
Kyung Hwan Yoon
Keyword(s):  
White Light ◽  
Low Cost ◽  
Main Idea ◽  
Injection Molding Process ◽  
Molding Process ◽  
Laser Method ◽  
High Productivity ◽  
Molded Parts ◽  
Injection Molded ◽  
Plastic Parts

Recently, injection molded plastic optical products are widely used in many fields, because injection molding process has advantages of low cost and high productivity. However, there remains residual birefringence and residual stresses originated from flow history and differential cooling. The present study focused on developing a technique to measure the birefringence in transparent injection-molded optical plastic parts using two methods as follows: (i) the two colored laser method, (ii) the R-G-B separation method of white light. The main idea of both methods came from the fact that more information can be obtained from the distribution of retardation caused by different wavelengths. The comparison between two methods is demonstrated for the same sample of which retardation is up to 850 nm.

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