Assessment of effectiveness of Gaviscon® Forte in the treatment of heartburn during pregnancy

2016 ◽  
pp. 84-90
Author(s):  
M.B. Scherbinina ◽  
◽  
T.V. Lugovskaya ◽  
N.A. Ivanchenko ◽  
G.A. Kovalenko ◽  
...  

Heartburn refers to the common dyspeptic manifestations experienced by up to 80% of pregnant women. The objective: To evaluate the efficacy of Gaviscon® Forte in the treatment of heartburn during pregnancy based on clinical data, the opinion study of pregnant women receiving the drug, and physicians provides their curation, as well as exploring the views of gynecologists, which have the practice of conducting such patients. Patients and methods. There were 94 pregnant women (Ј38 weeks of gestation), aged 18 to 34 years, with clinical manifestation of heartburn in the study. Oral Gaviscon® Forte mint suspension (the company «Rekkitt Benckiser Ukraine», UK) was appointed from 10 days to 1 month by 5–10 ml (1–2 tsp) 3 times a day after meals and 4th just before going to bed; or for 1 month by 5–10 ml (1–2 tsp) on demand. For the criteria of effectiveness of the drug have been taken: the time the relief of heartburn after a single reception; clinical dynamics of heartburn and related symptoms; opinion of pregnant women receiving the drug, and physicians provides their curation, opinions of gynecologists (n=258), which have the practice of conducting such patients. The evaluation of safety and tolerability of treatment was carried out by clinical monitoring. Results. The majority of women (54.2%) had the first pregnancy. The appearance of heartburn on trimesters was: I – 11.7%; II – 25.5%; III – 62.8%. Before pregnancy, 63.8% of women had a disease of the digestive system. Heartburn severity was in majority cases between 4 (43.6%) and 3-points (26.6%) by 5-point scale. The duration of heartburn without the use of drugs was an average of 30 minutes. 54.3% of women experienced heartburn at least 1 time per week, and the rest – on a daily basis; 34.4% mentioned nocturnal episodes of heartburn. There were non-cardiac chest pain, 8.5%, dysphagia – 12.8%, the feeling of a lump in the throat – 23.4%, cough – 9.6%, mainly burping air – 60.6%, and hiccups – 43% in conjunction with heartburn. During treatment with Gaviscon® Forte frequency and intensity of heartburn and related symptoms gradually decreased. According to pregnant women after a single dose of the drug the relief of heartburn started in 5±2.6 min; control of GERD symptoms was observed after 11±3.8 days of regular therapy; the effectiveness of the drug was assessed as «good» and «very good» in 85.1% of cases. According to the doctors, they estimated the effectiveness of the drug as «good» and «very good» – in 86.2%. Of surveyed gynecologists, 39.5% used alginates in the treatment of heartburn during pregnancy. They assessed the effectiveness of Gaviscon® Forte as «good» and «very good» in 100% of cases. Conclusions. The findings confirmed the high efficiency Gaviscon® Forte in the treatment of heartburn during pregnancy. The study allows confirming the advisability of administration of the drug for a quick and adequate removal of negative symptoms. Key words: heartburn during pregnancy, alginates, Gaviscon® Forte.

2018 ◽  
pp. 46-50
Author(s):  
O.V. Kravchenko ◽  

The objective: generalization of the experience of using chlorhexidine drugs in obstetric and gynecological practice. Materials and methods. The efficacy of using Depantol and Hexicon for non-specific colpitis in patients of adolescent, reproductive age, pregnant women, women in perimenopause, as well as in patients after cervical, vaginal and perineal operations was evaluated and generalized. The surveyed groups contained 30 to 50 patients. The diagnosis of nonspecific vaginitis was verified by clinical and laboratory examination. Criteria for recovery were complete clinical and bacterial sanation. The effectiveness of therapy was evaluated immediately after treatment and after 1 and 3 months. The data were compared with the appropriate control groups or with the condition prior to treatment. Results. High efficiency of chlorhexidine preparations in the treatment of nonspecific colpitis in patients of different age categories and conditions was noted. The experience of using Depantol and Gecikon in obstetrics and gynecology is generalized, priorities are determined in the application of these drugs. Conclusion. Preparations of chlorhexidine Geksikon and Depantol are highly effective against the main pathogens of inflammatory nonspecific vulvovaginitis. They do not interfere with the functional activity of lactobacilli, which helps maintain a normal vaginal biocenosis. The drug Geksikon with success can be recommended both for the treatment of gynecological patients of reproductive age, and pregnant women. The use of Depantol, due to the regenerative activity of the dexpanthenol component, is a priority in the treatment of infectious processes in adolescence, perimenopausal age and in patients after operations on the cervix, vagina and perineum. Key words: chlorhexidine preparations, obstetrics and gynecology, Depantol, Geksikon.


1970 ◽  
Vol 2 (2) ◽  
pp. 12-15
Author(s):  
Nira S Shrestha ◽  
Sumita Pradhan

Objectives: To evaluate the knowledge and attitude of Nepalese women towards mode of delivery and caesarean on demand. Study design: Hospital based cross sectional descriptive study where 200 pregnant women after 37 completed weeks of gestation were recruited randomly and interviewed, and their answers were analyzed. Results: Of the 200 interviewed pregnant women, all of them knew about normal vaginal delivery and caesarean delivery, but only 30% knew about instrumentally assisted delivery and 9% had heard about painless labour. Vaginal delivery was the preferred mode in 93% and 7% preferred caesarean delivery. Only 35% of the interviewed women believed that women should have the right to demand a caesarean section Conclusion: Knowledge assessment of two hundred women regarding the mode of delivery clearly indicates the need for strengthening counseling aspect of antenatal care and awareness program regarding mode of delivery. In Nepal on demand caesarean section is not provided in the University Teaching Hospital. However one third of women still felt that women should have the right to choose caesarean section on demand. Key words: Attitude, mode of delivery, Caesarean on demand. doi:10.3126/njog.v2i2.1448 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 12 - 15


1971 ◽  
Vol 3 (3) ◽  
pp. 267-280 ◽  
Author(s):  
N. Uddenberg ◽  
P.-E. Almgren ◽  
Å. Nilsson

One hundred and fifty-two randomly selected pregnant women were examined and followed up by interviews and psychological tests during pregnancy and after parturition. The present paper is focused upon factors which determine the woman's preference for the sex of her expected child. It was shown that women who already have one or more children generally wanted the expected child to be of the opposite sex to her youngest child. Thus, the main part of the study was limited to eighty-one nulliparous women.Associations were found between the woman's preference for the sex of the child and several factors such as the sex of her own siblings and her position among them, her education, intelligence and degree of field-dependence indicating immaturity and lack of autonomy.Several of the findings presented refute the common supposition that nulliparous women generally want to give birth to a son, and that the arrival of a son is more satisfactory. Women wishing for a son were found to be somewhat more field-dependent than other women and somewhat more often reported that they had experienced a range of mental symptoms before the current pregnancy. Women wishing for a boy also reported more mental symptoms during the post-partum period. Moreover, those women who gave birth to a son reperted more symptoms at this time than those who gave birth to a daughter, and paradoxically the most affected were those who had wished for a son and had had their wishes fulfilled. The arrival of a daughter therefore seems to be equally satisfactory to the mother, at least as measured by the criteria used in this investigation.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Anja W. M. M. Stevens ◽  
Stasja Draisma ◽  
Peter J. J. Goossens ◽  
Birit F. P. Broekman ◽  
Adriaan Honig ◽  
...  

Abstract Background and rationale Although it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood symptoms on a daily basis, such as the lifechart method (LCM). The aim of the present study is to investigate the course of BD during pregnancy by comparing LCM scores of pregnant and non-pregnant women. Methods Study design: Comparison of LCM scores of two prospective observational BD cohort studies, a cohort of pregnant women (n = 34) and a cohort of non-pregnant women of childbearing age (n = 52). Main study parameters are: (1) proportions of symptomatic and non-symptomatic days; (2) symptom severity, frequency, and duration of episodes; (3) state sequences, longitudinal variation of symptom severity scores. Results No differences in clinical course variables (symptomatic days, average severity scores, frequency, and duration of episodes in BD were found between pregnant and non-pregnant women. With a combination of State Sequence Analysis (SSA) and cluster analysis on the sequences of daily mood scores three comparable clusters were found in both samples: euthymic, moderately ill and severely ill. The distribution differences between pregnant and non-pregnant women were significant, with a majority of the pregnant women (68%) belonging to the moderately ill cluster and a majority of the non-pregnant women (46%) to the euthymic cluster. In pregnant women the average daily variation in mood symptoms as assessed with Shannon’s entropy was less than in non-pregnant women (respectively 0.43 versus 0.56). Conclusions Although the use of daily mood scores revealed no difference in overall course of BD in pregnant versus non-pregnant women, more pregnant than non-pregnant women belonged to the moderately ill cluster, and during pregnancy the variation in mood state was less than in non-pregnant women. Further research is necessary to clarify these findings.


2003 ◽  
Vol 2 (3) ◽  
pp. 75-80
Author(s):  
I. D. Yevtushenko ◽  
A. Sh. Makhmutkhodzhayev ◽  
T. V. Ivanova ◽  
O. V. Parshina ◽  
I. A. Ryzhova ◽  
...  

A clinical prospective examination of 90 women with complete pregnancy and indications for labor induction because of unsatisfactory maturity of uterus cervix has been made. The aim was to create a comparative analysis of efficiency of intravaginal introduction of prostaglandin synthetic analogue E1 misoprostol («Sytotec») and intracervical introduction of prostaglandin E2 dinoprostone («Prepidil» gel) for uterus cervix preparation and labor induction at complete pregnancy. Misoprostol in a dose of 25 mkg has been introduced to pregnant women of the 1 group (n=44), every 4 hours not more than 3 times. In case of discharge of waters or labor activity the second introduction has not been done. Dinoprostone has been introduced intracervically in a single dose to pregnant women of the 2 group (n=46). The use of misoprostol has been accompanied by spontaneous beginning of labor activity by 2 times more often than the use of dinoprostone. The quantity of vaginal births within 12 and 24 hours of observation has been surely greater and the duration of time between the beginning of introduction and labor has been surely smaller in the group of women received misoprostol as compared to the one received dinoprostone. It has not been revealed any differences between examined groups by the frequency of uterus hyperstimulation symptom development, labor duration, frequency of abdominal and vaginal labor, as well as perinatal outcomes.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Santosh Kr Karn

Background: Dehradun, India is going to most exceedingly influencing and breaking down air quality due to the burning of the discarded plastic, where the natural beauty is the prized component. Carelessly threw the disposed of plastic and burning affecting the environment and people’s health drastically. Consequently, various sicknesses and disease are the common phenomenon. Thus, this region urgently required an extensive evaluation by the governmental and non-governmental organization to solve this issue and make a strict control to stop the plastic on every day utilize premise. Their people groups endure much because of their own activity. Objectives: The objective of the current report about the majorly the environmental and public health concern due to the discard plastic burning on daily basis which causes severe respiratory disease and health hazards. Methods: The current study focused on the observation and collection of plastic burning activities done by the people of on daily basis in the last three year from August 2017 to July 2020. Results: As regularly as conceivable it can be found in every 20 houses there are cluster plastics burning on daily basis. Burnt Plastic, releasing lethal gases into the environment which include substances like dioxins, furans, mercury and polychlorinated biphenyls which is a hazardous compound and conceivably hurting to all kind of life. Dehradun, India is emerging as a hotspot for the broken air quality especially due to burning of discard plastic in this region and introducing smoke into the atmosphere. Due to this, numbers of affected people are increasing an everyday basis. This broken air quality is also responsible for greenhouse gases (GHG) and increasing global warming potential. Conclusions: Finally, I might want to focus this area move toward becoming a hotspot to look with crumbled air quality from the last couple of years. Numbers of multiple illnesses affected peoples increasing year by year. The level of dangerous compound increasing in the atmosphere, in this way it is needful to take preparatory measure to make strict regulation and develop treatment facility to save Dehradun. As this region is like a gift by nature.


2013 ◽  
Vol 274 ◽  
pp. 290-293
Author(s):  
Bao Gang Wang ◽  
Qi Hui Song ◽  
Guang Chi Xu

A wind-driven feeding mechanism of high efficiency is designed according to the TRIZ theory and its mechanical structure innovative design based on the principle of energy conversion. It aims at delivering of small granular, cylindrical, flakes and other materials in machinery, pharmaceuticals, electronics and other industries by transmission mechanism such as the typical gear mechanism and linkage mechanism. The prototype is produced combined with the specific parameters of the common materials. The modular innovative design is adopted, including the transmission module, driver module and material feeding module. By the inspection of the actual operation, each design module of the produced prototype is stable and reliable. At the same time the effect of material transportation is good.


2017 ◽  
Vol 5 (3) ◽  
pp. 444-453 ◽  
Author(s):  
Yangcui Qu ◽  
Ting Wei ◽  
Wenjun Zhan ◽  
Changming Hu ◽  
Limin Cao ◽  
...  

A re-usable supramolecular platform with the capability of high-efficiency capture and on-demand release of specific proteins and bacteria was developed.


Author(s):  
Geetanjali Rathee ◽  
Hemraj Saini

India is the largest democracy in the world, and in spite of that, it faces various challenges on a daily basis that hinder its growth like corruption and human rights violations. One of the ugliest phases of corruption and political mayhem is visible during the election process where no stone is kept unturned in order to gain power. However, it is the common citizen who suffers most in terms of clarity as well as security when it comes to his/her vote. Blockchain can play a very important role in ensuring that the voters registering their votes are legit and the counting of votes is not manipulated in any way. It is also needed in today's times where the world is available to people in their smart phones to also give them the opportunity to register their votes hassle free via their smart phones without having to worry about the system getting hacked. Therefore, in this chapter, the proposed layout will be based on a smart contract, using Ethereum software to create an e-voting app. In this chapter, the authors have proposed a secure e-voting framework through blockchain mechanism.


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