scholarly journals Modern approaches to the treatment of urogenital disorders in perimenopausal women

2020 ◽  
pp. 114-118
Author(s):  
L.V. Potapova ◽  
◽  
I.N. Shcherbina ◽  
Keyword(s):  
Malignant Tumors ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Menstrual Disorders ◽  
Surgical Interventions ◽  
The Past ◽  
Perimenopausal Women ◽  
The Common ◽  
Systemic Nature

In modern gynecology, hormone-dependent pathology is one of the most significant problems. The importance of solving this problem is due to the significant prevalence of this pathology, its long-term recurrent course and the presence of a medico-social task of preserving the reproductive function of patients. The age of women who develop dyshormonal diseases is already 30–35 years old, which leads to premature loss of reproductive function, an increase in the frequency of surgical interventions. The systemic nature of the lesion in dyshormonal pathology is due to the common links of pathogenesis. The leading factor in the pathogenesis of hormone-dependent pathology is absolute or relative hyperestrogenism. Menstrual disorders (MD) is one of the most overlooked problems in modern gynecology. Over the past decade, an increase in the frequency of MD in women of reproductive age has been noted in the world by almost 11 times. In the structure of gynecological morbidity, according to most authors, MD s account for about 60% of all dyshormonal disorders, which often lead to an underestimation of future not only reproductive, but also general somatic problems: from miscarriage and infertility to the formation of both benign and malignant tumors in the female organism. Keywords: hormone-dependent pathology, menstrual disorders, estrogens, progesterone, treatment, indole-3-carbinol, rod extract, Agidol.

Effective pharmacotherapeutic effect of indole-3-carbinol and rod extract as part of the drug Agidol

2020 ◽  
pp. 107-113
Author(s):  
T.V. Skritskaya ◽  
Keyword(s):  
Malignant Tumors ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Surgical Interventions ◽  
The Past ◽  
The Common ◽  
Systemic Nature

In modern gynecology, hormone-dependent pathology is one of the most significant problems. The importance of solving this problem is due to the significant prevalence of this pathology, its long-term recurrent course and the presence of a medico-social task of preserving the reproductive function of patients. The age of women who develop dyshormonal diseases is already 30–35 years old, which leads to premature loss of reproductive function, an increase in the frequency of surgical interventions. The systemic nature of the lesion in dyshormonal pathology is due to the common links of pathogenesis. The leading factor in the pathogenesis of hormone-dependent pathology is absolute or relative hyperestrogenism. Menstrual disorders (MD) is one of the most overlooked problems in modern gynecology. Over the past decade, an increase in the frequency of MD in women of reproductive age has been noted in the world by almost 11 times. In the structure of gynecological morbidity, according to most authors, MD s account for about 60% of all dyshormonal disorders, which often lead to an underestimation of future not only reproductive, but also general somatic problems: from miscarriage and infertility to the formation of both benign and malignant tumors in the female organism. Keywords: hormone-dependent pathology, menstrual disorders, estrogens, progesterone, treatment, indole-3-carbinol, rod extract, Agidol.

scholarly journals Acceptability of Naloxone Dispensing Among Pharmacists

2018 ◽  
Vol 33 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Vivian Do ◽  
Emily Behar ◽  
Caitlin Turner ◽  
Michelle Geier ◽  
Phillip Coffin
Keyword(s):  
San Francisco ◽  
Safety Net ◽  
Instructional Materials ◽  
Primary Care Clinics ◽  
Prescriptive Authority ◽  
The Past ◽  
Mandatory Training ◽  
Safety Net Clinics ◽  
The Common

Background: The San Francisco Department of Public Health initiated naloxone prescribing at 6 safety net clinics. We evaluated this intervention, demonstrating that naloxone prescribing from primary care clinics is feasible and acceptable. Objective: To evaluate acceptability of naloxone dispensing to patients prescribed opioids among pharmacists serving clinics participating in a naloxone intervention. Methods: We surveyed 58 pharmacists from November 2013 through January 2015 at pharmacies that serviced San Francisco safety net clinics. Surveys collected information on demographics, experiences in dispensing naloxone, and interest in prescriptive authority. We conducted descriptive analyses and assessed bivariate relationships. Results: Most respondents were staff (56.9%) or supervising pharmacists (34.5%). Most (92.9%) were aware their pharmacy stocked naloxone and 86.8% felt it should be prescribed to some or all patients on long-term opioids. Most (82.1%) dispensed naloxone at least once in the past 12 months. More than half were comfortable providing naloxone education. Nearly half (43.4%) indicated they would want authority to furnish without a prescription. Over half (55.2%) reported no problems dispensing. The common problem was insufficient naloxone knowledge. Only 12% reported more than one problem in dispensing naloxone, which was associated with being uncomfortable with educating patients ( P = .03). Conclusion: Naloxone dispensing was acceptable among pharmacists. Their most cited problem was insufficient naloxone education. This may be resolved with improved instructional materials, incentives for patient education, or mandatory training.

scholarly journals Current trends in the pharmacotherapy of uterine myoma, associated with heavy menstrual bleeding and anemia: review

2020 ◽  
Author(s):  
Z. V. Revazova ◽  
L. V. Adamyan ◽  
O. N. Loginova ◽  
L. M. Manukyan ◽  
K. N. Arslanyan
Keyword(s):  
Uterine Fibroids ◽  
Reproductive Function ◽  
Uterine Myoma ◽  
Reproductive Age ◽  
Heavy Menstrual Bleeding ◽  
Menstrual Bleeding ◽  
Cochrane Library ◽  
Pharmacological Agents ◽  
Surgical Interventions ◽  
Current Trends

Aim: to summarize results of up-to-date world researches on the current trends of symptomatic myoma treatment.Materials and Мethods. A search of publications was carried out in the main international databases in Russian and English languages: PubMed/MEDLINE, The Cochrane Library, Embase, eLibrary. The analysis included studies published over the past 10 years examining the clinical efficacy and safety of various groups of pharmacological agents for the treatment of uterine myoma combined with heavy menstrual bleeding in women of reproductive age.Results. Currently, the treatment of uterine fibroids is divided into three main methods: surgical, minimally invasive organ-preserving methods, and pharmacotherapy. Until now, surgical intervention remains the main method of treatment, and, unfortunately, is often carried out in the volume of hysterectomy. However, today it is important to have a personalized approach to the management of a patient with symptomatic uterine myoma, taking into account her desire to preserve reproductive function. The development of the possibilities of drug therapy made a great contribution to the optimization of managing such patients.Conclusion. The global trend is to decrease the number of radical interventions, as well as the development and improvement of new methods of treating symptomatic uterine fibroids. Currently, pharmacotherapy of leiomyoma can significantly improve the quality of life of patients, reduce radical surgical interventions, optimize surgical treatment, and in certain situations, completely eliminate the need for surgery.

scholarly journals How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 592 ◽  
Author(s):  
Patrice Forget ◽  
Jose A. Aguirre ◽  
Ivanka Bencic ◽  
Alain Borgeat ◽  
Allessandro Cama ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Surgical Techniques ◽  
Oncologic Outcomes ◽  
The European Union ◽  
European Network ◽  
Surgical Interventions ◽  
Cancer Resection ◽  
The Past ◽  
Current State

The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational clinical data have been published, but the results of prospective, randomized clinical trials are awaited. The European Union supports a pan-European network of researchers, clinicians and industry partners engaged in this question (COST Action 15204: Euro-Periscope). In this narrative review, members of the Euro-Periscope network briefly summarize the current state of evidence pertaining to the potential effects of the most commonly deployed anesthetic and analgesic techniques and other non-surgical interventions during cancer resection surgery on tumor recurrence or metastasis.

Anti-Immigration Propaganda in the Northern League and the Freedom Party of Austria

2021 ◽  
Vol 65 ◽  
pp. 81-100
Author(s):  
Caner Tekin
Keyword(s):  
Western Europe ◽  
Female Workers ◽  
The Past ◽  
Northern League ◽  
Female Migrants ◽  
The Common ◽  
Gender Perspectives ◽  
And Gender ◽  
Gender Images

Over the past two decades, populist-radical parties of Western Europe arguably re- vised their propaganda towards the rejection of Muslim migrants with gender-sen- sitive arguments. Among these parties, the Northern League (LN) and the Freedom Party of Austria (FPÖ) achieved their electoral breakthrough thanks to their anti-mi- gration campaigns, which, inter alia, aligned peculiar gender perspectives with long- term attitudes towards ethnicity, welfare and Islam. Drawing on the LN’s and FPÖ’s election programmes, visuals and leader statements from the early 2000s, the present article discusses the common assumptions regarding the populist radical right’s dis- cursive changes towards anti-Islamism. The paper argues that the two parties in the mentioned period forged their propaganda against the rejection of Muslim migrants in religious and gender-sensitive terms, but their ethnic and class-oriented exclusions equally remained. The documents in question also revealed that these parties recent- ly softened their attitudes towards migrant caregivers to preserve traditional gender images in Austria and Italy. The LN’s and FPÖ’s long-term preoccupations with Ital- ian and Austrian women’s roles in worklife, family and reproduction are likely to bring about changes in the conceptions of female migrants in the care sector. The question still remains whether the parties began to tolerate Muslim female workers, since their propaganda, in contrast to the literature, did not suggest the acknowledgement of Muslims in any of the labour fields.

CA125: an increasingly promising biomarker in heart failure

2021 ◽  
Vol 27 ◽  
Author(s):  
Chunqi Pan ◽  
Mengyun Zhou ◽  
Ying Jian ◽  
Yuanyuan Zeng ◽  
Mingwei Wang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Risk Stratification ◽  
Fluid Overload ◽  
Malignant Tumors ◽  
Promising Candidate ◽  
The Past ◽  
Inflammatory Stimuli ◽  
Echocardiographic Parameters ◽  
Serial Measurements

: CA125 is a well-known tumor marker for diagnosis, monitoring, and risk stratification in ovarian cancer. It is not specific for malignant tumors and may be elevated in benign disease. In the past two decades, increasing evidence has emerged suggesting that the plasma level of CA125 can serve as a novel surrogate of heart failure (HF). CA125 in patients with HF is synthesized by epithelial serous cells in response to both mechanical and inflammatory stimuli. In patients with HF, regardless of etiology, CA125 levels correlate with the severity of clinical, hemodynamic, and echocardiographic parameters and with other biomarkers. Elevated CA125 can identify patients at high risk of rehospitalization and mortality, whether short- or long-term. Serial measurements and combination with different pathophysiology biomarkers can provide more accurate prognosis value. It also can guide treatment due to as a robust biomarker of fluid overload and inflammation, particularly for diuretic dose optimization. These properties make it a very promising candidate for risk stratification and treatment guidance of HF.

scholarly journals Prevention of pregnancy and sickness after a sustained method of conservative myomectomy

2018 ◽  
Vol 22 (1) ◽  
pp. 152-155
Author(s):  
O.V. Golyanovskyy ◽  
M.A. Budchenko
Keyword(s):  
Argon Plasma Coagulation ◽  
Recovery Period ◽  
Argon Plasma ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Complex Method ◽  
Synthetic Analogue ◽  
Fetal Head ◽  
Adhesion Barrier ◽  
Surgical Interventions

The number of surgical interventions in the uterus, including conservative myomectomy in women of reproductive age, has increased significantly, and, accordingly, the percentage of patients with a scar on the uterus has increased. It is difficult for women to make a pregnancy plan, to determine the best way and time of delivery. After the performed myomectomy, pregnancy planning is required not earlier than 6 months after the operation (provided the normal state of health and absence of complications). The peculiarity of the course of pregnancy after myomectomy is the presence of scarring on the uterus, and the importance of the volume and nature of the operation performed. Childbirth through natural birth lines can be resolved by specialists in the following cases: in the absence of exacerbations in the recovery period; if laboratory-instrumental studies confirm the fact of the fullness of the lower segment of the uterus; at placental placenta outside the scar tissue of the uterus; when the mother's pelvis matches the fetal head; with obligatory tracking of childbirth process using monitors; if possible, a cesarean section urgently, but not later than fifteen minutes after the decision to intervene. We proposed innovative approach is conservative myomectomy performed using electrosurgical techniques (argon plasma coagulation and radio wave scalpel) and such medications as Terlipressin (synthetic analogue of vasopressin), Defensal (anti-adhesion barrier). The conducted clinical research has determined the effectiveness of the complex method of surgical treatment of uterine leiomyomas with the use of modern drugs and technical support for the improvement of reproductive function in treated women.

scholarly journals Clinicopathologic Aspects of Endometrial Proliferous Processes in Women of Reproductive Age

2018 ◽  
Vol 24 (4) ◽  
Author(s):  
Iryna Vovk ◽  
Nataliya Gorban ◽  
Valentyna Kondratiuk
Keyword(s):  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Statistical Data ◽  
Reproductive Age ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Endometrial Polyps ◽  
Morphological Research ◽  
Endometrial Pathology

The peculiarities of benign proliferative pathology of endometrium including their combination in women of reproductive age are reviewed in the article.Materials and methods. The results of pathohistological research of benign proliferative pathology of endometrium (without atypia) were analyzed. Statistical data processing was performed by means of MedStat software package.Results. The obtained results revealed that benign proliferative pathology of endometrium is one of the most frequent gynaecological malignancies among female patients of reproductive age accounting for 52.2 % cases. Endometrial polyps were found to be accompanied by morphological peculiarities indicating chronic inflammatory process in endometrium in 56.5% cases (р<0.05) in comparison with endometrial hyperplasia in 38.2% cases, proving the presence of long-term inflammation in endometrial tissue and its trigger role in the development of the proliferative processes. Among patients with chronic salpingo-oophoritis, infertility was revealed in almost half of cases (44.5% of patients with endometrial polyps, 40.5% of patients with endometrial hyperplasia and 48.3% of women with combined proliferative pathology of endometrium) clinically confirming the data of morphological research. Peculiar signs of proliferative processes in genitals were determined, namely coexistence of uterine and endometrial pathology: endometrial hyperplasia was found in 40.4% of patients with uterine leiomyoma and 30.3% of patients with adenomyosis. The same combinations were peculiar for patients with endometrial polyps: endometrial hyperplasia was found in 30.1% of patients with uterine leiomyoma and 36.3% of patients with adenomyosis. Menstrual disorders were revealed in every third woman with endometrial hyperplasia (30.3%) and co-existent polyposis (30.2%).

Hormone replacement therapy: update and practical prescribing

2021 ◽  
Vol 32 (4) ◽  
pp. 148-156
Author(s):  
Nikki Noble
Keyword(s):  
Hormone Replacement Therapy ◽  
Side Effects ◽  
Replacement Therapy ◽  
Health Professionals ◽  
Hormone Replacement ◽  
Reproductive Function ◽  
Physiological Event ◽  
The Common ◽  
Follicular Activity

Peri-menopause and menopause are a normal part of ageing. Nikki Noble gives an overview of hormone replacement therapy and practical prescribing tips Menopause is a physiological event of ovarian failure due to a loss of ovarian follicular activity. This leads to a lack of oestrogen, resulting in the cessation of menstruation and loss of reproductive function. This article discusses the symptoms of menopause and treatment with hormone replacement therapy. This includes practical prescribing, side effects and long-term benefits and risks. The current shortages of hormone replacement therapy are also addressed. The aim of this article is to enable health professionals to define menopause and gain an understanding of the symptoms associated with it. After reading this article you should be able to: describe when peri-menopause and menopause occur, describe the common symptoms that may be experienced during peri-menopause and menopause, understand of the hormones used in hormone replacement therapy, and understand the practical prescribing of hormone replacement therapy and the benefits, risks, contraindications and side-effects.

Ovarian endometriosis associated infertility: a modern view to the problem

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 44-49
Author(s):  
Mekan R. Orazov ◽  
Marina B. Khamoshina ◽  
Marianna Z. Abitova ◽  
Lyudmila M. Mikhaleva ◽  
Snezhana V. Volkova ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Assisted Reproductive Technologies ◽  
Negative Impact ◽  
Ovarian Tissue ◽  
Reproductive Function ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Ovarian Endometriosis ◽  
Surgical Interventions ◽  
Ovarian Endometriomas

This review summarizes current understanding of the pathogenesis of one of the most common forms of external genital endometriosis ovarian endometriomas. Due to their frequent occurrence in young women of reproductive age and extremely negative impact on the morphophysiological state of the ovaries, this disease makes a significant contribution to the structure of endometriosis-associated infertility. The main determinant of the negative effect of ovarian endometriomas on reproductive function is a decrease in ovarian reserve, which can occur either due to the direct gonadotoxic effect of the endometriod cyst itself, or due to the unintentional removal of healthy ovarian tissue during surgery or the use of aggressive methods of electrosurgery. Hence, the question of methods for achieving hemostasis during surgery in terms of iatrogenic effects on healthy ovarian tissue is debatable. The management strategy for patients with infertility associated with ovarian endometriosis consists of two components: surgical treatment and/or the use of assisted reproductive technologies. Laparoscopic cystectomy is indicated for cysts larger than 3 cm. Repeated surgical interventions in case of endometriosis do not improve fertility outcomes. Assisted reproductive technologies methods should be considered as a priority tactic in patients of older reproductive age with low ovarian reserve indicators or infertility duration of more than 2 years, as well as in cases of recurrent ovarian endometriomas. Management of such patients must be personalized and take into account the age, state of the ovarian reserve, duration of infertility, stage and number of surgical interventions for this disease.

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