PTP1B INHIBITORS FROM ISODON TERNIFOLIUS COLLECTED IN VIETNAM
2020 ◽
Vol 58
(5)
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pp. 533
Keyword(s):
From the whole plant of Isodon ternifolius collected in Vietnam, four triterpens including ursaldehyde (1), ursolic acid (2), b-sitosterol (3) and b-sitosteryl ferulate (4) were purified. Their chemical structures were determined by interpretation of NMR and MS data and comparison with the literatures. Compounds 1-4 were evaluated for their inhibitory activity against PTP1B enzyme activity using in vitro assay. Compounds 1 and 2 displayed potential activities with IC50 values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. This is the first time that compounds 1 and 4 have been isolated from the Isodon genus and I. ternifolius has been evaluated for the PTP1B inhibitory activity.
2019 ◽
Vol 34
(1)
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pp. 1474-1480
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Keyword(s):
1996 ◽
Vol 135
(5)
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pp. 1229-1237
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Keyword(s):
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2016 ◽
Vol 4
(2)
◽
pp. 127
Keyword(s):
1969 ◽
Vol 47
(4)
◽
pp. 400-402
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Keyword(s):