scholarly journals Cytomegalovirus Infection in Adolescents of Russian Federation: Results of Cross-Sectional Population Analysis of Seroprevalence

2021 ◽  
Vol 18 (6) ◽  
pp. 451-459
Author(s):  
Ekaterina Yu. Dubonosova ◽  
Leyla S. Namazova-Baranova ◽  
Elena A. Vishneva ◽  
Nikolay A. Mayanskiy ◽  
Tatiana V. Kulichenko ◽  
...  
Keyword(s):  
Immune Response ◽  
Russian Federation ◽  
Cytomegalovirus Infection ◽  
Well Being ◽  
Clear Understanding ◽  
Childbearing Age ◽  
Response Intensity ◽  
The Social ◽  
Group 2 ◽  
Group 1

Background. Cytomegalovirus infection (CMVI) is the reason of high mortality in perinatal period, disability in children from risk groups with further development of congenital malformations and chronic diseases. Clear understanding of epidemiology and determination of focus population groups is crucial for development of measures and algorithms of congenital CMVI prevention.Objective. The aim of the study is to study CMVI seroprevalence among immunocompetent adolescents in Russian Federation with reference to the gender, regional, social and economic, and age factors.Methods. We have used for our study data from the survey of senior schoolchildren from 7 municipalities representing various regions of Russian Federation: group 1 (10–12 years old) and group 2 (14–16 years old). The study of CMVI seroprevalence and immune response was performed via the analysis of the level of IgG antibodies to cytomegalovirus (CMV) in blood serum. The social and economic well-being of the region was determined by "RIA Rating" experts.Results. Serological prevalence of CMVI in the study group of adolescents (n = 1403) was 70.6% (n = 990). There were no statistically significant gender differences in the distribution of seropositive children in regions (p = 0.525). Infection in boys (72.6%; n = 455; median age — 12.9 (11.0; 14.9)) did not prevail over the infection in girls (68.8%; n = 535; median age — 13.1 (11.0; 14,9)); p = 0,117. The overall prevalence of CMVI increased statistically significant with age — from 68% (n = 486) in group 1 to 73% (n = 504) in group 2 (p = 0.036). The prevalence of CMVI varied statistically significant by region (p = 0.003). There was no correlation between the regional seropositive level and the social and economic situation in the region (r = 0.034, p = 0.192). Immune response intensity did not differ by age, gender, and region with the antibody median of 88.9 CU/ml.Conclusion. More than half of adolescents (by the age of 10) in Russian Federation are infected, and infection increases with approaching to childbearing age, however, age is not the only aspect associated with serological status. Factors affecting immune response intensity require further study. Understanding of the CMV prevalence among children is crucial for determining future prevention approaches in target groups.

scholarly journals Cytomegalovirus Infection in Adolescents of Russian Federation: Results of Cross-Sectional Population Analysis of Seroprevalence

2021 ◽  
pp. 354-362
Author(s):  
E. Yu. Dubonosova ◽  
L. S. Namazova-Baranova ◽  
E. A. Vishneva ◽  
N. A. Mayanskiy ◽  
T. V. Kulichenko ◽  
...  
Keyword(s):  
Immune Response ◽  
Russian Federation ◽  
Cytomegalovirus Infection ◽  
Well Being ◽  
Clear Understanding ◽  
Childbearing Age ◽  
Response Intensity ◽  
The Social ◽  
Group 2 ◽  
Group 1

Background. Cytomegalovirus infection (CMVI) is the reason of high mortality in perinatal period, disability in children from risk groups with further development of congenital malformations and chronic diseases. Clear understanding of epidemiology and determination of focus population groups is crucial for development of measures and algorithms of congenital CMVI prevention.Objective. The aim of the study is to study CMVI seroprevalence among immunocompetent adolescents in Russian Federation with reference to the gender, regional, social and economic, and age factors.Methods. We have used for our study data from the survey of senior schoolchildren from 7 municipalities representing various regions of Russian Federation: group 1 (10–12 years old) and group 2 (14–16 years old). The study of CMVI seroprevalence and immune response was performed via the analysis of the level of IgG antibodies to cytomegalovirus (CMV) in blood serum. The social and economic well-being of the region was determined by "RIA Rating" experts.Results. Serological prevalence of CMVI in the study group of adolescents (n = 1403) was 70.6% (n = 990). There were no statistically significant gender differences in the distribution of seropositive children in regions (p = 0.525). Infection in boys (72.6%; n = 455; median age — 12.9 (11.0; 14.9)) did not prevail over the infection in girls (68.8%; n = 535; median age — 13.1 (11.0; 14,9)); p = 0,117. The overall prevalence of CMVI increased statistically significant with age — from 68% (n = 486) in group 1 to 73% (n = 504) in group 2 (p = 0.036). The prevalence of CMVI varied statistically significant by region (p = 0.003). There was no correlation between the regional seropositive level and the social and economic situation in the region (r = 0.034, p = 0.192). Immune response intensity did not differ by age, gender, and region with the antibody median of 88.9 CU/ml.Conclusion. More than half of adolescents (by the age of 10) in Russian Federation are infected, and infection increases with approaching to childbearing age, however, age is not the only aspect associated with serological status. Factors affecting immune response intensity require further study. Understanding of the CMV prevalence among children is crucial for determining future prevention approaches in target groups.

scholarly journals Sociodemographic Predictors of Physical Functioning in the Elderly: A National Health Survey

2018 ◽  
Vol 16 (1) ◽  
pp. 37
Author(s):  
Milena Kostadinovic ◽  
Dejan Nikolic ◽  
Ivana Petronic ◽  
Dragana Cirovic ◽  
Mirko Grajic ◽  
...  
Keyword(s):  
Marital Status ◽  
Educational Level ◽  
Well Being ◽  
Population Based ◽  
Age Group ◽  
Place Of Residence ◽  
Gender Group ◽  
Group 2 ◽  
Level Group ◽  
Group 1

We aimed to evaluate the prevalence of sociodemographic factors with the presence and different degrees of walking difficulties in elderly above 65 years, and to analyze association between evaluated variables and the presence and degree of waking difficulties. In the population based study, 3540 individuals age above 65 years from Serbia were recruited. Further predictors were analyzed: gender, age, level of education, marital status, body mass index (BMI), index of well-being and place of residence. We assessed difficulty in walking half a km on level ground without the use of any aid (Group-1); and difficulty in walking up or down 12 steps (Group-2). Walking difficulties were categorized as no difficulty, some difficulty, a lot of difficulty and cannot do at all. For present difficulty significant predictors were: age (Group-1 (OR-3.022)/Group-2 (OR-3.825)), gender (Group-1 (OR-0.337)/Group-2 (OR-0.311)), educational level (Group-1 (OR-0.689)/Group-2 (OR-0.556)) and place of residence (Group-2 (OR-1.523)) while for non-performing the task, significant predictors were: age (Group-1 (OR-1.998)/Group-2 (OR-2.096)), gender (Group-1 (OR-0.629)/Group-2 (OR-0.495)), BMI (Group-1 (OR-1.219)/Group-2 (OR-1.305)), marital status (Group-1 (OR 0.764)/Group-2 (OR-0.769)), educational level (Group-1 (OR-0.679)/Group-2 (OR-0.719)) and index of well-being (Group-2 (OR-0.764)). Understanding of predictors, and their role on functional decline in elderly is of great importance for the development of specific population-based health programs to prevent further functional loss and preserve achieved functional gains.

The use of antiviral drug based on technologically processed antibodies to interferon-γ, CD4 receptor and histamine in the treatment of influenza in adults: results of a multicenter open-label randomized comparative trial with oseltamivir

2021 ◽  
Vol 19 (1) ◽  
pp. 39-57
Author(s):  
K.V. Zhdanov ◽  
◽  
R.F. Khamitov ◽  
V.V. Rafalsky ◽  
M.P. Mikhaylusova ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cell ◽  
Open Label ◽  
Virus Elimination ◽  
Antiviral Immune Response ◽  
Cd4 Receptor ◽  
Antiviral Efficacy ◽  
Ifn Γ ◽  
Group 2 ◽  
Group 1

Objective. A multicenter open-label randomized controlled clinical trial was aimed to compare the efficacy of the study drug (SD) containing technologically processed affinity purified antibodies (high dilutions) to IFN-γ, CD4 receptor and histamine (Ergoferon) with oseltamivir, and evaluate the influence of SD on the antiviral immune response in adults with seasonal influenza. Patients and methods. 184 outpatients aged 18–70 with confirmed influenza of mild/moderate severity were included and randomized into 2 groups (in a 1:1 ratio). Patients received SD (Group 1, n = 92) or oseltamivir (Group 2, n = 92), according to the instructions for medical use for 5 days. As the primary endpoint, the percentage of patients with recovery/improvement was assessed (according to the data of the patient's diary on days 2–7 and according to the clinical examination on days 3 and 7). Additionally, the duration and severity of influenza symptoms, the percentage of patients with virus elimination (according to RT-PCR of nasopharyngeal samples), the percentage of patients with complications, the percentage of patients prescribed antipyretic drugs, the change in concentration of T cell (IL-2, IL-18, IFN-γ) and B cell antigen-specific (IL-4, IL-16) immune response regulators in serum, the leukocyte phenotypes on days 1, 3 and 7 were evaluated. Statistical analysis was performed using a “Non-Inferiority” design (or no less efficiency/safety). Intention-to-Treat (ITT) analysis data are presented. Results. According to patients’ self-assessment, 53.3% of patients in Group 1 recovered/improved on the 6th day in the morning and 65.2% – in the evening (vs. 53.3% and 57.6% in Group 2, respectively). There were 73.9% recovered/ improved patients on the 7th day in the morning (vs. 67.4% in Group 2). A generalized analysis showed that the treatment results in both groups were comparable (p < 0.0001). According to objective medical examination, 79.3% of patients in the SD group and 74.0% of patients in the Оseltamivir group recovered/improved on the 7th day (p < 0.0001). The antiviral efficacy of SD was not inferior to oseltamivir, which was confirmed by comparable periods of virus elimination, duration and severity of fever and other influenza symptoms. A moderate activating effect of SD on the immune system was evaluated. A significant, compared to oseltamivir, increase in the concentration of IL-2 and IL-4 on the 3rd day of treatment (p = 0.03 and p = 0.04 vs. the oseltamivir group), and IFN-γ on the 3rd and the 7th days (p = 0.012 and p < 0.0001, respectively, vs. the oseltamivir group). No stimulating effect of SD on the growth and differentiation of immune cells was found. Conclusion. SD is effective and safe in the treatment of patients with influenza. The therapeutic and antiviral efficacy of SD is comparable to that of oseltamivir. The antiviral activity of SD affects the interferon system and the concentration of the cytokines IL-2 and IL-4, regulators of the T and B cell immune response. At the same time, there is no significant stimulation of interferon production with further development of hyporeactivity. Key words: influenza, oseltamivir, therapy, cytokines, Еrgoferon

scholarly journals Evaluation of the TGS TA system for the detection of anti-rubella antibodies

2017 ◽  
Vol 32 (2) ◽  
Author(s):  
Olivia Arpino ◽  
Annalisa Cianflone ◽  
Maria Teresa Manco ◽  
Alessia Paganini ◽  
Massimo De Paschale ◽  
...  
Keyword(s):  
Elisa Test ◽  
Childbearing Age ◽  
Past Infection ◽  
Recent Infection ◽  
Igm Antibodies ◽  
Igg Avidity ◽  
Group 3 ◽  
Group 2 ◽  
Sera Samples ◽  
Group 1

<p><em>Background and aims:</em> The aim of the present study was to evaluate the new Technogenetics TGS TA system for detecting antirubella IgG and IgM antibodies and IgG avidity. TGS TA system was compared with our routinely used system, LIAISON XL, for the detection of IgG and IgM antibodies. Only in positive IgM samples (retrospective study), TGS TA system was compared to an ELFA IgM test and with an ELISA test for the IgG avidity (if existent).<br /><em>Materials and methods:</em> Two hundred and seventy six sera samples from women were examined with TGS TA system and divided in 3 groups according to IgG and IgM screening LIAISON XL tests: 112 were of childbearing age and non-immune women (Group 1), 106 were pregnant with past infection or vaccinated (Group 2) and 49 were pregnant with positive or equivocal IgM (Group 3). <br /><em>Results</em>: The overall concordance of the IgG results between LIAISON XL and TGS TA was 93.3%: 86.6% in Group 1, 97.2% in Group 2 and 100% in Group 3. The overall concordance of the IgM results between LIAISON XL and TGS TA was 89.0%: 100% in Group 1, 100% in Group 2 and 35.6% in Group 3. In Group 3, the concordance between the results of the IgG avidity with the ELISA and TGS TA tests was 85.7%. Comparing the clinical diagnosis obtained with our protocol and that of the TGS TA system, the overall concordance was 97.4%: 86.6% in Group 1, 97.2% in Group 2 and 85.7% in Group 3. <br /><em>Conclusions</em>: TGA TS system shows to be a valuable tool with overall good clinical correlation and able to clearly identify nonspecific subjects, those with a non-recent infection or those who are vaccinated. The TGS TA test also seems to be especially sensitive in indicating vaccinated subjects with low IgG levels as immune.</p>

scholarly journals COMPARATIVE EVALUATION OF SAFETY AND IMMUNOGENICITY INACTIVATED VACCINE FOR POLYOMIELITIS PREVENTION (NETHERLANDS) AND VACCINE «IMOVAX POLIO» (FRANCE) IN CHILDREN USING TRIPLE IMMUNIZATION

2019 ◽  
Vol 1 (3) ◽  
pp. 53-60
Author(s):  
I. V. Feldblyum ◽  
V. V. Romanenko ◽  
M. G. Menshikova ◽  
I. A. Okuneva ◽  
A. E. Makarov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Multicenter Study ◽  
Safety Profile ◽  
Comparative Evaluation ◽  
Vaccination Schedule ◽  
Inactivated Vaccine ◽  
Poliomyelitis Vaccine ◽  
The Russian Federation ◽  
Group 2 ◽  
Group 1

Aim is comparative evaluation of the safety and immunogenicity of inactivated poliomyelitis vaccine (IPV) «Bilthoven Biologicals B.V.» (Netherlands) and «Imovax Polio» (France) with subcutaneous and intramuscular modes of administration. Materials and methods. In a doubleblind, comparative clinical randomized multicenter study, 120 children at the age of 3 months participated as volunteers. They were divided into 4 groups: 1 and 2 groups were given IPV intramuscular (group 1) and subcutaneous (group 2) mode of administration, children of groups 3 and 4 were given the vaccine «Imovax Polio». Results. IPV is characterized by a high safety profile and immunogenicity both in subcutaneous and intramuscular modes of administration and it is comparable in its characteristics with the vaccine «Imovax Polio». Conclusion. Vaccine IPV (Netherlands) is recommended for registration in the territory of the Russian Federation and its further using in the National Vaccination Schedule.

CMV Immunity Status in Older (>50 Years Old) Subjects after Non-Myeloablative or Reduced Intensity Regimen for Hematopoietic Cell Transplantation (HCT): A Comparison with a Younger Cohort after Ablative HCT.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3246-3246
Author(s):  
Ghislaine Gallez-Hawkins ◽  
Lia Thao ◽  
Simon F. Lacey2 ◽  
Joybelle Martinez ◽  
Anne E. Franck ◽  
...  
Keyword(s):  
Immune Response ◽  
Stem Cell ◽  
T Cell ◽  
Cell Transplantation ◽  
Immune Reconstitution ◽  
Cmv Infection ◽  
Cd8 Cells ◽  
Group 2 ◽  
Reduced Intensity ◽  
Group 1

Abstract Immunity declines with age as demonstrated by cell-mediated and humoral responses to alloantigens. The susceptibility of these elderly subjects to endogenous virus infection, such as human cytomegalovirus (HCMV) reactivation, is a particular concern during the process of hematopoietic stem cell transplantation (HCT) and immune reconstitution. In this report, the host contribution to stem cell engraftment and differentiation was evaluated by comparing the HCMV immune response in older subjects (&gt; 50 y.o.) to a younger (&lt; 50 y.o.) transplant population. This was a retrospective analysis of a subset of data collected prospectively and with IRB approval for characterization of the CMV immune response of allogeneic transplant patients. Within the dataset, two groups of patients were compared. Group 1 consisted of 10 patients &gt;50 y.o. who had received reduced intensity or non-myeloablative conditioning regimen, and Group 2 consisted of 13 patients &lt;50 y.o., most of whom had received a myeloablative regimen. Because 9 of 10 in Group 1 had had CMV reactivation, Group 2 was selected from the subset of younger patients with known post-transplant CMV infection. CMV infection was defined as either a positive CMV blood culture using shell vial assay or a positive CMV PCR on plasma. Subjects were assessed on days 40, 90, 120, 150, 180, and 360 post-HCT by CMV-specific tetramer-binding assay using CD8 cells, assays for intracellular INF-g response of CD4 and CD8 cells, and a T-cell receptor excision circle (TREC) assay. There were no significant differences observed in the CD4+/IFN-g+ cell responses to CMV antigen nor were the rates of activated CD4+/CD69+/IFN-g+ cells different between the groups. Group 1 was also characterized by a robust CD8+/IFN-g+ response to HLA-specific CMV peptides, and all subjects had ≥ 2cells/μl by day 150 post-HCT. The frequency of CMV tetramer positive cells (≥ 2cells/μl) was 50% in Group 1 by day 90 post-HCT and was not statistically different from Group 2. The T cell renewal in the thymus as measured by the TREC spanned over 0 -- 92 copies/μg of total cellular DNA in Group 1 and from 0 – 129 copies/μg in Group 2 during the first year post-HCT (n.s.). In conclusion, CMV immune reconstitution in older transplant subjects, who undergo a reduced intensity or non-myeloablative regimen, is robust and, in this small sampling, did not differ from that observed in a younger adult group.

scholarly journals The effect of salivarus on the immune response to Newcastle and Gumboro disease vaccines and on performance

2003 ◽  
Vol 27 (1) ◽  
pp. 134-145
Author(s):  
Ali A.H. Shalash ◽  
Ebtesam G. A. Al-Oubaidi
Keyword(s):  
Immune Response ◽  
Haemagglutination Inhibition ◽  
Feed Consumption ◽  
Broiler Chicks ◽  
Feed Conversion ◽  
Agar Gel ◽  
Group 2 ◽  
Performance Results ◽  
Newcastle Disease Vaccine ◽  
Group 1

A total of 50 day - old broiler chicks were divided equally into two groups and treated with Lactobacillus salivarus (L S) as follow Group 1: given 3.2X108 cfu/ ml of LS in crop at day 1 of age. Group 2:Untreated control  The two groups were vaccinated against Newcastle disease vaccine (ND vac) Lasota strain at age 10, 21, and 35 days direct in the crop.  The groups were vaccinated in the crop against Gumboro vaccine (G vac) leukert strain at 5, 14 and 24 day of age.  Haemagglutination inhibition test was used and determine antibodies titer (Abt) of (ND vac) and the agar gel precipitating test to 19, 29 and 39 of the chick's age.  The result showed significant (p < 0.05) increase in Abt most of the weeks in the first group compared with second groups  The performance results showed significant (p < 0.05) increase in the weight, weight gain , feed consumption and feed conversion ratio for chicks treated with LS.  It was concluded that oral administration of Lactobacillus salivarus to day – old chicks has a beneficial effect on immune response to ND vac and G vac and on chick's performance.

scholarly journals Experience of using plant complexes in physiological completion of lactation

2021 ◽  
pp. 54-58
Author(s):  
N. V. Kosei ◽  
O.V. Zanko ◽  
L.А. Vasylchenko ◽  
N.V. Iarotska
Keyword(s):  
Emotional Disorders ◽  
Emotional State ◽  
Depression Scale ◽  
Well Being ◽  
Mammary Glands ◽  
Control Group ◽  
Breast Pumping ◽  
Medical Counseling ◽  
Group 2 ◽  
Group 1

Ending breastfeeding is often quite a challenge for women, justifying the need for qualified medical counseling and accompaniment by a doctor. Quite frequently during weaning the baby, women complain about pain, discomfort and swelling of the breasts, which affects their overall physical and psychological well-being. However, due to possible rather serious side effects, medical support for stopping lactation is mostly recommended for women with clinical indications.Research aim: to determine the effectiveness of the proposed method with Normomens for physiological completion of lactation.Materials and methods. The study involved 65 women with an average duration of lactation 9 ± 1.23 months. Patients were divided into two groups: group 1 included 34 women who received Normomens according to the scheme to stop lactation; group 2 included 31 patients who did not receive any medication. Patients were gynecological examined and counseled by oncologist. Patients' diaries included questions about the duration of lactation, presence and severity of mastalgia according to the Visual Analogue Scale, necessity of analgesics, frequency of breast pumping per day, features of psycho-emotional state according to the Hospital Anxiety and Depression Scale. Prolactin levels were also determined at the screening visit and on 25th day after weaning.Results. On the background of Normomens use the process of lactation completion was significantly easier, its completion came mostly on the 3–4 day after drug use, patients almost never complained of pain and discomfort in mammary glands, they less frequently breast pumped and had a more stable psycho-emotional state compared to the control group. Рrolactin level with usage of Normomens had a quick decrease compared to the control group.Conclusion. Normomens using for support the physiological finishing of lactation lead to acceleration of involutive processes in mammary glands, reduces pain severity and prevented psycho-emotional disorders in women.

scholarly journals Interplay between productive traits, the social rank and the cow's stability in the order of entrance to the milking parlour

2020 ◽  
pp. 1-9
Author(s):  
E. Vargas-Bello-Pérez ◽  
J. Bastías-Ruz ◽  
P. Toro-Mujica ◽  
D.L. Teixeira ◽  
D. Enriquez-Hidalgo
Keyword(s):  
Social Rank ◽  
Dairy Farm ◽  
Production Traits ◽  
Order Of Entry ◽  
Lactation Stage ◽  
The Social ◽  
Group 3 ◽  
Productive Traits ◽  
Group 2 ◽  
Group 1

Abstract The aim of this study was to investigate whether social rank (SR) and stability in the order of entrance to the milking parlour are associated with production traits. The study was conducted on a dairy farm where cows (n = 215) were managed in three groups according to lactation stage (group 1: 78 cows, 0–100 days in milk (DIM); group 2: 65 cows, 101–200 DIM and group 3: 72 cows, >200 DIM). SR was calculated from observations made from agonistic behaviour performed at the water troughs and feed bunks of each pen (n = 3). The animals were classified into three levels of dominance based on at least five clear interactions, resulting in: 61 dominant, 75 intermediate and 69 subordinate cows based on SR. Stability in the order of entry was estimated as the standard deviation of the entry position. SR was weakly correlated with milk yield, urea and protein content in milk. The results showed that stable cows had higher milk production and entered the milking parlour after the non-stable animals. Stability in the order of entry to the milking parlour was not affected by SR. Overall, the use of milking facilities appears to be associated with production traits rather than SR.

Assessment of anti-SARS-CoV-2 antibodies post-Coronavac vaccination in the Amazon region of Brazil

2021 ◽  
Author(s):  
Carlos David Araújo Bichara ◽  
Maria Alice Freitas Queiroz ◽  
Ednelza da Silva Graça Amoras ◽  
Gergiane Lopes Vaz ◽  
Izaura Maria Vieira Cayres Vallinoto ◽  
...  
Keyword(s):  
Immune Response ◽  
Neutralizing Antibodies ◽  
Cross Sectional Study ◽  
Age Group ◽  
Lower Efficiency ◽  
Cross Sectional ◽  
Humoral Immune ◽  
High Prevalence ◽  
Group 2 ◽  
Group 1

Abstract The race to develop a vaccine against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has raised questions regarding the safety of immunizers, efficacy regarding the production of neutralizing antibodies, and the longevity of the immune response, especially when related to variables such as sex and age. The present study evaluated the frequency of seropositivity for anti-SARS-CoV-2 (S1 and S2) total antibodies and anti-SARS-CoV-2 (receptor binding domain - RBD - S1) neutralizing antibodies in individuals vaccinated with the immunizing agent Coronavac (Sinovac). This was a cross-sectional study involving 358 individuals divided into two groups. Group 1 consisted of 205 volunteers who were tested for anti-SARS-CoV-2 total antibodies (S1 and S2); group 2 consisted of 153 individuals tested for the presence of anti-SARS-CoV-2 neutralizing antibodies (RBD-S1). Seropositivity was greater than 70% in both groups, though approximately 20% of individuals showed no antibody production. The frequency of anti-SARS-CoV-2 total antibodies (S1 and S2) displayed a significantly different distribution between the sexes but not according to age. The frequency of anti-SARS-CoV-2 (RBD-S1) neutralizing antibodies was 93% in the age group from 21 to 40 years, which was significantly lower with advancing age, to 76% (41 to 60 years), 72% (61 to 80 years) and 47% (>80 years). Our results reveal a high prevalence of anti-SARS-CoV-2 total antibodies (S1 and S2) and anti-SARS-CoV-2 (RBD - S1) neutralizing antibodies in individuals who received both doses of the Coronavac vaccine, suggesting a lower efficiency of the humoral immune response among those older than 60 years of age, which might be associated with senescence of the immune system.

Sign in / Sign up

Export Citation Format

Share Document