scholarly journals Inflammatory Bowel Diseases and diet: an integrative review

2020 ◽  
Vol 66 (10) ◽  
pp. 1449-1454
Author(s):  
Regina Márcia Soares Cavalcante ◽  
Murilo Moura Lima ◽  
José Miguel Luz Parente ◽  
Mayara Storel Beserra de Moura ◽  
Nadir do Nascimento Nogueira
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Fruits And Vegetables ◽  
Scientific Evidence ◽  
Integrative Review ◽  
Animal Origin ◽  
Human Beings ◽  
Omega 3 ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Fermentable Carbohydrates

SUMMARY OBJECTIVE: To gather scientific evidence on the role of diet in inflammatory bowel diseases. METHODS: Integrative review with studies published in the last 10 years in national and international journals. Original studies developed with adult human beings aged ≥18 years were included and articles published before 2010, literature reviews, and those that did not focus on elements that answered the guiding question were excluded. RESULTS: 14 articles were selected that addressed important dietary elements in inflammatory bowel disease such as fermentable carbohydrates and polyols, foods of animal origin, foods rich in omega 3, consumption of fruits and vegetables, use of probiotic supplements, whey proteins and soy. CONCLUSION: The diet, as a potentially modifiable environmental factor, plays an important role in the prevention and treatment of inflammatory bowel diseases. The reduction in the consumption of fermentable carbohydrates and polyols combined with the increase in the consumption of fruits and vegetables as well as the exclusion of products of animal origin such as beef, pork, milk and eggs can help control inflammation and improve the quality of life of patients with inflammatory bowel diseases. The use of probiotics increases food tolerance and, whey and soy proteins, can alter body composition and reduce inflammation.

scholarly journals Animal models for inducing inflammatory bowel diseases: integrative review

2021 ◽  
Vol 11 (1) ◽  
pp. 80-87
Author(s):  
Nadja Maria da Costa Melo ◽  
Marília Virgo Silva Almeida ◽  
Daniel Melo de Oliveira Campos ◽  
Claudio Bruno Silva de Oliveira ◽  
Jonas Ivan Nobre Oliveira
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
Integrative Review ◽  
Chemical Models ◽  
Experimental Induction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Colitis Model

Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease.

scholarly journals Omega Fatty Acids and Inflammatory Bowel Diseases: An Overview

2019 ◽  
Vol 20 (19) ◽  
pp. 4851 ◽  
Author(s):  
Ledyane Taynara Marton ◽  
Ricardo de Alvares Goulart ◽  
Antonelly Cassio Alves de Carvalho ◽  
Sandra Maria Barbalho
Keyword(s):  
Fatty Acids ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Ω3 Fatty Acids ◽  
Number Of Patients ◽  
Bowel Diseases ◽  
Inflammatory Processes ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBD) are chronic, inflammatory processes that affect the gastrointestinal tract and are mainly represented by ulcerative colitis (UC) and Crohn’s disease (CD). Omega 3 (ω3) fatty acids (eicosapentanoic acid and docosahexaenoic acid) show an indispensable role in the inflammatory processes and, for these reasons, we aimed to review the effects of these acids on UC and CD. Databases such as PUMED and EMBASE were searched, and the final selection included fifteen studies that fulfilled the inclusion criteria. The results showed that ω3 fatty acids reduce intestinal inflammation, induce and maintain clinical remission in UC patients, and are related with the reduction of proinflammatory cytokines, decrease disease activity and increase the quality of life of CD patients. Furthermore, the consumption of these fatty acids may be related to a reduced risk of developing IBD. Many studies have shown the beneficial effects of ω3 as adjunctive in the treatment or prevention of UC or CD. Nevertheless, most were performed with a small number of patients and there are many variations in the mode of consumption, the type of food or the type of formulation used. All these factors substantially interfere with the results and do not allow reliable comparisons.

scholarly journals Diet supporting therapy for inflammatory bowel diseases

2021 ◽  
Author(s):  
Justyna Kikut ◽  
Nina Konecka ◽  
Maciej Ziętek ◽  
Danuta Kulpa ◽  
Małgorzata Szczuko
Keyword(s):  
Vitamin D ◽  
Inflammatory Bowel Diseases ◽  
Inflammatory Process ◽  
Raw Materials ◽  
Supportive Therapy ◽  
Omega 3 ◽  
Lipoxygenase Pathway ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Dietary Components

Abstract Purpose Non-specific inflammatory bowel diseases (IBD) include Crohn's disease and ulcerative colitis. More and more often attention is paid to the possibility of dietary support for inflammatory bowel diseases. Methods The following review article considers the role of dietary components in the treatment of IBD as: pteridines, probiotics, bovine immunoglobulin, vitamin D, omega-3, flavonoids, polyphenols, curcumin and phosphatidylcholine. The article also discusses plant raw materials of arjuna, soy protein and nettles, trying to summarize their effect on quenching the inflammatory process within the intestines. This review focuses on the possibilities of dietary components and supplementation use to improve the pharmacotherapy response as well as the general clinical patients’ condition. Results The mechanism of action of supportive therapy is based on reduction in oxidative stress, maintaining the adequate balance between Th1 and Th2 lymphocytes by affecting cytokines, increasing riboflavin supply for macrophages, increasing expression of vitamin D receptor, regulation by decreasing the expression of NF-κB in liver cells and ability to inhibit the COX2 entrance and inactivate prostaglandins that are involved in the inflammatory process and 12-lipoxygenase pathway inhibition. Conclusion Considering clinical researches, it seems that the use of the above-mentioned ingredients in the diet of patients suffering IBD may positively influence the treatment process and maintenance of remission.

scholarly journals Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Robert Carreras-Torres ◽  
Gemma Ibáñez-Sanz ◽  
Mireia Obón-Santacana ◽  
Eric J. Duell ◽  
Victor Moreno
Keyword(s):  
Fatty Acids ◽  
Body Fat ◽  
Inflammatory Bowel Diseases ◽  
Mendelian Randomization ◽  
Body Fat Percentage ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fat Percentage ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Several studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD in observational meta-analyses, influence IBD risk using a Mendelian randomization (MR) approach. A two-sample MR approach was applied on summary-level genome-wide association results. Genetic variants strongly associated with measures of tobacco smoking, obesity and fat distribution, physical activity, and blood levels of vitamins and fatty acids were evaluated on genetic data from international IBD consortia including a total of 25,042 IBD cases (12,194 cases of Crohn’s disease (CD) and 12,366 cases of ulcerative colitis (UC)) and 34,915 controls. Our results indicated that, among lifestyle exposures, being a smoker was positively associated with CD (OR 1.13, P = 0.02), but it was not associated with UC risk (OR 0.99, P = 0.88). Body-mass index (BMI) and body fat percentage were positively associated with CD (OR 1.11, P = 0.02, per standard deviation (SD) of 4.6 kg/m2; and OR 1.50, P = 3 × 10–10, per SD of 6.6%; respectively); while for UC, BMI was inversely associated (OR 0.85, P = 5 × 10–5; per SD) and body fat percentage showed a OR of 1.11 (P = 0.11; per SD). Additionally, among nutrient exposures, omega-3 fatty acids levels were inversely associated with CD (OR 0.67, P = 2 × 10–6). Our MR results did not support a protective effect for being a smoker on UC risk; however, they are compatible with a risk effect for higher body fat proportion and a protective role for higher levels of omega-3 fatty acids on CD etiology.

scholarly journals Family caregivers' burden in inflammatory bowel diseases: An integrative review

2020 ◽  
Vol 9 (1) ◽  
pp. 289
Author(s):  
ZahraSadat Manzari ◽  
SeyedMostafa Mohsenizadeh ◽  
Hasan Vosoghinia ◽  
Hossein Ebrahimipour
Keyword(s):  
Family Caregivers ◽  
Inflammatory Bowel Diseases ◽  
Integrative Review ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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