scholarly journals Haemolytic activity of Actinobacillus actinomycetemcomitans strains on different blood types

1995 ◽  
Vol 37 (3) ◽  
pp. 215-217 ◽  
Author(s):  
Mario Julio Avila-Campos
Keyword(s):  
Yeast Extract ◽  
Human Blood ◽  
Blood Type ◽  
Actinobacillus Actinomycetemcomitans ◽  
Haemolytic Activity ◽  
Blood Types ◽  
Microaerophilic Conditions

Haemolytic activity of sixty nine Actinobacillus actinomycetemcomitans strains on different animal and human blood types was examined by using a trypticase soy agar supplemented with yeast extract (0.5%). Blood types used were: rabbit, sheep and human (A, Rh+; A, Rh-; B, Rh+; B, Rh-; O, Rh+; O, Rh-; AB, Rh+; AB, Rh- groups). Plates were inoculated and, incubated in microaerophilic conditions, at 37ºC, for 48 h. The haemolytic activity of the tested strains was characterized as alpha-haemolysis. Only two isolates were not haemolytic on all blood types (2.9%), two strains were haemolytic only on human blood (one strain on AB, Rh+ group and another one on A, Rh+ and AB, Rh+ groups). No specificity between haemolysin produced by the tested strains and blood type was observed.

Exploration on human blood type case in teaching practice of genetics

2013 ◽  
Vol 35 (8) ◽  
pp. 1040-1044
Author(s):  
Yan PI ◽  
Xiao-Ying LI ◽  
Cong HUAI ◽  
Shi-Ming WANG ◽  
Shou-Yi QIAO ◽  
...  
Keyword(s):  
Human Blood ◽  
Teaching Practice ◽  
Blood Type

scholarly journals ABO blood types and sepsis mortality

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Theis S. Itenov ◽  
Daniel I. Sessler ◽  
Ashish K. Khanna ◽  
Sisse R. Ostrowski ◽  
Pär I. Johansson ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Meta Analysis ◽  
The United States ◽  
Endothelial Damage ◽  
Blood Type ◽  
Type B ◽  
Blood Concentrations ◽  
Soluble Thrombomodulin ◽  
Blood Types

Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

scholarly journals Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Eva Spada ◽  
Arianna Miglio ◽  
Daniela Proverbio ◽  
Maria Teresa Antognoni ◽  
Giada Bagnagatti De Giorgi ◽  
...  
Keyword(s):  
Blood Donors ◽  
Type A ◽  
Blood Type ◽  
Transfusion Reaction ◽  
Type B ◽  
Blood Typing ◽  
Blood Types ◽  
Blood Banks ◽  
Type Ab ◽  
Transfusion Reactions

Data from potential feline blood donors presented at two university blood banks in Italy were recorded. Blood typing was performed using an immunochromatographic method. Over the three years of the study 357 cats representing 15 breeds, 45.3% female and 54.7% male, with a mean age of 3.8 years were evaluated. Of these 90.5% were blood type A, 5.6% type B, and 3.9% type AB. The majority of the cats (54.6%) were European DSH (92.3% were type A, 5.1% type B, and 2.6% type AB), and 21% were Maine Coon (MCO) cats (100% blood type A). The estimated frequencies of transfusion reactions following an unmatched transfusion between DSH (donors and recipients), MCO (donor and recipients), DSH donors and MCO recipients, and MCO donors and DSH recipients were 4.8%, 0%, 0%, and 5.1% for major reactions and 7.2%, 0%, 7.7%, and 0% for minor transfusions reactions, respectively. In a population of blood donors that includes DSH and MCO the risk of transfusion reaction is between 5% and 8% if typing is not performed on donor and recipient blood. Blood typing should therefore be performed before transfusion to remove the risk of transfusion reactions due to blood type incompatibilities.

The Impact of Blood Type O on Major Outcomes in Patients With Severe Burns

2020 ◽  
Vol 41 (5) ◽  
pp. 1111-1117 ◽  
Author(s):  
Renqi Yao ◽  
Wenjia Hou ◽  
Tuo Shen ◽  
Shuo Zhao ◽  
Xingfeng He ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Clinical Outcomes ◽  
Poor Prognosis ◽  
Kidney Injury ◽  
Blood Type ◽  
Blood Types ◽  
Severe Burns ◽  
Icu Length Of Stay ◽  
Abo Blood Type ◽  
The Impact

Abstract ABO blood type has been reported to be a predictor of poor prognosis in critically ill patients. Here, we aim to correlate different blood types with clinical outcomes in patients with severe burns. We conducted a single-center retrospective cohort study by enrolling patients with severe burn injuries (≥40% TBSA) between January 2012 and December 2017. Baseline characteristics and clinical outcomes were compared between disparate ABO blood types (type O vs non-O type). Multivariate logistic and linear regression analyses were performed to identify an association between ABO blood type and clinical outcomes, including in-hospital mortality, the development of acute kidney injury (AKI), and hospital or ICU length of stay. A total of 141 patients were finally enrolled in the current study. Mortality was significantly higher in patients with type O blood compared with those of other blood types. The development of AKI was significantly higher in patients with blood type O vs non-O blood type (P = .001). Multivariate analysis demonstrated that blood type O was independently associated with in-hospital mortality and AKI occurrence after adjusting for other potential confounders. Our findings indicated the blood type O was an independent risk factor of both increased mortality and the development of AKI postburn. More prudent and specific treatments are required in treating these patients to avoid poor prognosis.

scholarly journals Novel optical biosensor method to identify human blood types using free space frequency modulated wave of NIR photon technology

2018 ◽  
Vol Volume 12 ◽  
pp. 9-20
Author(s):  
Ebraheem Sultan ◽  
Mariam Albahrani ◽  
Jasem Alostad ◽  
Hameed K. Ebraheem ◽  
Mahmud Alnaser ◽  
...  
Keyword(s):  
Human Blood ◽  
Free Space ◽  
Optical Biosensor ◽  
Blood Types ◽  
Space Frequency

scholarly journals ABO GENE AND AGING-RELATED OUTCOMES IN OVER 379,000 EUROPEAN-DESCENT PARTICIPANTS OF UK BIOBANK

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S925-S925
Author(s):  
Chia-Ling Kuo ◽  
Ziwei Pan ◽  
Luke C Pilling ◽  
George A Kuchel ◽  
David Melzer
Keyword(s):  
Breast Cancer ◽  
Type Ii Diabetes ◽  
Hemoglobin Concentration ◽  
Blood Type ◽  
Type Ii ◽  
Nucleotide Polymorphisms ◽  
Multiple Traits ◽  
Mineral Density ◽  
Blood Types ◽  
Wide Range

Abstract Genetic variants associated with multiple traits are potential targets to delay aging. Drugs supported by genetic evidence are twice as likely to succeed in human trials. Single nucleotide polymorphisms (SNPs) in the ABO gene were reported by genome-wide associations studies, associated with breast cancer, coronary artery disease, stroke, and type II diabetes. To evaluate the potential of ABO gene as a target for aging intervention, we conducted a phenome-wide association study (PheWAS) to associate the genotype-derived blood types (based on two SNPs in the ABO gene) with a wide range of aging-related outcomes. The genotype-derived blood type distribution (41% A, 9% B, 3% AB, and 47% O) is similar to that reported by the UK National Health Service (39% A, 10% B, 3% AB, and 48% O). The blood type was not associated with parental lifespan or extreme parental longevity. Non-O types had modestly lower risk of hypertension than O type but higher risk of type II diabetes and pancreatic cancer (e.g., OR= 1.37, 95% CI: 1.17 to 1.59 comparing A to O). Additionally, “A" type had modestly higher risk of breast cancer than other types. “A” allele (in A or AB type) was associated with lower heel bone mineral density, alkaline phosphatase (e.g., 0.41 standard deviation lower in A than that in O, 95% CI: -0.42 to -0.40), and hemoglobin concentration, but higher HbA1c, direct LDL, and cholesterol. Blood types with A allele(s) are less favored than other blood types, which however are adversely associated with some aging traits.

Race, ABO Blood Type, Gender, Age and Venous Thromboembolism Risk: Not Black and White

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 568-568 ◽  
Author(s):  
Chunhui Fang ◽  
Henny Heisler Billett
Keyword(s):  
Venous Thromboembolism ◽  
Gender Difference ◽  
Prognostic Score ◽  
Male Gender ◽  
Adult Patients ◽  
Blood Type ◽  
Lower Prevalence ◽  
Blood Types ◽  
Multiple Variables ◽  
Abo Blood Type

Abstract Abstract 568 Venous thromboembolism (VTE) prevalence has been noted to be different for different racial groups: Non-Hispanic blacks tend to have a higher risk compared with non-Hispanic whites. Different ABO blood types have also been previously shown to be associated with different risk of VTE, with individuals with O blood type carry the lowest VTE risk. Given that blacks have a higher percentage of O blood type, one would expect to see a lower prevalence of VTE. In order to explain this paradoxical finding, we utilized the Clinical Looking Glass (CLG) system to study the relative influence of race, gender, age, and ABO blood type on the VTE risk. A total of 61,077 adult patients admitted to our large diverse urban hospital between 2000 and 2009 who had blood typing performed were included in the study. Four cohorts were established according to ABO blood group and the prevalence of VTE among each cohort was examined. We confirmed the higher prevalence of VTE in blacks (7.05% vs. 6.75%, p<0.001). While it has been previously shown that male gender is associated with higher VTE risk, we found this to be true only for the younger patient population: in adult patients less than 45yrs, male carried a higher prevalence of VTE (5.97% vs. 3.06%, p<0.001); in patients aged between 45 and 64yrs, no gender difference in the prevalence of VTE could be determined (8.40% vs. 8.33%, p=0.86). For patients aged between 65 and 84yrs, male gender was actually associated with lower prevalence of VTE (10.11% vs. 12.07%, p=0.009). No gender difference was seen in patients older than 80 (11.11% vs. 11.99%, p=0.356). When the prevalence of VTE was examined within each blood type, we confirmed that O blood type in general carries a lower VTE risk compared with other non-O blood types (6.9% vs. 8.4%, p<0.001); this held true for both genders (See Figure). To better analyze this complex interaction between race, ABO blood type, gender, age and VTE risk, we used logistic regression analysis. Race appeared to be the strongest determinant (black vs. white OR 1.43; 95% CI: 1.33, 1.52), followed by ABO blood type (Type A 1.2, 95% CI: 1.13–1.3; Type AB 1.2, 95% CI: 1.05, 1.40; Type B 1.33, 95% CI 1.23, 1.44), then gender (male vs. female OR 1.11; 95% CI: 1.04, 1.18) and finally, age (OR 1.03; 95% CI 1.03 – 1.03).). In conclusion, VTE risk for any individual is a composite of multiple variables. Our study suggests that race, gender, ABO blood type and age might allow us, in combination with other known risk factors, to develop a prognostic score for VTE risk stratification for each patient. Disclosures: No relevant conflicts of interest to declare.

Exposure To ABO Compatible But Non-Group Identical Blood and In-Hospital Mortality

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 3651-3651
Author(s):  
Richard J Cook ◽  
Nancy Heddle ◽  
Ker-Ai Lee ◽  
Yang Liu ◽  
Rebecca Barty, MLT ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Research Funding ◽  
Cox Regression ◽  
Type A ◽  
Blood Type ◽  
Hospital Death ◽  
Trauma Patients ◽  
Factors Associated ◽  
Blood Types ◽  
Increased Risk

Abstract Background Transfusions that are ABO compatible but not group identical (mismatched) are given for a variety of reasons including inventory availability, avoiding wastage from outdating, and clinical urgency. A recent observation at our centre suggested that patient outcome was different for those patients that received a transfusion of units with a compatible but mismatched ABO group compared to those receiving ABO group identical blood. Hence, we performed a retrospective hospital registry study to explore the association between mismatched blood and in-hospital mortality in transfused patients. Study Design Our patient/blood utilization database included 35,487 transfused hospitalized patients from 3 acute care academic centres from April 1, 2002 to October 31, 2011. Information on transfused RBCs included duration of storage (days) and ABO type. Patient data included: sex; age; hemoglobin; creatinine; diagnosis; interventions; ABO blood group and hospital discharge status. Factors associated with mismatched blood and in-hospital mortality were examined using generalized estimating equations to account for the potential serial dependence over multiple transfusions. The effect of exposure to ABO mismatched blood on in-hospital death was examined through Cox regression with time-dependent strata defined by: year of first admission; disease group; and the cumulative number of units transfused (≤ 7 days of storage; > 7 days but ≤ 28 days storage; and, >28 days of storage); and, controlling for available baseline and time-varying characteristics. Results 18,843 patients (blood groups A, B and AB), with complete covariates contributed to the analysis. Factors associated with transfusion of mismatched blood included: younger patient age (p<0.0001); lower hemoglobin (p<0.0001); higher creatinine (p<0.0001); intervention during hospitalization (OR=4.6, p<0.0001); and, patient ABO group whereby blood types A and B were much less likely to receive a mismatched unit compared to type AB patients (p<0.0001). There was a statistically significant interaction between patient blood type and the effect of receiving mismatched blood (p=0.034) with type A patients incurring a 79% higher risk of death (RR=1.79, 95% CI: 1.20, 2.67; p=0.0047); other patient blood types did not suggest increased risk. Similar results were observed when suspected trauma patients (≥ 6 units within 24 hours) were excluded from the analysis (Table 1). Conclusion Controlling for known potential confounders through Cox regression yielded evidence of increased risk of in-hospital mortality among blood type A patients receiving group O red cells. This association remained after suspected trauma patients were excluded from the analyses. Further study of the association observed in this study is warranted. Disclosures: Cook: CIHR: Research Funding. Heddle:CIHR: Research Funding; Canadian Blood Services: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Health Canada: Research Funding. Eikelboom:CIHR: Research Funding.

ABO and RHD blood types distribution of the patients treated in the Federal Center of Cardiovascular Surgery of Krasnoyarsk

2016 ◽  
Vol 94 (5) ◽  
pp. 353-355
Author(s):  
Aleksnder A. Makovskiy ◽  
A. A. Popov ◽  
S. D. Gysev ◽  
L. I. Barhatova
Keyword(s):  
Cardiovascular Surgery ◽  
Type A ◽  
Blood Type ◽  
Transfusion Therapy ◽  
Blood Types ◽  
The People ◽  
Hospital Patients ◽  
Abo Blood Type ◽  
The Mean ◽  
Group B

The knowledge of blood types frequency in hospital patients helps to plan and perform transfusion therapy at blood donor centers. The distribution of patients’ blood by ABO groups and RhD allows to more efficiently organize and use donor blood banks. The risk of a disease is related to genome composition and is inherited with an ABO blood type. Every person should know his (her) ABO blood type and RhD to enable early identification of the first symptoms of an illness. Materials and methods. This work is based on the study of 4831 blood samples from patients treated at the Center of Cardiovascular Surgery in 2013 (2885 (59,7%) men of the mean age 55 years and 1946 (40,3 %) women of the mean age 57 years). Results. Type A blood occurred most frequently (1787 or 37,0% samples) followed by group O (1625 or 33,6% samples). Samples of group B made up 1025 of the total (21,2%), AB blood group was found in 394 samples (8,2%). Conclusion. The blood types distribution of the ABO system in the patients treated at the Center of Cardiovascular Surgery was characterized by the following pattern: A > O > B > AB. Group A was identified in 37,0% of the patients. Its frequency is similar to that in the population of the western part of Russia and Moscow but different from that in the people living in nearby regions. The frequency of RhD system antigens is comparable in all regions of Russia. CcDEe, ccDEe, CcDee, CCDee are considered to be the most widespread phenotypes. The residents of the Krasnoyarsk region and some nearby regions having blood type A apply to the Center of Cardiovascular Surgery with cardiovascular disorders more frequently than those with others ABO blood types.

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