scholarly journals Interictal electroencephalogram: sensibility in the diagnosis of epileptic seizures in childhood

2007 ◽  
Vol 13 (1) ◽  
pp. 17-20
Author(s):  
Raquel Rego ◽  
Paulo Breno Noronha Liberalesso ◽  
Mônica Jaques Spinosa ◽  
Simone Carreiro Vieira ◽  
Alaídes S. Fojo Olmos ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Epileptic Seizure ◽  
Background Activity ◽  
International System ◽  
Epileptic Seizures ◽  
Children's Hospital ◽  
The World ◽  
Pediatric Neurologist ◽  
Spike Wave ◽  
Abnormal Results

INTRODUCTION: It is currently estimated that more than 10 million children all over the world have epilepsy and the EEG is the most commonly used diagnostic test in the investigation of these patients. The aim of this study was to analyze the sensibility of the EEG in revealing abnormalities in children with the clinical hypothesis of an epileptic seizure. METHODS: Out of 970 EEGs obtained between April 2005 and August 2006 at Pequeno Príncipe Children's Hospital, Curitiba, PR, Brazil, 692 fit the criteria proposed (clinical hypothesis of an epileptic seizure after the evaluation of a pediatric neurologist). All EEGs were recorded digitally, with minimal duration of 20 minutes and electrodes positioned according to the International System 10-20. Neonates were excluded. RESULTS: Age ranged from 30 days to 16.5 years (mean of 6.4 years and median of 4.1 years), 403 were female (58.2%). Out of the 692 EEG included in the study, 281 (40.6%) yielded abnormal results, 96 (34.2%) with abnormalities of the background activity (disorganization and/or asymmetry) and 185 (65.8%) with epileptiform paroxysms. The sensibility of the EEG was 40.6%. Sharpe wave occurred in 77 cases (41.6%), spike in 21 (11.4%), polispike in 14 (7.6%), spike-wave in 17 (9.2%), polispike-wave in 24 (13.0%) and exams with discharges of more than one morphology in 32 (17.3%). CONCLUSION: Our data strengthen the concept that even though the diagnosis of epilepsy is clinical and based on the semiological description of the epileptic crisis, the EEG has a good sensibility when properly indicated.

Association of Epileptic and Non-epileptic Seizures and Changes in Circulating Plasma Proteins Linked to Neuroinflammation

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000011552
Author(s):  
John Gledhill ◽  
Elizabeth Brand ◽  
John Pollard ◽  
Richard St. Clair ◽  
Todd Wallach ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diagnostic Test ◽  
Epileptic Seizure ◽  
Plasma Proteins ◽  
Sandwich Elisa ◽  
Plasma Concentrations ◽  
Diagnostic Algorithm ◽  
Epileptic Seizures ◽  
Cost Effective ◽  
Class Iii

Objective:To develop a diagnostic test that stratifies epileptic seizure (ES) from psychogenic non-epileptic seizure (PNES) by developing a multimodal algorithm that integrates plasma concentrations of selected immune response associated proteins and patient clinical risk factors for seizure.Methods:Daily blood samples were collected from patients evaluated in the epilepsy monitoring unit (EMU) within 24 hours after EEG confirmed ES or PNES and plasma was isolated. Levels of 51 candidate plasma proteins were quantified using an automated, multiplexed, sandwich ELISA and then integrated and analyzed using our diagnostic algorithm.Results:A 51 protein multiplexed ELISA panel was used to determine the plasma concentrations of ES patients, PNES patients, and healthy controls. A combination of protein concentrations, TRAIL, ICAM-1, MCP-2 and TNF-R1 provided a probability that a patient recently experienced a seizure with TRAIL and ICAM-1 higher in PNES than ES, and MCP-2 and TNF-R1 higher in ES than PNES. The diagnostic algorithm yielded an AUC of 0.94±0.07, sensitivity of 82.6% (95% CI:62.9-93.0) and specificity of 91.6% (95% CI:74.2-97.7). Further, expanding the diagnostic algorithm to include previously identified PNES risk factors enhanced diagnostic performance with AUC of 0.97±0.05, sensitivity of 91.3%; (95% CI:73.2-97.6), and specificity of 95.8%; (95% CI:79.8-99.3).Conclusions:These four plasma proteins could provide a rapid, cost-effective, and accurate blood-based diagnostic test to confirm recent ES or PNES.Classification of Evidence:This study provides Class III evidence that variable levels of four plasma proteins, when analyzed by a diagnostic algorithm, can distinguish PNES from ES with sensitivity of 82.6% and specificity of 91.6%.

scholarly journals The State of the Art in Feature Extraction Methods for EEG Classification

2019 ◽  
Vol 3 (2) ◽  
pp. 16
Author(s):  
Hoger Mahmud Hussen
Keyword(s):  
Epileptic Seizure ◽  
Neurological Disease ◽  
State Of The Art ◽  
Epileptic Seizures ◽  
Extraction Methods ◽  
Eeg Classification ◽  
The World ◽  
Electroencephalogram Eeg ◽  
The Brain ◽  
Eeg Features

Epileptic seizure is a neurological disease that is common around the world and there are many types (e.g. Focal aware seizures and atonic seizure) that are caused by synchronous or abnormal neuronal activity in the brain. A number of techniques are available to detect the brain activities that lead to Epileptic seizures; one of the most common one is Electroencephalogram (EEG) that uses visual scanning to measure brain activities generated by nerve cells in the cerebral cortex. The techniques make use of different features detected by EEG to decide on the occurrence and type of seizures. In this paper we review EEG features proposed by different researches for the purpose of Epileptic seizure detection, also analyze, and compare the performance of the proposed features.

Aftershocks

2017 ◽  
Author(s):  
Seva Gunitsky
Keyword(s):  
Twentieth Century ◽  
Regime Change ◽  
International System ◽  
Political Legitimacy ◽  
Great Powers ◽  
Past Century ◽  
The Past ◽  
Sudden Rise ◽  
The World ◽  
National Borders

Over the past century, democracy spread around the world in turbulent bursts of change, sweeping across national borders in dramatic cascades of revolution and reform. This book offers a new global-oriented explanation for this wavelike spread and retreat—not only of democracy but also of its twentieth-century rivals, fascism, and communism. The book argues that waves of regime change are driven by the aftermath of cataclysmic disruptions to the international system. These hegemonic shocks, marked by the sudden rise and fall of great powers, have been essential and often-neglected drivers of domestic transformations. Though rare and fleeting, they not only repeatedly alter the global hierarchy of powerful states but also create unique and powerful opportunities for sweeping national reforms—by triggering military impositions, swiftly changing the incentives of domestic actors, or transforming the basis of political legitimacy itself. As a result, the evolution of modern regimes cannot be fully understood without examining the consequences of clashes between great powers, which repeatedly—and often unsuccessfully—sought to cajole, inspire, and intimidate other states into joining their camps.

Automated System for Epileptic Seizures Prediction based on Multi-Channel Recordings of Electrical Brain Activity

2018 ◽  
pp. 115-122 ◽  
Author(s):  
V. A. Maksimenko ◽  
A. A. Harchenko ◽  
A. Lüttjohann
Keyword(s):  
Epileptic Seizure ◽  
Brain Activity ◽  
Epileptic Seizures ◽  
Automated System ◽  
Brain Computer Interfaces ◽  
Electrical Brain Activity ◽  
Computer Interfaces ◽  
Prediction And Prevention ◽  
The Brain

Introduction: Now the great interest in studying the brain activity based on detection of oscillatory patterns on the recorded data of electrical neuronal activity (electroencephalograms) is associated with the possibility of developing brain-computer interfaces. Braincomputer interfaces are based on the real-time detection of characteristic patterns on electroencephalograms and their transformation  into commands for controlling external devices. One of the important areas of the brain-computer interfaces application is the control of the pathological activity of the brain. This is in demand for epilepsy patients, who do not respond to drug treatment.Purpose: A technique for detecting the characteristic patterns of neural activity preceding the occurrence of epileptic seizures.Results:Using multi-channel electroencephalograms, we consider the dynamics of thalamo-cortical brain network, preceded the occurrence of an epileptic seizure. We have developed technique which allows to predict the occurrence of an epileptic seizure. The technique has been implemented in a brain-computer interface, which has been tested in-vivo on the animal model of absence epilepsy.Practical relevance:The results of our study demonstrate the possibility of epileptic seizures prediction based on multichannel electroencephalograms. The obtained results can be used in the development of neurointerfaces for the prediction and prevention of seizures of various types of epilepsy in humans. 

The Unified World Order

2014 ◽  
Vol 31 (2) ◽  
pp. 75-100
Author(s):  
Bakare Adewale Muteeu
Keyword(s):  
Cultural Values ◽  
International System ◽  
World Order ◽  
Social Injustice ◽  
World Peace ◽  
Technological Determinism ◽  
Open World ◽  
The World ◽  
Capitalist World ◽  
The Rich

In pursuit of a capitalist world configuration, the causal phenomenon of globalization spread its cultural values in the built international system, as evidenced by the dichotomy between the rich North and the poor South. This era of cultural globalization is predominantly characterized by social inequality, economic inequality and instability, political instability, social injustice, and environmental change. Consequently, the world is empirically infected by divergent global inequalities among nations and people, as evidenced by the numerous problems plaguing humanity. This article seeks to understand Islam from the viewpoint of technological determinism in attempt to offset these diverging global inequalities for its “sociopolitical economy”1existence, as well as the stabilization of the interconnected world. Based upon the unifying view of microIslamics, the meaning of Islam and its globalizing perspectives are deciphered on a built micro-religious platform. Finally, the world is rebuilt via the Open World Peace (OWP) paradigm, from which the fluidity of open globalization is derived as a future causal phenomenon for seamlessly bridging (or contracting) the gaps between the rich-rich, rich-poor, poor-rich and poor-poor nations and people based on common civilization fronts.

Sovereignty at the Paris Peace Conference of 1919

2018 ◽  
Author(s):  
Leonard V. Smith
Keyword(s):  
World War Ii ◽  
International Relations ◽  
International System ◽  
International Relations Theory ◽  
League Of Nations ◽  
Great Power ◽  
World War ◽  
Treaty Of Versailles ◽  
The World ◽  
Paris Peace Conference

We have long known that the Paris Peace Conference of 1919 “failed” in the sense that it did not prevent the outbreak of World War II. This book investigates not whether the conference succeeded or failed, but the historically specific international system it created. It explores the rules under which that system operated, and the kinds of states and empires that inhabited it. Deepening the dialogue between history and international relations theory makes it possible to think about sovereignty at the conference in new ways. Sovereignty in 1919 was about remaking “the world”—not just determining of answers demarcating the international system, but also the questions. Most histories of the Paris Peace Conference stop with the signing of the Treaty of Versailles with Germany on June 28, 1919. This book considers all five treaties produced by the conference as well as the Treaty of Lausanne with Turkey in 1923. It is organized not chronologically or geographically, but according to specific problems of sovereignty. A peace based on “justice” produced a criminalized Great Power in Germany, and a template problematically applied in the other treaties. The conference as sovereign sought to “unmix” lands and peoples in the defeated multinational empires by drawing boundaries and defining ethnicities. It sought less to oppose revolution than to instrumentalize it. The League of Nations, so often taken as the supreme symbol of the conference’s failure, is better considered as a continuation of the laboratory of sovereignty established in Paris.

Focusing on India’s Look East Policy: India–China relationship from 1947 to 2020

2021 ◽  
pp. 223386592110183
Author(s):  
Kaushik Roy
Keyword(s):  
20Th Century ◽  
Industrial Revolution ◽  
International System ◽  
China Policy ◽  
Economic Competition ◽  
Intimate Contact ◽  
Late 20Th Century ◽  
Republic Of China ◽  
China And India ◽  
The World

Before the onset of the industrial revolution, China and India were the two biggest powers in Eurasia. Their total population comprised almost half of the world’s population. And the GNP of premodern China was half of the combined GNP of the world. Before circa 1600 CE, most of the textiles and iron in the world were manufactured in these two countries. China and India suffered a temporary eclipse during the age of colonialism. However, with the rise of the economic and military power of China and India from the late 20th century, it seems that these two countries are bound to reclaim their traditional positions as big powers in the international system. However, there is a caveat. In the premodern era, the Himalayas prevented any intimate contact between the ‘dragon’ and the ‘elephant’. But, from the mid-20th century, advances in technology, economic competition and the annexation of Tibet by the People’s Republic of China (PRC) among other factors resulted in China and India coming into direct contact with each other. The result has been cooperation–competition–conflict. And this has had consequences not only for these two countries but for the whole world. The present article attempts to trace the troubled trajectory of India’s China policy from the late 1940s (when these two countries became independent) up to the present day.

Democracy and Dictatorship in Interwar Western Europe Revisited

1998 ◽  
Vol 50 (3) ◽  
pp. 475-505 ◽  
Author(s):  
Thomas Ertman
Keyword(s):  
Political Parties ◽  
Economic Crisis ◽  
Western Europe ◽  
International System ◽  
Explanatory Framework ◽  
The World ◽  
Entire Universe ◽  
Western European ◽  
Methodological Advance

Almost none of the conditions that, according to the latest research, favor democratic durability were present in Western Europe between the world wars. Yet only four Western European states became dictatorships during this period, whereas the others remained democratic despite economic crisis, an unhelpful international system, and the lure of nondemocratic alternatives. Several recent works offer new explanations for this pattern of interwar outcomes. Insofar as these works analyze the entire universe of Western European cases, they represent an important methodological advance. However, they remain too wedded to a class-coalitional framework to provide both a parsimonious and a historically accurate account of why democracy collapsed in some states but not in others. This article proposes an alternative explanatory framework that focuses on how political parties can shape association life in such a way as to support or undermine democracy.

scholarly journals Punching above Weight: How the African Union Commission Exercises Agency in Politics

2021 ◽  
pp. 000203972199039
Author(s):  
Thomas Kwasi Tieku
Keyword(s):  
Decision Making ◽  
Agenda Setting ◽  
Policy Development ◽  
International System ◽  
African Union ◽  
African Continent ◽  
International Organisations ◽  
The World ◽  
International Issues ◽  
Decision Making Rule

Conventional narratives suggest that the African Union Commission (AUC), like most international public administrations and international organisations (IOs) housed in the less materially endowed regions of the world, exercises no meaningful agency on international issues. This article however seeks to show that the AUC is neither a glorified messenger and docile follower of orders of governments nor is it an empty vessel that timidly goes where the wind of governments blows. Rather, the AUC exercises significant agency on issues that affect not just the African continent but also the broader international system. The AUC is often at the heart of international agenda-setting, norm development, decision-making, rule creation, policy development, and it sometimes offer strategic leadership. The article demonstrates six pathways through which the AUC acts like a tail wagging a dog.

CHARACTERISTIC OF THE CONSTITUTION OF THE REPUBLIC OF UZBEKISTAN, COMPARATIVE ANALYSIS

2021 ◽  
Vol 6 (10) ◽  
pp. 5-11
Author(s):  
Muzaffar Nurbaev ◽  
Keyword(s):  
Best Practices ◽  
International System ◽  
Individual State ◽  
Universal System ◽  
Common Features ◽  
World Community ◽  
The Past ◽  
The World ◽  
The Republic ◽  
System States

The world community will turn into a common international system. States, which are a separate independent part of this universal system, develop in all spheres in interaction, interdependence and interdependence. Each individual state can benefit from the best practices of another state in the field of political, legal, legislative and state building.Naturally, the study of the experience of foreign parliamentarism is of great importance for Uzbekistan, which democratically restructures its political and legal system and moves towards the formation of a bicameral legislature through parliamentary reforms. Over the past two hundred years of the historical development of parliamentarism, an incredibly rich and meaningful experience has been accumulated. No matter how diverse the diversity in this regard, comparing the activities of existing parliaments on the planet, it will be possible to identify all important aspects, common features and features of this state-legal phenomenon. The essence, traditions and general laws of parliamentarism can be understood by comparing the legislative practice that has developed in advanced countries with the procedures formed in them. At the same time, it should be noted that a number of rare works have been published based on a comparison of the experience of different parliaments

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