scholarly journals ANALYSIS OF CERVICAL SAGITTAL PARAMETERS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 20 (2) ◽  
pp. 94-97
Author(s):  
Kaio Rodrigo Barreto Ramiro ◽  
Sylvio Mystro Neto ◽  
Ivan Guidolin Veiga ◽  
André Frazão Rosa ◽  
Mauricio Coelho Lima ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Sagittal Plane ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Control Group ◽  
Chi Square ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Thoracic Inlet ◽  
Sagittal Parameters

ABSTRACT Objective: To analyze the cervical sagittal parameters of patients with rheumatoid arthritis (RA) and compare them with the parameters obtained from healthy patients in a sample of the Brazilian population. Methods: Epidemiological data were collected and 72 radiographs of the cervical spine in the sagittal plane were evaluated by measuring the cervical sagittal parameters COG-C7 (distance measured between the center of gravity of the head and the C7 plumb line -cranial offset), C2-C7 lordosis (vertebrae from C2 to C7), T1S (T1 slope), TIA (thoracic inlet angle) and NT (neck tilt). Statistical analysis was performed using the Student’s t and chi-square tests. Results: The TIA and NT values in the RA group were 88.8° ± 12.6° and 54.5° ± 9.3°, respectively, while for the control group, they were 77.7° ± 7.9° and 50.5° ± 7.7°, respectively, the RA group values being statistically higher than the control group values (p <0.001 and p = 0.050, respectively). The values obtained for COG-C7, C2-C7 lordosis and T1S for the RA group were 9.4 ± 16.4mm, 25° ± 22.4° and 2.6° ± 10.1°, respectively, while for the control group they were 11.8 ± 17.6mm, 26.8° ± 12.5° and 30.9° ± 8.4°, respectively. Conclusions: Patients with RA present changes in the thoracic inlet parameters as compared to the control group, with a statistically significant increase in the TIA and NT values, outlining a characteristic compensatory pattern for maintaining cervical sagittal balance. Level of evidence III; Controlled cross-sectional study.

Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatih Öner Kaya ◽  
Yeşim Ceylaner ◽  
Belkız Öngen İpek ◽  
Zeynep Güneş Özünal ◽  
Gülbüz Sezgin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Healthy Volunteers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Joint Disease ◽  
Control Group ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Das 28 ◽  
Tnf Α

Aims: The etiopathogenesis of Rheumatoid Arthritis (RA) is not clearly understood. However, the role of the cytokines takes an important part in this mechanism. We aimed to bring a new approach to the concept of 'remission' in patients with RA. Background: RA is a chronic, autoimmune, inflammatory disease that involves small joints in the form of symmetrical polyarthritis and progresses with exacerbations and remissions. Pain, swelling, tenderness and morning stiffness are typical of the joints involved. Although it is approached as a primary joint disease, a wide variety of extra-articular involvements may also occur. It is an interesting pathophysiological process, the exact cause of which is still unknown, with many environmental, genetic and potentially undiscovered possible factors in a chaotic manner. Objective: In this cross-sectional study, sedimentation rate (ESR), C- Reactive protein (CRP), Tumor necrosis factor (TNF)-α, soluble-TNF-α receptor (TNF-R), Interleukin (IL)-1B and IL-10 were measured in three groups which were healthy volunteers, patients with RA in the active period, and patients with RA in remission. Disease activity score-28 (DAS-28) was calculated in active RA and RA in remission. Methods: This study included 20 healthy volunteers, 20 remission patients with RA and 20 active RA patients. Venous blood samples were collected from patients in both healthy and RA groups. Results: RA group consisted 43 (71.6%) female and 17 (28.4%) male. Control group consisted 11 (55%) female and 9 (45%) male. TNF-R was significantly high only in the active group according to the healthy group (p=0.002). IL-10 was significantly high in active RA according to RA in remission (p=0.03). DAS-28 was significantly high in active RA according to RA in remission (p=0.001). In the active RA group, ESR and TNF-R had a positive correlation (r:0.442; p=0.048). In the active RA group, there was also a positive correlation between TNF-R and CRP (r:0.621; p=0,003). Both healthy and active RA group had significant positive correlation between ESR and CRP (r: 0.481; p=0.032 and r: 0,697; p=0,001 respectively). Conclusion: TNF-R can be the main pathophysiological factor and a marker showing activation. TNF-R can be very important in revealing the effect of TNF on the disease and the value of this effect in the treatment and ensuring the follow-up of the disease with CRP instead of ESR in activation.

scholarly journals A Retrospective study on the dynamics of the clinical and Demographical evolution of Cutaneous Leishmaniasis in the Yazd province, Iran

2020 ◽  
Vol 3 (3) ◽  
pp. 80-83
Author(s):  
Ali Fattahi Bafghi ◽  
◽  
Elham Rezaee ◽  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Epidemiological Study ◽  
Age Groups ◽  
Epidemiological Data ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Personal Hygiene ◽  
Chi Square ◽  
Cross Sectional ◽  
The Past

Leishmaniasis is considered as an important health problem in the world. Cutaneous Leishmaniasis is epidemic in all of places of Iran, this disease begins as small swells and then they gradually grow and turn into wounds. Since the epidemiological study of this problem is effective in preventing and controlling it. The current research was conducted to study the epidemiological study of Cutaneous Leishmaniasis in Yazd province during the past 5(2014-2018) years. This cross-sectional study has been conducted on registered information and documents of the patients having problem in Yazd province remedial and health care centers over the past 5 years. First, the registered demographic and epidemiological data of the patients were extracted and then they were analyzed by using SPSS 18 software with chi-square test and descriptive statistics.897 patients included 457 males (51.06%) and 439 females (48.94%). The majority of the patients were between nine 20-29 years old and the minority of them were over the range of 5-9 years old. Most lesions were on the hand and leg of the patients. It was also found that there was a significant relationship between age groups and types of Leishmaniasis (P<0.05) as well as gender and type Leishmaniasis (P<0.05). According to our study, there has been an ascending trend in disease frequency in Yazd province from 2014 to 2018. This increase in diseases due to lack of health and educational status of the people-is also a lack of personal hygiene.

scholarly journals Scapular Dyskinesis in Young, Asymptomatic Elite Swimmers

2018 ◽  
Vol 6 (1) ◽  
pp. 232596711775081 ◽  
Author(s):  
Jacopo Preziosi Standoli ◽  
Francesco Fratalocchi ◽  
Vittorio Candela ◽  
Tiziano Preziosi Standoli ◽  
Giuseppe Giannicola ◽  
...  
Keyword(s):  
Sagittal Plane ◽  
Dynamic Test ◽  
Cross Sectional Study ◽  
Type I ◽  
Scapular Dyskinesis ◽  
Long Distance ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Overhead Athletes ◽  
Elite Swimmers

Background: Overhead athletes are at a greater risk of developing scapular dyskinesis (SD). Although swimming is considered an overhead sport, information regarding SD in these athletes is scarce. Purpose: To determine the prevalence of SD in young, asymptomatic elite swimmers. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 661 asymptomatic elite swimmers were enrolled in this study (344 male, 317 female; mean age, 15.83 ± 2.20 years). Anthropometric characteristics, training routine, and stroke specialty were recorded. SD was assessed using a dynamic test consisting of an examination of the shoulder blades throughout synchronous forward flexion motion in the sagittal plane and was deemed to be either present or absent. Each movement was repeated 5 times. These evaluations were performed with athletes at rest, before any training or competition. Statistical analysis was performed. Results: SD was detected in 56 (8.5%) participants. Type I SD was the most common (46.5%); male participants were 2 times as likely to have SD as female participants (39 male, 17 female; P < .01). No correlation was found between the dominant limb and side affected ( P = .258); rather, a correlation was found between the breathing side and side affected, in that swimmers with a preferred breathing side were more prone to develop SD in the opposite shoulder ( P < .05). Swimmers involved in long-distance races were found to have a greater risk of developing SD ( P = .01). Conclusion: SD may be an asymptomatic condition in elite young swimmers and is present in 8.5% of these athletes. Early diagnosis may be useful for asymptomatic athletes with SD and to avoid its possible evolution to a symptomatic condition.

scholarly journals Spinopelvic Parameters Do Not Predict the Sagittal Orientation of the Acetabulum

2020 ◽  
Vol 8 (10) ◽  
pp. 232596712095742
Author(s):  
Munif Hatem ◽  
Scott J. Nimmons ◽  
Anthony Nicholas Khoury ◽  
Hal David Martin
Keyword(s):  
Pelvic Incidence ◽  
Sagittal Plane ◽  
Cross Sectional Study ◽  
Sacral Slope ◽  
Spinopelvic Parameters ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Spinopelvic Parameter ◽  
Magnetic Resonance Arthrogram ◽  
Sagittal Orientation

Background: The orientation of the acetabulum has a fundamental role in impingement and instability of the hip, and the spinopelvic parameters are thought to predict the sagittal orientation of the acetabulum (SOA). However, similar to the acetabular version (axial orientation) and inclination (coronal orientation), the cephalic or caudal orientation of the acetabulum in the sagittal plane, or SOA, may primarily be an intrinsic feature of the acetabulum itself. Purpose: To determine whether the spinopelvic parameters predict the sagittal orientation of the acetabulum in individuals without lumbar deformity. Study Design: Cross-sectional study; Level of evidence, 4. Methods: A retrospective analysis was performed in 89 patients (94 hips; 62 female, 27 male; mean ± SD age, 45.9 ± 15.4 years) without lumbosacral deformity who underwent magnetic resonance arthrogram (MRA) for assessment of hip pain. The SOA was determined in the sagittal cut MRA. A line was drawn at the distal limit of the anterior and posterior acetabular horns longitudinally to the transverse ligament, and the angle between this line and the axial plane represented the SOA. The sacral slope, pelvic incidence, and spinopelvic tilt were determined using a 3-dimensional cursor and the axial, sagittal, and coronal cuts. All MRA studies were performed with the patient in the supine position. Results: The SOA had a mean ± SD cephalic orientation of 18° ± 6.6°. No significant correlation was observed between the SOA and the sacral slope ( r = –0.03; P = .77). A weak correlation was observed between the SOA and the pelvic incidence ( r = 0.22; P = .03) and between the SOA and the spinopelvic tilt ( r = 0.41; P < .01). Conclusion: The SOA cannot be presumed based on the spinopelvic parameter. Similar to the well-known parameters to assess the axial and coronal orientation of the acetabulum, the assessment of the SOA demands acetabular-specific parameters. Additional studies are necessary to assess the SOA in asymptomatic hips, including disparities between genders. Clinically significant values for abnormal SOA of the acetabulum remain to be defined.

scholarly journals Relationship between Periodontitis and Glaucoma: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Soo Hwan Byun ◽  
Dae Myoung Yoo ◽  
Minwook Chang ◽  
Hyo Geun Choi ◽  
Seok Jin Hong
Keyword(s):  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Epidemiology Study ◽  
Chi Square ◽  
Cross Sectional ◽  
History Of ◽  
And Control

The objective of this cross-sectional study was to evaluate the association between periodontitis and glaucoma. This prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study performed between 2004 and 2016. Among 173,209 participants, 9572 patients with periodontitis and 115,332 controls (nonperiodontitis) were selected. We analysed the history of glaucoma in periodontitis and control participants. The participants were interviewed regarding their history of hypertension, diabetes mellitus, hyperlipidaemia, periodontitis, glaucoma, smoking, and alcohol consumption by trained interviewers. A logistic regression model was created to analyse the odds ratio of having a history of glaucoma among patients with periodontitis. Two-tailed analyses using chi-square and independent t-tests were used for statistical analysis. The adjusted odds ratio of periodontitis as a risk factor for glaucoma was 3.44 (95% confidence interval = 2.99–3.97, p < 0.001 ). This study demonstrated that glaucoma was associated with periodontitis.

scholarly journals Influence of Insulin Resistance and TNF-αon the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Neide Tomimura Costa ◽  
Tatiana Mayumi Veiga Iriyoda ◽  
Ana Paula Kallaur ◽  
Francieli Delongui ◽  
Daniela Frizon Alfieri ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Insulin Resistance ◽  
Disease Activity ◽  
Inflammatory Process ◽  
Cross Sectional Study ◽  
Stress Index ◽  
Control Group ◽  
Cross Sectional ◽  
Clinical Trials Registry

The aim of this study was to evaluate the involvement of TNF-αand insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group,n=97) and RA patients (n=173). RA patients were divided into four groups: the first group without IR and not using antitumor necrosis factor-α(TNF-) (G1, IR− TNF−); the second group without IR and using anti-TNF-α(G2,IR-TNF+); the third group with IR and not using anti-TNF-α(G3, IR+TNF-); and the fourth group with IR and using anti-TNF-α(G4, IR+ TNF+). G3 and G4 had higher (p<0.05) advanced oxidation protein products (AOPPs) and oxidative stress index (OSI) compared to G1. G4 group presented higher (p<0.05) AOPPs and OSI than G2. TRAP was significantly lower in G3 compared to G1. Plasma TNF-αlevels were significantly higher in G4 and G2 compared to G1 (p<0.0001) and G3 (p<0.0001andp<0.01, resp.). The presence of insulin resistance was robustly associated with both oxidative stress and TNF-αlevels. More studies are warranted to verify if IR can be involved in therapeutic failure with TNF-αinhibitors. This trial is registered with Brazilian Clinical Trials Registry Register numberRBR-2jvj92.

scholarly journals Exposure To Cytotoxic Drugs Threatens The Health Of Staff In Oncology Wards

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Mohsen Momeni ◽  
Mehrdad Askarian ◽  
Hossein Azad ◽  
Mina Danaei
Keyword(s):  
Demographic Data ◽  
Cross Sectional Study ◽  
Cytotoxic Drugs ◽  
Control Group ◽  
Chronic Complications ◽  
Chi Square ◽  
Cross Sectional ◽  
Staff Members ◽  
Runny Nose ◽  
Acute Complications

Background — Cancer is one of the leading causes of death worldwide. Using cytotoxic drugs for cancer treatment is increased. The hazardous effects of occupational exposure to cytotoxic drugs are challenging. Objective — This study aimed to compare the frequency of adverse effects and using personal protective equipment (PPE) between the staff of oncology wards and other hospital wards staff in Iran. Methods — A cross-sectional study with a control group was conducted on female staff members in educational hospitals, selected through convenience sampling. A data collection form was designed for this study. It includes demographic data, acute complications (allergic and neurologic reactions), chronic complications (infertility, menstrual disorders, malignancy, and congenital malformations), and use of PPE. Data analysis was performed using SPSS software through Chi-square and Mann-Whitney tests. Results — The frequencies of chronic complications were not statistically different between the two groups. The frequency of itching (P=0.001), hair loss (P=0.003), itchy eyes (P=0.001), watery eyes (P=0.001), runny nose (P=0.003), headache (P=0.001), vertigo (P=0.007), and nausea (P=0.008) were significantly higher in oncology wards nurses. Among different PPE, only the frequency of using the mask (P= 0.001), and glasses (P=0.027) were significantly higher in the staff of oncology wards. Conclusion — Despite the frequency of acute complications of exposure to cytotoxic drugs, oncology staff does not fully adhere to the standard precautions. Providing effective training and emphasis on implementing accreditation laws can improve the existing situation.

scholarly journals OVERLAPPING OF FUNCTIONAL ESOPHAGEAL DISORDERS AND IRRITABLE BOWEL SYNDROME, IN MUSICIANS AND ATHLETES

2018 ◽  
Vol 24 (1) ◽  
pp. 69-72
Author(s):  
Sebastian Nedelcut ◽  
Daniel-Corneliu Leucuta ◽  
Dan Lucian Dumitrascu
Keyword(s):  
Associated Factors ◽  
Functional Gastrointestinal Disorders ◽  
Case Series ◽  
Cross Sectional Study ◽  
Control Group ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Functional Heartburn ◽  
Irritable Bowel Disease ◽  
Irritable Bowel

ABSTRACT Introduction: Functional gastrointestinal disorders (FGIDs) are the most common disorders in the general population. These disorders can overlap, decreasing the quality of life. Objective: We analyzed the prevalence of functional esophageal disorders (FED) and irritable bowel disease (IBS), and their overlapping and associated factors in musicians and athletes. Methods: A cross-sectional study was conducted using FGID and associated factors questionnaires administered to four groups: instrumentalists, singers, athletes, and a control group of healthy volunteers. Results: Of the 161 subjects, 62 (38.51%) had only FED, 76 (47.2%) had only IBS, and 23 (14.29%) had FED-IBS overlap. Subjects with FED-IBS overlap had more severe symptoms of IBS, especially hard and lumpy stools and constipation, compared to those with IBS alone. IBS subtype was more frequent in the overlap group, while not specified IBS type was less frequent. Regarding FED, we found that subjects with FED-IBS overlap had more functional heartburn and less functional dysphagia symptoms. There was a higher risk of overlap in instrumentalists and smokers. Conclusions: FED and IBS are frequently encountered in musicians and athletes. Subjects with FED-IBS overlap presented more frequent and severe symptoms. Instrumentalists and smokers are at higher risk of overlap. Level of Evidence IV; Case series.

scholarly journals Analysis of the Relation between Periodontitis and Chronic Gastritis/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data

2020 ◽  
Vol 17 (12) ◽  
pp. 4387 ◽  
Author(s):  
Soo Hwan Byun ◽  
Chanyang Min ◽  
Seok Jin Hong ◽  
Hyo Geun Choi ◽  
Dong Hee Koh
Keyword(s):  
Peptic Ulcer ◽  
Chronic Gastritis ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Cerebral Stroke ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Increased Risk ◽  
Financial Income

The aim of the present study was to investigate the association between periodontitis and chronic gastritis/peptic ulcer using a cross-sectional study design. The present prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study (KoGES) recorded from 2004 to 2016. Among 173,209 participants, 9983 with periodontitis and 125,336 with no periodontitis were selected. Histories of chronic gastritis and peptic ulcer between periodontitis and no periodontitis participants were analyzed. The participants were questioned around any history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke, ischemic heart disease, periodontitis, body mass index, smoking, alcohol consumption, nutritional intake, and financial income. Chi-square tests, independent t-tests, two-tailed analyses were used in statistical analysis of the data. The adjusted odds ratio of chronic gastritis was 2.22 (95% confidence interval [CI] = 2.10–2.34, p < 0.001) and that of peptic ulcer was 1.86 (95% CI = 1.74–1.98, p < 0.001) in model 2. This study demonstrated that periodontitis was associated with an increased risk of chronic gastritis/peptic ulcer. These findings provide additional evidence for an association between periodontitis and chronic gastritis/peptic ulcer.

scholarly journals CHARACTERIZATION OF PHYSICAL ACTIVITIES PERFORMED BY ADOLESCENTS FROM CURITIBA, BRAZIL

2019 ◽  
Vol 25 (3) ◽  
pp. 211-215
Author(s):  
Alexandre Augusto de Paula da Silva ◽  
Edina Maria de Camargo ◽  
Alice Tatiane da Silva ◽  
Jeruza Sech Buck Silva ◽  
Adriano Akira Ferreira Hino ◽  
...  
Keyword(s):  
Physical Activity ◽  
Household Survey ◽  
Cross Sectional Study ◽  
Physical Activities ◽  
Chi Square ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Gender Comparison ◽  
Soccer Fields ◽  
Weekly Frequency

ABSTRACT Introduction Various studies have been developed and published in relation to the recommendations for physical activity and associated factors. However, there is a lack of studies that detail the places where physical activity is practiced, as well as its frequency, duration and volume. Objective To describe the places, types, frequency, duration and volume of physical activities performed by adolescents in Curitiba, Brazil. Methods A cross-sectional study conducted in 2013-2014, through a household survey with 495 adolescents (12 to 17 years). The places used, and the frequencies of the practice of physical activity were self-reported as either “goes” or “does not go.” The practice of physical activity was determined through the Physical Activity Questionnaire for Adolescents, by type, frequency, duration and weekly volume. The types of physical activity were described with frequency distribution, weekly frequency, duration, and volume, by the median and interquartile range. Gender comparison was tested with the Chi-square and Mann-Whitney U tests (p<0.05). Results The most frequently reported places for physical activity were public squares, parks, soccer fields, schools and sports halls. Soccer fields, schools, sports halls and skate parks were more used by boys, while girls attended gyms (p<0.05). The physical activities most practiced were soccer, skating/rollerblading, cycling, walking and active games. A higher proportion of boys practiced soccer, skating/rollerblading, cycling, running/jogging, and basketball (p<0.05), whereas the physical activities most practiced by girls were walking, walking the dog, dancing, playing games, and gyms (p<0.05). Sports (720 min/week), aerobic exercises (400 min/week) and conditioning exercises (345 min/week) were the activities with the highest weekly volume. Boys showed higher weekly frequency, duration and volume of practice of sports and active games than girls (p<0.05). Conclusion Public places with structures were the most used places, and sports were the most practiced activities. Level of Evidence III; Study of nonconsecutive patients; without consistently applied ‘‘gold’’ reference standard.

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