scholarly journals Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

2010 ◽  
Vol 46 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Anapaula Sommer Vinagre ◽  
Ângela Della'Santa Rubio Origuella Rönnau ◽  
Sabrina Francisco Pereira ◽  
Lídia Uliano da Silveira ◽  
Elenir de Fátima Wiilland ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Diabetes ◽  
Diabetic Rats ◽  
Hepatic Glycogen ◽  
Citrate Buffer ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Toxicological Studies ◽  
Liver And Kidney ◽  
Diabetes Mellitus Management

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.

scholarly journals Antidiabetic and hypolipidemic potential of Campomanesia xanthocarpa seed extract obtained by supercritical CO2

2020 ◽  
Author(s):  
A. Regginato ◽  
L. Cunico ◽  
K.T. Bertoncello ◽  
M. S. Z. Schindler ◽  
R. Chitolina ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Serum Levels ◽  
Seed Extract ◽  
Blood Cholesterol ◽  
Hepatic Glycogen ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Blood Glucose Levels ◽  
Toxicological Studies ◽  
Decrease Blood Glucose

Abstract Campomanesia xanthocarpa, a plant belonging to the Myrtaceae family, is popularly known as gabiroba. Leaves of gabiroba has been popularly used to treat various diseases, including inflammatory, renal, and digestive, among others. Additionally, studies have shown an effect to reduce blood cholesterol levels. The aim of this study was to evaluate the antihyperglycemic and hypolipidemic effects of Campomanesia xanthocarpa seed extract in hyperglycemic rats. The results showed that 400 mg/kg of seed extract was able to decrease blood glucose levels and to increase the muscular and hepatic glycogen content as well as to inhibit the sucrase and maltase activity. At doses of 200 mg/kg and 800 mg/kg, the activity of these enzymes was also reduced. In the lipid profile 400 mg/kg produced a decrease in total and LDL cholesterol serum levels; and with 200 mg/kg there was an increase in HDL cholesterol levels. The extract did not present hepatic and renal toxic effects at the different doses tested. The results suggest that the treatment with Campomanesia xanthocarpa seeds extract is useful in reducing glycemia, total cholesterol and LDL levels with potential adjuvant therapeutic in the treatment of diabetes and hypercholesterolemia, however, additional pharmacological and toxicological studies are still required.

The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus

1997 ◽  
Vol 56 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Claudio Coimbra Teixeira ◽  
Luciano Pilla Pinto ◽  
Felix Henrique Paim Kessler ◽  
Lia Knijnik ◽  
Cristiano Pilla Pinto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Rats ◽  
Syzygium Cumini ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Streptozotocin Induced Diabetes

scholarly journals Studies on the Antidiabetic Activities ofCordyceps militarisExtract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan Dong ◽  
Tianjiao Jing ◽  
Qingfan Meng ◽  
Chungang Liu ◽  
Shuang Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Water Extract ◽  
Diabetic Rats ◽  
Cordyceps Militaris ◽  
Sprague Dawley ◽  
Alcohol Extract ◽  
Glucose Levels ◽  
Liver And Kidney ◽  
Antioxidative Effects

Due to substantial morbidity and high complications, diabetes mellitus is considered as the third “killer” in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities ofCordyceps militarison diet-streptozotocin-induced type 2 diabetes mellitus in rats. Diabetic rats were orally administered with water extract or alcohol extract at 0.05 g/kg and 2 g/kg for 3 weeks, and then, the factors levels related to blood glucose, lipid, free radicals, and even nephropathy were determined. Pathological alterations on liver and kidney were examined. Data showed that, similar to metformin,Cordyceps militarisextracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum.Cordyceps militarisextracts exhibit antioxidative effects indicated by normalized superoxide dismutase and glutathione peroxidase levels. The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection ofCordyceps militarisextracts against diabetic nephropathy, which was confirmed by pathological morphology reversion. Collectively,Cordyceps militarisextract, a safe pharmaceutical agent, presents excellent antidiabetic and antinephropathic activities and thus has great potential as a new source for diabetes treatment.

scholarly journals Beneficial effects of valencene on altered glycoprotein components in streptozotocin-nicotinamide induced diabetic rats

2019 ◽  
Vol 9 (4-A) ◽  
pp. 191-196
Author(s):  
Ellappan Pari ◽  
Pari Leelavinothan ◽  
Thangasamy Gunaseelan ◽  
Duraisamy Kannan
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Plasma Insulin ◽  
Experimental Diabetes ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Glycemic Status ◽  
Experimental Diabetes Mellitus ◽  
Citrate Buffer ◽  
Beneficial Effects

ABSTRACT Objective: To investigate the effect of valencene on dearrangement in glycoprotein levels in the streptozotocin(STZ)-nicotinamide(NA)induced diabetic rats. Materials and Methods: Diabetes was induced in experimental rats by a single intraperitoneal (i.p) injection of STZ (45 mg/kg b.w) dissolved in 0.1 M citrate buffer (pH 4.5) 15 minutes after the i.p injection of NA (110 mg/kg b.w). The levels of glycoproteins were altered in experimental diabetes mellitus. Valencene were administered to diabetic rats intragastrically at 100 & 200mg/kg bw for 30days. The effects of valencene on plasma glucose, insulin, plasma and tissue glycoproteins were studied. Results: Oral administration of valencene (200mg/kg b.w)for 30d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. The levels of plasma glucose were decreased with significant increase of plasma insulin level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. Conclusions: The results of the present study show the potent beneficial effects of valencene in modifying the levels of glycoprotein components in plasma and tissues of diabetic rats.

scholarly journals Paradoxical refractoriness developing with the allogeneic transfer of splenic lymphocyte total RNA from animals with treated alloxan diabetes to animals with untreated diabetes

2020 ◽  
pp. 37-46
Author(s):  
Н.М. Геворкян ◽  
Н.В. Тишевская ◽  
А.Г. Бабаева
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Blood Glucose ◽  
Alloxan Diabetes ◽  
Diabetic Rats ◽  
Female Rats ◽  
Diabetes Group ◽  
Total Rna ◽  
Glucose Levels ◽  
Blood Glucose Levels

Ранее нами было показано, что препараты аллогенной суммарной РНК, выделенной из лимфоидных и стволовых клеток здоровых животных, вызывают нормализацию уровня глюкозы крови у крыс со стойким аллоксановым сахарным диабетом. Цель исследования -- выяснение влияния суммарной РНК лимфоцитов селезенки крыс, ранее перенесших стойкий аллоксановый диабет, на особенности течения эксперименального аллоксанового диабета у животных. Методика. Эксперимент выполнен на 35 белых беспородных крысах-самках массой 250-280 г: 5 интактных животных, 20 - с экспериментальным аллоксановым сахарным диабетом и 10 животных, ранее перенесших стойкий аллоксановый диабет, у которых уровень глюкозы крови был полностью нормализован введением суммарных РНК клеток костного мозга, селезенки и поджелудочной железы. Диабет у этих животных моделировали однократным подкожным введением полного адъюванта Фрейнда (0,5 мл на крысу) и последующим подкожным введением аллоксана тригидрата в дозе 200 мг/кг. Достигнутая нормогликемия у животных подтверждалась в течение последующих 60 сут. Из селезенок и костного мозга этих животных методом фенол-хлороформной экстракции была выделена суммарная РНК. На 20 крысах с экспериментальным аллоксановым сахарным диабетом изучали эффекты однократного внутрибрюшинного введения полученной суммарной РНК (15 мкг/100 г массы тела животного). Результаты. Обнаружено, что при введении суммарной РНК селезенки крыс, ранее перенесших аллоксановый диабет, животным с аллоксановым диабетом у последних развивалась стойкая и длительная рефрактерность к лечению терапевтическими препаратами РНК. Заключение. 1. Выявлен феномен повышенной чувствительности крыс с аллоксановым диабетом к действию суммарной РНК селезенки животных, ранее перенесших аллоксановый диабет. 2. Предполагаемой причиной рефрактерности является клональный компонент суммарной РНК CD8+ Т-лимфоцитов памяти из селезенки животных, ранее перенесших аллоксановый диабет. 3. Предполагается наличие механизма адресного взаимодействия отдельных компонентов суммарной РНК селезенки крыс, ранее перенесших аллоксановый диабет, с их лимфоцитами-мишенями в организме реципиентов с аллоксановым диабетом. Introduction. Earlier we have shown that preparations of allogenic total RNA from lymphoid and stem cells of healthy animals contribute to normalization of blood glucose levels in white outbred rats with persistent alloxan-induced diabetes mellitus. The aim of this study was to find out whether allogenic total RNA isolated from the spleen of rats treated for alloxan diabetes affects its course, as determined by changes in blood glucose, in animals with persistent alloxan diabetes. Methods. Experiments were performed on 35 white outbred female rats weighing 250-280 g. Rats were divided into intact animals (n=5), rats with experimental alloxan diabetes mellitus (n=20), and rats after persistent alloxan diabetes (n=10) whose blood glucose level had been completely normalized by administrating total RNA of bone marrow, splenic, and pancreatic cells (post-diabetes group). Diabetes mellitus was modeled with a single subcutaneous (s.c.) injection of complete Freund’s adjuvant (0.5 ml) followed by a s.c. injection of alloxan trihydrate (200 mg/kg). Achievement of normoglycemia in animals of the post-diabetes group was confirmed over the next 60 days. Then total RNA was isolated from their spleen and bone marrow by phenol-chloroform extraction, and the effect of a single intraperitoneal injection of total RNA (15 μg/100 g body weight) was studied. Results. Administration of splenic total RNA from rats previously treated for alloxan diabetes to animals with alloxan diabetes resulted in development of stable and prolonged refractoriness of diabetic rats to the treatment with therapeutic RNA preparations [11]. Conclusions. This study discovered a phenomenon of hypersensitivity of rats with alloxan diabetes to the diabetogenic effect of total RNA from animals that had previously had alloxan diabetes. Apparently, this refractoriness was caused by the clonal component of the total RNA of CD8 + T memory lymphocytes from the spleen of post-diabetes animals. A mechanism is proposed for the interaction between individual components of splenic total RNA from post-diabetes rats and their target lymphocytes in recipients with alloxan diabetes.

scholarly journals Potential of karamunting (Rhodomyrtus tomentosa) fraction against kidney damage in diabetic rats

2021 ◽  
Vol 67 (2) ◽  
pp. 9-16
Author(s):  
Mgs Irsan Saleh ◽  
Rachmat Hidayat ◽  
Geri Febriyanto ◽  
Nita Parisa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Rats ◽  
Kidney Damage ◽  
Male Rats ◽  
Native Plant ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
The Impact ◽  
Rhodomyrtus Tomentosa

Summary Introduction: Karamunting (Rhodomyrtus tomentosa) is Indonesian native plant that contains high anti-oxidant compounds with the potential to suppress oxidative stress activity in cells. This study is the first research to specifically explore the role of the karamunting fraction in protecting kidney damage due to the formation of AGEs in the renal glomerulus in diabetes mellitus. Objective: This study aims to assess the impact of karamunting on blood glucose profile, HbA1c, insulin profile and kidney condition (AGEs expression, TNF-α and kidney histology) in diabetic rats. Methods: The karamunting extraction process was carried out by maceration with ethanol. Induction of diabetes mellitus was carried out using streptozotocin. Thirty male rats (Rattus norvegicus), Wistar strain weighing between 200–250 grams were the subject in this study. HbA1c, insulin, TNF-α, AGEs levels were evaluated in the kidney tissue. Histological assessment of the kidney was carried out. Results: Karamunting can improve blood glucose levels in diabetic rats. This improvement in blood glucose levels causes an improvement in the level of HbA1c. Administration of karamunting fraction can prevent AGEs deposition in renal tissue, which in turn will inhibits the inflammation and prevents further damage of kidneys. Conclusion: Karamunting fraction can improve blood glucose regulation so that it can prevent further damage and complications of kidney organs in diabetic rats.

scholarly journals Effect of turmeric on alloxan induced diabetes mellitus in albino rats

2019 ◽  
Vol 8 (2) ◽  
pp. 264
Author(s):  
Mugdha Rajeeva Padhye ◽  
Sangita Devrao Jogdand
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Adverse Effects ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Organ Systems ◽  
Mean Blood Glucose

Background: Diabetes mellitus is a chronic metabolic disorder of glucose metabolism characterised by hyperglycaemia. Long standing diabetes mellitus leads to various complications affecting multiple organ systems. Management of diabetes mellitus includes lifestyle modification and pharmacotherapy. Pharmacotherapy of diabetes mellitus includes a wide variety of drugs that help in achieving adequate glycaemic control. Anti-diabetic medications are however associated with several adverse effects. Phytochemicals are being used extensively for the treatment of various diseases. Use of phytochemicals would minimize adverse effects due to various anti-diabetic drugs and improve patient compliance. In the present study, authors studied the effect of turmeric on alloxan induced diabetes mellitus in albino rats.Methods: Albino Wistar rats of either sex weighing 180 - 250grams were utilized for the present study. Diabetes mellitus was induced by intraperitoneal administration of alloxan. Ethanolic extract of turmeric was administered to diabetic rats daily orally for duration of 28 days. Blood glucose levels were monitored using glucometer before and after intervention with turmeric.Results: Statistically significant reduction in mean blood glucose levels (p value <0.05) was seen after intervention with turmeric in diabetic rats. There was a significant reduction in mean blood glucose levels.Conclusions: Ethanolic extract of turmeric showed antihyperglycemic effect in diabetic rats.

Effect of 24R,25-Dihydroxyvitamin D3 in Experimental Diabetic Rats

1988 ◽  
Vol 16 (4) ◽  
pp. 300-304 ◽  
Author(s):  
T. Katoh ◽  
Y. Maeda ◽  
H. Yamato ◽  
T. Hirai ◽  
T. Fujii ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Calcium Content ◽  
Diabetic Rats ◽  
Controlled Study ◽  
Platelet Activity ◽  
Dihydroxyvitamin D ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Bone Calcium

The results are presented of a controlled study in male Wistar rats into the effects of 24 R,25-dihydroxyvitamin D3 on blood glucose levels, bone calcium content and ADP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 μg/kg 24 R,25-dihydroxyvitamin D3. The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 μg/kg 24 R,25-dihydroxyvitamin D3. It was also shown to exhibit dose-dependent anti-platelet activity. The data suggest that 24 R,25-dihydroxyvitamin D3 might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.

scholarly journals Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetes Mellitus in Rats: Role ofAlhagi maurorumExtracts

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
S. A. Sheweita ◽  
S. Mashaly ◽  
A. A. Newairy ◽  
H. M. Abdou ◽  
S. M. Eweda
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Glucose Levels ◽  
Blood Glucose Levels

Alhagi maurorum(camel thorn plant) is a promising medicinal plant due to the presence of flavonoids and phenolic compounds as major contents of its constituents. No previous study has been conducted before onA. maurorum extractsas an antioxidative stress and/or antidiabetic herb in STZ-induced DM in rats. Therefore, four groups of rats were allocated as control (C), STZ-induced DM (D), and STZ-induced DM supplemented with 300 mg/kg BW of either aqueous extract (WE) or ethanolic extract (EE) ofA. maurorum. The plasma levels of glucose, TG, TC, LDL-C and VLDL-C, MDA, and bilirubin and the activities of transaminases and GR were significantly increased in the diabetic group. Also, diabetic rats showed severe glucose intolerance and histopathological changes in their livers. In addition, levels of insulin, total proteins, GSH, and HDL-C and the activities of SOD, GPx, and GST were significantly decreased in the diabetic rats compared to those of the control group. The ingestion ofA. maurorumextracts lowered the blood glucose levels during the OGTT compared to the diabetic rats and restored all tested parameters to their normal levels with the exception of insulin level that could not be restored. It is concluded thatA. maurorumextracts decreased elevated blood glucose levels and hyperlipidemia and suppressed oxidative stress caused by diabetes mellitus in rats.

Sign in / Sign up

Export Citation Format

Share Document