PROGESTERONE RECEPTORS IN THE RAT UTERUS: VARIATIONS IN CYTOSOL AND NUCLEI DURING THE OESTROUS CYCLE AND PREGNANCY

1978 ◽  
Vol 76 (1) ◽  
pp. 43-48 ◽  
Author(s):  
M. T. VU HAI ◽  
F. LOGEAT ◽  
E. MILGROM
Keyword(s):  
Binding Sites ◽  
Total Concentration ◽  
Progesterone Receptors ◽  
Mean Value ◽  
Oestrous Cycle ◽  
Small Peak ◽  
Low Concentrations ◽  
The Mean ◽  
High Level ◽  
Very High

SUMMARY The concentration of progesterone receptors in rat uterine cytosol and nuclei was measured during the oestrous cycle and pregnancy. The method used allowed the measurement of the total concentration of binding sites (unbound and hormone-bound). During the oestrous cycle, the concentration of receptors in the cytosol peaked at pro-oestrus, low concentrations were observed at oestrus and metoestrus, and an increase was seen at dioestrus. In the nuclei, maximum concentrations occurred at pro-oestrus and dioestrus. The number of receptors in the cytosol was very low during the first half of pregnancy, but the concentration increased progressively after day 15 to attain a very high level (about 26 000 binding sites/cell) on day 22. In the nuclei, the concentration of receptors was low at the beginning of pregnancy. On day 5 (day of implantation) there was a slight increase, which corresponded to a decrease in the number of cytosolic receptors and a small peak in the level of progesterone in the plasma. Maximum concentrations were attained during a 'plateau' period between days 9 and 15. Thereafter, there was a decrease in the concentration of nuclear receptors and on day 22, the mean value was very low; in some animals, probably on the verge of parturition, no receptors were detectable in the nuclei.

scholarly journals AB0189 LIPOPROTEIN ABNORMALITIES IN RHEUMATOID ARTHRITIS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1119.1-1119
Author(s):  
L. Nacef ◽  
Y. Besbes ◽  
Y. Mabrouk ◽  
H. Ferjani ◽  
K. Maatallah ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Demographic Data ◽  
Calcium Score ◽  
Healthy Person ◽  
Mean Value ◽  
Immunological Parameters ◽  
American College Of Rheumatology ◽  
Patient Consent ◽  
The Mean ◽  
High Level

Background:The lipid paradox is termed the decreased cholesterol level in rheumatoid arthritis (RA). Nevertheless, the apolipoprotein levels are usually higher than a healthy person and are predictors of cardiovascular events.Objectives:We aimed to describe lipid abnormalities in RA patients and to look for predictor factors of these changes.Methods:The prospective study was carried out on patients with RA who met the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria. These patients were followed in the rheumatology department of the Kassab Institute.We collected the socio-demographic data, biological and immunological parameters.The lipid assessment included: a measurement of total cholesterol (TC), HDL, LDL, and triglycerides (TG). Lipoproteins APOA1 and APOB were measured. All data were collected after patient consent.Results:Of the 47 patients recruited, 78.7% were female. The mean age was 52.5 ±11.06 [32-76]. The average RA progressed from 86.25 ±63 months [5-288] and was erosive in 81.6% of cases. The rheumatoid factor (RF) was positive in 57.8% of patients, and citrullinated antipeptide antibodies (ACPA) were present in 62.2%. Eight patients had a previous CV history.Mean TC was 4.42 ±1.3 [1.2-7.58], mean HDL was 1.38 ±0.73 [0.18-4.10], mean LDL was 2.55 ±1.16 [0.24-5.54]. The mean TG value was 1.28 ±0.6 [0.24-5.54]. TC elevation was found in 9.1% of cases, HDL in 21.3% of cases, LDL in 5.5% of cases, and TG in 16.4% of cases. Mean APOB/APOA1 ratio was 0.67 ±0.18 [0,46-1,11]. LDL elevation was associated to a high DAS28 (p=0.06, r=0.512). APOA1 was associated to a low DAS28 (p=0.04, r=-0.642).The mean value of APO A1 was 1.36 ±0.21 [0.84-1.81], that of APOB was 0.90 ±0.22 [0.58-1.40]. APOA1 values were lower in patients with high-level LDL (p=0.767). The APOB value was associated with lipid disturbance without significant correlation (p=0.291).Conclusion:Lipid test abnormalities can be found in RA patients outside of any known CV risk factors. APOA1 seems to have a protective effect. Screening and treatment of these abnormalities can prevent CV risk.References:[1]Miguel Bernardes and al. Coronary artery calcium score in female rheumatoid arthritis patients: Associations with apolipoproteins and disease biomarkers. Int J Rheum Dis. 2019;00:1–16.[2]Anna So dergren and al. Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis. PLOS ONE. August 5, 2019.Disclosure of Interests:None declared

Literature Review : Burnout pada Perawat Selama Pandemi COVID-19

2021 ◽  
Vol 1 ◽  
pp. 1300-1305
Author(s):  
Arti Ayuningtiyas ◽  
Benny Arief Sulistyanto
Keyword(s):  
Literature Review ◽  
Emotional Exhaustion ◽  
Mean Value ◽  
Moderate Level ◽  
Personal Accomplishment ◽  
Google Scholar ◽  
Inclusion Criteria ◽  
Nurse Burnout ◽  
The Mean ◽  
High Level

AbstractDuring the Covid-19 pandemic, nurses are at the forefront. Many nurses experience stress and fatigue due to increased workload. Stress and fatigue that is obtained at work, both physical and psychological fatigue, is known as Burnout. This study aimed to describe the incidence of Burnout experienced by nurses during the Covid 19 Pandemic. This research is a literature review. This study was looking for some articles from PubMed,Garuda, and Google Scholar, with keyword. There were 5 articles that matched the research inclusion criteria. Critical analysis of 5 articles used the JBI instrument. These articles used the mean calculation. In the Emotional Exhaustion category, the mean value was 22.75 and SD was 8.828. it meant that the burnout level in the Emotional Exhaustion category was at a moderate level. In the depersonalization category, the mean value was 7.54 with SD 4.248. it meant that the burnout level in the depersonalization category was at a moderate level. In the personal accomplishment category, the mean was 19.676 with SD of 6.7. it mean that the burnout level in this category was a high level. The nurses experience burnout during the Covid-19 pandemic. The Emotional exhaustion category is a moderate level, depersonalization is at a moderate level, and personal accomplishment is at a high level.Keywords: Nurse, Burnout, Covid-19 pandemic AbstrakDimasa pandemi Covid-19 perawat berada pada garda terdepan, banyak perawat mengalami stress dan kelelahan dikarenakan beban kerja meningkat. Stress dan Kelelahan yang didapat saat kerja baik itu kelelahan fisik maupun psikis dikenal dengan nama Burnout penelitian ini bertujuan untuk mendeskripsikan kejadian Burnout yang dialami Perawat selama Pandemi Covid 19. Penelitian ini adalah literatur review. Hasil pencarian artikel dari database online yaitu Pubmed,Garuda dan Google Scholar, dengan kata kunci di dapatkan 5 artikel yang sesuai dengan kriteria inklusi penelitian. Analisa telaah kritis terhadap 5 artikel menggunakan instrument JBI. Terdapat 5 Artikel yang menggunakan perhitungan mean di dapatkan hasil kategori Emotional Exhaustion nilai mean sebanyak 22.75 dan SD 8.828 dimana hasil menunjukkan level burnout pada level sedang. Kategori depersonalization dengan nilai mean 7.54 dengan SD 4.248 dimana hasil burnout pada level sedang. Kategori personal accomplishment hasil mean 19.676 dengan SD 6.7 dimana hasil burnout menunjukkan level tinggi. Dari 5 Artikel yang di telaah di dapatkan Perawat mengalami Burnout selama pandemic Covid-19, kategori Emotional Exhaustion berada pada level sedang, depersonalization berada pada level sedang, dan personal accomplishment pada level tinggi.Kata Kunci : Perawat, Burnout, pandemi Covid-19

Operation of a nitrifying activated sludge airlift (NASA) reactor without biomass carrier

2000 ◽  
Vol 41 (4-5) ◽  
pp. 113-120 ◽  
Author(s):  
J.L. Campos ◽  
R. Mendez ◽  
J.M. Lema
Keyword(s):  
Activated Sludge ◽  
Air Flow ◽  
Small Diameter ◽  
Operation Time ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Total Biomass ◽  
Low Concentrations ◽  
The Mean ◽  
Very High

An ammonia loading rate of 4.1 kg N-NH4+/m3d was fully oxidized to nitrate using a nitrifying airlift without biomass carrier. The developed sludge, with a concentration of 12 gVSS/L and high density (100 gVSS/Lparticle), allowed particles to be retained with small diameter, having very low concentrations of solids in the effluent (5–10 mg VSS/L). The mean diameter of particles containing the majority of total biomass increased from 220 to 360 m during the operation time. The particle size analysis showed that the percentage of flocs with small diameter (1–3 m) is very high but the biomass content of these flocs is negligible with respect to the total biomass value. The oxygen transfer coefficient (KLa) was measured operating at different air flow rates, obtaining similar values during the overall operational period. The use of activated sludge without support gives high nitrifying rates with an easier fluidization and a lowercritical air flow rate than in a biofilm airlift reactor.

scholarly journals Coupling and Coordination Degrees of the Core Water–Energy–Food Nexus in China

2019 ◽  
Vol 16 (9) ◽  
pp. 1648 ◽  
Author(s):  
Shasha Xu ◽  
Weijun He ◽  
Juqin Shen ◽  
Dagmawi Mulugeta Degefu ◽  
Liang Yuan ◽  
...  
Keyword(s):  
Complex System ◽  
Sustainable Development ◽  
Mean Value ◽  
Key Factors ◽  
The Core ◽  
The Mean ◽  
Development Levels ◽  
High Level ◽  
Coordination Development ◽  
Coordination Degree

Achieving sustainable development in the water–energy–food (WEF) nexus is gaining global attention. The coupling and coordination degrees are a way to measure sustainable development levels of a complex system. This study assessed the coupling and coordination degrees of the core WEF nexus and identified key factors that affect sustainable development. First, an index system for assessing coupling and coordination degrees of the core WEF nexus was built. Second, the development levels of three subsystems as well as the coupling and coordination degrees of the core WEF nexus in China were calculated. The results showed that from 2007 to 2016, the mean value of the coupling degree was 0.746 (range (0.01, 1)), which was a high level. This proved that the three resources were interdependent. Hence, it was necessary to study their relationship. However, the mean value of the coordination degree was 0.395 (range (0, 1)), which was a low level. This showed that the coordination development of the core WEF nexus in China was low. It is necessary to take some measures to improve the situation. According to the key factors that affect the development levels of water, energy, and food subsystems, the authors put forward some suggestions to improve the coordination development of the WEF system in China.

SERUM PROGESTERONE AND SERUM CHORIONIC GONADOTROPHIN IN HYDATIDIFORM MOLE AND CHORIOCARCINOMA

1972 ◽  
Vol 70 (4) ◽  
pp. 791-800 ◽  
Author(s):  
Eng Soon Teoh ◽  
N. P. Das ◽  
M. Yusoff Dawood ◽  
S. S. Ratnam
Keyword(s):  
Petroleum Ether Extract ◽  
Hydatidiform Mole ◽  
Haemagglutination Inhibition ◽  
Normal Pregnancy ◽  
Chorionic Gonadotrophin ◽  
Serum Progesterone ◽  
Small Peak ◽  
Low Concentrations ◽  
Competitive Protein Binding Assay ◽  
The Mean

ABSTRACT Progesterone and human chorionic gonadotrophin (HCG) were measured in the sera of 25 patients with hydatidiform mole, 10 patients with choriocarcinoma and 200 normal pregnancies by a competitive protein-binding assay and a haemagglutination-inhibition assay respectively. Elution of the petroleum ether extract of mole serum on Sephadex LH-20 showed that the main fraction (92.8%) was progesterone, followed by a small peak of 20 α-hydroxyprogesterone. In 21 intact hydatidiform moles, the mean serum progesterone of 106.0 ng/ml (range 17.8–263 ng/ml) was higher than for normal pregnancy. Serum HCG (mean 833 IU/ml) was similarly elevated. Low concentrations of progesterone (0–17.3 ng/ml) and HCG (15–160 IU/ml) were present in 4 patients who had aborted. The mean serum progesterone was not further elevated in patients with theca lutein cysts of the ovary. There was no correlation between the serum progesterone and the uterine size, serum HCG or malignant sequelae. In 10 cases of choriocarcinoma, the serum progesterone ranged from 1.3–61 ng/ml (mean 16.9 ng/ml), the serum HCG from 0–960 IU/ml (mean 158 IU/ml) but there was no correlation between the two values. The evidence suggests a hyperactive steroidogenesis in hydatidiform mole and poor steroidogenesis in choriocarcinoma. An HCG secretion occurs in both cases.

Distraction-Lengthening of Digital Rays Using a Small External Fixator

1998 ◽  
Vol 23 (6) ◽  
pp. 781-784 ◽  
Author(s):  
M. SALOM ◽  
J. E. AROCA ◽  
V. CHOVER ◽  
R. ALONSO ◽  
R. VILAR
Keyword(s):  
External Fixator ◽  
Corrective Osteotomy ◽  
Functional Results ◽  
Iliac Crest Graft ◽  
Work Accident ◽  
The Mean ◽  
High Level ◽  
Gradual Distraction ◽  
Very High ◽  
Frequent Reason

We present 19 ray lengthenings in 14 patients done with a small external fixator. In six cases the thumb was lengthened and in the other 13 cases, other digital rays. The most frequent reason for lengthening was an amputation sustained in a work accident. All the lengthenings were done by an osteotomy and subsequent gradual distraction with a small external fixator. The mean lengthening achieved was 20 mm (range, 0–32). An iliac-crest graft was needed in nine cases, corrective osteotomy in five cases and a deepening of the web in the six cases of thumb lengthening. In five cases an additional technique was needed to achieve bony consolidation. We have analysed the functional results and the ability to perform activities of daily living and resume employment. Although most of the patients had multiples injuries, the results have been very favourable, achieving a very high level of patient satisfaction.

scholarly journals Market Orientation Practices among Micro-Sized Enterprises: A Descriptive Evidence using MKTOR Scale

2018 ◽  
Vol 2 (4) ◽  
pp. 1-8
Author(s):  
Dzulkarnain Musa
Keyword(s):  
Market Orientation ◽  
Random Sampling ◽  
Customer Orientation ◽  
Descriptive Analysis ◽  
Sampling Technique ◽  
Mean Value ◽  
Stratified Random Sampling ◽  
Competitor Orientation ◽  
The Mean ◽  
High Level

Previous studies have found that market orientation practices were important in benefiting the continuity of the business firms. In this regard, the study tries to focus on the market orientation practices using MKTOR scale including customer orientation, competitor orientation and coordination between functions. The survey type of study was carried out among 136 micro-sized enterprises in Perlis and grouped into four major towns using stratified random sampling technique. Results from the descriptive analysis were shown that the mean value for the three market orientation constructs was at medium high level. The issue gives an overview of moderate market orientation practices amongst such enterprises. This finding provides useful enlightenment to micro-sized enterprises and related parties in developing the business in the future. Some implications to the related parties and future suggestions were discussed.

scholarly journals A STUDY ON STUDENTS IN USING QUESTION TAG OF MODAL AUXILIARY FORM AT XI GRADE OF SMA PGRI TEMBILAHAN

2019 ◽  
Vol 1 (1) ◽  
pp. 35-43
Author(s):  
Rika Tri Ramadhani ◽  
Melda Yeni ◽  
Edi Ardian
Keyword(s):  
Test Scores ◽  
Quantitative Method ◽  
Sampling Technique ◽  
Individual Test ◽  
Class A ◽  
Good Score ◽  
The Mean ◽  
High Level ◽  
Number Of Classes ◽  
Very High

The purpose of this research is to know the students' ability in using question tags in the modal auxiliary format eleventh grade of SMA PGRI Tembilahan. Based on the limitation of the problem, the researcher limits the problem in using question tag in modal auxiliary form just focuses on the use modal of can, could, will, would, and should. The researcher conducted a short observation to know the number of classes at the eleventh grade of SMA PGRI Tembilahan. The number of eleventh-grade students just consists of one class, namely Class A. The total of the eleventh-grade students is 20 students. The population of this research was all of the eleventh-grade students because the sample of population less than 100 the researcher used total sampling technique. The researcher used a quantitative method to get the data needed. The research instrument in this research is testing and collected by individual test scores of students where they are asked to identify and using question tags according to the instruction given with the total correct (25). So that, each correct question tag in the modal auxiliary form will be scored by 4. Based on the result of the test, the mean score of the question tag in the modal auxiliary form was 82.6. It was categorized very high level, which included in the interval 81-100. Where 14 students get in a very good score, 5 students get in a good score, 1 student gets in a moderate score and there is no get in a low and very low score. Based on that explanation above, we can conclude that the students' ability in using question tag in modal auxiliary format eleventh grade of SMA PGRI Tembilahan includes in the realm of the category nice and understanding to use question tag in modal auxiliary form.

An Assessment of Radioimmunoassay Procedures for Determination of Anti-Acetylcholine Receptor Antibodies in the Sera of Patients with Myasthenia Gravis

1981 ◽  
Vol 18 (3) ◽  
pp. 146-152 ◽  
Author(s):  
B Carter ◽  
R Harrison ◽  
G G Lunt ◽  
H Morris ◽  
T Savage-Marengo ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Binding Sites ◽  
Mean Value ◽  
Normal Human ◽  
The Mean ◽  
Receptor Antibodies ◽  
Anti Acetylcholine

A reproducible radioimmunoassay procedure for the determination of anti-acetylcholine receptor antibodies in the sera of patients with myasthenia gravis is described and examined in detail. The assay combines features of a number of methods previously outlined and allows repeat determinations of antibody titre in a given myasthenic serum sample with coefficient of variation 6%. The mean ± standard deviation for normal human serum anti-acetylcholine receptor antibodies was found by this procedure to be 0·024 ± 0·033 nmol/l α-bungarotoxin binding sites whereas the range for myasthenic patients was 0–139·14 nmol/l with a mean value of 7·55 nmol/l α-bungarotoxin binding sites.

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