scholarly journals DIABETIC PNEUMOPATHY

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Robson Da Silva Almeida ◽  
Rosangela Carvalho De Melo ◽  
Marcus Silvane Sanches Chaves ◽  
Gustavo Magno Baptista ◽  
Stephânia Silva Margotto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Function ◽  
Literature Review ◽  
Pulmonary Function ◽  
Volume Reduction ◽  
Systemic Complications ◽  
Chronic Hyperglycemia ◽  
Search Form ◽  
Wide Range ◽  
Capillary Blood Volume

Introduction: Diabetes mellitus is a condition whose main characteristic is excessive blood glucose and, if not controlled, can cause chronic systemic complications such as, nephropathy, pulmonary dysfunction, retinopathy and vascular disorders, among others. Lung complications in diabetics, due to chronic hyperglycemia, have been studied more recently. Objective: This study aims to conduct a literature review on changes in lung function in diabetes mellitus, through an integrative bibliographical review. Method: Bibliographic survey, through an integrative literature review, to establish a correlation between glycemic control and lung function in diabetic subjects. The integrative review was made by searching the Medline international databases for review of manuscripts. Selection of these databases was based on the wide range of journals covered by each of them and our goal was to provide an overview of the scientific production devoted to the topic over the timeframe of analysis. The following inclusion criteria were considered during the review: use of the keywords “lung” OR “pneumopathy” OR “lung disease” MeSH “diabetes mellitus” entered into the search form, and availability of an abstract in English. Results: A total 12 scientific productions were selected by contain information about the pulmonary function alterations in diabetes. Conclusion: The main pulmonary function abnormalities found in diabetics are: lung volume reduction; lung elasticity reduced; capillary blood volume reduction; thickening of the capillary basement membrane; decrease in muscle strength; and paresis or bilateral diaphragmatic paralysis due to phrenic neuropathy.

scholarly journals THE EFFECT OF CHRONIC HYPERGLYCEMIA ON THE STATE OF MUSCULOSKELETAL SYSTEM (LITERATURE REVIEW)

2021 ◽  
Vol 21 (1) ◽  
pp. 184-187
Author(s):  
A.O. Ponyrko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Bone Tissue ◽  
Musculoskeletal System ◽  
Metabolic Disorder ◽  
Skeletal System ◽  
Complex Disorders ◽  
Chronic Hyperglycemia ◽  
Wide Range

Diabetes mellitus is a metabolic disorder that today has become a threatening problem for human health. Its prevalence has been constantly increasing throughout the world over the past decades. Diabetes mellitus is regarded as an incurable metabolic disorder characterized by hyperglycemia, which is caused by defects in insulin secretion. This disease annually affects almost 3% of the total population of the planet. Chronic hyperglycemia causes dysfunction of various organs of the body, such as the eyes, kidneys, heart, blood vessels, and nerves. The most common complications of diabetes include lesions of the vessels of the eye, kidneys, lower limbs and nervous system. A high level of glucose in the blood causes the development of a wide range of pathological disorders, which affect bones as well. Recent studies have shown that diseases of the skeletal system are often observed in diabetes mellitus. Speaking about the effect of hyperglycemia on bones, the development of osteopenia and osteoporosis should be noted. In this regard, an important area of research is to study changes in the bone tissue in patients with type 1 diabetes mellitus and the mechanisms that lead to disruption of bone structure and metabolism. The article highlights the pathophysiological mechanisms of hyperglycemia action in type 1 diabetes that explains complex disorders of the organs of the musculoskeletal system. The detrimental effect of hyperglycemia results in marked degenerative changes in bone cells. The pathogenic effect of hyperglycemia on bone tissue is manifested in a decrease in bone mineral density that is due to the lack of insulin and, as a consequence, significant metabolic disorders, a decrease in bone mass, inhibition of bone tissue formation, a significant decrease in the trace element composition of bone. The combination of these factors creates the appropriate pathomorphological basis for the development of diabetic osteopathy. The article highlights the mechanism of action of hyperglycemia on skeletal system in order to stimulate to a more detailed investigation of diabetes mellitus in experimental animals.

scholarly journals Diabetes Mellitus Type 2 in Hospitalized COPD Patients: Impact on Quality of Life and Lung Function

Folia Medica ◽  
2016 ◽  
Vol 58 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Evgeni V. Mekov ◽  
Yanina G. Slavova ◽  
Marianka P. Genova ◽  
Adelina D. Tsakova ◽  
Dimitar T. Kostadinov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Lung Function ◽  
Pulmonary Function ◽  
Newly Diagnosed ◽  
Impaired Glucose Metabolism ◽  
Copd Patients ◽  
Exacerbation Of Copd

Abstract Introduction: Diabetes mellitus (DM) is estimated to affect 2-37% of COPD patients, results varying widely between studies. DM may also correlate with quality of life and lung function. Aim: To examine correlations between DM and quality of life and lung function in COPD patients admitted to hospital with exacerbation of COPD. Patients and methods: A hundred and fifty-two patients were included in the study. They were all examined for diabetes mellitus. All patients completed CAT and mMRC questionnaires and underwent spirometry. Results: 13.2% (20/152) of patients received medications for DM. 21.7% (33/152) had newly diagnosed DM and 30.9% (47/152) had prediabetes. DM is not associated with reduced quality of life and worse pulmonary function. However, untreated DM is associated with both reduced quality of life and worse pulmonary function. HbA1c is negatively correlated with FVC and positively correlated with CAT score. Conclusions: COPD patients hospitalized for exacerbation are at high risk for impaired glucose metabolism. Untreated DM is associated with worse lung function and lower quality of life, which stresses the importance of screening for the disease. The patients may benefit from optimizing blood glucose level.

scholarly journals A Cross Sectional Study on Impact of Diabetes Mellitus on Lung function Parameters

2021 ◽  
pp. 52-58
Author(s):  
Nasrullah Aamer ◽  
Waseem Raja Memon ◽  
Shahzad Memon ◽  
Muhammad Amjad Kalhoro ◽  
Yar Muhammad Tunio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Function ◽  
Blood Sugar ◽  
Peak Expiratory Flow ◽  
Fasting Blood Sugar ◽  
P Value ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Chronic Hyperglycemia ◽  
Expiratory Flow

Chronic hyperglycemia in Type 2 Diabetes Mellitus (T2 DM) is associated with ongoing damage, dysfunction, and failure of many organs, particularly the eyes, kidneys, nerves, heart, lungs, blood vessels and the diabetic patients may have considerable reductions in lung functioning. Diabetes Mellitus, Peak Expiratory Flow, and Fasting Blood Sugar are some of the terms used in this study. One hundred T2 DM patients, ranging in age from 30-70 years old and of either gender, were submitted to spirometry, vital parameters were recorded, glycated hemoglobin (HbA1c) and fasting blood sugar (FBS) were evaluated, and healthy controls were a matched. Diabetics forced vital capacity (FVC) ranged from 1.51 to 4 (Liters) with a mean of 2.4 ±0.6SD, whereas controls' FVC ranged from 2.2 to 4.74 with a mean of 3.14 ±0.7SD and a significant P value. (P<0.001) diabetics peak expiratory flow rate (PEFR) ranged from 188 to 459 (liters per minute) with a mean of 288 ±70SD, whereas controls PEFR ranged from 243 to 571 with a mean of 373±74 and a significant P-value. When compared to male diabetics, the PEFR in female diabetics was 239 ±38SD with a significant P-value. Spirometric parameters in male diabetics were found to be insignificant when compared to healthy controls (P <0.001). In both sexes, HbA1c and FBS were shown to be extremely significant when compared to controls. Variable PEFR in healthy controls and in the lung function was found to be impaired in female diabetics, but male diabetics had a normal PEFR.

scholarly journals Association of Pulmonary Function Decline over Time with Longitudinal Change of Glycated Hemoglobin in Participants without Diabetes Mellitus

2021 ◽  
Vol 11 (10) ◽  
pp. 994
Author(s):  
Wen-Hsien Lee ◽  
Da-Wei Wu ◽  
Ying-Chih Chen ◽  
Yi-Hsueh Liu ◽  
Wei-Sheng Liao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Function ◽  
Pulmonary Function ◽  
Glycated Hemoglobin ◽  
Longitudinal Change ◽  
Type 2 Dm ◽  
Over Time ◽  
New Onset

Pulmonary damage and function impairment were frequently noted in patients with diabetes mellitus (DM). However, the relationship between lung function and glycemic status in non-DM subjects was not well-known. Here, we evaluated the association of longitudinal changes of lung function parameters with longitudinal changes of glycated hemoglobin (HbA1c) in non-DM participants. The study enrolled participants without prior type 2 DM, hypertension, and chronic obstructive pulmonary disease (COPD) from the Taiwan Biobank database. Laboratory profiles and pulmonary function parameters, including forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), were examined at baseline and follow-up. Finally, 7055 participants were selected in this study. During a mean 3.9-year follow-up, FVC and FEV1 were significantly decreased over time (both p < 0.001). In the multivariable analysis, the baseline (unstandardized coefficient β = −0.032, p < 0.001) and longitudinal change (unstandardized coefficient β = −0.025, p = 0.026) of FVC were negatively associated with the baseline and longitudinal change of HbA1c, respectively. Additionally, the longitudinal change of FVC was negatively associated with the risk of newly diagnosed type 2 DM (p = 0.018). During a mean 3.9-year follow-up, our present study, including participants without type 2 DM, hypertension, and COPD, demonstrated that the baseline and longitudinal change of FVC were negatively and respectively correlated with the baseline and longitudinal change of HbA1c. Furthermore, compared to those without new-onset DM, participants with new-onset DM had a more pronounced decline of FVC over time.

The complex interrelationship between Diabetes Mellitus, oral diseases and general health.

2021 ◽  
Vol 17 ◽  
Author(s):  
Daniela Grisi ◽  
Isabel Vieira ◽  
Ana Karolina Lima ◽  
Mariana Mattos ◽  
Nailê Damé-Teixeira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Health ◽  
Dental Caries ◽  
Signs And Symptoms ◽  
Self Control ◽  
Whole Body ◽  
Oral Diseases ◽  
Systemic Complications ◽  
Chronic Hyperglycemia ◽  
Dental Professionals

: There is emerging evidence that several oral diseases and conditions can be associated with DM. Dental caries, hyposalivation, fungal diseases and endodontics lesions may represent potential oral complications that can be aggravated by chronic hyperglycemia. Individuals with DM have low perception of oral diseases which can lead to clinically important oral and systemic complications. This review aims to provide data on the most common oral signs and symptoms related to DM and to explore the mechanisms that might explain associations between DM and oral diseases in order to clarify the risks posed by poor oral health in DM. Since the linkage between oral diseases and DM is part of multifactorial aspects related to chronic hyperglycemic status and several common conditions affecting the whole body, both require rigorous self-control from patients and attention from medical and dental professionals.

scholarly journals TYPE 2 DIABETES MELLITUS PREVENTION – PRESCRIPTIONS OFF-LABEL

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Luis Jesuino De Oliveira Andrade ◽  
Paulo Roberto Santana de Melo ◽  
Mércia Alves Silva Margotto ◽  
Alcina Maria Vinhaes Bittencourt
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Inclusion Criteria ◽  
International Database ◽  
Off Label ◽  
Search Form ◽  
Wide Range ◽  
Methods Of Treatment ◽  
Selection Of

The prescribing a drug without the indications for which the drug was originally approved by regulators is internationally known as prescribing “off-label”. Objective: To describe the off-label prescriptions in type 2 diabetes (DM2) prevention, reported international scientific literature, through an integrative bibliographical review. Method: An integrative review was made by searching the Medline international database for review of manuscripts. Selection of these databases was based on the wide range of journals covered by each of them and our goal was to provide an overview of the scientific production devoted to the topic over the timeframe under analysis. The following inclusion criteria were considered during the review: articles published between January 1985 and June 2013; use of the keywords “off-label use” OR “off-label” OR “off-label prescribing” OR “diabetes prevention” OR “prevention” MeSH “diabetes mellitus” entered into the search form, and availability of an abstract in English. Results: A total 852 scientific productions were identified, and 30 studies were selected by contain information about the off-label prescriptions in DM2. Conclusion: The practice of off-label prescribing itself has notable benefits. In some situations, an off-label prescription is the only treatment available to a patient, either because a more targeted drug is does not exist, or because other methods of treatment are ineffective or unavailable due to patient intolerance. In these situations, off-label uses of drugs provide the only chance of restored health.

scholarly journals A STUDY OF PULMONARY FUNCTION TESTS IN A PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THEIR ASSOCIATION WITH GLYCAEMIC CONTROL AND DURATION OF DIABETES AT TERTIARY CARE HOSPITAL

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Sonam Gupta ◽  
Dr. Yadvendra Gupta
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Tertiary Care ◽  
Care Hospital ◽  
Duration Of Diabetes ◽  
Chronic Hyperglycemia ◽  
Function Tests ◽  
Restrictive Pattern

Background- The pulmonary and other late complications of diabetes share a similar microangiopathy mechanism. Since, they share common mechanisms there may be associations between lung function and markers of microangiopathy. Therefore, we aimed to determine the association of pulmonary function with diabetes and the correlation of pulmonary function abnormalities with microvascular complications. Methods- This was a cross sectional comparative study carried out in a tertiary care teaching hospital in Jaipur,Rajasthan, India. Eligible participants included 100 adults below 60 years of age with T2DM attending the outpatient clinics or admitted to the wards during the study period, and an equal number of non-diabetic adults matched for age and gender who served as the comparative controls. Results- The present study clearly showed a highly statistically significant p value when the lung function tests (FVC, FEV1, and PEFR) were compared between type 2 diabetics and age, sex, BMI matched controls. The duration of DM and PFT correlation was found stastically significant and HbA1c and PFT correlation was found stastically Insignificant. Conclusion- Chronic hyperglycemia in diabetes may lead to diabetes associated systemic inflammation which results in airway and lung damage. Diabetes was more common in the sixth decade of life with slight male preponderance. The most common PFT derangement pattern in diabetic subjects is a restrictive pattern and having a significantly longer duration of a diabetic. The short-term indicators of glycemic controls were not significantly associated with a restrictive pattern of PFT. Keywords: Diabetes, Pulmonary function test, HbA1c, Duration of diabetes.

Pulmonary function in children with type 1 diabetes mellitus

2015 ◽  
Vol 28 (1-2) ◽  
Author(s):  
María Martín-Frías ◽  
Adelaida Lamas ◽  
Emma Lara ◽  
Milagros Alonso ◽  
Purificación Ros ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Lung Function ◽  
Pulmonary Function ◽  
Type 1 Diabetes Mellitus ◽  
Pulmonary Function Tests ◽  
Pubertal Development ◽  
Development Stage ◽  
Forced Expiratory Volume

AbstractTo assess lung function in children and adolescents with type 1 diabetes mellitus (T1DM).We conducted a case-control study of 100 patients with T1DM [median age 13 (10.6–14.7), 44% men, 23% prepubertal, and all nonsmokers] and 77 controls. None had evidence of lung disease or any other comorbidity. We performed pulmonary function tests, including spirometry [forced vital capacity (FVC), forced expiratory volume in 1 s (FEVThe duration of diabetes was 6.2±3.8 years with a median HbAThe lung is functionally involved in children with T1DM. Pubertal development stage influences the evaluation of lung function.

scholarly journals Efektifitas Terapi Pijat Refleksi Kaki Terhadap Pengendalian Glukosa Darah Pada Penderita Diabetes Melitus

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Mardiana Mardiana
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Literature Review ◽  
Metabolic Disorders ◽  
Literature Study ◽  
Glucose Levels ◽  
Chronic Hyperglycemia ◽  
Blood Glucose Levels ◽  
The Impact ◽  
Diabetes Melitus

Introduction: Diabetes mellitus is a group of metabolic disorders characterized by damaged insulin secretion, insulin action, or both, resulting in an increase in blood glucose levels (hyperglycemia). The impact of chronic hyperglycemia and metabolic disorders with diabetes mellitus, which causes damage to tissues and organs such as the eyes, nerves, kidneys and blood vessel systems.Purpose: This literature study aims to analyze the effectiveness of foot reflexology therapy in controlling blood glucose in diabetic patients.Methods: the database in making this literature review is pubmed and google scholar. The articles found were in the 2015-2021 timeframe with full text and were selected according to the appropriate literature study topic.Results: Based on the results of literature search, 331 articles were found, and there were 5 articles that met the criteria regarding the effectiveness of foot reflexology therapy in controlling blood glucose in diabetic patients.Conclusion: The results of research from several articles in this literature review indicate that foot reflexology therapy is effective in controlling blood glucose in diabetic patients.Keywords: Blood Glucose, Diabetes, Massage Therapy, Foot Reflexology

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