Clinical characteristics of rotaviruses disease

Rotaviruses are the major causes of viral gastroenteritis in infant and the young children. There are a wide spectrum of clinical signs and symptoms of rotavirosis. Rotavirus infection is fecal-oral infection. Rotaviruses prove with Latex agglutination test and electron microscopy. In a four year period 943 stool samples out of 527 hospitalized patients had been analyzed. A presence of rotavirus is proved with a LA and EM tests at 170 (32,2%) patients age 0-7 years, in their stool samples. Analyzing age groups of these patients, it was found that the rotavirusesinfection the most frequently occurred at age group from 7-24 months. From 170 positive patients, 122 or 71,8% were in this age group. At all patients was found diarrhea, vomiting in a 90,5% cases. Mild fever had 65,5% patients, signs of a respiratory infection appeared at 60,7% patients, abdominal pain at 13,3% patients. Severe dehydration had 49,9% patients and metabolic acidosis had 79,2% cases. Macroscopically blood in stool had 6,4% patients, slime in a stool 46,0% patients was found, and aholic stool had 8,4% patients. In all hospitalized patients disease lasted in average 12,6 days, and the hospitalization in average 10,2 days. None of the patient had any kind of complication, all of them very successfully cured. These results confirm that rotaviruses are important health problem among infant and the young children in Bosnia and Herzegovina.

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Clinical signs predictive of severe illness in young Pakistani infants

BMC Research Notes ◽

10.1186/s13104-021-05486-y ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Shahira Shahid ◽

Shiyam Sunder Tikmani ◽

Kanwal Nayani ◽

Ayesha Munir ◽

Nick Brown ◽

...

Keyword(s):

Age Groups ◽

Clinical Signs ◽

Severe Infection ◽

Signs And Symptoms ◽

Severe Illness ◽

Age Group ◽

Young Infants ◽

The Common ◽

Clinical Signs And Symptoms ◽

Sign Algorithm

Abstract Objective Early detection of specific signs and symptoms to predict severe illness is essential to prevent infant mortality. As a continuation of the results from the multicenter Young Infants Clinical Signs and Symptoms (YICSS) study, we present here the performance of the seven-sign algorithm in 3 age categories (0–6 days, 7–27 days and 28–59 days) in Pakistani infants aged 0–59 days. Results From September 2003 to November 2004, 2950 infants were enrolled (age group 0–6 days = 1633, 7–27 days = 817, 28–59 days = 500). The common reason for seeking care was umbilical redness or discharge (29.2%) in the 0–6 days group. Older age groups presented with cough (16.9%) in the 7–27 age group and (26.9%) infants in the 28–59 days group. Severe infection/sepsis was the most common primary diagnoses in infants requiring hospitalization across all age groups. The algorithm performed well in every age group, with a sensitivity of 85.9% and specificity of 71.6% in the 0–6 days age group and a sensitivity of 80.5% and specificity of 80.2% in the 28–59 days group; the sensitivity was slightly lower in the 7–27 age group (72.4%) but the specificity remained high (83.1%).

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Clinical Signs Predictive of Severe Illness in Young Pakistani Infants

10.21203/rs.3.rs-154678/v1 ◽

2021 ◽

Author(s):

Shahira Shahid ◽

Shiyam Sunder Tikmani ◽

Kanwal Nayani ◽

Ayesha Munir ◽

Nick Brown ◽

...

Keyword(s):

Age Groups ◽

Clinical Signs ◽

Severe Infection ◽

Signs And Symptoms ◽

Severe Illness ◽

Age Group ◽

Young Infants ◽

The Common ◽

Clinical Signs And Symptoms ◽

Sign Algorithm

Abstract Objective:Early detection of specific signs and symptoms to predict severe illness is essential to prevent infant mortality. As a continuation of the results from the multicenter Young Infants Clinical Signs and Symptoms (YICSS) study, we present here the performance of the seven-sign algorithm in 3 age categories (0-6 days, 7-27 days and 28-59 days) in Pakistani infants aged 0-59 days.Results:From September 2003 to November 2004, 2950 infants were enrolled (age group 0-6 days=1633, 7-27 days=817, 28-59 days=500). The common reason for seeking care was umbilical redness or discharge (29.2%) in the 0-6 days group. Older age groups presented with cough (16.9%) in the 7-27 age group and (26.9%) infants in the 28-59 days group. Severe infection/sepsis was the most common primary diagnoses in infants requiring hospitalization across all age groups. The algorithm performed well in every age group, with a sensitivity of 85.9% and specificity of 71.6% in the 0-6 days age group and a sensitivity of 80.5% and specificity of 80.2% in the 28-59 days group; the sensitivity was slightly lower in the 7-27 age group (72.4%) but the specificity remained high (83.1%).

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Infection surveillance in nursing homes in Stockholm County, Sweden, 2005 - 2014

International Journal of Infection Control ◽

10.3396/ijic.v12i3.019.16 ◽

2016 ◽

Vol 12 (3) ◽

Author(s):

Ann Tammelin

Keyword(s):

Nursing Homes ◽

Infection Control ◽

Urinary Catheter ◽

Clinical Signs ◽

Signs And Symptoms ◽

County Council ◽

Antibiotic Prescribing ◽

Viral Gastroenteritis ◽

Stockholm County ◽

Infection Surveillance

Swedish nursing homes are obliged to have a management system for systematic quality work including self-monitoring of which surveillance of infections is one part. The Department of Infection Control in Stockholm County Council has provided a simple system for infection surveillance to the nursing homes in Stockholm County since 2002. A form is filled in by registered nurses in the nursing homes at each episode of infection among the residents. A bacterial infection is defined by antibiotic prescribing and a viral infection by clinical signs and symptoms. Yearly reports of numbers of infections in each nursing home and calculated normalized figures for incidence, i.e. infections per 100 residents per year, as well as proportion of residents with urinary catheter are delivered to the medically responsible nurses in each municipality by the Department of Infection Control. Number of included residents has varied from 4,531 in 2005 to 8,157 in 2014 with a peak of 10,051 in 2009. The yearly incidences during 2005 - 2014 (cases per 100 residents) were: Urinary tract infection (UTI) 7.9-16.0, Pneumonia 3.7-5.3, Infection of chronic ulcer 3.4–6.8, Other infection in skin or soft tissue 1.4–2.9, Clostridium difficile-infection 0.2–0.7, Influenza 0–0.4 and Viral gastroenteritis 1.2–3.7. About 1 % of the residents have a suprapubic urinary catheter, 6–7 % have an indwelling urinary catheter. Knowledge about the incidence of UTI has contributed to the decrease of this infection both in residents with and without urinary catheter.

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1465. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children with Respiratory Syncytial Virus Infection (RSV) Infection

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1646 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S734-S735

Author(s):

Helena Brenes-Chacon ◽

Cristina Garcia-Maurino ◽

Melissa Moore-Clingenpeel ◽

Sara Mertz ◽

Fang Ye ◽

...

Keyword(s):

Young Children ◽

Disease Severity ◽

Age Groups ◽

Panel Member ◽

Signs And Symptoms ◽

Research Support ◽

Review Panel ◽

Viral Loads ◽

Age Dependent ◽

Rsv Infection

Abstract Background Differences in clinical presentation and viral loads according to age in young children with RSV, and their correlation with disease severity are poorly defined. The aim of this study was to define age-dependent the differences in demographic, clinical factors and viral loads between children < 2 years of age with mild RSV infection evaluated as outpatients versus those hospitalized with severe RSV infection. Figure 1. Sign and Symptoms according to disease severity and age in infants with RSV infection. Most relevant signs and symptoms were stratified in outpatients (orange) vs inpatients (blue) by age in (A) < 3 months, (B) between 3 and 6 months, and (C) > 6 to 24 months of age. The Y axis represents the signs and symptoms in the two disease severity groups and the X axis the frequency of that specific symptom (%). Numbers next to bars represent the exact number of patients with that specific sign/symptom. Comparisons by Fisher exact test. Symbol (*) indicate significant 2-sided p values Figure 2. Viral load differences according to age in infants with RSV infection. The Y axis represents RSV loads in log10 copies/mL and the X axis differences in viral loads in outpatients (orange) and inpatients (blue) in the three age groups. Comparisons by Mann Whitney test. Methods Previously healthy children < 2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and nasopharyngeal swabs were obtained for RSV typing and quantitation by real-time PCR. Patients were stratified by age (0-< 3, 3-6, and >6-24 months) and multivariable analyses were performed to identify clinical and viral factors associated with severe disease. Results From 2014-2018 we enrolled 534 children with RSV infection: 130 outpatients and 404 inpatients. Median duration of illness was 4 days for both groups, yet viral loads were higher in outpatients than inpatient in the three age groups (Fig 1). Wheezing was more frequent in outpatients of older age (>3 months) than in inpatients (p< 0.01), while fever was more common in inpatients that outpatients (p< 0.01) and increased with age (Fig 2). Adjusted analyses confirmed that increased work of breathing and fever were consistently associated with hospitalization irrespective of age, while wheezing in infants >3 months, and higher RSV loads in children >6-24 months were independently associated with reduced disease severity. Conclusion Age had a significant impact defining the interactions among viral loads, specific clinical manifestations and disease severity in children with RSV infection. These observations highlight the importance of patient stratification when evaluating interventions against RSV. Disclosures Octavio Ramilo, MD, Bill & Melinda Gates Foundation (Grant/Research Support)Janssen (Grant/Research Support, Advisor or Review Panel member)Medimmune (Grant/Research Support)Merck (Advisor or Review Panel member)NIH/NIAID (Grant/Research Support)Pfizer (Consultant, Advisor or Review Panel member)Sanofi/Medimmune (Consultant, Advisor or Review Panel member) Asuncion Mejias, MD, PhD, MsCS, Janssen (Grant/Research Support, Advisor or Review Panel member)Merck (Advisor or Review Panel member)Roche (Advisor or Review Panel member)

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Investigation of Children with Acute Gastroenteritis by Multiplex PCR Method in Central Part of Turkey

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0041-1740372 ◽

2022 ◽

Author(s):

Fatih Yılmaz ◽

Havva Kaya ◽

Mehmet Özdemir

Keyword(s):

Multiplex Pcr ◽

Acute Gastroenteritis ◽

Hospital Admissions ◽

Age Groups ◽

Viral Gastroenteritis ◽

Viral Agent ◽

Mortality And Morbidity ◽

Stool Samples ◽

Pcr Method ◽

Norovirus Gii

Abstract Objective Gastroenteritis is a disease that affects all age groups, especially children, and causes high mortality and morbidity in all countries. The most common agents of acute gastroenteritis are viral agents. As a result, millions of diarrhea attacks and hospital admissions occur worldwide every year due to viral gastroenteritis. This study uses the multiplex polymerase chain reaction (PCR) method to investigate the viruses that are the causative agents of viral gastroenteritis in the pediatric patient group in Konya, Turkey. Methods Stool samples of 94 patients aged 0 to 18 years sent from Emergency clinics and Pediatric outpatient clinics, Meram Medical Faculty Hospital Pediatric clinics, Konya Necmettin Erbakan University to Medical Microbiology Laboratory with a diagnosis of gastroenteritis between February and December 2018 were included in the study. Stool samples were stored at –80°C until the time of the analysis. Deoxyribonucleic acid/ribonucleic acid isolation from stool samples was performed with EZ1 Virus Mini Kit v2.0 (Qiagen, Hilden, Germany) using an automatic extraction system (BioRobot EZ1 system, Qiagen). The presence of astrovirus, rotavirus, adenovirus, norovirus (GI, GII), and sapovirus agents was investigated by the multiplex PCR method (Fast Track Diagnostics, Luxembourg) viral gastroenteritis kit. Results Viral gastroenteritis agents were detected in 56.3% of the patients. One viral agent was detected in 47 (50%) of these patients and at least two viral agents in 6 (6.3%) of them. Norovirus GII was detected in 20 (21.2%) of the children included in the study, adenovirus in 13 (13.8%), rotavirus in 11 (12.8%), astrovirus in 11 (11.7%), sapovirus in 4 (4.2%), and norovirus GI in 1 (1.06%). When the distribution of viral agents was examined by months, the most number of agents were observed (21; 35%) in May, followed by April and June (12; 20%). Considering the distribution of the prevalence of the agents by age, it was seen to be mainly between 0 and 12 months (42%). Conclusion Considering that the most common viral agent in our region is norovirus GII, it will be useful to investigate the norovirus that is not routinely examined in children who are admitted to clinics with the complaint of gastroenteritis. It will be appropriate to examine routinely adenovirus, rotavirus, and norovirus in the laboratory, especially in children with diarrhea and vomiting in the winter and spring months.

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Pathogenicity and non-opportunistic character of Blastocystis spp.: a hospital-based survey in Central Cameroon

The Journal of Infection in Developing Countries ◽

10.3855/jidc.10122 ◽

2018 ◽

Vol 12 (05) ◽

pp. 373-379 ◽

Cited By ~ 3

Author(s):

Stéphanie Jupsa-Mbiandou ◽

Samuel Fosso ◽

Edimo Billé ◽

Tito T Mélachio-Tanekou ◽

Gideon Ajeagah-Aghaindum ◽

...

Keyword(s):

Rural Areas ◽

Urban Areas ◽

Age Groups ◽

Clinical Signs ◽

Hiv Positive ◽

Cross Sectional ◽

Significant Difference ◽

Blastocystis Spp ◽

Stool Samples ◽

Hiv Negative

Introduction: Blastocystis spp. is a protist found in humans. Although usually the most frequent protozoa found in stool samples of both symptomatic and healthy subjects, its pathogenic or rather opportunistic role is yet to be clearly elucidated. To attempt to fill this gap, a cross-sectional study was conducted to compare the frequency of Blastocystis spp. in HIV positive (HIV+) versus HIV negative (HIV-) individuals in four health facilities of the Center Region of Cameroon. Methodology: Stool samples were collected from 283 HIV positive and 245 HIV negative subjects and analyzed using direct diagnostic tests. Results: A total of 46 (8.7%) individuals were found infected with Blastocystis spp., including 6.7% HIV positive and 11.0% HIV negative. This species was more frequent in urban and semi-urban areas than in rural areas, but evenly distributed among genders and age groups as well as among all sectors of activity. The prevalence of Blastocystis spp. (11.3%) was higher in HIV+ patients with a CD4 count ≥ 500 cells / mm3, but no significant difference was found among HIV clinical stages. Likewise prevalence, the mean number of cysts per gram of stool was similar between HIV positive and HIV negative individuals. People infected with Blastocystis spp. showed diverse clinical signs, but only flatulence was significantly more prevalent. The frequencies of these clinical signs were not related to HIV status. Conclusion: No clear relationship links the infection with Blastocystis spp. to HIV, although its presence was associated with digestive disorder, suggesting that this parasite might not be opportunist.

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PENGELOMPOKAN JUMLAH PENDUDUK BERDASARKAN KATEGORI USIA DENGAN METODE K-MEANS

Jurnal Teknik Informasi dan Komputer (Tekinkom) ◽

10.37600/tekinkom.v2i2.115 ◽

2019 ◽

Vol 2 (2) ◽

pp. 166

Author(s):

Sahat Sonang ◽

Arifin Tua Purba ◽

Ferri Ojak Imanuel Pardede

Keyword(s):

Young Children ◽

Human Resources ◽

Data Processing ◽

Early Adulthood ◽

Age Groups ◽

Early Adolescents ◽

Age Group ◽

Late Adolescents ◽

Economic Level ◽

The Government

Control of population is one of the tasks of the government in Indonesia. The increase and movement of population in each region makes a certain area to defeat changes in population surging, and this can affect the economic level of the area. This study aims to process the population of Pematangsiantar City in 2018 which is divided into age groups, namely: Toddlers, Young Children, Early Adolescents, Late Adolescents, Early Adolescents, Late Adulthood, Early Adulthood, Elderly, Late Elderly, and Upper Seniors. Data processing is done by using K-Means method clustering in accordance with the population of Pematangsiantar City per district. With this grouping, we can see that the number of population in each sub-district is based on each age group so that we can implement programs that are more appropriate in improving human resources.

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Meningitis—What Is It?

Continual Raving ◽

10.1093/oso/9780190677312.003.0001 ◽

2019 ◽

pp. 1-22

Author(s):

Janet R. Gilsdorf

Keyword(s):

Cerebrospinal Fluid ◽

Young Children ◽

Clinical Signs ◽

Signs And Symptoms ◽

Pathologic Examination ◽

Helen Keller ◽

Clinical Signs And Symptoms ◽

Almost All

Before the advent of antibiotics, meningitis was a dreadful infection by any standard; many of its victims were young children, and almost all died, succumbing to the disease from days to six weeks, or sometimes longer, after the onset of their illness. Incredibly, patients occasionally survived but were often left with varying degrees of neurologic damage. Before the first spinal tap, the diagnosis of meningitis was based on clinical signs and symptoms and could be confirmed only by pathologic examination of the brains of deceased patients during an autopsy. Since the advent of the spinal tap, the diagnosis of meningitis rests on examination of the cerebrospinal fluid. Treatment of meningitis depends on which bacteria cause the infection. Helen Keller may be a famous surviving victim of this disease.

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Detection of respiratory and enteric shedding of bovine coronaviruses in cattle in Northwestern Turkey

Acta Veterinaria Hungarica ◽

10.1556/avet.53.2005.1.13 ◽

2005 ◽

Vol 53 (1) ◽

pp. 137-146 ◽

Cited By ~ 15

Author(s):

M. Hasoksuz ◽

A. Kayar ◽

T. Dodurka ◽

A. Ilgaz

Keyword(s):

Seroconversion Rate ◽

Geometric Mean ◽

Age Groups ◽

Clinical Signs ◽

Feedlot Cattle ◽

Antibody Detection ◽

Age Group ◽

Adult Cattle ◽

Northwestern Turkey ◽

Significant Difference

Bovine coronavirus (BCoV) is an important cause of diarrhoea in calves, winter dysentery in adult cattle and respiratory tract disease in feedlot cattle. Serum, faecal and nasal swab samples were collected from a total of 96 cattle with clinical signs in 29 barns of 23 villages in Northwestern Turkey. The cattle were subdivided into 3 distinct age groups (0-30 days old, 4-12 months old and 2-7 years old). An indirect antigen-capture ELISA and an antibody-detection ELISA as well as geometric mean BCoV antibody titres were used to detect BoCV shed in the faeces and in the nasal secretions, respectively. Relationships between BCoV shedding and age group, seroconversion and clinical signs in cattle were also analysed. The rate of faecal shedding of BoCV was 37.1% (13/35) in 0-30 days old calves, 25.6% (10/39) in 4-12 months old feedlot cattle and 18.2% (4/22) in 2-7 years old cows. The overall rate of BCoV faecal shedding was 28.1% (27/96) in the cattle examined. Only one animal in the 4-12 months old age group was found to shed BoCV nasally. The analysis showed that there was a significant difference (P < 0.0001) with respect to faecal shedding between the clinical signs and the age groups. BCoV antibody titre in 50% of all cattle was ≤ 100 as detected by ELISA while 27.1% of the cattle had high titres ranging between 1,600 and 25,600. The seroconversion rate was 7.3% (7/96) in animals shedding BoCV in the faeces and 42.7% (41/96) in cattle negative for faecal shedding as detected by ELISA, and 20.8% of cattle with no seroconversion shed BCoV in the faeces. There was no statistically significant association between seroconversion and nasal or faecal BCoV shedding. These findings confirm the presence of BCoV infections in Turkey. Further studies are needed to isolate BCoV strains in Turkey and to investigate their antigenic and genetic properties.

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Development and Piloting of the Starship Posttraumatic Amnesia Scale for Children Aged Between Four and Six Years

Brain Impairment ◽

10.1375/brim.3.1.34 ◽

2002 ◽

Vol 3 (1) ◽

pp. 34-41 ◽

Cited By ~ 4

Author(s):

Kris Fernando ◽

Lynette Eaton ◽

Morag Faulkner ◽

Yogi Moodley ◽

Raylene Setchell

Keyword(s):

Young Children ◽

Age Groups ◽

Operational Definition ◽

Age Group ◽

Normal Children ◽

Posttraumatic Amnesia ◽

Standard Deviations ◽

Definition Of

AbstractThe aim of this study was to develop and pilot a posttraumatic amnesia scale (PTA) scale for children aged between four and six years. The scale consists of seven orientation questions and five memory items modelled on the Westmead PTA Scale which assesses posttraumatic amnesia in children from eight years onwards and adults. The sample consisted of 45 four-year-olds, 82 five-year-olds and 49 six-year-old children from a variety of cultural and socioeconomic backgrounds. Children were recruited from hospitals, kindergartens and schools. Results were analysed across age groups using means and standard deviations. The orientation and memory items were analysed separately as well as in combination. Early analyses indicate that the majority of normal children in the four to 6 year age group can answer most of the orientation questions correctly and remember the memory stimuli from day to day. The results indicate that the Starship PTA Scale is suitable for young children aged 4 to 6 years. It is simple and quick to administer and utilises an operational definition of posttraumatic amnesia in terms of measuring continuous memory.

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