scholarly journals An evaluation of the prevalence of malignant neoplasms in Russia using an incidence-mortality model

2019 ◽  
pp. 107-124
Author(s):  
Rustam Tursun-zade
Keyword(s):  
Cancer Incidence ◽  
Demographic Data ◽  
Disease Onset ◽  
Health Condition ◽  
Mortality Data ◽  
Malignant Neoplasms ◽  
Age At Death ◽  
Incidence And Mortality ◽  
Prevalence Of Cancer ◽  
Expansion Of Morbidity

This paper aims to estimate Russian cancer incidence and mortality derivatives given limited access to medical and demographic data. We use the population model of cancer proposed by J. Duchêne, which is a special case of a well-known multiple-decrement life table that makes it possible to obtain otherwise inaccessible indicators, such as the prevalence of cancer in the population. Applying this model to the publicly available Russian cancer incidence and mortality data, we were able to estimate the following indicators: average age at disease onset, average duration of disease, prevalence of malignant cancer, and average age at death from malignant cancer in Russia. We aimed to determine whether the prevalence of cancer is on the rise in the Russian Federation and, if it is, whether this increase is occurring due to an expansion of morbidity. It was found that the average age at disease onset and the average age at death from it in Russia are increasing, with the primacy of the latter. These processes are in turn resulting in an increase of the average number of years lived with cancer, thus justifying the hypothesis of an expansion of morbidity. This phenomenon, along with the increase in the incidence of malignant cancer, is what is causing the increased cancer prevalence. Groups of cancer localizations with the highest and lowest prevalence were identified, as well as localizations with a visible tendency toward an expansion of morbidity. It was found that in Russia the general trend is towards the expansion of morbidity, expressed by an increase in the number of years lived in an imperfect health condition. Malignant neoplasms of the lip, oral cavity and oesophagus (C00-C15) in females is the only localization for which the expansion of morbidity does not occur. For this localization a compression of morbidity is observed that is an antipode to the expansion. The main  limitations and drawbacks of the study are discussed in a separate section.

scholarly journals Cancer incidence and mortality in the municipality of Pasto, 1998 – 2007

2012 ◽  
pp. 256-266 ◽  
Author(s):  
Maria Clara Yepez ◽  
Luis Eduardo Bravo ◽  
Arsenio Hidalgo Troya ◽  
Daniel Marcelo Jurado ◽  
Luisa Mercedes Bravo
Keyword(s):  
Cancer Incidence ◽  
Cancer Mortality ◽  
Urban Areas ◽  
Population Level ◽  
Cancer Registries ◽  
Population Based ◽  
Mortality Data ◽  
Major Health Problem ◽  
Incidence And Mortality ◽  
Cancer Morbidity

Introduction: In Colombia, information on cancer morbidity at the population level is limited. Incidence es­timates for most regions are based on mortality data. To improve the validity of these estimates, it is necessary that other population-based cancer registries, as well as Cali, provide cancer risk information. Objective: To describe the incidence and cancer mortality in the municipality of Pasto within the 1998-2007 period. Methodology: The study population belongs to rural and urban areas of the municipality of Pasto. Collection, processing, and systematization of the data were performed according to internationally standardized parame­ters for population-based cancer registries. The cancer incidence and mortality rates were calculated by gender, age, and tumor site. Results: During the 1998-2007 period 4,986 new cases of cancer were recorded of which 57.7% were in female. 2,503 deaths were presented, 52% in female. Neoplasm-associated infections are the leading cause of cancer morbidity in Pasto: stomach cancer in males and cervical cancer in females. Discussion: Cancer in general is a major health problem for the population of the municipality of Pasto. The overall behavior of the increasing incidence and cancer mortality in relation to other causes of death show the need to implement and strengthen prevention and promotion programs, focusing especially on tumors that produce greater morbidity and mortality in the population.

scholarly journals Thyroid cancer incidence and mortality in Latin America

2018 ◽  
Author(s):  
Fábia Cheyenne Gomes de Morais Fernandes ◽  
Dyego Leandro Bezerra de Souza ◽  
Maria Paula Curado ◽  
Isabelle Ribeiro Barbosa
Keyword(s):  
Latin America ◽  
Thyroid Cancer ◽  
Costa Rica ◽  
Cancer Incidence ◽  
World Health ◽  
International Agency ◽  
Mortality Data ◽  
Incidence Trends ◽  
Incidence And Mortality ◽  
Thyroid Cancer Incidence

This study analyzed trends in thyroid cancer incidence and mortality in countries of Latin America. Ecological study of time series, with incidence data extracted from the International Agency for Research on Cancer (IARC), in the 1990-2012 period and mortality data obtained from 16 countries of the World Health Organization (WHO), in the 1995-2013 period. The trend of incidence rate was analyzed by the Joinpoint regression. The average annual percentage change (AAPC) and the 95% confidence interval (CI 95%) were calculated for incidence and mortality. The average rate of thyroid cancer incidence was higher in Quito (Ecuador) between the ages of 40 to 59 years old, 42.2 new cases per 100,000 inhabitants, as well as mortality 4.8 deaths per 100,000 women inhabitants above 60 years old. There was an increase in thyroid cancer incidence trends in women, for all age groups, in Cali, Costa Rica and Quito and men in Costa Rica; there was stability above the age of 60 years old in Cali, Goiania, Quito and Valdivia in men, as well as women in Goiania and Valdivia. There was a trend of increasing mortality for females in three countries: Ecuador (AAPC= 3,28 CI 95% 1,36;5,24), Guatemala (AAPC= 6,14 CI 95% 2,81;9,58) and Mexico (AAPC= 0,67 CI 95% 0,16;1,18). Thyroid cancer in Latin America showed a high incidence, with increased incidence in women. Stability in mortality was observed for most countries of Latin America.

A Simulation Model for Small-area Cancer Incidence Rates

2004 ◽  
Vol 43 (05) ◽  
pp. 493-498 ◽  
Author(s):  
A. Daugs ◽  
M. Meyer ◽  
M. Radespiel-Tröger
Keyword(s):  
Cancer Patient ◽  
Cancer Incidence ◽  
Small Area ◽  
Age Distribution ◽  
Incidence Rates ◽  
Cancer Registration ◽  
Mortality Data ◽  
Simulation Tool ◽  
Incidence And Mortality ◽  
Cancer Incidence Rates

Summary Objectives: Cancer epidemiologists are often asked by members of the interested public about possible associations between suspected carcinogens and apparently increased small-area cancer incidence rates. Frequently, no systematic incidence differences can be demonstrated. Nevertheless, it is necessary to address public concerns about suspected cancer clusters. To facilitate explanations about the large random variation of small-area tumor incidence, we implemented a software simulation tool in R. Methods: Under the assumption of no cancer causes other than chance, the tool simulates a small village population with an average number of five inhabitants per house and allows graphical visualisation of ten streets with 100 houses. Published age-specific incidence and mortality data are used for event sampling based on the binomial distribution. Program parameters include sample size, age distribution, cancer incidence, and mortality rates. Results: On average, 22 percent (2.2/10) of all houses per street have been inhabited by at least one cancer patient during the last five years in our simulated small village. A situation where all (10) houses in a street have been inhabited by at least one cancer patient during the last five years appears to be very rare (less than one in a million streets). Conclusions: Our software tool can be used effectively for numerical and graphical visualisation of small-area tumour incidence and prevalence rates due to chance alone. The explanation of basic epidemiological concepts to members of the public can help to increase public motivation and support for population-based cancer registration. Our simulation tool can be used to support this goal.

Analysis of Cancer Incidence in the Population of the Leningrad Region

2021 ◽  
pp. 23-32
Author(s):  
АА Kovshov ◽  
YuA Novikova ◽  
VN Fedorov ◽  
NA Tikhonova ◽  
OA Istorik
Keyword(s):  
Russian Federation ◽  
Cancer Incidence ◽  
Average Rate ◽  
Incidence Rates ◽  
Malignant Neoplasms ◽  
Leningrad Region ◽  
Comparison Results ◽  
Incidence And Mortality ◽  
The Russian Federation ◽  
Incident Cases

Introduction: Extensive measures are taken in the Russian Federation to reduce cancer incidence and mortality in the population but the proportion of incident cases in advanced stages is still large while correct registration of deaths and diseases remains a challenge. Our objectives were to study the incidence of malignant neoplasms in the Leningrad Region, to establish territories at risk, and to analyze carcinogenic risk factors associated with environmental conditions in these territories. Materials and methods: We used data of the Federal Statistical Observation Forms No. 7 “Information on Malignant Neoplasms”, No. 12 “Information on the Number of Diseases Registered in Patients Living in the Service Area of a Medical Organization”, No. 18 “Information on the Sanitary Condition of the Subject of the Russian Federation”, and information on the size of population by sex and age in the Leningrad Region and its districts for 2008–2018. We applied a direct method of standardizing incidence rates by age, analyzed the dynamics of incidence, and estimated statistical significance of differences in the incidence rates between the territories of comparison. Results: Cancer incidence in the Leningrad Region was lower than that in Russia. In 2008–2018, the highest rates were registered in the Kirishsky and Podporozhsky districts. In the Podporozhsky district, the standardized incidence rate in 2018 was 328.1 cases per 100,000 population or 1.79 times higher than the regional average, while the average rate for 2008–2018 exceeded the regional average by 1.36 times. The Kirishsky district ranked second by the incidence of malignant neoplasms in the Leningrad Region in 2018 (241.4 cases per 100,000 population or 1.32 times higher than the regional average), while the average rate for 2008–2018 exceeded the regional one by 1.47 times. Conclusions: Additional research is necessary to establish the causes of high cancer incidence rates in the Kirishsky and Podporozhsky districts of the Leningrad Region.

scholarly journals Prediction of Cancer Incidence and Mortality in Korea, 2020

2020 ◽  
Vol 52 (2) ◽  
pp. 351-358 ◽  
Author(s):  
Kyu-Won Jung ◽  
Young-Joo Won ◽  
Seri Hong ◽  
Hyun-Joo Kong ◽  
Eun Sook Lee
Keyword(s):  
Regression Model ◽  
Cancer Incidence ◽  
Linear Trend ◽  
Cancer Control ◽  
Incidence Rates ◽  
Cancer Site ◽  
Mortality Data ◽  
Control Programs ◽  
Incidence Data ◽  
Incidence And Mortality

PurposeThis study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea’s current cancer burden.Materials and MethodsCancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. A <i>Joinpoint</i> regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend.ResultsIn total, 243,263 new cancer cases and 80,546 cancer deaths are expected to occur in Korea in 2020. The most common cancer site is expected to be the lung, followed by the stomach, thyroid, colon/rectum, and breast. These five cancers types are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer among people who die is expected to be lung cancer, followed by liver, colon/rectal, pancreatic, and stomach cancers.ConclusionThe incidence rates for all types of cancer in Korea are estimated to decrease gradually. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.

scholarly journals Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

2019 ◽  
Vol 22 (2) ◽  
pp. 99-107 ◽  
Author(s):  
Axel Skytthe ◽  
Jennifer R. Harris ◽  
Kamila Czene ◽  
Lorelei Mucci ◽  
Hans-Olov Adami ◽  
...  
Keyword(s):  
General Population ◽  
Cancer Incidence ◽  
Cancer Registries ◽  
Incidence Rates ◽  
Malignant Neoplasms ◽  
Cancer Risk Factors ◽  
Background Population ◽  
Incidence And Mortality ◽  
Risk Of Cancer

AbstractThe Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.

scholarly journals But other than mesothelioma? An estimate of the proportion of work-related cancers in Quebec

2016 ◽  
Vol 23 (2) ◽  
pp. 144 ◽  
Author(s):  
F. Labrèche ◽  
P. Duguay ◽  
A. Boucher ◽  
R. Arcand
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Preventive Measures ◽  
Mortality Data ◽  
Occupational Cancer ◽  
Work Related ◽  
The United Kingdom ◽  
Female Breast ◽  
Incidence And Mortality ◽  
Attributable Fractions

Background More than 30 exposures in the workplace are proven carcinogens. In the present study, we aimed to estimate the burden of occupational cancer in Quebec so as to increase awareness among stakeholders and to prioritize research activities.Methods Work-attributable fractions—that is, the proportions of cancers attributable to work—as published in Finland and the United Kingdom were applied to Quebec 2002–2006 cancer incidence and mortality data to estimate the number of work-related cases for 28 cancer sites.Results Overall, 6.0% of incident cancers (men: 9.1%; women: 2.7%) and 7.6% of cancer deaths (men: 11.8%; women: 2.8%) could be attributable to work, resulting annually in an average of 2160 new cancer diagnoses and 1190 cancer deaths in Quebec. Incident cancers of the lung, prostate, skin, bladder, and (female) breast were the most numerous; cancer sites resulting in more deaths were lung, (female) breast, and pleura. During the same period, compensation statistics reported annual averages of 94.3 incident cancers and 61.9 cancer deaths, mostly involving mesothelioma (64% of compensated incident cancers) and lung cancer (30% of compensated incident cancers).Conclusions Increased recognition of workplace cancers by all stakeholders, from workers and employers to treating physicians, will foster appropriate preventive measures for safer workplaces.

scholarly journals Long-Term Trends of Liver Cancer Incidence and Mortality in China 1990–2017: A Joinpoint and Age–Period–Cohort Analysis

2019 ◽  
Vol 16 (16) ◽  
pp. 2878 ◽  
Author(s):  
Fang Wang ◽  
Sumaira Mubarik ◽  
Yu Zhang ◽  
Lu Wang ◽  
Yafeng Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Incidence ◽  
Cohort Analysis ◽  
Cohort Effects ◽  
Mortality Data ◽  
Period Effect ◽  
Birth Cohorts ◽  
Incidence And Mortality ◽  
Long Term Trends

Liver cancer (LC) is one of the most common causes of cancer-related deaths: this study aims to present the long-term trends and age–period–cohort effects of the incidence of and mortality from LC in China during 1990–2017. Incidence and mortality data were obtained from the Global Burden of Disease Study 2017. We determined trends in the age-standardized incidence rate (ASIR) and mortality rate (ASMR) using Joinpoint regression. An age–period–cohort (APC) analysis was performed to describe the long-term trends with intrinsic estimator methods. The ASMR decreased markedly before 2013 and increased thereafter, with overall average annual percent change (AAPC) values of −0.5% (95% confidence interval (CI): −0.6%, −0.3%) for men and −1.3% (−1.6%, −1.0%) for women during 1990–2017. The ASIR significantly increased by 0.2% (0.1%, 0.3%) in men and decreased by 1.1% (−1.2%, −1.0%) in women from 1990 to 2017. The risks of LC incidence and mortality increased with age in both genders. The period effect risk ratios (RRs) of incidence and mortality displayed similar monotonic increasing trends in men and remained stable in women. The cohort effect showed an overall downward trend and almost overlapping incidence and mortality in both genders, and later birth cohorts experienced lower RRs than previous birth cohorts. Older age, recent period, and birth before 1923 were associated with a higher risk of liver cancer incidence and mortality. The net age and period effects showed an increasing trend, while the cohort effects presented a decreasing trend in incidence and mortality risk. As China’s population aging worsens and with the popularization of unhealthy lifestyles, the burden caused by liver cancer will remain a huge challenge in China’s future.

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