scholarly journals Comparative analysis of efficacy and safety of Bilastine 20 mg and Levocetirizine 5 mg in the treatment of Allergic Rhinoconjunctivitis

2020 ◽  
Vol 5 (8) ◽  
pp. 231-136
Author(s):  
Dr. Devendra Sharma ◽  
◽  
Dr. Hemendra Bamaniya ◽  
Keyword(s):  
Symptom Score ◽  
Allergic Rhinoconjunctivitis ◽  
Post Treatment ◽  
P Value ◽  
Primary Efficacy ◽  
Efficacy And Safety ◽  
Before And After ◽  
Efficacy Parameter ◽  
Excellent Safety Profile ◽  
A Prospective Study

Objective: The present study was conducted to assess the efficacy and safety of bilastine 20 mgand compare the results with that of levocetirizine 5 mg in the treatment of allergicrhinoconjunctivitis. Material and Methods: It was a prospective study conducted in theDepartment of Ophthalmology and Department of Otorhinolaryngology at a tertiary institute ofsouthern Rajasthan, India during the period of 6 months from September 2019 to February 2020.100 patients of chronic allergic rhinoconjunctivitis were included in the study, of which 50 weretreated with Bilastine 20 mg, and the rest 50 patients were treated with levocetirizine 5 mg. Theprimary assessment was done by calculating the total symptom score (TSS) before and after the 7thand 14th post-treatment day. Results: The age of the patients ranges from 10 years to 65 yearswith a mean age of 32±5.2 years. The primary efficacy parameter for assessment was a reduction intotal symptom score (TSS). Both bilastine 20 mg and levocetirizine 5 mg significantly reduced theTSS on the 7th and 14th post-treatment days (p-value< 0.001). There was no significant differencebetween TSS of bilastine and levocetirizine after 7 days (p-value= 0.41) and after 14 days treatment(p-value= 0.68). Adverse events were reported by 10% of patients in the bilastine group and by38% of patients in the levocetirizine group. Conclusion: Bilastine is a selective H1 antihistaminewith good efficacy and excellent safety profile and it is highly recommended to use it as a first-linetreatment for allergic rhinoconjunctivitis.

scholarly journals Evaluation of Efficacy and Safety Profile of Intense Pulsed Light Treatment in Melasma in Darker Skin Type

2020 ◽  
Vol 12 (1) ◽  
pp. 3-8
Author(s):  
Nishant Choudhary ◽  
Abhishek De ◽  
Amrita Sil ◽  
Gobinda Chatterjee
Keyword(s):  
Safety Profile ◽  
Severity Index ◽  
Skin Type ◽  
Intense Pulsed Light ◽  
P Value ◽  
Efficacy And Safety ◽  
Pulsed Light ◽  
First Line Therapy ◽  
Type Iv ◽  
Before And After

AbstractIntroduction. We undertook a prospective, interventional study to evaluate the efficacy and safety profile of Intense Pulsed light (IPL) treatment of melasma in dark skin phenotypes.Material and Methods. The study was conducted in 32 patients of skin type IV and V. IPL with 640 nm and 690 nm filters was used. The patients were called once a month to undergo 6 sessions. Melasma area and severity index (MASI) and Clinician Global Impression Scores were used for evaluation. We followed “per protocol” analysis.Results. Out of 26 patients who completed the treatment, 12 patients showed improvement, MASI remained unchanged in 10 patients and 4 patients showed deterioration. MASI scores before and after treatment were 6.70 ± 3.53 and 6.32 ± 3.90 (p value=0.6891). Erythema and pain were the common side effects noted. Seventeen out of 32 patients had thyroid disorders.Conclusion. IPL should be avoided as a first line therapy in darker skin type. However, it can be used as an adjuvant therapy in some cases after careful deliberations.

scholarly journals Testing the Cow’s Milk-Related Symptom Score (CoMiSSTM) for the Response to a Cow’s Milk-Free Diet in Infants: A Prospective Study

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2402 ◽  
Author(s):  
Silvia Salvatore ◽  
Elisabetta Bertoni ◽  
Federica Bogni ◽  
Valentina Bonaita ◽  
Chiara Armano ◽  
...  
Keyword(s):  
Symptom Score ◽  
Immunoglobulin E ◽  
Gastrointestinal Symptoms ◽  
Cow’S Milk ◽  
P Value ◽  
Cow's Milk ◽  
Related Symptom ◽  
Receiver Operation Characteristic ◽  
Ige Mediated ◽  
A Prospective Study

The diagnosis of cow’s milk allergy (CMA) is particularly challenging in infants, especially with non-Immunoglobulin E (IgE)-mediated manifestations, and inaccurate diagnosis may lead to unnecessary dietary restrictions. The aim of this study was to assess the accuracy of the cow’s milk-related symptom score (CoMiSSTM) in response to a cow’s milk-free diet (CMFD). We prospectively recruited 47 infants (median age three months) who had been placed on a CMFD due to persisting unexplained gastrointestinal symptoms. We compared data with 94 healthy controls (median age three months). The CoMiSSTM score was completed at recruitment and while on the exclusion diet. In 19/47 (40%) cases a response to the diet occurred. At recruitment CoMiSSTM was significantly higher in cases compared to controls (median score 8 vs. 3; p-value: <0.05), 9 cases had a score ≥12 and 8/9 normalized on CMFD. An oral milk challenge was performed in all 19 responders and six of these had a positive reaction to cow’s milk (CM). In eight infants IgE allergy tests were positive. The receiver operation characteristic (ROC) curve identified a CoMISSTM score of 9 to be the best cut-off value (84% sensitivity, 85% specificity, 80% positive (PPV) and 88% negative predictive value (NPV)) for the response to CMFD. We found CoMiSSTM to be a useful tool to help identify infants with persisting gastrointestinal symptoms and suspected CMA that would benefit from CMFD.

Prospective study of post-ESWL infections of the urinary tract

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 134-136
Author(s):  
G. Zanetti ◽  
E. Montanari ◽  
A. Guarneri ◽  
M. Seveso ◽  
A. Trinchieri ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Prospective Study ◽  
Renal Stones ◽  
Post Treatment ◽  
Maximum Diameter ◽  
Symptomatic Infection ◽  
Before And After ◽  
Low Incidence ◽  
Set Up ◽  
A Prospective Study

Throughout the world ESWL is nowadays the treatment of choice in renoureteral stones and ever smaller stones can be treated. We have undertaken the present study to evaluate post treatment infective complications in low-risk patients. A prospective study has been performed on 150 non-infected patients before ESWL treated for renal stones whose maximum diameter was less than 15 mm. None out of this group underwent pretreatment manoeuvres. Urinecultures were checked before and after treatment (3 days – 30 days). Out of 150 third day urine cultures 11 were positive but only 5 patients presented a symptomatic infection. All patients whose urineculture was positive received antibiotic treatment. All urinecultures were negative at the 30 days follow-up. The low incidence of urinary symptomatic and asymptomatic infections in our series and the rapid cure by antibiotic therapy suggest performing ESWL treatment in selected patients without any antibiotic prophylaxis. Antibiotic therapy will be set up just in symptomatic or asymptomatic post-treatment infections.

Comparative Study of Organizational Measures on Helmet Use Rate in Trang Hospital Personnel

2021 ◽  
Vol 104 (2) ◽  
pp. 247-251
Keyword(s):  
Video Camera ◽  
P Value ◽  
Policy Measure ◽  
Chi Square ◽  
Helmet Use ◽  
Before And After ◽  
Chi Square Test ◽  
Policy Measures ◽  
The Mean ◽  
A Prospective Study

Objective: To compare the efficacy of organizational measures on helmet use rate of the motorcycle driver and rider in Trang Hospital. Materials and Methods: The present study was a prospective study comparing the helmet use rate before and after the measures including helmet policy, supportive and incentive organizational measure, and penalizing organizational measure. The personnel of Trang Hospital included 1,441 people. There were 637 drive-only personnel, 143 ride-only personnel and 443 drive-ride personnel. The helmet use rate was collected at the front gate of the hospital by closed circuit video camera monitoring during 07:00 am to 08:30 am every day for one week before and after the various measures. The mean helmet use rates were compared by the chi-square test was considered significant at the p value of less than 0.05. Results: The increased rate of helmet use in driver after the supportive and incentive organizational measure and the penalizing organizational measure compared to the helmet use rate before the policy measures were statistically significant (p<0.001). Unlike the increased rate of helmet use in driver and rider after the policy measure compared to the helmet use rate before the policy measure were not statistically significant (p=0.220, 0.470, consecutively). The increased helmet use of the rider after the penalizing organizational measure was statistically significant when compared to the helmet use rate before the policy (p<0.001), and the supportive and incentive measure (p=0.019). However, the increased rate of helmet use in driver after the penalizing organizational measure compared to the helmet use rate after the supportive and incentive organizational measure were not statistically significant (p=0.990). Conclusion: Only the policy measure has not significantly increased the rate of helmet use in both drivers and riders. The supportive and incentive organizational measure have significantly increased the helmet use rate in the drivers, but not significantly increased the rate of helmet use in the riders. However, the penalizing organizational measure has significantly increased the rate of helmet use in the riders, but not significantly increased the rate of helmet use in the drivers. Keywords: Helmet implementation, Organizational measure, Head injury prevention, Motorcycle accident, Helmet use rate

scholarly journals Effectiveness of Integrated Teaching Module among Final Year Medical students

2016 ◽  
Vol 06 (02) ◽  
pp. 024-026
Author(s):  
Akshatha Rao Aroor ◽  
Dileep K. S. ◽  
Rama Prakasha Saya ◽  
Sudheendra Rao
Keyword(s):  
Medical Students ◽  
Medical Curriculum ◽  
Teaching Method ◽  
Tertiary Care ◽  
General Medicine ◽  
P Value ◽  
College Hospital ◽  
Before And After ◽  
The Mean ◽  
A Prospective Study

AbstractBackground: Didactic lectures and the current practice of teaching in Medical colleges has many limitations. Correlation and integration of knowledge into practice becomes difficult in the absence of integrated teaching at appropriate levels in medical curriculum.Aim: To assess the effectiveness of the vertical integrated teaching method among the final year MBBS students and to study the attitude towards integrated teaching. Materials and Methods: This is a prospective study conducted among 102 final year MBBS students at a tertiary care medical college hospital in South India. The teaching was implemented by the active participation of faculty from the departments of Physiology, Pathology and General Medicine on a single topic. Students' knowledge about the subject before and after the session was evaluated by a questionnaire of 20 questions (Pre-test and Post-test). The mean score before and after the session was compared using the paired't' test. The students were also asked to give their feedback about the usefulness of this method in improving their knowledge.Results: The mean scores before and after the session were 8.8± 2.87 and 16.88±1.23 (p value < 0.001). Majority of the students (97.1%) opined the need for integrated teaching to be a part of medical curriculum. Most of them (54.9%) felt the need for integrated teaching to be conducted monthly. On self-grading the knowledge on a scale of 1 to 10 before and after the session, the mean scores were 4.73±1.84 and 7.83±1.86 respectively (p value < 0.001). Conclusion: The integrated teaching was found to be an effective method of teaching. Medical students had a positive attitude towards integrated teaching.

scholarly journals A prospective study of clinicoepidemiology, metabolic and hormonal profile of women with hirsutism in Konaseema region of Andhra Pradesh

2021 ◽  
Vol 10 (10) ◽  
pp. 3875
Author(s):  
M. Smitha
Keyword(s):  
Insulin Resistance ◽  
Cushing Syndrome ◽  
Mean Value ◽  
P Value ◽  
Hormonal Profile ◽  
Number Of Patients ◽  
Menstrual Irregularities ◽  
Before And After ◽  
The Mean ◽  
A Prospective Study

Background: Hirsutism is defined as presence of excess coarse hairs appear in male pattern in women.There is various aetiology of hirsutism like Idiopathic hirsutism, PCOS, androgen secreting ovarian tumours, menopause, CAH, Cushing’s syndrome, drugs which increases testosterone level, insulin resistance and tumour secreting androgen. We have designed present study with an aim to study the clinicoepidemiology, metabolic and hormonal profile of women with hirsutism in Konaseema region of Andhra Pradesh.Methods: All patients with hirsutism attending gynaecology outpatient department were selected for study based on inclusion and exclusion criteria. After that patient were examined clinically, BMI was calculated for each patient. Patients were clinically evaluated for signs of excess androgen secretion, Cushing syndrome, metabolic syndrome and hyperprolactinemia. Modified Ferriman-Gallwey scoring system was used for evaluating and quantifying hirsutism.Results: The mean Fasting plasma insulin12.42±2.41 (mIU/dl), the mean of HOMA-IR was 3.14±1.18. The mean value of dehydroepiandrosteronesulphate (DHEAS) 355.78±15.41 mcg/dl. There was statistically significant reduction in modified Ferriman-Gallwey scoring in before and after treatment (12.38± 1.55 vs. 9.62±1.6), the p value was 0.00001. The number of patients with menstrual irregularities were reduced from 63.3% to 20% after treatment and this difference is statistically significant (p=0.04).Conclusions: Hirsutism is associated with insulin resistance and DHEAS concentration was high. Modified Ferriman-Gallwey score was significantly reduced and there was significant weight loss and improvement in menstrual irregularities after treatment.

scholarly journals CORRELATION BETWEEN VISUAL PROSTATE SYMPTOM SCORE & INTERNATIONAL PROSTATE SYMPTOM SCORE IN EVALUATION OF MEN WITH BPH: A PROSPECTIVE STUDY FROM AN NORTH EAST INDIAN POPULATION

2020 ◽  
pp. 1-4
Author(s):  
Pavan Kumar Koliwad ◽  
Arpan Yadav ◽  
Akoijam Kaku Singh
Keyword(s):  
Symptom Score ◽  
International Prostate Symptom Score ◽  
P Value ◽  
Medical Sciences ◽  
East Indian ◽  
North East ◽  
Number Of Patients ◽  
Significant Difference ◽  
A Prospective Study ◽  
Educated Person

Introduction: The international prostate symptom score (IPSS) is widely used to assess the severity of lower urinary tract symptoms (LUTS), but is very complicated & difficult to comprehend. Visual Prostate Symptom Score (VPSS) was introduced to overcome the drawbacks of the International Prostate Symptom Score (IPSS). Materials & Methods: This was a prospectively designed study conducted at Regional Institute of Medical Sciences, Imphal. A total of 200 patients who presented to the urology outpatient department with LUTS due to BPH were enrolled in the study. All patients were given both questionnaires. The correlation test was used to assess the correlation between two symptom scores and various parameters. Observations with a P value < 0.05 were considered statistically significant. Results: Of 200 patients, 61% of them were above the age of 60 years; mean ± standard deviation age was 62.72 ± 9.11 (range 48– 84 years). Total time taken to complete IPSS & VPSS were 589.30 ± 190.74 sec & 175.35± 62.59 sec respectively. There was a statistically significant difference in the number of patients requiring assistance to fill the questionnaires according to their education level. There was a positive correlation between IPSS total score and VPSS total score (r = 0.54; P < 0.001), IPSS Qol versus VPSS Qol (r = 0.53; P < 0.001). A negative correlation was observed between total VPSS and Qmax (r= -0.719; P < 0.001), total IPSS and Qmax (r= -0.654; P < 0.001). All VPSS questions showed statistically significant correlation with the corresponding IPSS questions. Conclusion: VPSS can be used as a better alternative to IPSS which is easier, more compliant, takes lesser time and even can be understood by a less educated person.

scholarly journals Efficacy and Safety of Lycoprozen®, a Novel Tomato-Based Food Supplement in Patients with Benign Prostatic Hyperplasia

2018 ◽  
Vol 3 (2) ◽  
pp. 1-5
Author(s):  
Alberto Cellini ◽  
Pier Giorgio Natali ◽  
Manuela Iezzi ◽  
Mauro Piantelli ◽  
Vincenzo Fogliano ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Side Effects ◽  
Food Supplement ◽  
Prostatic Hyperplasia ◽  
Controlled Study ◽  
P Value ◽  
Efficacy And Safety ◽  
Suitable Alternative ◽  
International Prostatic Symptom Score ◽  
Before And After

Objective: To evaluate the efficacy and safety of a novel tomato-based food supplement on the lower urinary tract symptoms (LUTS) of patients with benign prostatic hyperplasia (BPH). Methods: Twenty patients with BPH were enrolled in this observational study. They were assigned to consume daily a sachet of Lycoprozen® (5 grams) dissolved in water for two months. Results: All patients successfully completed the Lycoprozen scheduled regimen and the IPSS (International Prostatic Symptom Score) questionnaire before and after treatment. No side effects due to treatment were noticed. In this preliminary study, we have found that Lycoprozen® significantly reduced the LUTS severity (paired t-test, two-tailed p value < 0.0001). The IPSS mean values before and after the treatment were 16.95+6.0 SD (range 31-6) and 12.2+4.9 SD (range 20-2), respectively. Conclusions: Based on these data, Lycoprozen® may represent a suitable alternative option for the treatment of symptomatic BPH patients which worth of further testing in a phase 2 prospective randomized double blind placebo controlled study. The treatment was without side effects and acceptance among patients was high.

scholarly journals Teaching Glasgow Coma Scale Assessment by Videos: A Prospective Interventional Study among Surgical Residents

2020 ◽  
Vol 11 (03) ◽  
pp. 381-384
Author(s):  
Jitin Bajaj ◽  
Sanjay Rathore ◽  
Vijay Parihar ◽  
Pawan Agarwal ◽  
Yad Ram Yadav ◽  
...  
Keyword(s):  
Glasgow Coma Scale ◽  
General Surgery ◽  
P Value ◽  
Chi Square ◽  
Coma Scale ◽  
Maximum Benefit ◽  
Before And After ◽  
Chi Square Test ◽  
The Difference ◽  
A Prospective Study

Abstract Objective Glasgow Coma Scale (GCS) assessment is vital for the management of various neurological, neurosurgical, and critical care disorders. Learning GCS scoring needs good training and practice. Due to limitation of teachers, the new entrants of the clinical team find it difficult to learn and use it correctly. Training through videos is being increasingly utilized in the medical field. This study aimed to evaluate the efficiency of video teaching of GCS scoring among general surgery residents. Materials and Methods A prospective study was done utilizing the freely available video at glasgowcomascale.org. The participants (general surgery residents, 1st–3rd year) were asked to assess and record their responses related to GCS both before and after watching the video. A blinded neurosurgeon recorded the correct responses separately. Statistical Analysis The difference between correct responses of the residents before and after watching the video was calculated using the “chi-square test.” p-Value ≤ 0.05 was taken as significant. Results There was a significant improvement in GCS scoring by residents after watching the videos (p < 0.05). On estimating the responses separately, all the three responses (eye, verbal, and motor) improved significantly for 1st-year residents while only the motor response improved significantly for 2nd- and 3rd-year residents. The mode subjective improvement for the 1st-, 2nd-, and 3rd-year residents was 5, 4, and 3, respectively. Conclusion Training GCS scoring through videos is an effective way of teaching the surgery residents with maximum benefit to the junior-most ones.

scholarly journals Validating 7-items Overactive Bladder Symptom Score (OABSS) through Arabic linguistic version

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fadi Sawaqed ◽  
Mohammed Suoub
Keyword(s):  
Overactive Bladder ◽  
Symptom Score ◽  
Arabic Language ◽  
Arabic Version ◽  
Before And After ◽  
Registration Number ◽  
Bladder Symptom ◽  
Definition Of ◽  
A Prospective Study ◽  
Overactive Bladder Symptom Score

AbstractThe scoring of the 7-item Overactive Bladder Symptom Score (OABSS) questionnaire is unusual because its scale varies with the same maximum and minimum scoring values and quantifies all aspects of OAB. The questionnaire also contains a graded response for urgency. The current study is mainly concerned with the development and validation of the OABSS questionnaire for Jordanian patients. The process of translating the English OABSS questionnaire into the Arabic language involved forward and backward translations. Afterward, a prospective study was conducted to validate the Arabic version of the OABSS questionnaire by examining 235 patients from the outpatient clinics of Karak Governorate Teaching Hospital. The Arabic OABSS questionnaire was completed by all the enrolled patients before and after three months of treatment with solifenacin 5 mg taken once daily. The study included 235 regular patients (152 females and 83 males) diagnosed with OAB in accordance with the definition of the International Continence Society (ICS). The results showed major and significant differences on all seven domains of the questions on the OABSS questionnaire before and after receiving treatment (p < 0.05). Confirmatory Factor Analysis was used to measure the reliability and the questionnaire was found to be highly reliable for the construct variables. The findings derived from the current study would be beneficial for local urologists and researchers, as the Arabic version of the OABSS questionnaire was proven to be a reliable instrument for use in the assessment of OAB. Future studies are needed to compare different translated questionnaires relating to OAB.Trial registration number: NCT04309890.

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