Статья посвящена формированию методологии разработки и реализации стратегии институциональных преобразований промышленных комплексов в условиях цифровой экономики. Предложены авторские определение и структурно- содержательная схема методологии. Сформирована методологическая матрица, систематизирующая категориальный аппарат, принципы, подходы, методики, методы и модели построения стратегии по уровням научного знания. Разработан алгоритмизированный методологический подход к созданию и реализации стратегии институциональной трансформации промышленного комплекса в цифровой среде. The paper is devoted to creating the methodology and to the topical issues of developing and implementing the strategy for the industrial complexes institutional transformations under the conditions of the digital economy. The paper investigates general scientific and economic understanding of the methodology notion, shows its specific characteristics. The definition of the methodology for developing and implementing the strategy for the industrial complex transformations was proposed. It is an integrated set of principles, approaches and tools, united by a common logic of construction and the relevant categorical apparatus, that allows to solve theoretical and conceptual, organizational, economic, managerial and other issues of institutional strategy, digital innovations and enterprise transformation. The methodological matrix, which systematizes categorical apparatus, principles, approaches, methods and models of the strategy development according to the levels of scientific knowledge was generated. The structural scheme of the methodology and algorithm-based methodological approach to the development and implementation of the strategy for the industrial complex institutional transformation in the digital environment were developed. The content of each stage of the methodological approach was substantiated. The means of the investigation included the general-scientific and special methods: analysis, synthesis, structuring and description, systems and process approaches. The results of the investigation can be used as a theoretical and methodological basis for the formation and implementation of the strategy for the industrial complex transformation in the digital economy.