scholarly journals Comparison Of Modeling Schemes for Natural Course Of Pulmonary Tuberculosis

Author(s):  
K.K. Avilov ◽  
A.A. Romanyukha ◽  
E.M. Belilovsky ◽  
S.E. Borisov

In construction of mathematical models of propagation and control of pulmonary tuberculosis, presence or absence of bacterioexcretion is often used as the marker of disease severity. There are two major schemes of modeling for natural corse of tuberculosis. The first one is so called parallel scheme, the more frequently used, which assumes that a fraction of incident cases develops bacterioexcretion rapidly and retains it till the end of the disease. The second one is serial scheme, the less often used one, which assumes that tuberculosis always starts without bactrioexcretion, and then a fraction of cases progresses to the bacterioexcretion stage. In this article, we compare these two modeling schemes on the basis of their fit to the real data from Moscow city, 2013-2018, which contain information on time and results of the last fluorography examination of the detected tuberculosis cases and their health condition at the moment of detection. Such data limit the possible duration of the disease, and, thus, permit an estimation of the dynamics of progression to bacterioexcretion for untreated tuberculosis. We have developed an agent-based model with realistic profiles of mortality and undergoing fluorography examinations and with an analog of the traditional compartmental model of natural history of tuberculosis on the basis of ordinary differential equations. On the basis of computational experiments with the model, the serial modelling scheme turned out to be closer to reality. On the other hand, due to the bad fit to the real data, we concluded that both the detection submodel and the submodel of natural course of pulmonary tuberculosis should be redesigned.

2012 ◽  
Vol 260-261 ◽  
pp. 163-168 ◽  
Author(s):  
Mostafa Zamani Mohi Abadi ◽  
Seyed Mohammad Hessam Mohammadi ◽  
Seyed Ali Akbar Safavi ◽  
Seyed Vahid Naghavi

This paper presents a control study of the real Shiraz 250KW solar power plant together with a modeling and a monitoring interface. Here, a PID controller is developed to control the outlet oil temperature of the collector field of the solar power plant as a standard tool for industrial automation. First the power plant is modeled within MATLAB environment and the model is verified with the real data of the power plant. Then an HMI environment is developed within the LabVIEWsoftwarewhile incorporating the model developed in MATLAB. The simulation results showed that a fixed-coefficient PID failed to provide the desired results over a year and the best coefficients for each month were calculated. The friendly and accurate developed environment within MATLAB and LabVIEW provide a valuable tool for modeling and control studies and monitoring of the real power plant.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S247-S248
Author(s):  
Alainna Jamal ◽  
Brenda Coleman ◽  
Jennie Johnstone ◽  
Kevin Katz ◽  
Matthew P Muller ◽  
...  

Abstract Background Though CPE in Canada are mainly acquired abroad, outbreaks/transmission in Canadian hospitals have been reported. We determined the incidence of HA CPE in southern Ontario, Canada, to inform prevention and control programs. Methods Toronto Invasive Bacterial Diseases Network (TIBDN) has performed population-based surveillance for CPE in the Toronto area/Peel region of southern Ontario, Canada, since CPE were first identified in October 2007. Clinical microbiology laboratories report all CPE isolates to TIBDN; annual lab audits are performed. Incidence calculations used first isolates as numerator; denominator (patient-days/fiscal year for Toronto/Peel hospitals) was from the Ontario Ministry of Health and Long-Term Care. Results The incidence of HA CPE has risen from 0 in 2007/2008 to 0.45 and 0.28 per 100,000 patient-days for all and clinical cases, respectively, in 2017/2018 (Figure, P < 0.0001). 190/790 (24%) incident cases of CPE colonization/infection in southern Ontario from October 2007 to December 2018 were likely HA (hospitalized in Ontario with no history of hospitalization abroad/high-risk travel). Eighty (25%) were female and the median age was 73 years (IQR 57–83 years). 157 (83%) had no prior travel abroad and 33 (17%) had prior low-risk travel. 122 (64%) had their CPE identified >72 hours post-admission (of which 83 also had ≥1 other prior Ontario hospitalization); 68 (36%) had their CPE identified at admission but had recent prior Ontario hospitalization. HA cases vs. foreign acquisitions were significantly more likely K. pneumoniae (48% vs. 38%, P = 0.02) and Enterobacter spp. (20% vs. 7%, P < 0.0001) and less likely E. coli (20% vs. 48%, P < 0.0001). Genes of HA vs. foreign acquisitions were significantly more likely blaKPC (34% vs. 12%, P < 0.0001) and blaVIM (12% vs. 2%, P < 0.0001) and less likely blaNDM±OXA (38% vs. 56%, P < 0.0001) and blaOXA (13% vs. 27%, P = 0.0001). 36 (19%) HA cases had a negative CPE screen before their first positive CPE test (10/36 (28%) were on admission). The median incidence of HA CPE per 100,000 patient-days at each hospital was 0.44 (IQR 0.15–0.68) (P < 0.0001). Conclusion A quarter of CPE cases in southern Ontario were HA and the incidence of HA cases is increasing. Most cases were admitted to >1 Ontario hospital. Strategies to control transmission are critical. Disclosures All authors: No reported disclosures.


Ekonomia ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 55-72
Author(s):  
Dawid Mikołajczak

Money neutrality and selected currents in economicsThe history of the idea of neutrality of money begins with David Hume. There are at least five types of money neutrality. They could be grouped into neutrality relating to the moment static neutrality and institutional neutrality and neutrality relating to the period dynamic neutrality, superneutrality, monetary neutrality. In mainstream economics, views on neutrality have changed over the years. Monetarism has differentiated views on the neutrality of money. The Austrian school remains sceptical about this simplification of the monetary economy. The theory of the real business cycle accepts any kind of neutrality in the period, and neutrality at the moment is not an important issue for it. Keynesianism focuses on neutrality in the short term and is sceptical about it.


2021 ◽  
Vol 336 ◽  
pp. 02018
Author(s):  
Shunyao Yang ◽  
Xubin Sun

The utilization of regenerative braking energy is of great significance to the energy saving of subway. Therefore, this paper proposes an optimization method for scheduling and control integration, which not only adjusts the timetable but also optimizes the speed curves of trains. When there is a train braking, this method will try to find a train that accelerates to absorb the regenerative energy generated by the braking train. Firstly, this paper establishes the timetable energy saving optimization model, based on which the speed curves will be optimized. Furthermore, we design a scheduling optimization algorithm based on genetic algorithm, and optimizes speed curves of trains by binary search method to obtain a good solution. Finally, simulations are given using the real data of Beijing Metro Line 4 to evaluate the proposed method, and the results show that the integrated scheduling and control optimization method can reduce energy consumption by 15.18%. In the random disturbance simulations, the proposed method shows good robustness, which makes it possible to apply this method to the real subway operations.


Literary Fact ◽  
2021 ◽  
pp. 8-60
Author(s):  
Margarita M. Pavlova ◽  
Bogomolov Bogomolov

The journal “Severny Vestnik” (1891 –1898), around which relatively young Petersburg writers — A. Volynsky, N. Minsky, D. Merezhkovsky and Z. Gippius, F. Sologub — were grouped in the last years of the 19th century, was of exceptional importance for the early stage of Russian Symbolism. The publication presents new archival materials on the history of the journal: an article “Symbolism of the 1890s and the journal 'Severny Vestnik'” by L.Ya. Gurevich, prepared for an unpublished collection of articles “Russian Symbolism” edited by N.K. Gudzii and read in the form of a report at a meeting of the Literary Subsection of the State Academy of Arts, as well as the minutes of the meeting dated May 14, 1926 with the discussion of this report. An addition to L. Gurevich’s article is her notes (1897 –1898), which record the real and biographical context of the publication of “Severny Vestnik” from the moment the journal passed into her hands until it was closed, as well as her plan for reorganizing the journal. These materials will be presented in the second part of the publication. Documents introduced into scientific circulation allow expanding the range of sources for studying the history of “Severny Vestnik” and early Russian Symbolism.


2020 ◽  
pp. 10-14
Author(s):  
N. V. Spiridonova ◽  
A. A. Demura ◽  
V. Yu. Schukin

According to modern literature, the frequency of preoperative diagnostic errors for tumour-like formations is 30.9–45.6%, for malignant ovarian tumors is 25.0–51.0%. The complexity of this situation is asymptomatic tumor in the ovaries and failure to identify a neoplastic process, which is especially important for young women, as well as ease the transition of tumors from one category to another (evolution of the tumor) and the source of the aggressive behavior of the tumor. The purpose of our study was to evaluate the history of concomitant gynecological pathology in a group of patients of reproductive age with ovarian tumors and tumoroid formations, as a predisposing factor for the development of neoplastic process in the ovaries. In our work, we collected and processed complaints and data of obstetric and gynecological anamnesis of 168 patients of reproductive age (18–40 years), operated on the basis of the Department of oncogynecology for tumors and ovarian tumours in the Samara Regional Clinical Oncology Dispensary from 2012 to 2015. We can conclude that since the prognosis of neoplastic process in the ovaries is generally good with timely detection and this disease occurs mainly in women of reproductive age, doctors need to know that when assessing the parity and the presence of gynecological pathology at the moment or in anamnesis, it is not possible to identify alarming risk factors for the development of cancer in the ovaries.


2008 ◽  
Vol 8 (3) ◽  
pp. 74-78
Author(s):  
hank shaw

Portugal has port, Spain has sherry, Sicily has Marsala –– and California has angelica. Angelica is California's original wine: The intensely sweet, fortified dessert cordial has been made in the state for more than two centuries –– primarily made from Mission grapes, first brought to California by the Spanish friars. Angelica was once drunk in vast quantities, but now fewer than a dozen vintners make angelica today. These holdouts from an earlier age are each following a personal quest for the real. For unlike port and sherry, which have strict rules about their production, angelica never gelled into something so distinct that connoisseurs can say, ““This is angelica. This is not.”” This piece looks at the history of the drink, its foggy origins in the Mission period and on through angelica's heyday and down to its degeneration into a staple of the back-alley wino set. Several current vintners are profiled, and they suggest an uncertain future for this cordial.


2019 ◽  
Vol 60 ◽  
pp. 424-428
Author(s):  
Alexandra I. Vakulinskaya

This publication is devoted to one of the episodes of I. A. Ilyin’s activity in the period “between two revolutions”. Before the October revolution, the young philosopher was inspired by the events of February 1917 and devoted a lot of time to speeches and publications on the possibility of building a new order in the state. The published archive text indicates that the development of Ilyin’s doctrine “on legal consciousness” falls precisely at this tragic moment in the history of Russia.


Author(s):  
Stephen Verderber

The interdisciplinary field of person-environment relations has, from its origins, addressed the transactional relationship between human behavior and the built environment. This body of knowledge has been based upon qualitative and quantitative assessment of phenomena in the “real world.” This knowledge base has been instrumental in advancing the quality of real, physical environments globally at various scales of inquiry and with myriad user/client constituencies. By contrast, scant attention has been devoted to using simulation as a means to examine and represent person-environment transactions and how what is learned can be applied. The present discussion posits that press-competency theory, with related aspects drawn from functionalist-evolutionary theory, can together function to help us learn of how the medium of film can yield further insights to person-environment (P-E) transactions in the real world. Sampling, combined with extemporary behavior setting analysis, provide the basis for this analysis of healthcare settings as expressed throughout the history of cinema. This method can be of significant aid in examining P-E transactions across diverse historical periods, building types and places, healthcare and otherwise, otherwise logistically, geographically, or temporally unattainable in real time and space.


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