Survey conducted by a consumer organization for the presence of bacterial and viral pathogens on high risk fresh produce from the Belgian market

2018 ◽  
pp. 459-466
Keyword(s):  
High Risk ◽  
Fresh Produce ◽  
Consumer Organization ◽  
Viral Pathogens

scholarly journals Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease

2020 ◽  
Vol 14 ◽  
pp. 175346662095105 ◽  
Author(s):  
Paul A. Yates ◽  
Steven A. Newman ◽  
Lauren J. Oshry ◽  
Robert H. Glassman ◽  
Ashton M. Leone ◽  
...  
Keyword(s):  
High Risk ◽  
Pulmonary Disease ◽  
Safety Profile ◽  
Viral Pathogens ◽  
Safety Issues ◽  
Doxycycline Treatment ◽  
Potential Efficacy ◽  
Moderate Disease ◽  
Stage Disease ◽  
Attractive Candidate

Infection with novel SARS-CoV-2 carries significant morbidity and mortality in patients with pulmonary compromise, such as lung cancer, autoimmune disease, and pneumonia. For early stages of mild to moderate disease, care is entirely supportive. Antiviral drugs such as remdesivir may be of some benefit but are reserved for severe cases given limited availability and potential toxicity. Repurposing of safer, established medications that may have antiviral activity is a possible approach for treatment of earlier-stage disease. Tetracycline and its derivatives (e.g. doxycycline and minocycline) are nontraditional antibiotics with a well-established safety profile, potential efficacy against viral pathogens such as dengue fever and chikungunya, and may regulate pathways important in initial infection, replication, and systemic response to SARS-CoV-2. We present a series of four high-risk, symptomatic, COVID-19+ patients, with known pulmonary disease, treated with doxycycline with subsequent rapid clinical improvement. No safety issues were noted with use of doxycycline. Doxycycline is an attractive candidate as a repurposed drug in the treatment of COVID-19 infection, with an established safety profile, strong preclinical rationale, and compelling initial clinical experience described here. The reviews of this paper are available via the supplemental material section.

scholarly journals NGS Techniques Reveal a High Diversity of RNA Viral Pathogens and Papillomaviruses in Fresh Produce and Irrigation Water

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1820
Author(s):  
Marta Itarte ◽  
Sandra Martínez-Puchol ◽  
Eva Forés ◽  
Ayalkibet Hundesa ◽  
Natàlia Timoneda ◽  
...  
Keyword(s):  
Irrigation Water ◽  
Fruits And Vegetables ◽  
Quantitative Polymerase Chain Reaction ◽  
Fresh Produce ◽  
Critical Factor ◽  
Food Samples ◽  
Viral Pathogens ◽  
Production Chain ◽  
Next Generation Sequencing Ngs ◽  
High Diversity

Fresh fruits and vegetables are susceptible to microbial contamination at every stage of the food production chain, and as a potential source of pathogens, irrigation water quality is a critical factor. Next-generation sequencing (NGS) techniques have been flourishing and expanding to a wide variety of fields. However, their application in food safety remains insufficiently explored, and their sensitivity requires improvement. In this study, quantitative polymerase chain reaction (qPCR) assays showed low but frequent contamination of common circulating viral pathogens, which were found in 46.9% of samples of fresh produce: 6/12 lettuce samples, 4/12 strawberries samples, and 5/8 parsley samples. Furthermore, the application of two different NGS approaches, target enrichment sequencing (TES) for detecting viruses that infect vertebrates and amplicon deep sequencing (ADS), revealed a high diversity of viral pathogens, especially Norovirus (NoV) and Human Papillomavirus (HPV), in fresh produce and irrigation water. All NoV and HPV types found in fresh fruit and vegetable samples were also detected in irrigation water sources, indicating that these viruses are common circulating pathogens in the population and that irrigation water may be the most probable source of viral pathogens in food samples.

scholarly journals Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

2021 ◽  
Author(s):  
Wan-Ting He ◽  
Xin Hou ◽  
Jin Zhao ◽  
Jiumeng Sun ◽  
Haijian He ◽  
...  
Keyword(s):  
High Risk ◽  
Influenza A ◽  
Virus Transmission ◽  
Disease Emergence ◽  
Viral Pathogens ◽  
Wildlife Species ◽  
Avian Influenza A Virus ◽  
First Time ◽  
Bat Coronavirus ◽  
Game Animals

Game animals are wildlife species often traded and consumed as exotic food, and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1725 game animals, representing 16 species and five mammalian orders, sampled across China. From this we identified 71 mammalian viruses, with 45 described for the first time. Eighteen viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high risk viruses. We identified the transmission of Bat coronavirus HKU8 from a bat to a civet, as well as cross-species jumps of coronaviruses from bats to hedgehogs and from birds to porcupines. We similarly identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.

The Diagnosis of Viral Disease by Electron Microscopy

1982 ◽  
Vol 40 ◽  
pp. 270-273
Author(s):  
William B. McCombs ◽  
Cameron E. McCoy
Keyword(s):  
Electron Microscopy ◽  
Hospital Stay ◽  
Viral Infections ◽  
Medical Profession ◽  
Bacterial Pathogens ◽  
Viral Disease ◽  
Viral Pathogens ◽  
Academic Interest ◽  
The Past

Recent years have brought a reversal in the attitude of the medical profession toward the diagnosis of viral infections. Identification of bacterial pathogens was formerly thought to be faster than identification of viral pathogens. Viral identification was dismissed as being of academic interest or for confirming the presence of an epidemic, because the patient would recover or die before this could be accomplished. In the past 10 years, the goal of virologists has been to present the clinician with a viral identification in a matter of hours. This fast diagnosis has the potential for shortening the patient's hospital stay and preventing the administering of toxic and/or expensive antibiotics of no benefit to the patient.

A Community Based High Risk Register for Hearing Loss

1982 ◽  
Vol 47 (4) ◽  
pp. 373-375 ◽  
Author(s):  
James L. Fitch ◽  
Thomas F. Williams ◽  
Josephine E. Etienne
Keyword(s):  
Hearing Loss ◽  
System Identification ◽  
High Risk ◽  
Language Learning ◽  
Education Program ◽  
Communication System ◽  
Auditory Signal ◽  
Early Age ◽  
Community Based ◽  
Children With Hearing Loss

The critical need to identify children with hearing loss and provide treatment at the earliest possible age has become increasingly apparent in recent years (Northern & Downs, 1978). Reduction of the auditory signal during the critical language-learning period can severely limit the child's potential for developing a complete, effective communication system. Identification and treatment of children having handicapping conditions at an early age has gained impetus through the Handicapped Children's Early Education Program (HCEEP) projects funded by the Bureau of Education for the Handicapped (BEH).

A Community Based High Risk Register for Hearing Loss

1983 ◽  
Vol 48 (1) ◽  
pp. 110-110
Keyword(s):  
Hearing Loss ◽  
High Risk ◽  
Community Based

For the November 1982 JSHD article, "A Community Based High Risk Register for Hearing Loss," the author would like to acknowledge three additional individuals who made valuable contributions to the study. They are Marie Carrier, Gene Lyon, and Bobbie Robertson.

The development of allergy in high-risk children

1997 ◽  
Vol 27 (11) ◽  
pp. 1247-1253 ◽  
Author(s):  
M. L. BURR ◽  
T. G. MERRETT ◽  
F. D. J. DUNSTAN ◽  
M. J. MAGUIRE
Keyword(s):  
High Risk ◽  
High Risk Children
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