scholarly journals Blood coagulation parameters in pregnant women with COVID-19

2021 ◽  
Vol 86 (3) ◽  
pp. 34-39
Author(s):  
D. Krenytska ◽  
A. Rachkovska ◽  
O. Savchuk ◽  
V. Karbovskiy
Keyword(s):  
Pregnant Women ◽  
Blood Clotting ◽  
Acute Inflammation ◽  
Scientific Information ◽  
Activated Partial Thromboplastin Time ◽  
Huge Number ◽  
Hemostatic System ◽  
Number Of Patients ◽  
The World ◽  
D Dimer

The CoViD-19 pandemic have been lasting since 2019 year. It is a serious threat for health care system around the world because a huge number of patients requires of intensive assistance. Firstly, SARS-CoV-2 causes damage of the respiratory system. However, researches demonstrate that CoViD-19 is the hidden enemy for our body. It causes suffering of other organs. Coagulopathy often develops in SARS-CoV-2 patients. It includes acute inflammation, hypercoagulation and violation of the integrity and functions of the endothelium. A lot of scientific information has accumulated about changed in the hemostatic system during deveploment of CoViD-19. However, clinical researches are ambiguous, but abnormal blood clotting is demonstrated in most hospitalized patients with acute CoViD-19. Our research is aimed to analyse the main parameters of the hemostatic system in the pregnant women with infection of SARS-CoV-2 and the comparison with conventionally healthy pregnant patients. We have revealed the concentration of fibrinogen is increasing by 2,1 g/L, levels of D-dimer are increased by 500 ng/mL, the prothrombic time is rising by 1,2 seconds in plasma of the CoViD-19 pregnant patients unlike by conventionally healthy pregnant patients. Changes in the duration of activated partial thromboplastin time weren`t detected in plasma of the CoViD-19 pregnant patients unlike by conventionally healthy pregnant patients. Our research could be useful for diagnostic complications of the hemostatic system in CoViD-19 patients, for detection of blood clotting disorders during early stages of development, suppression of the spread of pathological processes of the fetus in pregnant women and for creation of effective treatment

Prospective Evaluation of Hemostatic System Activation and Thrombin Potential in Healthy Pregnant Women with and without Factor V Leiden

1999 ◽  
Vol 82 (10) ◽  
pp. 1232-1236 ◽  
Author(s):  
Ansgar Weltermann ◽  
Karl Philipp ◽  
Erich Hafner ◽  
Alexandra Kaider ◽  
Eva-Maria Kittl ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Pregnant Women ◽  
Factor V Leiden ◽  
Fibrinolytic System ◽  
Factor V ◽  
Uncomplicated Pregnancy ◽  
Hemostatic System ◽  
Increased Risk ◽  
System Activation ◽  
D Dimer

SummaryNormal pregnancy is associated with alterations of the hemostatic system towards a hypercoagulable state and an increased risk of venous thromboembolism. The risk of venous thrombosis is higher in pregnant women with factor V Leiden (FVL) than in those with wildtype factor V. Routine laboratory assays are not useful to detect hypercoagulable conditions. A prospective and systematic evaluation of hemostatic system activation in women with and without FVL during an uncomplicated pregnancy employing more sensitive markers of hypercoagulability, such as prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), D-Dimer, or the endogenous thrombin potential (ETP), an indicator of the plasma’s potential to generate thrombin, has not been performed. We prospectively followed 113 pregnant women with (n = 11) and without (n = 102) FVL and measured F1+2, TAT, D-Dimer and the ETP at the 12th, 22nd and 34th gestational week as well as 3 months after delivery (baseline) in each subject. None of the women developed clinical signs of venous thromboembolism during pregnancy or postpartum. Pregnant women with and without FVL exhibited substantial activation of the coagulation and fibrinolytic system as indicated by a gradual increase of F1+2, TAT and D-Dimer throughout uncomplicated pregnancy up to levels similar to those found in acute thromboembolic events (p < 0.0001 by analysis of variance for each parameters). Levels of F1+2 and TAT were comparable between women with and without FVL, but levels of D-Dimer were significantly higher in women with FVL than in those without the mutation (p = 0.0005). The ETP remained unchanged in both women with and without FVL at all timepoints. Our data demonstrate a substantial coagulation and fibrinolytic system activation in healthy women with and without FVL during uncomplicated pregnancy. An elevated F1+2, TAT or D-Dimer level during pregnancy is not necessarily indicative for an acute thromboembolic event. The normal ETP in both women with and without FVL suggests that the capacity of the plasma to generate thrombin after in vitro activation of the clotting system is not affected by pregnancy. Higher levels of D-Dimer in women with FVL than in women with wildtype factor V at baseline as well as during pregnancy indicate increased fibrinolytic system activation in carriers of the mutation.

scholarly journals Sensorized Garments Developed for Remote Postural and Motor Rehabilitation

2015 ◽  
pp. 511-536
Author(s):  
Giovanni Saggio ◽  
Valentina Sabato ◽  
Roberto Mugavero
Keyword(s):  
Home Care ◽  
Social Workers ◽  
Medical Staff ◽  
Motor Training ◽  
Motor Rehabilitation ◽  
Huge Number ◽  
Rehabilitation Process ◽  
Self Sufficiency ◽  
Number Of Patients ◽  
The World

Every day, all around the world, millions of people request postural and/or motor rehabilitation. The rehabilitation process, also known as Tertiary Prevention, intends to be a sort of therapy to restore functionality and self-sufficiency of the patient, and regards not only millions of patients daily, but involves also a huge number of professionals in medical staffs, i.e. specialists, nurses, physiotherapists and therapists, social workers, psychologists, physiatrists. The care is given in hospitals, clinics, geriatric facilities, and with territorial home care. For the large number of patients as well as the medical staff and facilities necessary to support the appropriate postural and motor training, the monetary costs of rehabilitation is so large, it is difficult to estimate. So, every effort towards a simplification of the rehabilitation route is desirable and welcome, and this chapter covers this aspect.

scholarly journals Sensorized Garments Developed for Remote Postural and Motor Rehabilitation

2013 ◽  
pp. 265-289
Author(s):  
Giovanni Saggio ◽  
Valentina Sabato ◽  
Roberto Mugavero
Keyword(s):  
Home Care ◽  
Social Workers ◽  
Medical Staff ◽  
Motor Training ◽  
Motor Rehabilitation ◽  
Huge Number ◽  
Rehabilitation Process ◽  
Self Sufficiency ◽  
Number Of Patients ◽  
The World

Every day, all around the world, millions of people request postural and/or motor rehabilitation. The rehabilitation process, also known as Tertiary Prevention, intends to be a sort of therapy to restore functionality and self-sufficiency of the patient, and regards not only millions of patients daily, but involves also a huge number of professionals in medical staffs, i.e. specialists, nurses, physiotherapists and therapists, social workers, psychologists, physiatrists. The care is given in hospitals, clinics, geriatric facilities, and with territorial home care. For the large number of patients as well as the medical staff and facilities necessary to support the appropriate postural and motor training, the monetary costs of rehabilitation is so large, it is difficult to estimate. So, every effort towards a simplification of the rehabilitation route is desirable and welcome, and this chapter covers this aspect.

scholarly journals The Effect of Various Fractions of Hemiscorpius Lepturus Scorpion (Scorpionida: Hemiscorpiidae) Venom on Hemostatic System in Peripheral Blood of Rats in Comparison to Whole Venom

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Khataminia ◽  
Mohammad Razi Jalali ◽  
Seyedeh Missagh Jalali ◽  
Hedieh Jafari
Keyword(s):  
Activated Partial Thromboplastin Time ◽  
Male Rats ◽  
Control Group ◽  
Gel Chromatography ◽  
Hemostatic System ◽  
Significant Prolongation ◽  
Scorpion Stings ◽  
Hemiscorpius Lepturus ◽  
Sampling Times ◽  
D Dimer

Background: Hemiscorpius lepturus is the most critical scorpion in Khuzestan, Iran, responsible for the majority of deaths caused by scorpion stings. Objectives: This prospective randomized experimental study was performed from June to August 2019 to investigate the effects of various venom fractions on the hemostatic system. Methods: Lyophilized venom of H. lepturus was separated into six fractions by Sephadex G-50 gel chromatography. A total of 96 Albino male rats were treated in eight equal groups; Control: 0.5 ml normal saline (IP); Whole venom group: H. lepturus Lyophilized venom, one mg/kg, IP; F1-F6 groups: Isolated venom fraction 1-6, 0.12 mg/kg, 0.43 mg/kg, 0.08 mg/kg, 0.18 mg/kg, 0.06 mg/kg and 0.13 mg/kg, IP, respectively. Blood sampling was performed at 1, 3, and 24 hours after injection. Results: Plasma fibrinogen was significantly elevated in the whole venom group, while it was significantly decreased in F3, F5, and F6 groups compared to the control group. Prothrombin time (PT) and activated partial thromboplastin time (APTT) assessment revealed that there was a significant prolongation of both tests in whole venom and fraction 5 and 6 receiving groups while fraction 2 only caused a significant PT extension, compared to the control group. Conversely, fraction 3 and 4 resulted in PT and APTT in comparison to the control group. The concentration of FDP and D-dimer was significantly increased in whole venom and F2 group compared to the control group at all sampling times. Conclusions: It seems that H. lepturus venom has both procoagulant and anticoagulant properties which are distinct characteristics of it. Further purification and sequencing of the amino acids in the fraction of peptides can lead to a more precise identification of the mechanisms of venom-induced coagulopathies.

Screening coagulation tests in normal pregnancy

2020 ◽  
pp. 58-60
Author(s):  
S.I. Zhuk ◽  
◽  
I.V. Us ◽  
Keyword(s):  
Pregnant Women ◽  
Partial Thromboplastin Time ◽  
Fibrinogen Level ◽  
Normal Pregnancy ◽  
Activated Partial Thromboplastin Time ◽  
Control Group ◽  
Term Pregnancy ◽  
Hemostatic System ◽  
Keywords Screening ◽  
Coagulation Tests

The objective: to evaluate the performance of screening coagulation tests in normal pregnancy. Materials and methods. A study of screening coagulation tests was conducted with the participation of 124 patients with normal pregnancy in terms of 12–14, 20–22, 28–30 and 37–40 weeks of gestation. The control group consisted of 82 patients who were at the pregravid stage of pregnancy planning. Coagulation tests were determined on a HELENA 2000 coagulometer. Namely, the activated partial thromboplastin time, the percentage of prothrombin by Quick and fibrinogen were examined. Results. During normal pregnancy, a dynamic, statistically significant increase in plasma fibrinogen level was determined. This indicator during full-term pregnancy differed from that of non-pregnant women by 1.8 times. During all normal pregnancies, there was no statistically significant dynamics of the activated partial thromboplastin time and the percentage of prothrombin by Quick, but there was a tendency towards these indicators increase in coagulation potential with an increase in the gestation term. Conclusion. When assessing a screening coagulation tests, pregnancy term should be taken into account first of all, rather than comparing the obtained values with reference indices for non-pregnant women. Keywords: screening coagulation tests, hemostatic system, fibrinogen level, prothrombin percentage by Quick, activated partial thromboplastin time.

Coronavirus diseases and pregnancy: COVID-19,SARS, and MERS

2020 ◽  
pp. 276-289
Author(s):  
Mobina Fathi ◽  
Kimia Vakili ◽  
Niloofar Deravi
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Retardation ◽  
Negative Impact ◽  
World Health ◽  
Wuhan City ◽  
Intrauterine Growth ◽  
Exponential Increase ◽  
The World ◽  
Health Organization ◽  
Respiratory Droplets

Around the end of December 2019, a new beta-coronavirus from Wuhan City, Hubei Province, China began to spread rapidly. The new virus, called SARS-CoV-2, which could be transmitted through respiratory droplets, had a range of mild to severe symptoms, from simple cold in some cases to death in others. The disease caused by SARS-CoV-2 was named COVID-19 by WHO and has so far killed more people than SARS and MERS. Following the widespread global outbreak of COVID-19, with more than 132758 confirmed cases and 4955 deaths worldwide, the World Health Organization declared COVID-19 a pandemic disease in January 2020. Earlier studies on viral pneumonia epidemics has shown that pregnant women are at greater risk than others. During pregnancy, the pregnant woman is more prone to infectious diseases. Research on both SARS-CoV and MERS-CoV, which are pathologically similar to SARS-CoV-2, has shown that being infected with these viruses during pregnancy increases the risk of maternal death, stillbirth, intrauterine growth retardation and, preterm delivery. With the exponential increase in cases of COVID-19 throughout the world, there is a need to understand the effects of SARS-CoV-2 on the health of pregnant women, through extrapolation of earlier studies that have been conducted on pregnant women infected with SARS-CoV, and MERS-CoV. There is an urgent need to understand the chance of vertical transmission of SARS-CoV-2 from mother to fetus and the possibility of the virus crossing the placental barrier. Additionally, since some viral diseases and antiviral drugs may have a negative impact on the mother and fetus, in which case, pregnant women need special attention for the prevention, diagnosis, and treatment of COVID-19.

HIPEREMESIS GRAVIDARUM PADA IBU HAMIL DI KLINIK BIDAN SUPRIYATI SRIBIT BERBAH SLEMAN

2019 ◽  
Vol 14 (1) ◽  
pp. 51
Author(s):  
Pramukti Dian Setianingrum ◽  
Farah Irmania Tsani
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Unwanted Pregnancy ◽  
The Body ◽  
Nausea And Vomiting ◽  
Daily Activities ◽  
World Health ◽  
The World

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

COGNITIVE DEFICIENCY AT ISCHEMIC OM STROKE

2020 ◽  
Vol 1 (1) ◽  
pp. 55-57
Author(s):  
Dildora Khaydarova ◽  
◽  
Hilola Davronova ◽  
Asliddin Akbarov ◽  
Keyword(s):  
Social Problems ◽  
Cerebrovascular Diseases ◽  
Cerebral Stroke ◽  
Number Of Patients ◽  
High Prevalence ◽  
The World ◽  
Cognitive Deficiency ◽  
Complications And Mortality

Cerebrovascular diseases remain one of the most pressing medical and social problems in many countries of the world, due to their high prevalence, severity of complications and mortality. In Uzbekistan, the number of patients with cerebral stroke is quite large -about 40-45 thousandcases of cerebral stroke are registered annually

Identifying the Predictors of Self-Management Behaviors in Patients with Diabetes Based on Ecological Approach: A Systematic Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Mahnaz Davari ◽  
Hamed Rezakhani Moghaddam ◽  
Aghil Habibi Soola
Keyword(s):  
Scientific Information ◽  
The Self ◽  
Self Management ◽  
Ecological Approach ◽  
Selection Strategy ◽  
Diabetic Patients ◽  
Personal Factors ◽  
Management Interventions ◽  
Number Of Patients ◽  
Management Behaviors

Background: Recognizing and promoting the factors that affect the self-management behaviors of diabetes leads to a reduction in the number of patients and an improvement in the quality of care. The ecological approach focuses on the nature of people's interactions with their physical and socio-cultural environments. Objective: The purpose of this study was to identify the predictors of self-management behaviors with a comprehensive approach in these patients. Methods: The Keywords were investigated in the relevant national and international databases, including PubMed, Google Scholar, Science Direct, Scopus, and Scientific Information Database, Magiran, and Iran Medex to obtain the articles published from 2009 to 2019. The search and article selection strategy was developed based on the Prisma checklist and was carried out in three steps. Results: Most studies have shown that personal factors had the highest prediction power for the self-management of diabetes. Then, the interpersonal factors, society and policy-making factors, and group and organization factors were most frequently reported predictors of self-management behaviors in diabetic patients. Conclusion: Self-management of diabetes is necessary for controlling it because 95% of care is done by the patient. When designing self-management interventions, factors based on the individual level that increasing self-management behaviors should be taken into account.

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