scholarly journals Features of cellular and humoral immunity athletes Khanty-Ugra

2016 ◽  
Vol 12 (1) ◽  
pp. 201-203
Author(s):  
Maksim V Stogov ◽  
Natalya D Nenenko
Keyword(s):  
Physical Activity ◽  
Humoral Immunity ◽  
Immune Status ◽  
Adaptive Immune Response ◽  
Climatic Conditions ◽  
Adaptive Immune ◽  
Sport Activities ◽  
Cellular And Humoral Immunity ◽  
Different Levels ◽  
Status Of Women

The study found some features of the immune status of women with different levels of physical activity, living in climatic conditions of Khanty-Ugra, regarding the reference values. Marked changes in cellular and humoral immunity can be regarded as a manifestation of the adaptive immune response to ecological conditions of the region. Sport activities help to maintain and improve the adaptability of the female body to the climate-geographical conditions of Khanty-Ugra.

scholarly journals Glycosylation is a key in SARS-CoV-2 infection

2021 ◽  
Author(s):  
Celso A. Reis ◽  
Rudolf Tauber ◽  
Véronique Blanchard
Keyword(s):  
Adaptive Immune Response ◽  
Protective Role ◽  
Host Cells ◽  
Target Cells ◽  
Receptor Binding Domain ◽  
Serological Testing ◽  
Virus Binding ◽  
Adaptive Immune ◽  
Cytokine Cascade ◽  
Different Levels

AbstractSARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing.

scholarly journals Features of the immune status of athletes of various specializations, living and practicing in the conditions of Khanty-Mansiysk Autonomus Area - Yugra

2015 ◽  
Vol 11 (1) ◽  
pp. 83-85
Author(s):  
D Nenenko Natalya
Keyword(s):  
Motor Activity ◽  
Humoral Immunity ◽  
Immune Status ◽  
Elite Athletes ◽  
Different Levels

The study found differences in the immune status of individuals with different levels of motor activity living in Khanty-Mansiysk Autonomus Area - Yugra. Athletes of various specializations differed expressed suppression of humoral immunity. This fact may be the reason for the failure of adaptation and the increasing incidence of elite athletes.

scholarly journals Features of a functional state of girls with different levels of physical activity, living in the Khanty-Ugra

2016 ◽  
Vol 12 (1) ◽  
pp. 189-191
Author(s):  
Roman V Kuchin ◽  
Tatyana A Maksimova
Keyword(s):  
Physical Activity ◽  
Functional Status ◽  
Functional State ◽  
Climatic Conditions ◽  
Physiological Parameters ◽  
Favorable Effect ◽  
Cardiorespiratory System ◽  
Cross Country Skiing ◽  
Cross Country ◽  
Different Levels

The study found some features of physiological parameters in girls with different levels of physical activity, born and living in Khanty-Ugra. The study found an increase in the adaptive reserves of the organism athletes. Thus, cross-country skiing and volleyball have a favorable effect on the functional status of the cardiorespiratory system in extreme climatic conditions Khanty-Ugra.

scholarly journals Parameters of homocystein and features of the immune status in persons working in the chemical industry

2006 ◽  
Vol 5 (4) ◽  
pp. 52-56
Author(s):  
T. T. Radzivil ◽  
I. V. Krat ◽  
I. V. Oradovskaya
Keyword(s):  
Risk Factor ◽  
Immune System ◽  
Humoral Immunity ◽  
Chemical Industry ◽  
Independent Risk Factor ◽  
Immune Status ◽  
Cellular And Humoral Immunity ◽  
Increased Activity

The indices of the immune status and homocystein in persons working in the chemical industry are studied. As a result, the laboratory indications of activation of the immune system are revealed, as well as the increased activity of cellular and humoral immunity. Moderate homocysteinemia is found among men aging of 56—65 with an idiopathic hypertensia. Homocystein appears to be an independent risk factor of coronary, cerebral and peripheral vessels diseases.

scholarly journals Features of immune status in athletes specializing in rowing and handball

2015 ◽  
Vol 22 (1) ◽  
pp. 65-67
Author(s):  
V. S. Vasilenko ◽  
N. D. Mamiev
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Immune Status ◽  
Relative Number ◽  
Lymphocyte Apoptosis ◽  
Cellular And Humoral Immunity ◽  
Immunoglobulin Levels ◽  
Over Time

The work is perfromed at the department of the hospital therapy GPMU, laboratory of llergiology and immunology of the research-practical Center of Dental faculty of SpbGMU named after I. Р. Pavlov. State of cellular and humoral immunity at the beginning and at the end of the training year of 15-17 years old young sportsmen of the first level and candidates masters of sports involved in an academic rowing and handball was studied. The athletes of both groups showed significant improvements as compared to the persons not involved in sports, lymphocyte apoptosis inducers (CD95+), the natural killer cells (CD16 + ) and B-lymphocytes (CD20 + ). Over time, in the athletes, regardless the sport, unidirectional changes are detected, encompassing the enhancing of the relative number of CD25+ with receptors for IL2, and immunoglobulin levels.

scholarly journals Peculiarities of cellular and humoral immunity in 3–12 months old infants with atopic dermatitis

2020 ◽  
Vol 10 (6) ◽  
pp. 35-44
Author(s):  
Elena A. Dementieva ◽  
Olga P. Gurina ◽  
Aleksandr E. Blinov ◽  
Olga N. Varlamova ◽  
Georgiy A. Blinov ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Lymphocytes ◽  
Humoral Immunity ◽  
Immune Status ◽  
Strong Negative Correlation ◽  
Age Related ◽  
Group 3 ◽  
Group 2 ◽  
Cellular And Humoral Immunity ◽  
Group 1

The increasing frequency and severity of allergopathology in childhood dictate the need to deepen theoretical knowledge about the pathogenesis of immune reactions in allergies. The aim of the work is to analyze the indicators of cellular and humoral immunity in children of the first year of life suffering from atopic dermatitis. Materials and methods. 61 children were examined. Three groups were formed: group 1 children aged 35 months (30 children), group 2 69 months (19 children), group 3 1012 months (22 children). The study of the immune status was carried out by immunological tests of the first level. Immunophenotyping of lymphocytes-by flow cytometry. Results. The subpopulation composition of lymphocytes revealed some age-related features: children of group 1 are characterized by the development of T-lymphocytopenia, group 2 B- and T-cell lymphocytopenia, group 3 B-lymphocytopenia. In all age groups, there is a decrease in the content of activated NK-lymphocytes, HLA-DR+ T-lymphocytes, and an increase in -T-lymphocytes. Decrease in the immunoregulatory index in group 1 23.3% of cases, in group 2 26.3%, in group 3 45.5%. Violation of the process of phagocytosis is noted in 22.4% of children. All examined children have hyperimmunoglobulinemia E, which is ten times higher than the age norm. In group 3, a strong negative correlation was found between the value of the immunoregulatory index and the concentration of total IgE (r = 0.6). The content of immunoglobulins A, M, G in the blood serum tends to develop of hyperimmunoglobulinemia. However, more than 40% of children older than 6 months have a deficiency in the synthesis of one or two classes of immunoglobulins. Conclusion. The detected changes in the immune status are predisposing for the development of a secondary immunodeficiency state in the future. The study of the immune status in children with atopic dermatitis is necessary for individual immunocorrection in order to increase the effectiveness of basic therapy, reduce the severity of the disease, the frequency of exacerbations.

Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old

2019 ◽  
Vol 21 (1) ◽  
pp. 7-19 ◽  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Aging ◽  
Oldest Old ◽  
Adaptive Immune Response ◽  
Effector T Cells ◽  
Immune Defense ◽  
Supporting Evidence ◽  
Therapeutic Approaches ◽  
Related Data ◽  
Adaptive Immune

Multifaceted evidence supports the hypothesis that inflammatory-immune mechanisms contribute to Alzheimer disease (AD) neuropathology and genetic association of several immune specific genes (TREM2, CR1, and CD33) suggests that maladaptive immune responses may be pivotal drivers of AD pathogenesis. We reviewed microglia-related data from postmortem AD studies and examined supporting evidence from AD animal models to answer the following questions: i) What is the temporal sequence of immune activation in AD progression and what is its impact on cognition? ii) Are there discordant, "primed", microglia responses in AD vs successful cognitive aging? iii) Does central nervous system (CNS) repair in aging depend on recruitment of the elements of cellular adaptive immune response such as effector T cells, and can the recruitment of systemic immune cells ameliorate AD neuropathology? iv) How effective are the immune-system-based therapeutic approaches currently employed for the treatment of AD?

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