scholarly journals Modern technologies for the production of vaccines against avian infectious diseases

2021 ◽  
Vol 19 (3) ◽  
pp. 241-262
Author(s):  
Andrei M. Rumyantsev ◽  
Anton V. Sidorin ◽  
Elena V. Sambuk ◽  
Marina V. Padkina
Keyword(s):  
Infectious Diseases ◽  
Dna Vaccines ◽  
Recombinant Vaccines ◽  
Virus Like Particles ◽  
Advantages And Disadvantages ◽  
Different Types ◽  
Inactivated Vaccines ◽  
Modern Technologies

Vaccination is one of the most effective and versatile ways to prevent infectious diseases. The development of modern technologies makes it possible to obtain vaccines with desired properties. The review presents data on different types of vaccines used for the prevention of infectious diseases of birds. The advantages and disadvantages of traditional attenuated and inactivated vaccines, as well as recombinant vaccines vector, subunit, based on virus-like particles and DNA vaccines are considered. Possibilities of bacterial, yeast, baculovirus and plant systems for the expression of heterologous genes for the production of recombinant vaccines are discussed.

Studies on Chemical Methods to Expose Gate/Tunnel Oxide and Identification of Gate/Tunnel Oxide Defects in Wafer Fabrication

2002 ◽  
Author(s):  
Y. N. Hua ◽  
G. B. Ang ◽  
S. Redkar ◽  
Yogaspari ◽  
Wilma Richter
Keyword(s):  
Acetic Acid ◽  
Silicon Oxide ◽  
Wafer Fabrication ◽  
Chemical Methods ◽  
Advantages And Disadvantages ◽  
Different Types ◽  
Capacitor Structure ◽  
Oxide Defects ◽  
Buffer Oxide Etchant ◽  
Etch Time

Abstract In failure analysis of wafer fabrication, currently, three different types of chemical methods including 6:6:1 (Acetic Acid/HNO3/HF), NaOH and Choline are used in removing polysilicon (poly) layer and exposing the gate/tunnel oxide underneath. However, usage is limited due to their disadvantages. For example, 6:6:1 is a relatively fast etchant, but it is difficult to control the etch time and keep the oxide layer intact. Also, while using NaOH to remove poly and expose the silicon oxide, the solution needs to be heated. It is also difficult to etch a poly layer with a WSix or a CoSix silicide using NaOH. In this paper, we will discuss these 3 etchants in terms of their advantages and disadvantages. We will then introduce a new poly etchant, called HB91. HB91 is useful for removing poly to expose the gate/tunnel oxide for identification of related defects. HB91 is actually a mixture of two chemicals namely nitric acid (HNO3) and buffer oxide etchant (BOE) in a 9:1 ratio. The experimental results show that it is highly selective in poly removal with respect to the gate/tunnel oxide and is a suitable poly etchant especially for removing polysilicon with/without WSix and CoSix in the large capacitor structure. Application results of this poly etchant (HB91) will be presented.

scholarly journals Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1072
Author(s):  
Raquel Cid ◽  
Jorge Bolívar
Keyword(s):  
Infectious Diseases ◽  
Mammalian Cells ◽  
Vaccine Development ◽  
Low Cost ◽  
Cost Effective ◽  
Insect Larvae ◽  
Subunit Vaccines ◽  
Effective Strategies ◽  
Alternative Systems ◽  
Inactivated Vaccines

To date, vaccination has become one of the most effective strategies to control and reduce infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were developed as live-attenuated or inactivated pathogens, and, although they still represent the most extended human vaccine types, they also face some issues, such as the potential to revert to a pathogenic form of live-attenuated formulations or the weaker immune response associated with inactivated vaccines. Advances in genetic engineering have enabled improvements in vaccine design and strategies, such as recombinant subunit vaccines, have emerged, expanding the number of diseases that can be prevented. Moreover, antigen display systems such as VLPs or those designed by nanotechnology have improved the efficacy of subunit vaccines. Platforms for the production of recombinant vaccines have also evolved from the first hosts, Escherichia coli and Saccharomyces cerevisiae, to insect or mammalian cells. Traditional bacterial and yeast systems have been improved by engineering and new systems based on plants or insect larvae have emerged as alternative, low-cost platforms. Vaccine development is still time-consuming and costly, and alternative systems that can offer cost-effective and faster processes are demanding to address infectious diseases that still do not have a treatment and to face possible future pandemics.

scholarly journals Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1861
Author(s):  
Armin Mooranian ◽  
Melissa Jones ◽  
Corina Mihaela Ionescu ◽  
Daniel Walker ◽  
Susbin Raj Wagle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Viable Cell ◽  
Cell Delivery ◽  
Artificial Organ ◽  
Bioartificial Pancreas ◽  
Advantages And Disadvantages ◽  
Wide Range ◽  
Bioartificial Organs ◽  
Significant Interest ◽  
Modern Technologies

The utilisation of bioartificial organs is of significant interest to many due to their versatility in treating a wide range of disorders. Microencapsulation has a potentially significant role in such organs. In order to utilise microcapsules, accurate characterisation and analysis is required to assess their properties and suitability. Bioartificial organs or transplantable microdevices must also account for immunogenic considerations, which will be discussed in detail. One of the most characterized cases is the investigation into a bioartificial pancreas, including using microencapsulation of islets or other cells, and will be the focus subject of this review. Overall, this review will discuss the traditional and modern technologies which are necessary for the characterisation of properties for transplantable microdevices or organs, summarizing analysis of the microcapsule itself, cells and finally a working organ. Furthermore, immunogenic considerations of such organs are another important aspect which is addressed within this review. The various techniques, methodologies, advantages, and disadvantages will all be discussed. Hence, the purpose of this review is providing an updated examination of all processes for the analysis of a working, biocompatible artificial organ.

Optimizing the Introduction of Wearable Sensors Into the German Armed Forces for Military Medical Applications

2021 ◽  
Author(s):  
Lorenz Scheit
Keyword(s):  
Wearable Sensors ◽  
Armed Forces ◽  
Medical Applications ◽  
Expert Interviews ◽  
German Armed Forces ◽  
Expert Interview ◽  
Different Types ◽  
Master's Thesis ◽  
Interdisciplinary Networking ◽  
Modern Technologies

ABSTRACT Introduction A wide variety of different types of wearable sensors are being developed around the world and introduced into the armed forces for military purposes. Competing states must rapidly develop ready-to-use systems that are robust, functional, valid, and practical. There appears to be potential for optimizing the successful and effective introduction of wearable sensors into the German armed forces (Bundeswehr) for military medical applications. The purpose of this study was to identify specific options for improving and optimizing the introduction of modern technologies such as wearable sensors into the structures of the German armed forces. Materials and Methods Nine stakeholders were identified who could provide a qualified statement on the introduction of wearable sensors, of which six agreed to participate in an expert interview. The six qualitative expert interviews, which were conducted for a master’s thesis at the Bundeswehr University in Hamburg, were selected on the basis of their thematic involvement and readiness for an interview and provided the basis for exploring processes that can possibly optimize the introduction of wearable sensors into modern armed forces such as the Bundeswehr. These interviews were carried out and analyzed using the Lamnek’s method. Results Six expert interviews were analyzed and the most relevant statements were summarized and presented. Thirteen options for optimization were identified and included, for example, interdisciplinary networking, optimization of information flow, and strategic weighting. Conclusions Several potential options have been identified that can optimize the introduction of wearable sensors into the German armed forces to a greater or lesser extent. Bundeswehr experts agree that above all structurally relevant improvements such as “development of data analysis standards,” “legal requirements,” “interdisciplinarity,” “acceleration of development,” and “centralization and structured cooperation” should play an important role in the implementation of wearable sensors.

Lexical-Grammatical Status and Lexicographic Presentation of Two-Component Stable Prepositional Combinations

2021 ◽  
pp. 32-51
Author(s):  
Elena V. Generalova ◽  
Keyword(s):  
Summary Table ◽  
Complex Issue ◽  
Dictionary Entry ◽  
Figurative Meaning ◽  
Advantages And Disadvantages ◽  
Unresolved Question ◽  
Two Component ◽  
Different Types ◽  
Syntactic Properties ◽  
Theoretical Issues

The aim of the article is to review the ways of dictionary presentation of stable prepositional combinations and the factors essential for their lexical-grammatical status and the type of optimal lexicographic description. The object of the study is twocomponent prepositional combinations with stable meanings and the “preposition+noun” structure. The material of the article is data of different dictionaries of Russian presenting stable prepositional combinations. In the course of the study, the following questions were answered: why the definition and interpretation of the lexical-grammatical nature of stable prepositional combinations are so difficult and ambiguous; what lexicographic interpretation these units have in dictionaries of different types; what the advantages and disadvantages of different ways of dictionary interpretation of such language material are. The following methods were used: introspective (observation, generalization, classification), systematic lexicographic description according to dictionary parameters, dictionary definition analysis. The summary table of the lexicographic presentation of stable combinations allows seeing both the unresolved question of dictionary interpretation of such units and the patterns of their interpretation depending on the type of a dictionary. As a result of the analysis the following conclusions were drawn. 1) In modern Russian there is a rather large (about 2,000 units) class of language units (prepositional combinations), the lexical-grammatical status of which is not defined, and there is no term for their definition; this class is historically formed and continues to replenish. 2) The type of dictionary presentation of stable prepositional combinations is determined by the dictionary concept, grammatical and syntactic properties, presence of figurative meaning and possibility of component variation of such combinations. 3) The unresolved theoretical issues have as a result the lexicographic discrepancy in the presentation of these language units. Extreme lexicographic solutions are a separate dictionary entry for each combination and the presentation of such units only as stable combinations in the entry of a noun (presented in academic explanatory dictionaries). 4) Taking into account only the factor of presence/absence of a gap seems to formalize the dictionary presentation of adverbs with both conjoined and split spelling, really existing in Russian, and the position of recognition of these units with independent words and their isolate presentation is not impeccable for dictionary users. 5) In the author’s opinion, the presentation of stable prepositional combinations exclusively as independent vocabules is inferior to the traditional lexicographic approach because the isolated presentation of this material breaks the semantic connections of these complex lexical units; the most complex issue is the differentiation of adverbs with split spelling and stable combinations.

Udziały jednostek samorządu terytorialnego w podatkach państwowych

Studia BAS ◽  
2021 ◽  
Vol 1 (65) ◽  
pp. 147-169
Author(s):  
Katarzyna Wójtowicz
Keyword(s):  
Fiscal Federalism ◽  
Final Section ◽  
National Income ◽  
Income Taxes ◽  
Local Revenue ◽  
Advantages And Disadvantages ◽  
Different Types ◽  
Fiscal Efficiency ◽  
Tax Sharing ◽  
Basic Features

The aim of this paper is to explore the rationale for the reform of the shares of local government units (LGUs) in national income taxes in Poland as well as to evaluate the selected proposals for changes in this area. The paper begins by outlining the definition and the basic features of tax sharing in the context of fiscal federalism. The next section provides an overview of the tax shares operating in some OECD countries. The main part of the article focuses on the key principles of the tax sharing system in Poland. The author briefly examines the fiscal efficiency of this source of local revenue in different types of Polish LGUs and the most significant dysfunctions of Polish local tax shares. The final section investigates the most important proposals for the reform of tax sharing and discusses their advantages and disadvantages.

Introduction of FECs and its Applications on Internet & Wireless Communications

2011 ◽  
Vol 403-408 ◽  
pp. 1776-1780
Author(s):  
Yan Ma ◽  
Chun Lan Ma
Keyword(s):  
Wireless Communications ◽  
Error Correction ◽  
Error Correction Coding ◽  
Advantages And Disadvantages ◽  
Coding Method ◽  
Different Types

This article focuses on FECs which is an error correction coding method and its applications in Internet and wireless communications. First, this article begins with the principles and the types of FECs. Then some typical applications n Internet and Wireless communications for each type of FECs are outlined. The next step is a comparison of the advantages and disadvantages between different types of FECs.

Using Plasmids as DNA Vaccines for Infectious Diseases

Plasmids ◽  
2015 ◽  
pp. 651-668
Author(s):  
John S. Tregoning ◽  
Ekaterina Kinnear
Keyword(s):  
Infectious Diseases ◽  
Dna Vaccines

scholarly journals Place of Transport in the Sales Policy of the Industrial Enterprise

2021 ◽  
pp. 5-11
Author(s):  
О. A Hodoskina ◽  
О. Y Moiseienkova
Keyword(s):  
Continuous Process ◽  
Industrial Enterprise ◽  
Production Structure ◽  
Functional Dependencies ◽  
Advantages And Disadvantages ◽  
Marketing Policy ◽  
Different Types ◽  
Marketing Activities ◽  
Weak Points ◽  
Mode Of Transport

Purpose. Currently, the organization of sales at the enterprise is the main and continuous process that provides the enterprise with its economic efficiency and bringing the goods to the consumer. The purpose of this work is to analyze and compare modes of transport and its role in the marketing of products by an enterprise. Methodology. To build a model for the marketing activity of an enterprise, as well as when modeling the mechanism of functioning of its organizational, economic and production structure and the place of transport in the structure of an industrial enterprise, elements of economic and mathematical modeling were used. Analysis of the data obtained allows you to choose the best method of transportation, which is extremely important to ensure that the needs of the enterprise, as well as the needs of consumers, are met. Findings. Marketing and logistics services of the enterprise need, having studied all the advantages and disadvantages of all types of transport, to choose the most optimal mode of transport when transporting goods. For the sale of its products, the enterprise should take into account that over time, the costs of different types of transport may change, and the transportation schemes should be revised. The paper compares the modes of transport and the structure of freight turnover by mode of transport (as a percentage of the total). Originality. The use of a mathematical apparatus in the construction of functional dependencies that make up a general economic and mathematical model that characterizes the organization of the marketing activities of an enterprise will allow not only to identify «weak» points, but also to adjust the marketing policy of the enterprise accordingly, relying not on abstract conclusions, but on the obtained clear dependencies. Practical value. The result is, first of all, a reduction in costs in the marketing policy of the enterprise and an increase in competitiveness, an increase in profits and maximum satisfaction of consumer requirements.

scholarly journals Investigation of a Turbogenerator Based on the Vortex Expansion Machine with a Peripheral Side Channel

2021 ◽  
Vol 8 (1) ◽  
pp. F11-F18
Author(s):  
S.M. Vaneev ◽  
V.S. Martsynkovskyy ◽  
A. Kulikov ◽  
D.V. Miroshnichenko ◽  
Ya.І. Bilyk ◽  
...  
Keyword(s):  
Electricity Generation ◽  
Experimental Studies ◽  
Geometric Parameters ◽  
Working Fluid ◽  
Advantages And Disadvantages ◽  
Lateral Channel ◽  
Different Types ◽  
Flow Part ◽  
Special Stand ◽  
Constant Improvement

The creation of energy-saving turbogenerators is an essential component of the development of small energy systems. The gradual growth of interest in distributed electricity generation necessitates the constant improvement of these units. Moreover, they implement a more environmentally friendly generation method than when using microturbine units that use fuel to carry out the work process. Nowadays, turbogenerators are created based on different types of expansion machines, which have their advantages and disadvantages, given in this article. Compared to competitors, vortex expansion machines have good prospects and the necessary potential to expand their research and produce turbogenerators. An experimental vortex expansion machine with a peripheral-lateral channel and ability to change the geometric parameters of its flowing part was created to meet these needs. Experimental studies of the machine were performed on a special stand with air as a working fluid. As a result of the tests, the data were successfully obtained and processed. They are presented in the form of tables and graphical dependencies. The nature of the influence of thermodynamic parameters and geometric parameters of the flow part on the efficiency of the vortex expansion machine and turbogenerator based on it to further improve and create new turbogenerators is clarified.

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