scholarly journals Efficiency of the combination of transdermal estrogens and a hormone-releasing intrauterine system for the correction of menopausal symptoms

2020 ◽  
Vol 69 (1) ◽  
pp. 37-44
Author(s):  
Irina N. Medvedevа ◽  
Kseniya S. Svyatchenko
Keyword(s):  
Hormonal Therapy ◽  
Biochemical Parameters ◽  
Test Group ◽  
Main Group ◽  
Menopausal Symptoms ◽  
Control Group ◽  
Two Phase ◽  
Good Tolerability ◽  
Blood Biochemical ◽  
Tablet Preparation

Hypothesis/aims of study. The aim of this study was to assess the efficiency of Mirena (levonorgestrel-releasing intrauterine system) combined with EstroGel (17-estradiol transdermal gel) being applied in the test group of peri- and postmenopausal women as menopausal hormonal therapy. Study design, materials and methods. The study involved 62 patients aged 42 to 55 years. The main group included 33 women who were prescribed Mirena in combination with EstroGel. The control group consisted of 29 women who were prescribed a combined two-phase tablet preparation containing micronized 17-estradiol as an estrogen component and dydrogesterone as a gestagen component. The condition of the patients was evaluated at the beginning of therapy and after 3, 6 and 12 months. Results. During therapy, patients in the main group decreased climacteric symptoms and improved lipid profile and blood biochemical parameters characterizing the hepatobiliary system. Patients in the control group had a comparable decrease in menopausal symptoms; however, there were changes in biochemical parameters, such as hypertriglyceridemia and a significant increase in bilirubin and transaminases, which required discontinuation of therapy. All the patients using Mirena in combination with EstroGel demonstrated good tolerability, efficiency of the therapy and no significant symptoms requiring its withdrawal. During the menopausal hormonal therapy, there were no cases of relapse of endometrial hyperplasia, growth of myomatous nodes and an increase in endometriosis prevalence. Patients in the control group during the first three months of therapy noted acyclic spotting, breast engorgement and tenderness, headaches, and exacerbation of cholelithiasis, which resulted in decreased adherence to therapy. Conclusion. The use of estrogen transdermally in combination with the intrauterine administration of levonorgestrel is an effective and safe method that helps to relieve menopausal symptoms and to improve the health and quality of life of women with extragenital pathology, endometrial and mammary gland hyperplastic processes, endometriosis, and menometrorrhagia.

Reproductive traits and blood biochemical parameters of sows when using a vitamin feed additive “LipoCar”

2020 ◽  
pp. 25-31
Author(s):  
I. A. Pushkaryev ◽  
N. M. Kostomakhin ◽  
S. V. Burtseva ◽  
N. A. Novikov
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Total Duration ◽  
Reproductive Traits ◽  
Feed Additive ◽  
Control Group ◽  
Large White ◽  
Basic Diet ◽  
Blood Biochemical ◽  
Experimental Group

The reproductive traits of sows are of paramount importance in the production of high-quality pork. The world experience of pig farming shows the need to solve first of all the feed problem. Diets unbalanced in the content of vitamins restrain the manifestation of genetically inherent high prolificacy of sows. The purpose of the research was to study the influence of feeding the vitamin feed additive “LipoCar” on the reproductive traits of sows and the biochemical parameters of blood serum. The results of research on the introduction of vitamin feed additive “LipoCar” into the diet of pregnant sows have been presented in the article. The experiment has been carried out in the production conditions in JSC “Linevsky pedigree farm” on sows of Large White breed. Pregnant sows have received a basic diet, balanced for all the normalized elements of nutrition. Sows of the experimental group in the composition of the basic diet fed the feed additive “LipoCar”. The dosage of the drug “Lipocar” was 2,1 g/head/day. “Lipocar” has been fed for 20 days. The total duration of the experiment was 3 months. When introducing the vitamin feed additive “LipoCar” into the main diet of sows in the second half of pregnancy the increase in the number of piglets in the litter by 1,6-6,8 % and the weight of the litter – by 5,6-56,2 % (P ≤ 0,001) have been revealed in comparison with the control group of animals. There was a higher content of carotene in the blood serum of sows of the experimental group by 50,0 % (P ≤ 0,01), vitamin A - by 48,7 % (P ≤ 0,05), and total protein – by 4,9 % (P ≤ 0,05).

scholarly journals Features of the second half of pregnancy in women with labor abnormalities

2021 ◽  
Vol 14 (6) ◽  
pp. 659-665
Author(s):  
U. G. Shokirova ◽  
S. P. Pakhomov ◽  
A. S. Ustyuzhina ◽  
A. V. Matrosova
Keyword(s):  
Laboratory Data ◽  
International Normalized Ratio ◽  
Study Data ◽  
Main Group ◽  
Individual Risk ◽  
Control Group ◽  
Systematic Analysis ◽  
Laboratory Parameters ◽  
Blood Biochemical ◽  
Labor Abnormalities

Aim: conduct a systematic analysis of pregnancy development, investigate clinical and laboratory data affecting development of labor abnormalities in women residing in the Belgorod region. Materials and Methods. From 2014 to 2018, 484 women were examined and divided into 2 groups: main group consisted of those who had childbirth complicated with labor abnormalities (n = 344), whereas control group consisted of women lacking complications during delivery (n = 140). The following methods were used in the study: questionnaires, general clinical methods, biochemical blood tests in pregnant and postpartum women, populational statistics as well as methods of standard and multivariate statistics. Results. In the second half of pregnancy in women with labor abnormalities revealed higher rate of moderate preeclampsia (34.30 ± 2.56 % vs. 10.71 ± 2.61%; p < 0.05), polyhydramnios (11.34 ± 1.71 % vs. 5.71 ± 1.96 %; p < 0.05), chronic intrauterine hypoxia (29.6 ± 2.46 % vs. 12.86 ± 2.83 %; p < 0.05), chronic utero-placental insufficiency (60.47 ± 2.64 % vs. 20.00 ± 3.38 %; p < 0.05), sexually transmitted infections (3.78 ± 1.03 % vs. 0.71 ± 0.71 %; p < 0.05), acute respiratory viral infection (8.72 ± 1.52 % vs. 3.57 ± 1.57 %; p < 0.05) as well as a combination of several types of pathology (8.72 ± 1.52 % vs. 13.57 ± 2.89 %; p < 0.05). Laboratory parameters in women with labor abnormalities compared with control antepartum group were noted to have significantly decreased count of red blood cells (3.89 ± 0.38×1012/L vs. 3.99 ± 0.40×1012/L; p = 0.006), eosinophils (0.95 ± 0.69×109/L vs. 1.20 ± 0.67×109/L; p = 0.026) and platelets (226.29 ± 62.71×109/L vs. 245.44 ± 60.32×109/L; p = 0.0003). Blood biochemical parameters in women with labor abnormalities vs. control group were featured with significantly decreased level of bilirubin (6.76 ± 3.16 μmol/L vs. 9.88 ± 3.60 μmol/L; p < 0.05) and alanine aminotransferase (13.94 ± 10.08 U/L vs. 19.41 ± 14.40 U/L; p = 0.004). Analyzing coagulation parameters in the main group showed significantly reduced fibrinogen level (4.30 ± 1.00 g/L) compared with control group (4.71 ± 1.14 g/L; p < 0.05) as well as elevated international normalized ratio (1.07 ± 0.11 vs. 1.03 ± 0.10; p = 0.001). Conclusion. Our study data found that pregnant women with labor abnormalities had altered clinical and laboratory parameters observed as early as in the second half of gestation, which may be used to calculate an individual risk of such labor complication.

scholarly journals Effect Of Arginine On The Some Blood And Biochemical Parameters For Local Goat Females.

2019 ◽  
Vol 12 (1) ◽  
pp. 24-36
Author(s):  
A Ahmed ◽  
T Mohammed
Keyword(s):  
Amino Acid ◽  
Biochemical Parameters ◽  
Protein Concentration ◽  
White Blood Cells ◽  
Biochemical Properties ◽  
Control Group ◽  
Blood Samples ◽  
Blood Biochemical ◽  
T1 And T2 ◽  
Different Doses

This study was conducted in one of the private sector fields in Anbar province - Hit city - Albasaer village (70 km west of the Ramadi city,), for the period from 28/6/2018 to 1/9/2018. Twenty one local female goats aged between 2-4 years and weighing between 24.5 to 36.5 kg were used, Which have previous one birth or more. All female goats were tested using ultrasound to make sure they were not pregnant before the experiment began. Females were randomly divided into three equal groups (7 goats in each group).Vaginal sponges (60 mg MAP) were injected into the three groups at the same time. The first group T1 was injected intramuscularly with the amino acid, arginine (US Nevada manufacturing) in the muscles at 200μmol.kg Five days before the sponge was pulled out until the 17 day after the sponge was pulled out, While the second group T2 was injected with amino acid (arginine) at 160 μmol.kg. Five days before the sponge was pulled until the 17th day after that. The third group T3 control group was injected with 5 ml Normal Saline intramuscularly of the animal. All animals were injected three times daily from the eighth day after the sponge was placed (five days before removing of the sponge) until 17 days after the removing of sponge. Where the total number of injection days was 22 days. Blood samples were taken from the jugular vein before injection of the arginine on day 7 and day 12 of the sponge placed either after the sponge pulled the blood samples were taken on the days 2, 3, 4, 6, 9, 13, 18, respectively of the experiment After sponges removing. The objective of the study was to measure changes in the blood, biochemical parameters, during arginine treatment. The results of this study showed significant differences. T1 and T2 group were superior compared to control group in blood properties which include PCV in periods 2, 5, the number of white blood cells in periods 2, 3, 4, 5, 6, 9, MID in periods 3, 9 and Lymphocytes in periods 4, 5, 6, 9, While the neutrophil cells the period of 3. In terms of biochemical properties, the results showed a significant differences, between the treatments of T1 and T2 were superior compared to control treatments in the total protein concentration in period 6, and the globulin in period 6. We conclude that the use of different doses of arginine can improve the health status of female goats.

scholarly journals Investigation of Health Hazards in Vehicle Refueling Stations Attendants at Malakand, Khyber Pakhtunkhwa, Pakistan

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Imran Khan ◽  
Saleem Ur Rahman ◽  
Muhammad Ilyas ◽  
Ayaz Ali Khan
Keyword(s):  
Biochemical Parameters ◽  
Blood Parameters ◽  
Control Group ◽  
Blood Biochemical Parameters ◽  
Khyber Pakhtunkhwa ◽  
Blood Biochemical ◽  
Large Size ◽  
Routine Work ◽  
Size Population ◽  
And Control

Vehicles refueling station workers are a class of labors prone to long term petroleum product toxicity due to their routine work at vehicles refueling stations. Health problems posed by the pollutants at the work environment of an individual are closely linked to the nature and level of exposure to these hazardous chemicals. The adverse effect of the toxicants in such environment is a common phenomenon in all the developing countries. The awareness about this problem is lacking in Pakistan, particularly in Khyber Pakhtunkhwa. In present study, blood biochemical parameters like calcium, cholesterol, glucose, magnesium, potassium, phosphorus and triglyceride levels were determined among workers and control individuals. The results of the workers showed an increase in glucose, cholesterol and phosphorus level; while significant decrease was observed in calcium and potassium level as compared to the control group of individuals. While the level of magnesium and triglyceride level was same in both groups. In comparative picture, the blood biochemical parameters were normal in control as that of workers. Further study may be conducted to investigate the effect of such environment on other blood parameters and large size population may be included in the study.

Biodistribution and Toxicity Study of Titanium Dioxide Nanoparticles of Different Sizes after Intravenous Injection in Mice

2014 ◽  
Vol 998-999 ◽  
pp. 196-199
Author(s):  
Jie Fang ◽  
Lu Lu Yuan ◽  
Chen Jie Yao ◽  
Yan Li Wang ◽  
Ming Hong Wu
Keyword(s):  
Titanium Dioxide ◽  
Biochemical Parameters ◽  
Titanium Dioxide Nanoparticles ◽  
Control Group ◽  
Quantitative Distribution ◽  
Blood Biochemical ◽  
Long Time ◽  
Liver And Kidney ◽  
Kidney Functions

Titanium dioxide nanoparticles (TiO2-NPs) are widely used in many fields. The bio-distribution and toxicology of different sizes (25 nm and 50 nm) of TiO2-NPsin vivois evaluated in this paper. The results of quantitative distributionin vivoshow that it is difficult for TiO2-NPs to excretion clearly from tissues and organs. At the endpoint of experiment of different groups, there are still many TiO2-NPs located in the main organs such as spleen, liver and lung after 120 days. Blood biochemical parameters keep unchanged compared with control group. However, pathological results show that lesions in spleen, liver and lung where TiO2-NPs particles are mainly accumulated and retained are getting serious with the time prolonging. The results indicate that TiO2-NPs are low toxic to mice but may have some potential effects on liver and kidney functions after exposure long time. The fundamental importance information gained from such a study will give the guidance on the application of TiO2-NPs.

scholarly journals Performance, Biochemical Profile and Antioxidant Activity of Hens Supplemented with Addition of Milk Thistle (Silybum marianum) Seed Cakes in Diet

2019 ◽  
Vol 67 (4) ◽  
pp. 993-1003 ◽  
Author(s):  
Ondřej Šťastník ◽  
Eva Mrkvicová ◽  
Leoš Pavlata ◽  
Andrea Roztočilová ◽  
Barbora Umlášková ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biochemical Parameters ◽  
Laying Hens ◽  
Control Group ◽  
Egg Mass ◽  
Milk Thistle ◽  
Feed Mixture ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Experimental Group

The aim of this study was to evaluate the effect of milk thistle seed cakes addition in laying hens diet to performance, blood biochemical parameters and antioxidant activity. A total of 30 Bovans Brown hens were included to the experiment. The trial was performed from the age of 69 weeks to 80 weeks of hens age. The experimental group received feed mixture containing 7% milk thistle seed cakes. Control group received feed mixture without milk thistle seed cakes. After the 69th week of age, the laying hens in the experimental group reached a higher number of eggs and produced more egg mass compared to the control group. In the evaluation of the egg quality parameters, higher Haugh units, a higher millimeter height of the egg and thinner eggshell in the group receiving 7% of the seed cakes were found. When evaluating health indicators, higher antioxidant activity was found in the experimental group. Blood biochemical parameters was without any differences.

scholarly journals Effect of L-glutamic acid on some biochemical parameters of rat blood under the action of sodium nitrite

2016 ◽  
Vol 20 (1) ◽  
pp. 74-77
Author(s):  
N. Salyha ◽  
R. Iskra
Keyword(s):  
Antioxidant Enzymes ◽  
Glutamic Acid ◽  
Sodium Nitrite ◽  
Biochemical Parameters ◽  
Control Group ◽  
Glucose Content ◽  
Rat Blood ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Different Doses

The effect of different doses of L-glutamic acid on activity of antioxidant enzymes and some blood biochemical parameters in rats under the influence of sodium nitrite was studied. It was shown that administration of sodium nitrite leads to decreased activity of antioxidant enzymes and and hemoglobin and glucose content in the blood of animals.It was established, that changes of studied parameters were less expressed in rats administered of L-glutamic acid compared to the control group of animals.

scholarly journals Effect Of Arginine On The Some Blood And Biochemical Parameters For Local Goat Females.

2019 ◽  
Vol 12 (1) ◽  
pp. 24-36
Author(s):  
A Ahmed ◽  
T Mohammed
Keyword(s):  
Amino Acid ◽  
Biochemical Parameters ◽  
Protein Concentration ◽  
White Blood Cells ◽  
Biochemical Properties ◽  
Control Group ◽  
Blood Samples ◽  
Blood Biochemical ◽  
T1 And T2 ◽  
Different Doses

This study was conducted in one of the private sector fields in Anbar province - Hit city - Albasaer village (70 km west of the Ramadi city,), for the period from 28/6/2018 to 1/9/2018. Twenty one local female goats aged between 2-4 years and weighing between 24.5 to 36.5 kg were used, Which have previous one birth or more. All female goats were tested using ultrasound to make sure they were not pregnant before the experiment began. Females were randomly divided into three equal groups (7 goats in each group).Vaginal sponges (60 mg MAP) were injected into the three groups at the same time. The first group T1 was injected intramuscularly with the amino acid, arginine (US Nevada manufacturing) in the muscles at 200μmol.kg Five days before the sponge was pulled out until the 17 day after the sponge was pulled out, While the second group T2 was injected with amino acid (arginine) at 160 μmol.kg. Five days before the sponge was pulled until the 17th day after that. The third group T3 control group was injected with 5 ml Normal Saline intramuscularly of the animal. All animals were injected three times daily from the eighth day after the sponge was placed (five days before removing of the sponge) until 17 days after the removing of sponge. Where the total number of injection days was 22 days. Blood samples were taken from the jugular vein before injection of the arginine on day 7 and day 12 of the sponge placed either after the sponge pulled the blood samples were taken on the days 2, 3, 4, 6, 9, 13, 18, respectively of the experiment After sponges removing. The objective of the study was to measure changes in the blood, biochemical parameters, during arginine treatment. The results of this study showed asignificant differences. T1 and T2 group were superior compared to control group in blood properties which include pcv in periods 2, 5, the number of white blood cells in periods 2, 3, 4, 5, 6, 9, MID in periods 3, 9 and Lymphocytes in aperiods 4, 5, 6, 9, While the neutrophil cells the period of 3. In terms of biochemical properties, the results showed asignificant differences, between the treatments of T1 and T2 were superior compared to control treatments in the total protein concentration in period 6, and the globulin in period 6. We conclude that the use of different doses of arginine can improve the health status of female goats.

Interpretation of cows blood biochemical parameters on rations with the inclusion of corn grain

2021 ◽  
pp. 3-12
Author(s):  
K. V. Kireeva ◽  
N. M. Kostomakhin ◽  
I. A. Pushkaryev ◽  
T. V. Kureninova
Keyword(s):  
Milk Yield ◽  
Biochemical Parameters ◽  
The Body ◽  
Control Group ◽  
Physiological Status ◽  
Lactating Cows ◽  
Blood Biochemical ◽  
Group 5 ◽  
Experimental Group ◽  
Corn Grain

Primary changes in the physiological status of animals can be traced in the deviation from the norm of indicators of a number of substances in biological fl uids, since biochemical indicators are a kind of indicator of processes occurring in the body. Having knowledge of hematological changes in the body of cattle, managers and specialists of livestock farms can manage the productivity and health of highly productive animals. The purpose of the research was to determine and analyze the biochemical parameters of the blood of cows in the dry period and at the increasing the milk yield when wet crushed corn grain was introduced into their ration. The research has been carried out on cows of Black-and-White breed in LLC “Agrofi rma “Urozhai” in the Zonal district in the Altai Territory. During the research the prevalence of productivity indicators of cows of the experimental group over analogues from the control group was proved. Thus average daily milk yield for the accounting period (60 days) it was 30,9 kg, which was 5,2 kg more than the control herdmates (P > 0,95). The total productivity of one head was 1541,57 kg of milk in the control group and 1854,69 kg in the experimental group, which was 313,12 kg more (P > 0,95). It has been found that most of the studied biochemical parameters corresponded to the physiological norm. The exception was the increased content of total protein in the blood of lactating cows of the experimental group 5 g/l above the upper limit of the norm (P > 0,999). A low albumin content in the blood of animals of the experimental group has been noted, and this indicator was signifi cantly lower than that in the control group by 3,45 g/l (P > 0,99). An excess of the physiological norm of globulin in the blood of animals of both groups has been found, the indicators of the experimental group signifi cantly exceeded the control group by 9,5 g/l (P > 0,99). There was a low level of chlorides after the increasing the milk yield 88,1 mmol/l in the control group and 89,2 mmol/l in the experimental group, then excess of manganese after the increasing the milk yield was 4,50 mmol/l in the control group and 8,14 mmol/l in the experimental group, which could be associated with the increased content of this element in feed and soil.

scholarly journals The influence of probiotic additives or multienzyme composition on blood biochemical parameters and milk quality of Lithuanian Black-and-White cattle

2018 ◽  
Vol 70 (3) ◽  
pp. 939-945 ◽  
Author(s):  
J. Dailidavičienė ◽  
R. Budreckienė ◽  
R. Gružauskas ◽  
S. Kerzienė ◽  
V. Andrulevičiūtė ◽  
...  
Keyword(s):  
Milk Yield ◽  
Milk Fat ◽  
Biochemical Parameters ◽  
Control Group ◽  
Blood Biochemical Parameters ◽  
Black And White ◽  
Organic Selenium ◽  
Blood Biochemical ◽  
Group A ◽  
Live Yeast

ABSTRACT The aim of the study was to determine the effect of Saccharomyces cerevisiae, multienzyme composition supplementation on milk yield, quality, blood biochemical parameters of Lithuanian-Black-and-White cows. For this reason 28 cows were divided into four groups (three experimental and one control) each with seven cows fed balanced ration (control group) and following experimental groups: addition of 40g supplement of live yeast with organic selenium (group A); 40g supplement of live yeast with aromatic additives (group B); and 0.2g supplement of multienzyme composition (group C) during a 90 days period. The study showed that milk yield was 2.64%, 1.75%, 1.4% higher in groups A, B, C respectively, comparing with the control group. The milk SCC in experimental groups were lower comparing to the control group. The percentage of milk fat was significantly higher in group A - 0.33%, B - 0.31% and C - 0.16% comparing with the control group. All used additives ensure positive dynamics of investigated biochemical parameters in cattle blood. The results indicated that probiotic additives and multienzyme composition supplementation to dairy cows increased cows productivity and milk fat as well. Probiotic additives supplementation decreased SCC values in milk.

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