scholarly journals Perioperative serum cortisol levels at different operative accesses to femoral segment arteries

2012 ◽  
Vol 93 (5) ◽  
pp. 717-720
Author(s):  
A V Maximov ◽  
A K Feiskhanov ◽  
M V Plotnikov ◽  
E V Begicheva ◽  
E V Tuisheva
Keyword(s):  
Cortisol Level ◽  
Vital Capacity ◽  
Serum Cortisol ◽  
Group Iv ◽  
Serum Cortisol Level ◽  
Surgical Trauma ◽  
Group I ◽  
Reconstructive Operations ◽  
Cortisol Levels ◽  
The Difference

Aim. To compare invasiveness of reconstructive operations on arteries of aortofemoral segment using different accesses to surgical site. Methods. The analysis of the post-operative period was carried out in 40 patients who underwent aortofemoral bifurcation bypass surgery. Patients were assigned to 4 groups, each containing 10 patients. In group I surgeries were performed using mini-access of 5-7 cm, group II - mini-laparotomic access of 8-12 cm, group III - retroperitoneal mini-access, group IV - standard laparotomy. For invasiveness objectification, serum cortisol levels, forced lungs vital capacity and postoperative pain levels were measured. Results. All surgeries were performed as planned without inoperative complications. No deaths were registered. After mini-access surgeries intestinal peristalsis was defined by auscultation as soon as on 18-24 hour after the operation. Prolonged (more than 3 days) post-operative ileus was diagnosed in 3 patients, all operated using standard laparotomy. Serum cortisol level was typically elevated at the end of the surgery, but the difference was only statistically significant in patients from the group IV compared to baseline level as well as to patients with mini-access surgeries. Serum cortisol level reduced to normal at the second 24-hours after the surgery. Patients in which standard laparotomy was used reported more intense pain at the second day. Forced lungs vital capacity at day 4 was significantly reduced in patients of groups I, III and IV, with the significantly worse reduction in patients who overcame standard laparotomy compared to others. Conclusion. Mini-access reconstructive surgeries on aortofemoral segment arteries provide significant reduction of surgical trauma, which is proved by objective measurements.

scholarly journals Effects of Surgical Stress on Serum Cortisol Level: A Comparative Study between Elective and Emergency Surgery

1970 ◽  
Vol 2 ◽  
pp. 28-33
Author(s):  
SM Selimuzzaman ◽  
Noorzahan Begum ◽  
Nadira Islam ◽  
Shelina Begum
Keyword(s):  
Surgical Treatment ◽  
Cortisol Level ◽  
Surgical Stress ◽  
Serum Cortisol ◽  
Study Groups ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Surgical Interventions ◽  
Group I ◽  
Healthy Control

The study was designed to observe the effects of surgical stress on serum level of cortisol in patients undergoing surgical treatment and to find out any differences in hormonal response between elective and emergency surgical procedures. A total number of 60 male subjects aged between 18 and 45 years were included in the study. Of them, 20 were healthy control (Group I), 20 underwent elective surgical treatment (Group II) and emergency surgical interventions were applied in rest 20 subjects (Group III). Study Groups were further divided into subgroups A (preoperative samples were collected 1- hour before operation), B (postoperative samples were collected 1-hour after the end of the operation) and C (postoperative samples were collected 24-hours after operation).Serum cortisol level was estimated by invitro-immunolytic test.Statistical analysis was done by paired, unpaired ‘t' test and regression analysis. The preoperative mean serum cortisol concentration in elective surgical cases was almost similar to that of healthy control. On the contrary, in the emergency surgical cases, a significantly increased mean cortisol level were observed (I vs IIIA and IIA vs IIIA; P < 0.05). The serum cortisol concentrations were increased both in elective and emergency surgical cases after operations but the magnitude of rise was more marked in emergency group of patients (IIB vs IIIB; P < 0.05). Therefore, this study reveals that surgical intervention causes increase in serum cortisol which is more marked in emergency procedure. Key Words: Stress; Cortisol; Surgery DOI:10.3329/jbsp.v2i0.981 J Bangladesh Soc Physiol. 2007 Dec;(2): 28-33.

scholarly journals Effects of Serum Cortisol Levels on Perinatal Prognosis in Patients with Hypertensive Disorder

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Gaoxiang Huo ◽  
Yeqiang Qin ◽  
Xiucui Bao ◽  
Xiaoling Yao ◽  
Zhangwei Pu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cortisol Level ◽  
Gestational Hypertension ◽  
Serum Cortisol ◽  
The Other ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Hypertensive Disorder ◽  
Cortisol Levels ◽  
Case Number

Objective: To investigate the effect of serum cortisol level on perinatal prognosis in patients with hypertensive disorder during pregnancy. Methods: In this study, different degrees of patients with hypertensive disorder during pregnancy who were admitted from August 2018 to August 2019 in our hospital were selected as the research subjects, and divided into groups according to the severity of the patients' conditions. The 120 patients were divided into gestational hypertension group, preeclampsia group and eclampsia group, with 40 cases each, and another 40 healthy pregnant women were selected. The detection of serum cortisol levels was carried out for the above 4 groups of pregnant women. Results: The serum cortisol level in the control group was (260.35 ± 10.96) nmol / L. The case number of neonatal asphyxia was 1 (2.50%), the case number of premature births was 1 (2.50%), the number of fetal growth restriction was 1 (2.50%), the number of deaths was 0, and the other three groups were higher than this. It showed as gestational hypertension <preeclampsia <eclampsia. The Apgar score of pregnant women in the control group was (9.13 ± 0.29), the ZL index was (1.07 ± 0.07), and the other three groups were lower than this. It showed as gestational hypertension> preeclampsia> eclampsia. There were significant differences between groups (all P<0.05). Conclusion: Early detection of serum cortisol levels in pregnant women is beneficial to timely improve the symptoms of gestational hypertension, thereby suppressing the effects of serum cortisol on perinatal infants and improving the prognosis of newborns.

scholarly journals Comparison of Cortisol level by Shift Cycle in Korean Firefighters

2020 ◽  
Vol 17 (13) ◽  
pp. 4760 ◽  
Author(s):  
Ga-Young Lim ◽  
Tae-Won Jang ◽  
Chang-Sun Sim ◽  
Yeon Soon Ahn ◽  
Kyoung Sook Jeong
Keyword(s):  
Circadian Rhythm ◽  
Cortisol Level ◽  
Serum Cortisol ◽  
Work Load ◽  
Urinary Cortisol ◽  
Urine Cortisol ◽  
Cortisol Levels ◽  
The Difference ◽  
Current Shift ◽  
Night Shifts

(1) Study Objectives: By investigating the change of cortisol levels during shift cycles among professional firefighters in Korea, this study aims to evaluate the difference between individuals’ stress response and the recovery of their circadian rhythm after working night shifts. (2) Methods: A total of 325 shift firefighters, who were working in 3, 6, 9, or 21 day cycles, participated in the study. Their urinary and serum cortisol levels were measured during the day (09–18), during the night (18–09), and every 24 h (09–09) per shift cycle, and adjustments were made for confounding factors. (3) Results: Serum cortisol levels were significantly increased after working during the night or for 24 h compared with that of working throughout the day. However, whether working night or 24 h shifts, the serum cortisol levels were undoubtedly different based on the 3, 6, 9, or 21 day cycles. In all shift cycles, the urinary cortisol level decreased during the night or throughout the 24 h shifts compared with sleeping during this time, but this was considered to be significantly applicable only to those working in 21 day cycles. Additionally, in serial measurements, the recovery of urinary cortisol secretion after a night or 24 h shift was successful for individuals working in 9 day cycles, but the recovery was delayed for those working in 6 or 21 day cycles. (4) Conclusions: After analyzing the urine cortisol levels, the study indicates that only subjects working in 9 day cycles fully recovered their circadian rhythm while those working in 6 day or 21 day cycles did not completely recover. Therefore, it is important to recognize how stressful night shifts can be, and it is crucial to enhance firefighters’ current shift cycles in order to allow sufficient recovery of their circadian rhythm as well as the prevention of disrupting their circadian rhythm after working at night. Further research is necessary to take into account the amount of work load, the challenges of being sleep deprived, and the individual’s capacity to overcome sleepiness.

The Impact of High Cortisol Level in Increasing Incidence of Infection Cases Among Acute Stroke Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 3079-3084
Author(s):  
Indah Ari Handaayani ◽  
Muhammad Hamdan ◽  
Paulus Sugianto ◽  
Achmad Firdaus Sani ◽  
Mohammad Saiful Ardhi ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Cortisol Level ◽  
Venous Blood ◽  
Serum Cortisol ◽  
Operational Definition ◽  
Serum Cortisol Level ◽  
Stroke Patients ◽  
Cortisol Levels ◽  
High Level ◽  
The Impact

Infection in the stroke was a treatment major problem, because it determines the prognosis. In the acute phase of stroke, high level cortisol may lead to a decreased immune system and patients tend to be more susceptible to infection. The correlation of serum cortisol level among acute stroke patients with incidence of infection was not fully investigated. The aim of this study was to determine the relationship between initial serum cortisol levels and the incidence of infection in acute stroke patients. A prospective cohort study was conducted on 32 of acute stroke patients who admitted in RSUD Dr. Soetomo Surabaya during the period December 2015 to February 2016. Total of 2 cc to the venous blood within 48 hours in onset of stroke being examined of serum cortisol. During the 7 days of hospitalization, the patient was observed for signs of infection, both clinically and the investigation in accordance with the operational definition. In the infected group there were 8 people (50%) with high cortisol levels (p = 0.015; RR 15,000; 95% IK 1.583-143,171); 6 people were (50%) using urine catheter (p = 0.049; RR 6,667; 95% IK 1.067-30.085); And 6 people were (54.5%) using NGT (p = 0,035; RR 7,200; 95% IK 1.311-39,557). In multivariate analysis obtained that Odds Ratio (OR) 15,468 based on high cortisol and OR 7,469 based on NGT usage. High cortisol levels and the use of NGT had the effect on the incidence of infection in acute stroke.

scholarly journals Continuous Etomidate Infusion for the Management of Severe Cushing Syndrome: Validation of a Standard Protocol

2018 ◽  
Vol 3 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Ty B Carroll ◽  
William J Peppard ◽  
David J Herrmann ◽  
Bradley R Javorsky ◽  
Tracy S Wang ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Cushing Syndrome ◽  
Effective Means ◽  
Case Series ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Retrospective Case ◽  
Life Threatening ◽  
Cortisol Levels ◽  
Infusion Protocol

Abstract Objective Demonstrate the safety and efficacy of a standardized intravenous etomidate infusion protocol in normalizing cortisol levels in patients with severe and life-threatening hypercortisolism. Methods A retrospective case series of seven patients representing nine episodes of severe hypercortisolism at two large academic medical centers was conducted. Patients were included in this series if they received an etomidate infusion for the treatment of severe and life-threatening hypercortisolism. The etomidate infusion was administered via a newly developed protocol designed to safely reduce cortisol levels until more long-term medical or definitive surgical therapy could be instituted. Results Seven patients representing nine episodes received etomidate treatment. In eight of nine episodes of therapy, rapid control of hypercortisolemia was achieved, generally defined as a serum cortisol level of 10 to 20 µg/dL. Patients with a median baseline cortisol of 105 µg/dL (range, 32 to 245 µg/dL) achieved a median nadir serum cortisol of 15.8 µg/dL (range, 6.9 to 27 µg/dL) after a median of 38 hours (range, 26 to 134 hours). Conclusions A standardized continuous intravenous etomidate infusion protocol is a safe and effective means of achieving a serum cortisol level of 10 to 20 µg/dL in patients with severe hypercortisolemia.

scholarly journals Critical Illness – Related Corticosteroid Insufficiency

2015 ◽  
Vol 4 (1) ◽  
pp. 59
Author(s):  
Hamdollah Karamifar ◽  
Hossein Moravej ◽  
Zohreh Karamizadeh ◽  
Gholamhossein Amirhakimi
Keyword(s):  
Critical Illness ◽  
Corticosteroid Therapy ◽  
Steroid Therapy ◽  
Cortisol Level ◽  
Pediatric Intensive Care ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Critically Ill Children ◽  
Cortisol Levels ◽  
Corticosteroid Insufficiency

In some acute critical illnesses, the function of Hypothalamus-Pituitary-Adrenal axis can be impaired. This event is called "Critical Illness-Related Corticosteroid Insufficiency" (CIRCI). We conducted a study to determine which of the CIRCI patients need steroid therapy. This study was performed on patients who were admitted in Pediatric Intensive Care Unit (PICU) in Nemazee Hospital, affiliated to Shiraz University of Medical Sciences, Iran.In first 24 hour of PICU admission, Serum cortisol levels were measured immediately before, 30 and 60 minutes after IV administration of 250 μg of synthetic adrenocorticotropic hormone (Synacthen®).Their clinical conditions and paraclinical data were followed and recorded. Twenty four patients were enrolled in the study. Twelve patients (50%) had CIRCI. CIRCI was defined as Random Serum Cortisol (RSC)<10 μg/dl or elevation of serum cortisol level after Synacthen administration below 9 µg/dl.The results of serum cortisol level usually were ready one day after blood sampling. Based on general condition, blood pressure and serum electrolyte levels, all CIRCI patients were improved when serum cortisol levels were determined. Therefore, steroid therapy was not started for them. Finally, all of the CIRCI patients improved and after a few days, all of them were discharged from the hospital with good conditions. Findings of our study showed that corticosteroid therapy is not needed as a routine treatment for CIRCI patients. This is in agreement with some other studies. but in contrast to some articles who recommended corticosteroid therapy for patients with CIRCI. There is lack of consensus about optimal approach to CIRCI in children, therefor; well-designed RCTs and systematic reviews are needed to determine proper treatment recommendations for these critically ill children before administration.

scholarly journals Determination of cortisol levels in plasma and saliva in women exposed to chronic stress

2008 ◽  
Vol 55 (3) ◽  
pp. 163-169
Author(s):  
Elena Krsljak ◽  
Katarina Gosic
Keyword(s):  
Chronic Stress ◽  
Cortisol Level ◽  
Working Hours ◽  
Serum Cortisol ◽  
Sampling Procedure ◽  
Serum Cortisol Level ◽  
Medication Therapy ◽  
Acute And Chronic Stress ◽  
Cortisol Levels

Introduction: It is known fact from the literature data that acute and chronic stress influence serum cortisol level. As with serum cortisol, the level of cortisol in saliva is also a reliable marker of stress. Material and method: this study was performed on 25 individuals, females, age 40-50 years. The participants were exposed to long term stress, held two jobs of 8 working hours, six days a weak, domestic work was not included. All of them were high educated, and none of them were on other medication therapy Aim: The Aim of this study was to evaluate possible differences in cortisol levels in stimulated and non stimulated saliva and serum and determine their association with long term stress. Results: Obtained results showed that cortisol level in saliva do not depend on saliva flow rate and increases in the afternoon period in individuals exposed to chronic stress. Correlation (r) between salivary cortisol and plasma cortisol is r= 0.91. Non-invasive sampling procedure suggests that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.

scholarly journals Study of serum cortisol levels in complicated and uncomplicated Plasmodium vivax malaria patients

2020 ◽  
Vol 9 (1) ◽  
pp. 254
Author(s):  
Sandeep B. R. ◽  
M. G. Bhutto ◽  
Suresh Babu K. P.
Keyword(s):  
Plasmodium Vivax ◽  
Cortisol Level ◽  
Vivax Malaria ◽  
Serum Cortisol ◽  
Treatment Modalities ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Significant Difference ◽  
Plasmodium Vivax Malaria ◽  
Cortisol Levels

Background: Malaria results in pathological changes in various body organs, as the parasite invade and multiply in circulating red blood cells. Despite of advances in diagnostic and treatment modalities, worldwide incidences of malaria are significant. Current study was conducted to investigate serum cortisol level changes as a promising biomarker for risk prediction in malaria and to study adrenal insufficiency in malaria patients.Methods: Current investigation was a prospective observational study, conducted on complicated and uncomplicated Plasmodium vivax malaria patients. Serum cortisol levels in patients were investigated through immunoassay using direct chemiluminescent technology and were statistically correlated with Plasmodium vivax malaria infection.Results: Results of present investigation revealed that on day 1 there was significant difference in mean serum cortisol levels between the Plasmodium vivax malaria patients and control group and cortisol levels were significantly higher in complicated Plasmodium vivax malaria patients compared to uncomplicated cases on day 1 and 7. Cortisol levels were observed to be normal on day 1 and 7 in uncomplicated malaria cases and in patients with bleeding manifestations, renal failure and jaundice. In 10 out of 15 cases of cerebral malaria, significant increase in serum cortisol levels were observed on day 1, while on day 7 levels were normal in all 15 cases.Conclusions: Rise in serum cortisol level had a positive correlation with temperature and thus can be useful to predict the severity of disease in Plasmodium vivax malaria patients. No cortisol insufficiency was observed in during active and convalescent stages of illness.

scholarly journals CORRELATION OF SERUM CORTISOL LEVEL WITH THE PROGNOSIS OF STROKE: A CROSS SECTIONAL STUDY

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Rukmani Vaishnav ◽  
Enugala Ravi Kiran ◽  
Vikas Saxena
Keyword(s):  
Cortisol Level ◽  
Poor Response ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Time Duration ◽  
Cross Sectional ◽  
Ischemic Lesion ◽  
Adrenal Axis ◽  
Cortisol Levels ◽  
Pituitary Adrenal Axis

Introduction: Cortisol is a hormone of immense importance in the hypothalamo-pituitary-adrenal axis & it has got paramount effects on the metabolism of lipid, glucose & protein. With reference to stroke, a stress response implies rise in the levels of catecholamines & cortisol during the 1st week after the acute episode. Such kind of response is evident in infarction of cerebrum & bleeding in the cerebral cortex. There is ample amount of evidence from past studies that raised levels of serum cortisol levels are associated with volume of ischemic lesion. Patients and methods: Subjects included were patients who were admitted in the hospital within six hours after the stroke episode. Every patient was monitored for Scandinavian Stroke Scale (SSS) after the admission. This test was conducted per two hours in first twenty four hours, then per four hours in the next 48 hours & then every day up-to seventh day. Blood samples were extracted for the estimation of serum cortisol. Time duration of 01:00 AM to 07:00 AM was excluded for sample extraction. Results: Serum cortisol level was significantly higher in subjects with insular involvement (635 nmol/l) as compared to patients without insular involvement. Conclusion: It’s quite clear from our study that raised cortisol levels are highly associated with bad outcome & poor response in patients with stroke. Keywords: Serum Cortisol, hypothalamo-pituitary-adrenal axis, Stroke.

Nighttime serum cortisol level for diagnosis of hypercortisolism in hospitalized patients

2019 ◽  
Author(s):  
Liana Khatsimova ◽  
Uliana Tsoy ◽  
Natalia Kuritsyna ◽  
Elena Grineva ◽  
Elena Litvinenko ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Serum Cortisol ◽  
Hospitalized Patients ◽  
Serum Cortisol Level
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