scholarly journals Lymphocyte-platelet adhesion and aggregation of platelets in patients with erysipelas

2012 ◽  
Vol 93 (2) ◽  
pp. 216-220
Author(s):  
A N Emel’yanova ◽  
Yu A Vitkovskiy
Keyword(s):  
Platelet Adhesion ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Absolute Number ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Platelet Hyperaggregation ◽  
Aggregation Of Platelets ◽  
Primary Form

Aim. To study the lymphocyte-platelet adhesion in patients with various forms of erysipelas in the dynamics of treatment. Methods. 90 patients with erysipelas participated in the study: 20 with the erythematous-bullous form and 20 with the erythematous form. According to the recurrence of the disease the patients were divided into two groups: the main group (40 patients with the primary form of erysipelas) and the comparison group (50 people with recurrent erysipelas). The control group, which was comparable by sex and age, was comprised of 55 healthy people. The index of lymphocyte-platelet adhesion and hemostasis were studied in all patients. Results. The index of lymphocyte-platelet adhesion sharply declined already during the onset of the disease, despite the fact that no significant changes in the content of the absolute number of lymphocytes compared to healthy individuals during this period were identified. Severe course (erythematous-bullous form) was accompanied by significant shifts in the parameters of lymphocyte-platelet adhesion, and their dynamics made it possible to evaluate the effectiveness of treatment. Conclusion. The ability of lymphocytes to adhere to the surface of platelets is reduced during erysipelas; platelet hyperaggregation develops during the first days of onset of clinical manifestations, the nature and duration of which depends on the form of the disease.

scholarly journals INVESTIGATION OF ENTEROCOCCUS FAECALIS POPULATION IN PATIENTS WITH POLYP AND COLORECTAL CANCER IN COMPARISON OF HEALTHY INDIVIDUALS

2019 ◽  
Vol 56 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Maryam GERAVAND ◽  
Parviz FALLAH ◽  
Mojtaba Hedayat YAGHOOBI ◽  
Fatemeh SOLEIMANIFAR ◽  
Malihe FARID ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Enterococcus Faecalis ◽  
Copy Number ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Faecal Flora ◽  
Copy Numbers ◽  
Significant Difference ◽  
The Mean

ABSTRACT BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.

scholarly journals Prevalence of chronic infection foci in patients with dermatoses

2018 ◽  
Vol 94 (3) ◽  
pp. 30-38
Author(s):  
A. V. Patrushev ◽  
A. V. Samtsov ◽  
A. M. Ivanov ◽  
A. V. Sukharev ◽  
D. D. Asfendiarov
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
General Population ◽  
Epidemiological Study ◽  
Alopecia Areata ◽  
Chronic Infection ◽  
Healthy People ◽  
Chronic Tonsillitis ◽  
Control Group ◽  
Healthy Individuals

This paper presents the results of a retrospective epidemiological study carried out to detect chronic infection foci (CIF) in patients affected by T-cell mediated dermatoses. The values obtained for the CIF prevalence are compared with those in the general population, as well as in the control group. The latter comprised generally healthy people according to the results of in-depth medical examination. It is found that patients with psoriasis demonstrate a higher prevalence of chronic tonsillitis compared to the values both in the general population and in the control group (p = 0.001). Patients with eczema are characterized by an increased prevalence of chronic granulomatous periodontitis, but only in comparison with generally healthy individuals (p = 0.046). The results obtained for patients with atopic dermatitis, lichen planus and alopecia areata are found to be statistically significant for chronic tonsillitis, which occurs therein more frequently than in the general population and in the group of generally healthy people (p = 0.001).

Нарушения антиэндотоксиновой защиты у больных лейкемией и миелодиспластическим синдромом

2017 ◽  
pp. 83-90
Author(s):  
Ан.И. Гордиенко ◽  
А.В. Кубышкин ◽  
Ал.И. Гордиенко ◽  
В.А. Кубышкин
Keyword(s):  
Myelodysplastic Syndrome ◽  
Normal Values ◽  
Serum Antibody ◽  
Clinical Manifestations ◽  
Chronic Phase ◽  
Lymphocytic Leukemia ◽  
Healthy People ◽  
Myelogenous Leukemia ◽  
Refractory Anemia ◽  
Control Group

Цель исследования - оценка состояния антиэндотоксинового иммунитета у больных лейкемией и миелодиспластическим синдромом. Методика. Проведено лабораторное обследование 275 больных, страдающих острой миелоидной лейкемией (ОМЛ, n = 70), хронической миелоидной лейкемией (ХМЛ, n = 75), миелодиспластическим синдромом (хроническая миеломоноцитарная лейкемия - ХММЛ, n = 23; рефрактерная анемия с избытком бластов - РАИБ, n = 18) и В-клеточной хронической лимфоцитарной лейкемией (В-ХЛЛ, n = 71). В контрольную группу вошло 37 здоровых людей, у которых в анамнезе не было каких-либо хронических заболеваний, а на момент обследования отсутствовали клинические проявления острой инфекционной патологии. По полу и возрасту контрольная группа здоровых людей соответствовала указанным выше группам больных. У всех обследованных лиц методом твердофазного иммуноферментного анализа определяли уровни сывороточных антиэндотоксиновых антител классов A, M и G (анти-ЭТ-IgA, анти-ЭТ-IgM и анти-ЭТ-IgG). Концентрацию общих иммуноглобулинов классов A, M и G в крови определяли иммунотурбидиметрическим методом. Результаты. Установлено, что до начала лечения у больных ХМЛ, ХММЛ, РАИБ и В-ХЛЛ уровни сывороточных анти-ЭТ-IgA и анти-ЭТ-IgM были статистически значимо снижены. Исключение составляли лишь данные больных ОМЛ, у которых в первом остром периоде заболевания уровни анти-ЭТ-IgA значимо не отличались от нормальных значений. Вместе с тем уровни сывороточных анти-ЭТ-IgG у больных из указанных групп были либо повышенными (больные ОМЛ в первом остром периоде заболевания, ХМЛ в фазе акселерации и ХММЛ), либо не отличались от нормы (РАИБ и В-ХЛЛ). В стадии клинико-гематологической ремиссии у больных ОМЛ и В-ХЛЛ выявлено статистически значимое возрастание уровней сывороточных анти-ЭТ-антител всех трех классов, тогда как у больных ХМЛ в хронической фазе значимо повышаются только уровни анти-ЭТ-IgM, а содержание анти-ЭТ-антител других классов существенно не меняется. При этом направленность изменений уровней анти-ЭТ-антител чаще всего не совпадает с тенденцией изменений концентрации в крови общих иммуноглобулинов этих же классов, а какие-либо значимые корреляции между этими показателями не обнаружены. Заключение. Нарушения гуморального антиэндотоксинового иммунитета следует учитывать при персонализованном подходе к комплексному лечению и иммунореабилитации больных, страдающих лейкемией и миелодиспластическим синдромом. The purpose. Investigate the antiendotoxin immunity in patients with leukemia and myelodysplastic syndrome. Methods. We examined 257 patients with acute myeloid leukemia (AML, n = 70), chronic myelogenous leukemia (CML, n = 75), myelodysplastic syndrome (chronic myelomonocytic leukemia - CMML, n = 23; refractory anemia with excess blasts - RAEB, n = 18) and B-cell chronic lymphocytic leukemia (B-CLL, n = 71). The control group included 37 healthy people who have not a history of any chronic disease, and the clinical manifestations of acute diseases were absent at the time of the survey. By sex and age, the control group of healthy people matched to a groups of patients with leukemia and myelodysplastic syndrome. Levels of serum antibody classes A, M and G to endotoxin (anti-ET-IgA, anti-ET-IgM and anti-ET-IgG) were determined by ELISA. The concentration of total immunoglobulin classes A, M and G in the blood was determined by immuno turbidimetry. Results. It was found that before treatment in patients with CML, CMML, RAEB and B-CLL levels of serum anti-ET-IgA and anti-ET-IgM were significantly reduced. The only exceptions were patients with AML in the first acute stage of the disease (AML-AS) levels of anti-ET-IgA were not significantly different from the normal values. However, the levels of serum anti-ET-IgG in patients of these groups were either significantly higher (patients with AML-AS, CML in accelerated phase and CMML), or not different from the normal values (patients with RAEB and B-CLL). Under clinical remission in patients with AML and CLL showed a significant increase in the levels of serum anti-ET antibodies of all classes, while in patients with CML in chronic phase alone significantly increased levels of anti-ET-IgM, and the content of the anti-ET antibodies other classes were not significantly changed. The direction of changes in the levels of anti-LPS antibodies often do not coincide with the trend of changes in the concentration of immunoglobulins in the blood of the same classes. Any significant correlations between these parameters are not found. Conclusion. The results should be considered in a personalized approach to treatment and immunorehabilitation patients with these diseases.

CHANGES IN THE PARAMETERS OF THROMBODYNAMICS AND BLOOD CLOT CONTRACTION IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 58 (3) ◽  
pp. 294-303
Author(s):  
A. D. Peshkova ◽  
T. A. Evdokimova ◽  
T. B. Sibgatullin ◽  
F. I. Ataullakhanov ◽  
R. I. Litvinov
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Clot ◽  
Clinical Manifestations ◽  
Control Group ◽  
Healthy Individuals ◽  
Plasma Clot ◽  
Autoimmune Pathology ◽  
Clot Contraction ◽  
Hemostatic Disorders

Autoimmune diseases, including rheumatoid arthritis (RA), are risk factors for thrombotic events. Understanding the pathogenetic role of hemostatic changes in RA can assist in developing measures for prevention, prognosis, early diagnosis, and treatment of immune thromboses. Objective: to investigate the state of platelet and plasma hemostasis in patients with RA, as compared to other laboratory parameters and clinical manifestations of the disease. Subjects and methods. Hemostasis was investigated using two relatively new laboratory tests: thrombodynamics and kinetics of blood clot contraction (BCC). Examinations were made in 60 patients with RA and in 50 apparently healthy individuals of the control group. Results and discussion. In patients with RA, the parameters of thrombodynamics and BCC were found to be significantly different from the normal values. According to thrombodynamics, there was an increase in plasma clot growth rate, size, and density, which indicates chronic hypercoagulation. The rate and completeness of BCC were substantially reduced due to platelet dysfunction in patients with RA compared to healthy individuals. The changes in the parameters of thrombodynamics and BCC correlated with the laboratory signs of systemic inflammation and depended on the radiographic stage of the disease. Conclusion. The results of this investigation confirm that hemostatic disorders are present in RA and indicate the informative value of thrombodynamics and BCC tests as indicators of a pre-thrombotic state, including autoimmune pathology.

scholarly journals Studying of the interleukin-36γ expression level in the skin of patients with plaque psoriasis

2019 ◽  
Vol 95 (4) ◽  
pp. 31-39 ◽  
Author(s):  
A. Yu. Pashkin ◽  
A. S. Zhukov ◽  
V. R. Khairutdinov ◽  
I. E. Belousova ◽  
A. V. Samtsov ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Lichen Planus ◽  
Plaque Psoriasis ◽  
Direct Relationship ◽  
Skin Diseases ◽  
Comparison Group ◽  
Healthy People ◽  
Expression Level ◽  
Control Group ◽  
Biopsy Specimens

Currently, it has been established that the cytokines of the IL-36 family occupy a significant place in the initiation and regulation of the inflammatory process in psoriasis.Objective: studying the expression level of IL-36γ cytokines in the skin of patients with plaque psoriasis.Material and methods. Skin biopsy specimens of 31 patients with plaque psoriasis were studied. The comparison group consisted of 20 biopsy samples of the skin of patients with lichen simplex, discoid eczema, lichen planus, mycosis fungoides (plaque stage). As a control group studied the skin bioptates of 10 healthy people. An immunohistochemical study of the skin was carried out using anti-IL-36γ antibodies.Results. An increase in the relative expression area of IL-36γ in the affected skin of patients with plaque psoriasis (7.4 %) was found, compared with the unaffected areas (0.10 %) and the control group (0 %). The expression of IL-36γ in the skin of patients with psoriasis in the progressive period (8.85 %) was 1.42 times higher than in the stationary period of the disease (6.2 %). A strong direct relationship was revealed (r = 0.71) between the level of IL-36γ expression in the affected skin and the value of the PASI index, a moderate direct relationship between the level of IL-36γ expression and epidermal thickness (r = 0.34). In the affected skin of psoriasis patients, expressed expression of IL-36γ was observed in the upper layers of the epidermis, patients of the comparison group (discoid eczema, lichen simplex, lichen planus, mycosis fungoides) were weak or moderate, in the unaffected areas of the skin of patients with psoriasis and healthy people — weak or absent.Findings. It was found that the expression of IL-36γ in the skin of patients with plaque psoriasis is significantly higher than with other skin diseases. The data obtained allow us to consider this cytokine as a possible diagnostic marker and use it in the differential diagnosis. 

scholarly journals “Long covid” (postcovid syndrome). Mechanism of occurrence, diagnosis and rehabilitation

2022 ◽  
pp. 156-164
Author(s):  
En. D. Choi
Keyword(s):  
Light Scattering ◽  
Comparison Group ◽  
Integrated Approach ◽  
Laboratory Method ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Coronavirus Infection ◽  
Methods Of Treatment

Introduction. The article is devoted to the study of the mechanism of occurrence of postcovid syndrome, a new laboratory method for its diagnosis and issues of drug and non-drug rehabilitation of patients who have suffered COVID-19.The purpose of this work was to study the possibilities of using the method of monochrome analysis of nanoparticles for instrumental and laboratory diagnostics of postcovid syndrome and to substantiate the use of complex therapeutic approaches to the treatment of patients.Materials and methods. The biomaterial (saliva) of 250 patients who underwent COVID-19 in mild, moderate and severe forms, with a slight predominance of males, in the age range from 18 to 75 years, who were in the Center of Eastern and European Medicine (Moscow) on rehabilitation treatment in the period from June 2020 to September 2021, was studied by the method of monochrome analysis of nanoparticles. According to the results of the work carried out, it was found that the most typical saliva spectrum of patients diagnosed with “postcovid syndrome” was multimodal (three or more peaks) with the greatest contribution (45%) to light scattering on agglomerates of  nanoparticles with a  diameter of  more than 1000  nm, with detectable nanoparticles of the middle sub-range of the spectrum from 119 to 122 nm with a 15% contribution to light scattering and an increased contribution to light scattering up to 41% on small nanoparticles with a diameter of 22 nm.Results. Analysis of the results of the study showed a statistically significant (p < 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group). Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment. >< 0.01) appearance of a peak of 119 nm on the histogram of patients, which was not observed either in the group of practically healthy individuals (control group) or in the group of patients with general somatic pathology (comparison group).Conclusions. An algorithm for non-invasive diagnosis of postcovid syndrome by saliva was developed. Also, special attention was paid during the study to the development of an integrated approach to the rehabilitation of patients who have undergone a new coronavirus infection, including medicinal and non-medicinal methods of treatment.

scholarly journals Fluid resuscitation patients with burn sepsis

2020 ◽  
pp. 42-43
Author(s):  
O.M. Kovalenko ◽  
O.I. Osadcha ◽  
A.A. Kovalenko ◽  
A.S. Grisha ◽  
O.M. Lynnyk ◽  
...  
Keyword(s):  
Comparison Group ◽  
Total Body Surface Area ◽  
Clinical Manifestations ◽  
Main Group ◽  
Oxidation Products ◽  
Control Group ◽  
Carbonyl Groups ◽  
Septic Complications ◽  
Endogenous Intoxication ◽  
Lipid Oxidation Products

Objective. The purpose the of the study is to improve the fluid therapy regimens for burn sepsis patient. Materials and methods. The study is based on the observation 52 patients with burn sepsis aged 23 to 65 years, with a total body surface area more than 35 % at the Kyiv City Clinical Hospital № 2 during 2016-2019. Patients were divided into two groups: the main group – 30 patients were treated with crystalloids, plasma, albumin and Rheosorbilact (RSL); control group – 16 patients received treatment without using of RSL. Clinical and biochemical parameters of endogenous intoxication (tissue destruction products, medium weight molecules (MWM), concentrations of lipid oxidation products (LOP) – by diene conjugate content and oxidatively modified proteins (OMP) – by carbonyl groups) were studied. Results and discussion. Syndrome of endogenous intoxication was an increase in burn sepsis patients, which correlated with an increase in the number of LOP, OMP, MWM, namely an increase in the hydrophobic (most toxic) fraction of MWM, which is 2-3 times higher than in healthy, sick and both groups. MWM and hydrophobic fraction remained high during the observation period in patients of the comparison group. MWM decreased by 1.35 times in patients of the main group relative to the group of crystalloids. The level of carbonyl groups of serum OMP in patients of the comparison group was 50 % higher than in the main group. The indicators of LOP exceeded 1.45 times in the comparison group, which testified to the continuation of oxidative stress and the continuation of systemic inflammation. Acute respiratory distress syndrome (ARDS) was characterized by the appearance of bilateral infiltrates in the lungs, according to radiography. This common organ dysfunction was detected in 75 % of patients in the comparison group and in 63 % of patients in the RSL-group. The duration of mechanical ventilation in the main group decreased by 1,6 days. Conclusions. The use of Rheosorbylact for patients with burn sepsis at a dose of 15 ml/kg has led to a decrease in the manifestations of intoxication syndrome, reduction of MWM, LOP, OMP, clinical manifestations of systemic inflammatory response, septic complications by 1.3 times, septic shock from 16 to 12 %, and the incidence of ARDS from 75 to 63 %.

scholarly journals Evaluation of Risk Behavior in Gambling Addicted and Opioid Addicted Individuals

2021 ◽  
Vol 14 ◽  
Author(s):  
Edward J. Gorzelańczyk ◽  
Piotr Walecki ◽  
Monika Błaszczyszyn ◽  
Ewa Laskowska ◽  
Aleksandra Kawala-Sterniuk
Keyword(s):  
Response Time ◽  
Risk Behavior ◽  
Risk Behaviors ◽  
Risky Behavior ◽  
Iowa Gambling Task ◽  
Healthy People ◽  
Control Group ◽  
Gambling Task ◽  
Healthy Individuals ◽  
Significant Difference

Evidence suggests that both opioid addicted and gambling addicted individuals are characterized by higher levels of risky behavior in comparison to healthy people. It has been shown that the administration of substitution drugs can reduce cravings for opioids and the risky decisions made by individuals addicted to opioids. Although it is suggested that the neurobiological foundations of addiction are similar, it is possible that risk behaviors in opioid addicts may differ in detail from those addicted to gambling. The aim of this work was to compare the level of risk behavior in individuals addicted to opioid, with that of individuals addicted to gambling, using the Iowa Gambling Task (IGT). The score and response time during the task were measured. It was also observed, in the basis of the whole IGT test, that individuals addicted to gambling make riskier decisions in comparison to healthy individuals from the control group but less riskier decisions in comparison to individuals addicted to opioids, before administration of methadone and without any statistically significant difference after administration of methadone—as there has been growing evidence that methadone administration is strongly associated with a significant decrease in risky behavior.

SPECIFICS OF THE ECZEMA PATIENTS` IMMUNE SYSTEM DEPENDING ON THE CLINICAL COURSE OF DERMATOSIS

2021 ◽  
Vol 74 (10) ◽  
pp. 2624-2626
Author(s):  
Yuriy V. Andrashko ◽  
Mahmood K. Khwaileh
Keyword(s):  
Immune System ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Control Group ◽  
Healthy Individuals ◽  
Clinical Form ◽  
Systemic Immunity ◽  
Wide Range ◽  
Definition Of ◽  
Cellular Components

The aim: Definition of the systemic immunity cellular components and autoimmune factor in eczema patients depending on the clinical manifestations of dermatosis. Materials and methods: The study involved 95 eczema patients. 29 of them were diagnosed the true dermatosis form, while 39 and 27 subjects had infectious (microbial) and infectious (mycotic) form of the disease, accordingly. The control group consisted of 30 healthy individuals. CD3+, CD4+, CD8+, CD16 +, CD22 + and CD 95+ cells and autoantibodies to TPO and TG were counted. Results: The eczema patients present uniform, but somewhat labile changes in the state of the immune system. For example, cellular disorders, except for CD8+ count, do not statistically significantly depend on the clinical form of dermatosis, the severity of inflammatory process, and the duration of the disease. At the same time, the decrease of CD8+ count in infectious (mycotic) form of the disease and in acute and subacute course reflects a certain variability of changes in cellular immunity with intact values in true and infectious (microbial) genesis and chronic manifestations of eczema. Conclusions: Eczema patients should be subjected to valuation of cellular components of the systemic immunity and autoimmune profile. The CD8 + count of eczema patients can serve as one of the “conditional markers” of a degree of involvement of systemic immunity in the progression of eczema. Therapy of eczema patients should include medicines that possess a wide range of immunomodulatory effect.

scholarly journals Biomarkers of bone remodeling in ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs: results of an ETHICS research program

2017 ◽  
Vol 89 (12-2) ◽  
pp. 185-189
Author(s):  
I Z Gaydukova ◽  
A V Aparkina ◽  
E V Khondkaryan ◽  
A P Rebrov
Keyword(s):  
Ankylosing Spondylitis ◽  
Bone Resorption ◽  
Comparison Group ◽  
Control Group ◽  
Type I ◽  
Healthy Individuals ◽  
On Demand ◽  
Ethics Research ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. To evaluate changes in the concentration of biomarkers for osteoproliferation and bone resorption in ankylosing spondylitis (AS) patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in different regimens. Subjects and methods. Forty patients with AS (according to the modified New York criteria), who had BASDAI ≥ 4.0 at baseline and at 52 weeks of on-demand NSAID treatment were examined and randomized into 2 groups: 1) 30 patients who used continuously oral tenoxicam 20 mg daily (a study group); 2) 10 patients who continued previous therapy (a comparison group). BASDAI and ASDAS were calculated; the serum levels of C-reactive protein, C-terminal type I procollagen propeptide (PICP), and C-terminal telopeptide of type I collagen (CTX-I) were measured at baseline and at 52 and 56 weeks of treatment. A control group consisted of 19 healthy volunteers. Results. The continuous use of NSAIDs (tenoxicam) decreased higher baseline BASDAI and ASDAS scores. There were no changes in the indicators of AS activity in the patients who took on-demand NSAIDs. Baseline CTX-I levels did not differ between the patients with AS and the healthy individuals; those declined during continuous intake of tenoxicam and remained unchanged during on-demand administration. In the patients with AS, baseline PICP levels exceeded those in the healthy individuals. In the tenoxicam-treated patients, the concentrations of PICP at baseline and at 52 and 56 weeks were 17.1±9.0, 16.8±9.9, and 13.29±6.7 ng/ml, respectively (p=0.0001 for differences between the baseline and week 56 levels); in the comparison group, PICP levels did not change statistically significantly (p≥0.05 for all intergroup comparisons). Conclusion. Changing the inefficient long-term on-demand use of NSAIDs to their continuous intake is associated with a rapid decrease in clinical AS activity (within 4 weeks) with a reduction in the higher baseline concentration of the marker for osteoproliferation and in the normal level of the marker for bone resorption.

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