scholarly journals Prevalence of chronic infection foci in patients with dermatoses

2018 ◽  
Vol 94 (3) ◽  
pp. 30-38
Author(s):  
A. V. Patrushev ◽  
A. V. Samtsov ◽  
A. M. Ivanov ◽  
A. V. Sukharev ◽  
D. D. Asfendiarov
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
General Population ◽  
Epidemiological Study ◽  
Alopecia Areata ◽  
Chronic Infection ◽  
Healthy People ◽  
Chronic Tonsillitis ◽  
Control Group ◽  
Healthy Individuals

This paper presents the results of a retrospective epidemiological study carried out to detect chronic infection foci (CIF) in patients affected by T-cell mediated dermatoses. The values obtained for the CIF prevalence are compared with those in the general population, as well as in the control group. The latter comprised generally healthy people according to the results of in-depth medical examination. It is found that patients with psoriasis demonstrate a higher prevalence of chronic tonsillitis compared to the values both in the general population and in the control group (p = 0.001). Patients with eczema are characterized by an increased prevalence of chronic granulomatous periodontitis, but only in comparison with generally healthy individuals (p = 0.046). The results obtained for patients with atopic dermatitis, lichen planus and alopecia areata are found to be statistically significant for chronic tonsillitis, which occurs therein more frequently than in the general population and in the group of generally healthy people (p = 0.001).

scholarly journals INVESTIGATION OF ENTEROCOCCUS FAECALIS POPULATION IN PATIENTS WITH POLYP AND COLORECTAL CANCER IN COMPARISON OF HEALTHY INDIVIDUALS

2019 ◽  
Vol 56 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Maryam GERAVAND ◽  
Parviz FALLAH ◽  
Mojtaba Hedayat YAGHOOBI ◽  
Fatemeh SOLEIMANIFAR ◽  
Malihe FARID ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Enterococcus Faecalis ◽  
Copy Number ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Faecal Flora ◽  
Copy Numbers ◽  
Significant Difference ◽  
The Mean

ABSTRACT BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.

scholarly journals Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 862
Author(s):  
Magdalena Trzeciak ◽  
Berenika Olszewska ◽  
Monika Sakowicz-Burkiewicz ◽  
Małgorzata Sokołowska-Wojdyło ◽  
Jerzy Jankau ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Expression Profiles ◽  
Skin Barrier ◽  
Control Group ◽  
Mrna Levels ◽  
Barrier Dysfunction ◽  
Cornified Envelope ◽  
Protein Levels ◽  
T Cell Lymphomas

The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of both diseases. The levels of FLG, FLG2, RPTN, HRNR, SPRR1A, SPRR1B, SPRR3 and LELP-1 mRNA were determined by qRT-PCR, while protein levels were examined using the ELISA method in skin samples. We have found that mRNA levels of FLG, FLG2, LOR, CRNN and SPRR3v1 were decreased (p ≤ 0.04), whereas mRNA levels of RPTN, HRNR and SPRR1Av1 were increased in lesional and nonlesional AD skin compared to the healthy control group (p ≤ 0.04). The levels of FLG, FLG2, CRNN, SPRR3v1 mRNA increased (p ≤ 0.02) and RPTN, HRNR and SPRR1Av1 mRNA decreased (p ≤ 0.005) in CTCL skin compared to the lesional AD skin. There was a strong correlation between the stage of CTCL and increased SPRR1Av1 gene expression at both mRNA (R = 0.89; p ≤ 0.05) and protein levels (R = 0.94; p ≤ 0.05). FLG, FLG2, RPTN, HRNR and SPRR1A seem to play a key role in skin barrier dysfunction in CTCL and could be considered a biomarker for differential diagnosis of AD and CTCL. SPRR1Av1 transcript levels seem to be a possible marker of CTCL stage, however, further studies on a larger study group are needed to confirm our findings.

Alexithymia and body-self relations among patients with alopecia areata

Physiotherapy ◽  
2014 ◽  
Vol 22 (2) ◽  
Author(s):  
Marta Kuty-Pachecka ◽  
Katarzyna Stefańska
Keyword(s):  
Alopecia Areata ◽  
Psychological Evaluation ◽  
Control Group ◽  
Healthy Individuals ◽  
Toronto Alexithymia Scale ◽  
Integral Treatment ◽  
Body Self ◽  
High Level

AbstractThe aim of the study: The aim of the study was the assessment of alexithymia and body-self relations among patients with alopecia areata.Material and methods: The study included 79 people: 30 with alopecia areata and 49 healthy individuals, showing no psychodermatological disorders (control group). During the study, Toronto Alexithymia Scale (TAS-26) and the Multidimensional Body-Self Relations Questionnaire (MBSRQ) were used.Results: The subjects had a high level of alexithymia. Moreover, the persons less satisfied with their bodies dominated in the group diagnosed with alopecia areata.Conclusions: Alexithymia and lesser satisfaction with own is characteristic for patients with alopecia areata. These data suggest that it is necessary to make a proper psychological evaluation for integral treatment of alopecia areata.

scholarly journals Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata

2017 ◽  
Vol 5 (3) ◽  
pp. 305-309 ◽  
Author(s):  
Javad Ghaffari ◽  
Ghasem Rahmatpour Rokni ◽  
Armaghan Kazeminejad ◽  
Hosein Abedi
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Alopecia Areata ◽  
Allergic Diseases ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Significant Difference ◽  
History Of ◽  
And Control

BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.RESULTS: In this study, the mean age of the participants was 2.55 ± 14.26 and 3.19 ± 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.

scholarly journals Pityrosporum orbiculare ‐Reactive T‐Cell Lines in Atopic Dermatitis Patients and Healthy Individuals

1998 ◽  
Vol 47 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Tengvall Linder ◽  
Johansson ◽  
Bengtsson ◽  
Holm ◽  
Härfast ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Cell Lines ◽  
Healthy Individuals ◽  
Pityrosporum Orbiculare ◽  
T Cell Lines

scholarly journals Evaluation of Risk Behavior in Gambling Addicted and Opioid Addicted Individuals

2021 ◽  
Vol 14 ◽  
Author(s):  
Edward J. Gorzelańczyk ◽  
Piotr Walecki ◽  
Monika Błaszczyszyn ◽  
Ewa Laskowska ◽  
Aleksandra Kawala-Sterniuk
Keyword(s):  
Response Time ◽  
Risk Behavior ◽  
Risk Behaviors ◽  
Risky Behavior ◽  
Iowa Gambling Task ◽  
Healthy People ◽  
Control Group ◽  
Gambling Task ◽  
Healthy Individuals ◽  
Significant Difference

Evidence suggests that both opioid addicted and gambling addicted individuals are characterized by higher levels of risky behavior in comparison to healthy people. It has been shown that the administration of substitution drugs can reduce cravings for opioids and the risky decisions made by individuals addicted to opioids. Although it is suggested that the neurobiological foundations of addiction are similar, it is possible that risk behaviors in opioid addicts may differ in detail from those addicted to gambling. The aim of this work was to compare the level of risk behavior in individuals addicted to opioid, with that of individuals addicted to gambling, using the Iowa Gambling Task (IGT). The score and response time during the task were measured. It was also observed, in the basis of the whole IGT test, that individuals addicted to gambling make riskier decisions in comparison to healthy individuals from the control group but less riskier decisions in comparison to individuals addicted to opioids, before administration of methadone and without any statistically significant difference after administration of methadone—as there has been growing evidence that methadone administration is strongly associated with a significant decrease in risky behavior.

scholarly journals Lymphocyte-platelet adhesion and aggregation of platelets in patients with erysipelas

2012 ◽  
Vol 93 (2) ◽  
pp. 216-220
Author(s):  
A N Emel’yanova ◽  
Yu A Vitkovskiy
Keyword(s):  
Platelet Adhesion ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Absolute Number ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Platelet Hyperaggregation ◽  
Aggregation Of Platelets ◽  
Primary Form

Aim. To study the lymphocyte-platelet adhesion in patients with various forms of erysipelas in the dynamics of treatment. Methods. 90 patients with erysipelas participated in the study: 20 with the erythematous-bullous form and 20 with the erythematous form. According to the recurrence of the disease the patients were divided into two groups: the main group (40 patients with the primary form of erysipelas) and the comparison group (50 people with recurrent erysipelas). The control group, which was comparable by sex and age, was comprised of 55 healthy people. The index of lymphocyte-platelet adhesion and hemostasis were studied in all patients. Results. The index of lymphocyte-platelet adhesion sharply declined already during the onset of the disease, despite the fact that no significant changes in the content of the absolute number of lymphocytes compared to healthy individuals during this period were identified. Severe course (erythematous-bullous form) was accompanied by significant shifts in the parameters of lymphocyte-platelet adhesion, and their dynamics made it possible to evaluate the effectiveness of treatment. Conclusion. The ability of lymphocytes to adhere to the surface of platelets is reduced during erysipelas; platelet hyperaggregation develops during the first days of onset of clinical manifestations, the nature and duration of which depends on the form of the disease.

scholarly journals The role of cutaneous T-cell attracting chemokine in the development of different phenotypes of atopic dermatitis in children

2021 ◽  
Vol 26 (3) ◽  
pp. 39-46
Author(s):  
V.O. Dytiatkovsky ◽  
O.Є. Abaturov ◽  
N.V. Naumenko ◽  
O.O. Alifirenko ◽  
I.A. Filatova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gastrointestinal Tract ◽  
T Cell ◽  
Serum Level ◽  
Significant Risk ◽  
Main Group ◽  
Control Group ◽  
Serum Concentrations ◽  
Atopic Diseases

The goal of this study was to detect the risk of developing different atopic dermatitis (AD) phenotypes in children (isolated or combined with other comorbid atopic diseases (AtD)) depending on serum concentrations of cutaneous T-cell attracting chemokine (CTACK)/CCL27. The main group comprised 39 children aged 3 to 18 years old suffering from different AD phenotypes – isolated (18 patients) and combined with comorbid AtD – AR/ARC and/or bronchial asthma (21 patients). The control group comprised 47 children aged 3 to 18 years old, suffering from diseases of the gastrointestinal tract (GIT). Serum CTACK/CCL 27 concentrations were detected in all children. In the full main group, the average level of CTACK/CCL27 was significantly higher compared to the patients of the control group: 4403.6 pg/ml (95% CI: 3726.2; 5148.7, p<0.001) and 3495.9 pg/ml (95% CI: 3197.8; 4186.8, p<0.001), respectively. Mean serum CTACK/CCL27 levels in patients of the main group with different AD phenotypes were higher than those in the full main group: with isolated AD – 4549.4 pg/ml (LQ; HQ: 3923.5; 5175.2, p<0.05), with AD associated with other AtD – 5116.6 pg/ml (LQ, HQ: 4062.8; 6170.5, p<0.05). In phenotypes of overall and isolated AD, the cut-off value of serum CTACK/ CCL27 is 3586.5 pg/ml (76.9% and 77.8%, respectively, and 38.3% in the control group). The risk of development at this concentration is 5.37 (95% CI: 2.05; 14.07, p<0.001) for the total AD phenotype and 5.64 (95% 1.56; 20.32, p<0.05) for the isolated AD phenotype. In AD phenotype combined with comorbid AtD, the cut-off value of serum CTACK/CCL27 is 4308.8 pg/ml (66.7% of the main and 21.3% in the control group). The risk of developing this AD phenotype at this concentration is 7.40 (95% CI: 2.30; 23.76, p<0.001). Serum CTACK/CCL27 levels are the reliable biomarker of the risk for developing different AD phenotypes in children. In the serum level of CTACK/CCL27=3658.5 pg/ml, the significant risk of developing total AD phenotype is 5.37, and isolated – AD=5.64. In the serum concentration of CTACK/CCL27=4308.8 pg/ml, the significant risk of developing AD phenotype combined with comorbid AtD is 7.40.

scholarly journals Comparative characteristics of changes in visual acuity according to test lighting in healthy people and in patients with myopia

2021 ◽  
Vol 12 (33) ◽  
pp. 408-415
Author(s):  
Tamara Gumarovna Tlupova ◽  
Diana Arsenovna Teuvazhukova ◽  
Aslan Alekseevich Teuvov ◽  
Arthur Mukharbievich Baziev ◽  
Irina Korneevna Tkhabisimova ◽  
...  
Keyword(s):  
Visual Acuity ◽  
High Myopia ◽  
Healthy People ◽  
Control Group ◽  
Healthy Individuals ◽  
Small Step ◽  
Optimal Correction ◽  
Lighting Conditions ◽  
Strenuous Work ◽  
The Difference

The objective of the work consisted of comparing the characteristics of the changes in visual acuity as a function of the illumination of the tests in healthy individuals and in patients with myopia, examining two groups (50 people each): a control group of healthy individuals and patients with high myopia with visual acuity with optimal correction above 1.0. Visual acuity was determined under different lighting conditions (from 50Lx to 400Lx) using optotype tables with a small step of 0.05, and increasing the function δ, which is the difference between these values. δ in healthy individuals is 0.7, and in individuals with myopia it is equal to 0.55, which is a fairly high indicator and confirms the absence of contraindications to attract this category of patients to various types of visually strenuous work, including driving.

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