Biomodelling Angiogenesis
Success or failure of studies in various areas of biology depend on the presence or absence of convenient and effective adequate models of pathologic processes with fair predictability. In spite of variability of models used in contemporary angiology neither of them can be considered to be “golden standard” or etalon for elaborating new methods targeted at blood vessels. The need for a score of different models for studies of each stage of angiogenesis is one of major difficulties in forming a universal concept describing angiogenesis in humans and animals. A hypothesis of malignant neoplasma growth inhibition by means of blocking angiogenesis inducing factors, their receptors or direct destruction of microvessels’ wall is a starting point for profound angiogenesis studies using various in vitro and in vivo models. A wide spectrum of oncogenesis models allows to scrutinize it from various angles revealing general principles of neoplasma development, mechanisms of its interaction with normal tissues and organs, including the circulation system. Using transgenic с animals helped to disclose the key role of angiogenesis in the development of the organism as well as get results maximally close to the effects characteristic of studies of various aspects of angiogenesis in human beings.