scholarly journals The assessment of the environmental hazard of isomers of 1,2,4-triazole phenolic derivatives for natural ecosystems

2021 ◽  
Vol 10 (1) ◽  
pp. 151-156
Author(s):  
Ekaterina Sergeevna Selezneva ◽  
Zoya Petrovna Belousova ◽  
Robert Olegovich Artyukov

Its necessary to synthesize homologues of compounds frequently used in practice and to analyze their biological activity in laboratory experiments using screening tests that provide an integral assessment of biological responses to assess the effect of anthropogenic xenobiotics with different structures on ecosystems adjacent to agricultural complexes. We analyzed alcohol solutions of 2-(1H-1,2,4-triazolyl-methyl)phenol (ortho-isomer) and 4-(1H-1,2,4-triazolyl-methyl)phenol (para-isomer) in three concentrations: 0,0001; 0,001; 0.01 mg/ml using the Allium-test. The solvent was 0,1% isopropyl alcohol; the test object was Allium fistulosum L. The duration of the experiment was 5 days. Triazolide solutions significantly inhibited seed germination at all investigated concentrations. However, no significant differences were found between the isomers and the studied concentrations. Both isomers inhibited root growth at all concentrations tested. The toxicity of a triazolide containing an OH group in the para-position didnt change over the selected concentration range. For its ortho-isomer, toxicity increased with increasing concentration, reaching the toxicity of its homologue at a dose of 0,01 mg/ml. Both tested compounds significantly inhibited the proliferation of meristem cells as compared to the control. At the same time, no differences were observed in the effect of homologues with the OH-group in the para- and ortho-position on the value of the mitotic index. However, we found a paradoxical reaction: both homologues showed maximum cytotoxicity at a minimum concentration of 0,0001 mg/ml, and cytotoxicity decreased with increasing concentration compared to control. A triazolid containing an OH group in the para-position caused a block at the metaphase and anaphase stages at the lowest concentration. The specificity of its action disappeared with an increase in concentration, which was expressed in a general prophase and metaphase block. Its ortho-isomer inhibited cell division at all concentrations at the prophase stage. Both compounds are mutagenic. The number of chromosomal aberrations depended on both the structure of the compounds and their concentration. The para-homologue is less mutagenic than ortho. In the ortho-homologue, mutagenicity decreased slightly with increasing concentration. The highest mutagenicity was found for the ortho-homologue at its lowest concentration. The paper discusses possible mechanisms of action of isomers and their negative impact on plant organisms in ecosystems.

2019 ◽  
Vol 8 (2) ◽  
pp. 62-66
Author(s):  
Ekaterina Sergeevna Selezneva ◽  
Sergey Vladimirovich Saksonov

The influence of many anthropogenic xenobiotics constantly falling into natural ecosystems is poorly understood, so laboratory experiments are needed to understand the consequences of such actions. It is especially important to study this effect on plants that are unable to avoid uncomfortable conditions. It is necessary to use a variety of test objects and screening tests that give an integral assessment of biological responses. Such tests include the Allium -test, which allows to evaluate toxicity at both the organismic and cellular levels, as well as mutagenicity of xenobiotics. We analyzed the response of three species of the genus Allium ( Allium cepa, Allium ramosum, Allium fistulosum ) to exposure to alcohol solutions of benzotriazole in extremely low concentrations. This heterocyclic compound is widely used in industry as a light stabilizer for polymers and as an anti-corrosion agent protecting various metals and alloys. The biological activity of two concentrations (0,0001; 0,001 mg/ml) was studied. The solvent was 0,5% isopropyl alcohol. Allium test was used to analyze a biological response of the selected onions. The duration of the experiment was 5 days. The effect of benzotriazole stimulated growth processes in A. cepa and A. ramosum in the lowest concentration and inhibited growth processes in a higher dose compared to the control. Benzotriazole had a stimulating effect on A. fistulosum in both of the concentrations studied, however, the stimulating effect in a high concentration was less pronounced. The solution in low concentration stimulates the proliferative activity in the cells of the root meristem of all species. However, cells of A. cepa and A. ramosum meristem are not sensitive to the action of a higher concentration of benzotriazole solution, unlike A. fistulosum , in which cell division is inhibited in comparison with the control. It was found that A. fistulosum , in which benzotriazole causes a block at the anaphase stage in both concentrations studied, is the most sensitive to the mitosis-modifying action of benzotriazole. In the other two species, only exposure to benzotriazole in high concentration led to inhibition of mitosis at the prophase stage. A. ramosum is resistant to the genotoxicity of model xenobiotics, and A. cepa is highly sensitive to benzotriazole mutagenicity. The paper discusses the relationship between the adaptive capabilities of a species and its resistance to anthropogenic xenobiotics, as well as the use of tolerant species as test objects for ecological genetic monitoring.


Author(s):  
Elena I. Sarapultseva ◽  
Darya V. Uskalova ◽  
Ksenya V. Ustenko

Despite the fact that there are still conflicting opinions about the damage caused by modern wireless communication technologies, most scientists report on the negative biological effects of low-intensity radio frequency electromagnetic radiation at different levels of the organization of live nature. There is no doubt that there is a need not only for a sanitary and hygienic assessment of man-made electromagnetic effects on humans, but also for an environmental assessment for biota. The purpose of the study was to assess the potential environmental risk of electromagnetic impact in the centimeter range on natural ecosystems. The initial data were the authors' own results in the field of radiobiology of non-ionizing radiation, as well as published of other researchers. The article analyzes the biological effects of radio frequency electromagnetic fields detected in organisms of different systematic groups and levels of organization. The data on the non-thermal biological effects of electromagnetic fields indicate a high sensitivity of different species to this factor. The analyzed research results emphasize the need to take into account the features of non-thermal effects of electromagnetic radiation on biota, since these radiations can have a negative impact on different hierarchical levels in natural ecosystems.


2021 ◽  
Vol 2021 (23) ◽  
pp. 237-250
Author(s):  
Anatolii Morozov ◽  
◽  
Tetiana Morozova ◽  
Inessa Rutkovska ◽  
◽  
...  

Introduction.The main environmental risks posed by roads are population depletion (deaths on roads) and barrier effects (habitat fragmentation). Barrier effects - animals avoid crossing roads, which leads to a decrease in the size and quality of habitat, optimal population size, reduced ability to find food and partner, increased genetic structuring and local extinction (Forman et al. 2003; Andrews et al. 2015; van der Ree et al. 2015). These risks against the background of other stressors, in particular the presence of invasive species, pollution, pesticide use, climate change, plant and animal diseases, may threaten the survival of populations.This issue is especially relevant for herpetofauna due to their biological characteristics. In particular, reptiles and amphibians move slowly, are too small (for drivers to see), do not avoid roads, and in cold periods roads attract amphibians (thermoregulation) because the coating absorbs and retains heat (Case and Fisher 2001; Jochimsen et al. 2004).The principle of ensuring ecological continuity is to identify priority efforts to mitigate environmental risks for animals and reduce the negative impact of the transport complex as a spatial barrier and source of pollution by introducing a number of technical means (eco-crossings, screens, embankments, landscaping). As it is not possible to change the environmental risks on all roads and for all species at present, it is necessary to identify the most vulnerable species, assess the risks to populations and the need for mitigation based on analysis of road density and traffic intensity.Problem Statement. With the advent of land transport there was a progressive environmental problem - the transformation of landscapes, it first appeared in countries with developed road infrastructure in Western Europe and the United States, and quickly spread around the globe (Ellenberg, et al., 1981; Fetisov, 1999; Zagorodnyuk, 2006, Ilyukh, Khokhlov, 2012). Numerous publications by both foreign and domestic authors are devoted to the study of the impact of transport infrastructure. Special attention of European authors is paid to the study of the phenomenon of fragmentation of natural ecosystems. In Europe, there is a network of experts and institutions of IENE, which is studying the possibility of implementing preventive measures for landscape fragmentation, promotes the development of transport infrastructure in accordance with environmental requirements, by creating a safe, environmentally sustainable European transport infrastructure.The ecological trail of the road network significantly exceeds its length (Vozniuk, 2014). This is due to the effects of, in particular, mortality on the roads of mammals, reptiles, reptiles (Forman et al. 2003), landscape fragmentation (roads divide the area into isolated areas, with low populations (sometimes below the minimum), so such populations lose genetic diversity and may become extinct locally), the loss of habitats of species and a decrease in the level of connectivity. In addition to these obvious effects, noise and vibration pollution are added, which inhibit the ability of reptiles, birds and mammals to detect prey or avoid predators (Forman et al. 2003), disturbed light regime (Rich and Longcore 2006). Roads contribute to the development of soil erosion processes, the spread of invasive and introduced species (300-800 seeds/m2 per year are transported to roadside ecotones by vehicles (Von der Lippe and Kowarik 2007), which contributes to the formation of local pseudo-populations), create obstacles and sources. (Forman et al. 2003).Purpose. Substantiation of the principle of ecological continuity regarding the negative impact of transport infrastructure on natural ecosystems and search for possible ways to minimize and prevent such impact.Materials and methods. The main research methods are the application of theoretical general scientific approaches to study: analysis and synthesis of international and domestic scientific and theoretical works, EU documentation (charters, design requirements), Ukrainian legal framework, literature sources; collection and analysis of statistical data to identify the dangers of the impact of road infrastructure on biodiversity and determine the value of the natural landscape.Results. The result is an analysis of the scientific literature on the negative impact of transport infrastructure on animals, systematization of the main impacts for the preparation of methodological documents for organizations planning and designing transport infrastructure in Ukraine to reduce the negative impact.Conclusions. The principle of ensuring ecological continuity is to minimize the negative consequences for the environment. In particular, by leveling the spatial barrier of the public highway. When laying a road through natural ecosystems, it is necessary to build transitions and passages for animals. In this case, their density and type must correspond to the natural rank of the territory. The construction of crossings for animals should be mandatory for all types of roads that cross ecological corridors. This is especially true for smaller roads, completely devoid of any transitions for animals, noise shields (on such roads are more likely to hit animals). An important point is the need to plan preventive methods at the planning stage of road construction. The analysis of the European experience shows that the negative impact of transport infrastructure on biota can be solved by consolidating the efforts of road transport specialists and specialists in the field of nature protection.Keywords:motor road,wildlife crossing, biodiversity, road infrastructure, ecological continuity


2008 ◽  
Vol 86 (7) ◽  
pp. 682-685 ◽  
Author(s):  
Barbara Szpakiewicz ◽  
Maria Grzegożek

3-, 5-, 6-, 7- and 8-Nitroquinolines react with 4-amino-1,2,4-triazole in basic medium (potassium tert-butoxide-dimethyl sulfoxide) giving amino products of the vicarious nucleophilic substitution (VNS) of hydrogen, predominantly at ortho position to the nitro group, except 8-nitroquinoline, which reacts at para position. Additionally, furazano[3,4-f]- and furazano[3,4-h]quinoline were obtained in the case of 5- and 8- nitroquinoline, respectively. 2-Nitroquinoline was aminated to 2-quinolino(1,2,4-triazol-4-yl)amine in these conditions.Key words: nitroquinolines, vicarious nucleophilic substitution (VNS), 4-amino-1,2,4-triazole.


2017 ◽  
Vol 29 (11) ◽  
pp. 1771-1784 ◽  
Author(s):  
Annie Pye ◽  
Anna Pavlina Charalambous ◽  
Iracema Leroi ◽  
Chrysoulla Thodi ◽  
Piers Dawes

ABSTRACTBackground:Cognitive screening tests frequently rely on items being correctly heard or seen. We aimed to identify, describe, and evaluate the adaptation, validity, and availability of cognitive screening and assessment tools for dementia which have been developed or adapted for adults with acquired hearing and/or vision impairment.Method:Electronic databases were searched using subject terms “hearing disorders” OR “vision disorders” AND “cognitive assessment,” supplemented by exploring reference lists of included papers and via consultation with health professionals to identify additional literature.Results:1,551 papers were identified, of which 13 met inclusion criteria. Four papers related to tests adapted for hearing impairment; 11 papers related to tests adapted for vision impairment. Frequently adapted tests were the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MOCA). Adaptations for hearing impairment involved deleting or creating written versions for hearing-dependent items. Adaptations for vision impairment involved deleting vision-dependent items or spoken/tactile versions of visual tasks. No study reported validity of the test in relation to detection of dementia in people with hearing/vision impairment. Item deletion had a negative impact on the psychometric properties of the test.Conclusions:While attempts have been made to adapt cognitive tests for people with acquired hearing and/or vision impairment, the primary limitation of these adaptations is that their validity in accurately detecting dementia among those with acquired hearing or vision impairment is yet to be established. It is likely that the sensitivity and specificity of the adapted versions are poorer than the original, especially if the adaptation involved item deletion. One solution would involve item substitution in an alternative sensory modality followed by re-validation of the adapted test.


2021 ◽  
Author(s):  
Daniel Osuna Gómez ◽  

This paper estimates the impact of the capture of leaders of criminal organizations on the labor market in municipalities where these organizations operated between 2004 and 2006. The difference-in-difference analysis compares different employment outcomes in cartel locations and the rest, before and after the capture of cartel leaders. The results show that captures caused a decrease in nominal wages and paid employment in cartel municipalities. Using Economic Census Data, I find that captures also caused a fall in the number of establishments and had a negative impact on other establishment outcomes. This document focuses exclusively on the impact of the capture of leaders of criminal organizations on the labor market until 2011 without studying other possible consequences, and thus does not make an integral assessment of this policy


2019 ◽  
Vol 32 (1) ◽  
pp. 26-40 ◽  
Author(s):  
Paul Shrivastava ◽  
Laszlo Zsolnai ◽  
David Wasieleski ◽  
Mark Stafford-Smith ◽  
Thomas Walker ◽  
...  

The Anthropocene era is characterized by a pronounced negative impact of human and social activities on natural ecosystems. To the extent finance, economics and management underlie human social activities, we need to reassess these fields and their role in achieving global sustainability. This article briefly presents the scientific evidence on accelerating impacts of human activities on nature, which have resulted in breach of planetary boundaries and onset of global climate change. It offers some potential leverage points for change toward sustainability stewardship by highlighting the important role of finance and economics in addressing climate change. We examine the role of financial stakeholders in addressing planetary boundaries and offer a modified stakeholder theory, from which we propose future directions for finance in the Anthropocene.


2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Irina A. Tarasenko ◽  
Alexander V. Zin’kov ◽  
Aleksei S. Kholodov ◽  
Muhammad Riaz ◽  
Valeriy I. Petukhov ◽  
...  

Elevated contents of hazardous elements in natural ecosystems are often associated with human activities. Significant quantities of these elements, including heavy metals, are concentrated in tailings. The goal of the study was to assess the mineralogical and geochemical features of the old tailings of the decommissioned Krasnorechenskaya concentrating mill (located in Primorsky Krai, Russian Federation), which was processing complex tin-polymetallic and silver-lead-zinc ores, the chemical features of tailings pond waters, and the extent of environmental impact on the nearby Rudnaya river. In addition to the analysis of rock and water samples, the software modeling of the water-rock-gas system was carried out. In the study area, the minerals and rocks undergo changes that lead to the formation of highly mineralized, acidic waters saturated with various elements. In the tailings ponds, the maximum permissible concentrations were exceeded for Zn, Cd, Cu, Mg, Fetotal, Pb, Mn, Al, As, Co, Be, Sr, Ni, and Ba. The drainage from the tailings pond tripled the total mineralization of the Rudnaya river relative to the background values. However, the intoxication of the ecosystem by tailing products is partially inhibited by the secondary minerals in the tailings ponds. The negative impact is of a local nature, and 500 m downstream the concentration of many of the above elements is reduced. Despite this, the system that forms the chemical composition of highly mineralized waters is far from the equilibrium state. The oxidation of sulfides, dissolution of other minerals, and migration of oxidation and hydrolysis products will continue affecting the environment. In this regard, it is necessary to conduct environmental monitoring and undertake activities aimed at the recovery of mature concentration tailings or at suppressing the activity of hazardous elements by the conservation of tailings ponds.


1970 ◽  
Vol 16 (5) ◽  
pp. 369-372 ◽  
Author(s):  
Ishwari Prasad

3′,4′-Dichloropropionanilide; its biodegradation products 3,4-dichloroaniline and 3,3′,4,4′-tetrachloroazobenzene; and related chloroaniline and chlorobenzenes were tested for effects on the back mutation frequency of the meth3 locus in Aspergillus nidulans. 3,4-Dichloroaniline was more mutagenic than 3,3′,4,4′-tetrachloroazobenzene and 3′,4′-dichloropropionanilide. Chlorine in the para position on benzene ring increased mutagenicity more than chlorine in the meta or ortho position. Chloroaniline was more mutagenic than the corresponding dichlorobenzene.


SPE Journal ◽  
2015 ◽  
Vol 20 (04) ◽  
pp. 729-742 ◽  
Author(s):  
J.. Fahimpour ◽  
M.. Jamiolahmady

Summary Significant reduction in well productivity of gas/condensate reservoirs occurs because of reduced gas mobility caused by the presence of condensate/water liquid phases around the wellbore. There are certain fluorinated wettability modifiers that are capable of delivering a good level of oil and water repellency to the rock surface, making it intermediate gas-wet and alleviating such liquid blockages. The main objective of this experimental work has been to evaluate the performance of such chemicals for wettability alteration of carbonate rocks, which have received much less attention in comparison with sandstone rocks. Screening tests, including contact-angle measurements, unsteady-state-flow tests, and compatibility tests with brine, were performed by use of mainly anionic and nonionic fluorosurfactants. Results demonstrated that on positively charged carbonate surfaces, the anionic chemicals were sufficiently effective to repel the liquid phase, whereas the nonionic chemicals showed an excellent stability in brine media. A new approach of combining anionic and nonionic chemical agents was proposed to benefit from these two positive features of an integrated chemical solution. A number of low- and high-permeability carbonate-core samples were successfully treated by use of chemicals selected through screening tests. Optimization of the solution composition and its filtration before injecting it into the core proved very effective in reducing/eliminating the risk of possible permeability damage because of deposition of large chemical aggregates on the rock surface. The chemical solution optimized in this study can be considered as a potential wettability modifier for mitigating the negative impact of condensate/water banking in gas/condensate carbonate reservoirs.


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