scholarly journals Synthesis, Characterization and Evaluation of Biological Activity of some Substituted(E)-2-Benzylidenehydrazinecarbothio Amides

2015 ◽  
Vol 59 ◽  
pp. 199-211
Author(s):  
R. Vijayakumar ◽  
M. Rajarajan ◽  
R. Senbagam ◽  
S. Balaji ◽  
V. Manikandan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Nmr Spectra ◽  
Pathogenic Bacteria ◽  
Antimicrobial Activities ◽  
Fungal Species ◽  
Significant Activity ◽  
Ir And Nmr Spectra ◽  
Physical Constants ◽  
Human Pathogenic Bacteria ◽  
Substituted Benzaldehydes

A series of substituted (E)-2-benzylidenehydrazinecarbothioamide compounds were synthesized by condensation of thiosemicarbazide with substituted benzaldehydes. The synthesized substituted (E)-2-benzylidenehydrazinecarbothioamide compounds were characterized by their physical constants, UV, IR and NMR spectra. The antimicrobial activities of these synthesized substituted (E)-2-benzylidenehydrazinecarbothioamide compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized (E)-2-benzylidenehydrazinecarbothioamide compounds have shown significant activity.

Antimicrobial Effect of Brazillian Propolis/Polycaprolactone Polymer on some Human Pathogenic Bacteria

2012 ◽  
Vol 506 ◽  
pp. 537-540 ◽  
Author(s):  
S. Sanpa ◽  
Krit Sutjarittangtham ◽  
Tawee Tunkasiri ◽  
Sukum Eitssayeam ◽  
P. Chantawannakul
Keyword(s):  
Pathogenic Bacteria ◽  
Antimicrobial Effect ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Electrospinning Technique ◽  
Propolis Extract ◽  
Human Pathogenic Bacteria ◽  
Polymer Nanofiber ◽  
History Of Use

The antimicrobial activities of propolis against some bacterial strains have been studied. However, there are few reports on biopolymers from propolis. Polycaprolactone (PCL) is a biodegradable polymer that has a long history of use in the biomedical field. In this work, the polymer nanofiber was grown from a Brazillian propolis extract solution on PCL using an electrospinning technique. Antimicrobial activities were investigated by the disc diffusion method. The propolis extract and polymer nanofiber could inhibit some human pathogenic bacteria. In addition, the inhibitory effects on tested microorganism depended on the concentration of propolis extract mixed with the polymer nanofiber. Such properties of the propolis/PCL nanofiners can be further developed for biomedical applications.

scholarly journals Investigation on antimicrobial activities of the plant Swertia chirata Ham.

1970 ◽  
Vol 2 (2) ◽  
pp. 31-34 ◽  
Author(s):  
Mst Jesmin Sultana ◽  
Md Tamzid Hossain Molla ◽  
MT Alam ◽  
Fazle Rabbi Shakil Ahmed
Keyword(s):  
Bacillus Megaterium ◽  
Brine Shrimp ◽  
Pathogenic Bacteria ◽  
Biological Activities ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Significant Activity ◽  
Neutral Alumina ◽  
Swertia Chirata

Biological activities of fresh stem of the plant Swertia chirata Ham. (F. Gentianaceae) extracted in rectified spirit is reported here. The crude rectified spirit extract was fractionated by using standard chromatographic techniques on alumina, which gave six fractions (A, B, C, D, E & F). When subjected to column chromatographic analysis on neutral alumina, fraction D yielded a pure compound tentatively known as AJ-1 that have melting point of 178° C. AJ-1 was screened for its antibacterial activities against 12 pathogenic bacteria, 6 Gram positive and 6 Gram negative, by disc diffusion method at a concentration of 200 μg/disc. The results obtained were compared with those for a standard antibiotic Kanamycin. AJ-1 showed significant activity against Bacillus megaterium (11 mm), Bacillus subtilis (9 mm), Salmonella typhi-A (10 mm), Shigella flexeneriae (10 mm) and Klebsiella sp (11 mm) but a little activity against Staphylococcus aureus. The Minimum Inhibitory Concentrations (MIC) of AJ-1 determined against Bacillus megaterium and Salmonella typhi-A were 128 μg/ml and 128 μg/ml, respectively when tested in a nutrient broth medium. AJ-1 also showed significant activity against the brine shrimp (Artemia salina) nauplii (LC50 value of 9.34 μg/ml), in which the mortality rate increased with the increasing concentration of the compound, suggesting a positive correlation between brine shrimp toxicity and cytotoxicity. Key words: Biological activity; Swertia chirata; Gentianaceae; pathogenic bacteria DOI: 10.3329/jles.v2i2.7494 J. Life Earth Sci., Vol. 2(2) 31-34, 2007

scholarly journals Bridelia retusa (L.) Spreng. Fruits: Antimicrobial Efficiency and their Phytochemical Constituents

2016 ◽  
Vol 8 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Aniel Kumar OWK ◽  
Mutyala Naidu LAGUDU
Keyword(s):  
Pathogenic Bacteria ◽  
Antimicrobial Activities ◽  
Fungal Species ◽  
Dilution Method ◽  
Phytochemical Analysis ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Antimicrobial Efficiency ◽  
Bridelia Retusa

Antimicrobial analysis of hexane, chloroform, methanol and aqueous extracts of Bridelia retusa fruits was performed by agar well method and minimum inhibitory concentration was determined by serial two-fold dilution method. Seven human pathogenic bacteria species including Gram positive and Gram negative bacteria and three fungal species were used in the study and the results indicated that the Gram positive bacteria and fungi were more sensitive than the Gram negative bacteria, to both solvent and aqueous Bridelia retusa fruit extracts. Moreover, Enterococcus faecalis was found as the most sensitive bacteria, whereas Proteus vulgaris and Aspergillu niger were the most resistant to the tested extracts. Phytochemical analysis of fruits revealed the presence of secondary metabolites like alkaloid, saponins and terpenoids, which have been implicated in antimicrobial activities. Hence, it would be recommended to explore the maximum potential of Bridelia retusa in the medicinal and pharmaceutical field and investigation are endorsed for further application useful in phytomedicine.

Antimicrobial activity of leaf extracts of Eupatorium triplinerve Vehl. against some human pathogenic bacteria and phytopathogenic fungi

1970 ◽  
Vol 37 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Md Shafiqur Rahman ◽  
Mohammad Junaid
Keyword(s):  
Antimicrobial Activity ◽  
Mycelial Growth ◽  
Pathogenic Bacteria ◽  
Antimicrobial Activities ◽  
Chloroform Extract ◽  
Phytopathogenic Fungi ◽  
Zone Of Inhibition ◽  
Leaf Extracts ◽  
Human Pathogenic Bacteria ◽  
Ethyl Acetate Extracts

Petroleum ether, carbon tetrachloride, chloroform, and ethyl acetate extracts of Eupatorium triplinerve Vehl. leaves were investigated for their antimicrobial activities against 11 human pathogenic bacteria and six phytopathogenic fungi. The crude extracts showed good activity against the organisms tested herein. The chloroform extract exhibited the largest zone of inhibition (22 mm in diam with 1000 μg/disc extract) against Vibrio and the highest inhibition of fungal radial mycelial growth (73.5% with 100 μg extract/ml medium) against Colletotrichum corchori. The chloroform extract exhibited the lowest MIC against Vibrio (250 μg/ml) and C. corchori (62.5 μg/ml). It appeared that E. triplinerve could be a potential natural source of new antimicrobial agent.    Key words: Antimicrobial activity, Leaf extract, Eupatorium triplinerve doi:10.3329/bjb.v37i1.1570 Bangladesh J. Bot. 37(1): 89-92, 2008 (June)

scholarly journals The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 6081
Author(s):  
Fatimah Al-Otibi ◽  
Shahad K. Alkhudhair ◽  
Raedah I. Alharbi ◽  
Abdulaziz A. Al-Askar ◽  
Reem M. Aljowaie ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Silver Nanoparticles ◽  
Pathogenic Bacteria ◽  
Uv Spectroscopy ◽  
Grape Seed ◽  
Antimicrobial Activities ◽  
Fungal Species ◽  
Gas Chromatography Mass Spectrometry ◽  
Grape Seeds ◽  
Antibacterial And Antifungal Activities

Grape seed extract (GSE) is a natural source of polyphenolic compounds and secondary metabolites, which have been tested for their possible antimicrobial activities. In the current study, we tested the antibacterial and antifungal activities of aqueous GSE and the biosynthesized silver nanoparticles loaded with GSE (GSE-AgNPs) against different pathogens. The biosynthesized GSE-AgNPs were assessed by UV spectroscopy, dynamic light scattering (DLS), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and gas chromatography/mass spectrometry (GC/MS). The antimicrobial activities were assessed against different bacterial and fungal species. DLS analysis showed that GSE-AgNPs had a Z-Average of 91.89 nm while UV spectroscopy showed that GSE-AgNPs had the highest absorbance at a wavelength of ~415 nm. FTIR analysis revealed that both of GSE and GSE-AgNPs consisted of different functional groups, such as hydroxyl, alkenes, alkyne, and aromatic rings. Both FE-SEM and TEM showed that GSE-AgNPs had larger sizes and rough surfaces than GSE and AgNO3. The results showed significant antimicrobial activities of GSE-AgNPs against all tested species, unlike GSE, which had weaker and limited effects. More studies are needed to investigate the other antimicrobial activities of GSE.

scholarly journals Steroids from Marine-Derived Fungi: Evaluation of Antiproliferative and Antimicrobial Activities of Eburicol

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 372 ◽  
Author(s):  
Dos Santos Dias ◽  
Couzinet-Mossion ◽  
Ruiz ◽  
Lakhdar ◽  
Etahiri ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Pathogenic Bacteria ◽  
Culture Media ◽  
Cancer Cell Lines ◽  
Antimicrobial Activities ◽  
Significant Activity ◽  
Bioactive Lipids ◽  
Fungal Strains ◽  
Mcf 7

The most common sterol in fungi is ergosterol, which has frequently been investigated in human pathogenic fungal strains. This sterol, and others isolated from fungal strains, has also demonstrated cytotoxicity against cancer cell lines and antimicrobial activities. Marine fungi can produce high amounts of bioactive compounds. So, a screening was performed to study sterol composition using GC/MS in 19 marine fungal strains and ergosterol was always the major one. One strain, Clonostachys rosea MMS1090, was selected due to its high amount of eburicol and a one strain many compounds approach was performed on seven culture media to optimize its production. After purification and structural identification by NMR, eburicol was assessed against four cancer cell lines, MCF-7, MDA-MB-231, NSCLC-N6-L16 and A549, and seven human pathogenic bacteria Staphylococcus aureus, Bacillus sp., Bacillus cereus, Listeria ivanovii, Escherichia coli, Citrobacter freundii and Salmonella spp. The most significant activity was cytotoxicity against MCF-7 cells (2 µM). This is the first report of such an accumulation of eburicol in the marine fungal strain C. rosea confirming its potential in the production of bioactive lipids.

ANTIMICROBIAL ACTIVITIES OF METHANOL EXTRACT FROM UNIDENTIFIED SPONGE ASSOCIATED BACTERIA IN LEMUKUTAN ISLAND, KALIMANTAN BARAT

2009 ◽  
Vol 1 (2) ◽  
Author(s):  
Risa Nofiani ◽  
Siti Nurbetty ◽  
Ajuk Sapar
Keyword(s):  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Pathogenic Bacteria ◽  
Methanol Extract ◽  
Agar Medium ◽  
Antimicrobial Activities ◽  
Antimicrobial Compounds ◽  
Associated Bacteria ◽  
Minimum Inhibitory Concentrations ◽  
Sponge Associated Bacteria

<p>The increase of issues on the antibiotics resistant pathogenic bacteria has triggered high exploration for new antimicrobial compounds. One of the potential sources is sponge-associated bacteria. The aim of this study was to get sponge-associated bacteria extract containing antimicrobial activities. On the basis screening of antimicrobial activity using by streaking on agar medium, there were two potential isolates with antimicrobial activities namely LCS1 and LCS2. The two isolates were cultivated,then secondary metabolite product were extracted using methanol as a solvent. Minimum inhibitory concentrations (MICs) of extract LCS 1 were 1,000 μg/well for S. aureus, 950 μg/well for Salmonella sp.and 800 μg/well for Bacillus subtilis. Minimum inhibitory concentrations of extract LCS 2 were 500 μg/well for S. aureus, 1,050 μg/well for Salmonella sp., 750 μg/well for Bacillus subtilis, 350 μg/well for P. aeruginosa, 750 μg/sumur terhadap B. subtilis. Based on the MIC values, the two assay extracts have a relatively low antimicrobial activity.</p> <p>Keywords:Antimicrobial,Sponges associated bacteria,MICs</p>

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