scholarly journals Analysis of the Knowledge Landscape of 3D Bioprinting in Latin America

2019 ◽  
Vol 5 (2.3) ◽  
Author(s):  
Marisela Rodriguez-Salvador ◽  
Diego Villarreal-Garza ◽  
Mario Moisés Alvarez ◽  
Grissel Trujillo-de Santiago
Keyword(s):  
Latin America ◽  
Relevant Information ◽  
Scientific Publication ◽  
Living Cells ◽  
3D Bioprinting ◽  
Natural Consequence ◽  
Research Groups ◽  
Publication Trends ◽  
High Quality Research ◽  
Technology Intelligence

Bioprinting, the printing of living cells using polymeric matrixes (mainly hydrogels), has attracted great attention among science and technology circles. North America has been one of the sources of bioprinting-related technology in recent years. As a natural consequence of geography, high-quality research in the area of bioprinting has started to permeate Latin America. Here, we describe and analyze the knowledge landscape of bioprinting in Latin America using a competitive technology intelligence methodology. Our analysis provides relevant information, such as the scientific publication trends in Latin America and the scientific networks among research groups in Latin America and the world.

scholarly journals Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador
Keyword(s):  
Optical Properties ◽  
3D Printing ◽  
Clinical Training ◽  
Three Dimensional ◽  
Biological Tissues ◽  
3D Bioprinting ◽  
Technology Intelligence ◽  
Biomedical Device ◽  
Tissue Phantoms ◽  
Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

scholarly journals Fabrication of 3D Printing Scaffold with Porcine Skin Decellularized Bio-Ink for Soft Tissue Engineering

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3522
Author(s):  
Su Jeong Lee ◽  
Jun Hee Lee ◽  
Jisun Park ◽  
Wan Doo Kim ◽  
Su A Park
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
3D Printing ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Research Groups ◽  
Porcine Skin ◽  
Alginate Hydrogel ◽  
Chemical Treatments ◽  
Soft Tissue Engineering

Recently, many research groups have investigated three-dimensional (3D) bioprinting techniques for tissue engineering and regenerative medicine. The bio-ink used in 3D bioprinting is typically a combination of synthetic and natural materials. In this study, we prepared bio-ink containing porcine skin powder (PSP) to determine rheological properties, biocompatibility, and extracellular matrix (ECM) formation in cells in PSP-ink after 3D printing. PSP was extracted without cells by mechanical, enzymatic, and chemical treatments of porcine dermis tissue. Our developed PSP-containing bio-ink showed enhanced printability and biocompatibility. To identify whether the bio-ink was printable, the viscosity of bio-ink and alginate hydrogel was analyzed with different concentration of PSP. As the PSP concentration increased, viscosity also increased. To assess the biocompatibility of the PSP-containing bio-ink, cells mixed with bio-ink printed structures were measured using a live/dead assay and WST-1 assay. Nearly no dead cells were observed in the structure containing 10 mg/mL PSP-ink, indicating that the amounts of PSP-ink used were nontoxic. In conclusion, the proposed skin dermis decellularized bio-ink is a candidate for 3D bioprinting.

scholarly journals Paper Productivity of Ground-based Large Optical Telescopes from 2000 to 2009

2011 ◽  
Vol 28 (3) ◽  
pp. 249-260 ◽  
Author(s):  
Sang Chul Kim
Keyword(s):  
Scientific Publication ◽  
Publication Trends ◽  
Publication Data ◽  
Large Telescopes ◽  
Optical Telescopes ◽  
Infrared Telescopes

AbstractWe present an analysis of the scientific (refereed) paper productivity of the current largest (diameter > 8m) ground-based optical (and infrared) telescopes during the ten-year period from 2000 to 2009. The telescopes for which we have gathered and analysed the scientific publication data are the two 10-m Keck telescopes, the four 8.2-m Very Large Telescopes (VLT), the two 8.1-m Gemini telescopes, the 8.2-m Subaru telescope, and the 9.2-m Hobby–Eberly Telescope (HET). We have analysed the numbers of papers published in various astronomical journals produced by using these telescopes. While the total numbers of papers from these observatories are largest for the VLT, followed by Keck, Gemini, Subaru, and HET, the number of papers produced by each component of the telescopes is largest for Keck, followed by VLT, Subaru, Gemini, and HET. In 2009, each telescope of the Keck, VLT, Gemini, Subaru, and HET observatories produced 135, 109, 93, 107, and 5 refereed papers, respectively. We have shown that each telescope of the Keck, VLT, Gemini, and Subaru observatories is producing 2.1 ± 0.9 Nature and Science papers annually and these papers make up 1.7 ± 0.8% of all refereed papers produced by using each of those telescopes. Extending this relation, we propose that this ratio of the number of Nature and Science papers to the total number of refereed papers that will be produced by future extremely large telescopes (ELTs) will remain similar. From a comparison of the publication trends of the above telescopes, we suggest that (i) having more than one telescope of the same kind at the same location and (ii) increasing the number of instruments available at the telescope are good ways to maximize the paper productivity.

A Prototype of a 3D Bioprinter

2015 ◽  
Vol 237 ◽  
pp. 221-226 ◽  
Author(s):  
Jakub Mielczarek ◽  
Grzegorz Gazdowicz ◽  
Jakub Kramarz ◽  
Piotr Łątka ◽  
Marcin Krzykawski ◽  
...  
Keyword(s):  
Control System ◽  
Drug Testing ◽  
Three Dimensional ◽  
Living Cells ◽  
Layer By Layer ◽  
3D Bioprinting ◽  
Innovative Method ◽  
Layer Deposition ◽  
Potential Applications ◽  
Technical Details

3D bioprinting is an innovative method of manufacturing three-dimensional tissue-like structures. The method is based on a layer-by-layer deposition of biocompatible materials successively forming a scaffold for living cells. The technology allows to fabricate complicated tissue morphology, including vascular-like networks. The range of potential applications of 3D bioprinting is immense: from drug testing, across regenerative medicine, to organ transplantation. In this paper, we describe a prototype of a 3D bioprinter utilizing gelatin methacrylate (GelMA) doped with a photoinitiator as the printing substance. Biological requirements for the material, its synthesis and application adequacy for the bioprinting process are discussed. Technical details of the mechanical construction of the bioprinter and its control system are presented

scholarly journals Voxar Labs

2020 ◽  
Vol 4 (2) ◽  
pp. 43-46
Author(s):  
Veronica Teichrieb ◽  
Francisco Simões ◽  
Lucas Figueiredo ◽  
João Paulo Lima ◽  
João Marcelo Teixeira ◽  
...  
Keyword(s):  
Computer Vision ◽  
Latin America ◽  
Technology Transfer ◽  
Augmented Reality ◽  
Human Resources ◽  
Research Groups ◽  
Large Area ◽  
Natural Interaction ◽  
Scientific Publications ◽  
Spatial Computing

Voxar Labs is a research group focused in augmenting experiences through research, innovation and collaboration with academia and industry. It develops cutting-edge multi-disciplinary research in the large area of Spatial Computing, tackling the inner areas of Extended Reality, Computer Vision and Natural Interaction. The laboratory aims to create impact through R&D&I, technology transfer, scientific publications, patents and human-resources formation. It is one of the most productive Augmented Reality research groups in the Latin America, also being recognized with seven best papers and ten first-place competitions’ prizes over the nine years of its existence. Voxar Labs is part of the Informatics Center of the Federal University of Pernambuco, located in Recife – Pernambuco, Brazil.

scholarly journals Associated factors with reaching a scientific publication during medical training: evidence from 40 medical schools surveyed in Latin America.

2020 ◽  
Author(s):  
Mario J. Valladares-Garrido ◽  
Christian R. Mejia ◽  
Annel B. Rojas-Alvarado ◽  
Mary M. Araujo-Chumacero ◽  
Jhacksson S. Córdova-Agurto ◽  
...  
Keyword(s):  
Latin America ◽  
Medical Students ◽  
Latin American ◽  
Medical Training ◽  
English Proficiency ◽  
Scientific Publication ◽  
Scientific Writing ◽  
Scientific Society ◽  
Scientific Societies ◽  
Scientific Publications

Abstract Background Scientific publication during medical training is key to promote an enduring cutting-edge knowledge. The promotion of science among medical students in Latin America is a multi-sphere issue hampered by the unawareness of governments to invest in national research, as well as a lack of support from local universities. This study aims to determine the factors associated to reach a scientific publication during medical training among Latin American medical students of local scientific societies. Methods This is a secondary-data-analysis of a study conducted in 2016 to evaluate the use of information and communications technologies (TICs) among medical students of 40 local scientific societies of medical students affiliated to the Latin American Federation of Medical Students Scientific Societies (FELSOCEM, in Spanish). Local teams in each local scientific society surveyed self-reported scientific publications and explored its association with socioeconomic, academic, and research training conditions. We included medical students enrolled in the 2016-I term and excluded medical interns. We implemented nested models to identify covariates associated with self-reported scientific publication until reaching a parsimonious mixed-effect multilevel model clustered by medical scientific society. Results We surveyed 11,587 medical students. The prevalence of scientific publications increased in 36% among medical students affiliated to a Scientific Society of Medical Students [parsimonious prevalence ratio (PRp)=1.36, 95%CI=1.16–1.59], 51% among medical students with advanced English proficiency [PRp=1.51, 95%CI=1.21 – 1.87], 85% among medical students who attended a scientific writing skills course [PRp=1.85, 95%CI=1.59–2.15], 81% among medical students who use Sci-hub [PRp=1.81, 95%CI=1.50–2.20], and 108% among medical students who have access to a pirated academic account [PRp=2.08, 95%CI=1.83–2.36]. Conclusions Reaching a scientific publication among medical students is associated with being affiliated to a Scientific Society of Medical Students, English proficiency, training in scientific writing, use of Sci-Hub, and pirated academic accounts.

scholarly journals Promoting high quality research into priority health needs in Latin America and Caribbean

BMJ ◽  
2018 ◽  
pp. k2492 ◽  
Author(s):  
Fabio Zicker ◽  
Luis Gabriel Cuervo ◽  
Luis Alejandro Salicrup
Keyword(s):  
Latin America ◽  
Health Needs ◽  
High Quality ◽  
High Quality Research ◽  
Quality Research ◽  
Latin America And Caribbean

scholarly journals Bioprintability: Physiomechanical and Biological Requirements of Materials for 3D Bioprinting Processes

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2262 ◽  
Author(s):  
Andrea S. Theus ◽  
Liqun Ning ◽  
Boeun Hwang ◽  
Carmen Gil ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Hybrid Systems ◽  
Manufacturing Process ◽  
Three Dimensional ◽  
Living Cells ◽  
Clinical Applications ◽  
Fine Tuning ◽  
Biological Processes ◽  
3D Bioprinting ◽  
Qualitative Methodologies

Three-dimensional (3D) bioprinting is an additive manufacturing process that utilizes various biomaterials that either contain or interact with living cells and biological systems with the goal of fabricating functional tissue or organ mimics, which will be referred to as bioinks. These bioinks are typically hydrogel-based hybrid systems with many specific features and requirements. The characterizing and fine tuning of bioink properties before, during, and after printing are therefore essential in developing reproducible and stable bioprinted constructs. To date, myriad computational methods, mechanical testing, and rheological evaluations have been used to predict, measure, and optimize bioinks properties and their printability, but none are properly standardized. There is a lack of robust universal guidelines in the field for the evaluation and quantification of bioprintability. In this review, we introduced the concept of bioprintability and discussed the significant roles of various physiomechanical and biological processes in bioprinting fidelity. Furthermore, different quantitative and qualitative methodologies used to assess bioprintability will be reviewed, with a focus on the processes related to pre, during, and post printing. Establishing fully characterized, functional bioink solutions would be a big step towards the effective clinical applications of bioprinted products.

scholarly journals Tissue engineering: Designing for health

2003 ◽  
Vol 25 (5) ◽  
pp. 19-21
Author(s):  
Tim Hardingham
Keyword(s):  
Tissue Engineering ◽  
Biomedical Research ◽  
Gain Control ◽  
Living Cells ◽  
Scientific Understanding ◽  
Biological Processes ◽  
Research Groups ◽  
Living Tissues

The tissue engineering that is now emerging in biomedical research groups is concerned with living tissues and how we can harness biological processes to achieve healing and repair, where it is otherwise failing. It aims to develop our scientific understanding of how living cells function, so that we can gain control and direct their activity to the promote the repair of damaged and diseased tissue1.

scholarly journals Revealing emerging science and technology research for dentistry applications of 3D bioprinting

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador ◽  
Laura Ruiz-Cantu
Keyword(s):  
Alveolar Bone ◽  
Science And Technology ◽  
Three Dimensional ◽  
Bone Diseases ◽  
3D Bioprinting ◽  
Oral Diseases ◽  
Technology Intelligence ◽  
Dental Tissues ◽  
Synthetic Materials ◽  
Development Analysis

Science and technology (S&T) on three-dimensional (3D) bioprinting is growing at an increasingly accelerated pace; one major challenge represents how to develop new solutions for frequent oral diseases such as periodontal problems and loss of alveolar bone. 3D bioprinting is expected to revolutionize the health industry in the upcoming years. In dentistry, this technology can become a significant contributor. This study applies a Competitive Technology Intelligence methodology to uncover the main S&T drivers in this domain. Looking at a 6-year period from 2012 to 2018 an analysis of scientific and technology production was made. Three principal S&T drivers were identified: Scaffolds development, analysis of natural and synthetic materials, and the study of scaffold characteristics. Innovative hybrid and multiphasic scaffolds are being developed to regenerate periodontal tissue and alveolar bone by combining them with stem cells from the pulp or periodontal ligament. To improve scaffolds performance, biodegradable synthetic polymers are often used in combination with bioceramics. The characteristics of scaffolds such as fiber orientation, porosity, and geometry, were also investigated. This research contributes to people interested in bringing innovative solutions to the health industry, particularly by applying state-of-the-art technologies such as 3D bioprinting, in this case for dental tissues and dental bone diseases.

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