scholarly journals Level of serum uric acid in patients with preeclampsia compared to controls and its relation to feto-maternal outcome

2019 ◽  
Vol 8 (6) ◽  
pp. 2471
Author(s):  
Ramraj Meena ◽  
Purnima Pachori ◽  
Sandhya Chaudhary ◽  
Chandrakanta .
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Serum Uric Acid ◽  
Gestational Age ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Age Group ◽  
Normal Birth Weight ◽  
Normal Birth

Background: Uric acid is the final product of the purine metabolism in humans. The two final reactions in its production which catalyze the conversion of hypoxanthine to xanthine and the latter to uric acid are catalyzed by the enzyme xanthine oxidoreductase. The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease. The present study was done to see the level of uric acid in preeclampsia and  healthy pregnant controls, to relate serum uric acid results to the severity of hypertension and its relation to fetomaternal outcome in patients attending OPD at RMC Ajmer.Methods: 100 cases of preeclampsia of age group between 20-40 year and gestational age ≥28 weeks and 100 normal healthy women with similar gestational age and age group were included in the study and maternal serum uric acid was estimated in both groups.Results: Mean serum uric acid levels in preeclampsia was 7.65±081 mg/dl and 3.21±072 mg/dl in control group. Perinatal complication was more in case group, 74 % were preterm compared to 11% in control group. Mean birth weight in study group was 2.07 kg, of which 24% babies were VLBW 52% were LBW, and 24% babies had normal birth weight, in control group mean birth weight was 2.82 kg. The difference was found to be statistically significant (p value 0.001). In the study group, the MSUA concentration is found higher in LBW and VLBW babies compared to normal birth weight babies.Conclusions: There is a positive correlation between SUA & severity of preeclampsia, and a significant adverse fetal outcome is observed with raised MSUA in preeclamptic patients.

scholarly journals Plasma homocysteine and blood pressure in small for gestational age children

2016 ◽  
Vol 53 (5) ◽  
pp. 254
Author(s):  
Irene Melinda Louis ◽  
Adrian Umboh
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Homocysteine Level ◽  
Age Group ◽  
Normal Birth Weight ◽  
Normal Birth ◽  
Gestational Age At Birth ◽  
Age At Birth

Background Homocysteine is associated with endothelial damage and hypertension. Increased plasma homocysteine levels are often accompanied by cardiovascular impairment, including hypertension. Small for gestational age children have been found to have morbidity and mortality in cardiovascular diseases.Objective To assess for a possible association between homocysteine level and blood pressure in small for gestational age children.Methods This observational study was undertaken from December 2011 to April 2012 in Prof. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, on children who were born small for gestational age in year 2004-2005. Data was analyzed by T-test to compare homocysteine levels in small for gestational age and normal birth weight children. Regression analysis and simple coefficient test were used to assess for an association between homocysteine levels and blood pressure in children who were small for gestational age at birth.Results The mean homocysteine level in small for gestational age children was significantly higher than that of normal birth weight children (P<0.001). We observed no correlation between homocysteine level and systolic blood pressure in the small for gestational age group (r=0.151, P=0.189). However, there was a weak correlation between homocysteine level and diastolic blood pressure in the small for gestational age group (r=0.237, P=0.049).Conclusion Children who were small for gestational age at birth have significantly higher mean homocysteine level than that of normal birth weight children. Higher homocysteine levels are associated with higher diastolic blood pressure in children who were small for gestational age at birth.

scholarly journals Outcome of expectantly managed small-for-gestational-age pregnancies with normal Doppler parameters- a prospective cohort study

2021 ◽  
Vol 10 (3) ◽  
pp. 1134
Author(s):  
Sneha Mishra ◽  
Krishna Agarwal
Keyword(s):  
Birth Weight ◽  
Caesarean Section ◽  
Gestational Age ◽  
Expectant Management ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Biophysical Profile ◽  
Group 3 ◽  
The Mean

Background: SGA foetuses with normal Dopplers are not at risk of IUD. However, there is lack of consensus about timing of delivery of SGA foetuses. Clinicians commonly induce all SGA pregnancies at 37 weeks. Expectant management of SGA foetuses beyond 37 weeks is not well studied.Methods: We followed up women with clinically suspected growth restriction with foetal biometry, Doppler and biophysical profile. Pregnancies with foetal AC between 10th to 3rd centile with normal Dopplers were recruited in the study group. The women were allowed to go in spontaneous labor till 39+6/7 weeks or were induced at 39+6/7 weeks. The outcome of such cases was compared with controls who were induced at 37+0/7 weeks.Results: Spontaneous labor occurred in 42% subjects in study group whereas in control group all were induced. Mean gestation at delivery in the study group was increased (39.57±0.71 versus 37.0±0.0, p value <0.001). Almost 81% of the subjects in study group delivered after 39 weeks. The rate of caesarean section was significantly lower in study group (3% versus 22%, p value-0.024). Also, the risk of intrapartum foetal distress was lower in study group (3/36 versus 1/36).The mean birth weight in the study group was higher (2426.5±154.1 gm versus 2297.9±101.4 gm, p value <0.001.Conclusions: Expectant management of SGA pregnancies with normal Doppler parameters leads to a significant increase in gestational age at birth and the mean birth weight and a significant reduction in caesarean section rate. 

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

Berat Badan, Panjang Badan dan Faktor Genetik sebagai Prediktor Terjadinya Stunted pada Anak Sekolah

2017 ◽  
Vol 19 (2) ◽  
pp. 95
Author(s):  
Hetriana Leksananingsih ◽  
Slamet Iskandar ◽  
Tri Siswati
Keyword(s):  
Birth Weight ◽  
Nutritional Status ◽  
School Children ◽  
Genetic Factors ◽  
Control Group ◽  
Case Group ◽  
Normal Birth Weight ◽  
Chi Square ◽  
Normal Birth ◽  
Chi Square Test

Background: Riskesdas in 2013 showed that Yogyakarta (DIY) had a prevalence of stunted new kid in school is less than the national average, which is 14.9% (MOH, 2013). Stunted or short, is a linear growth retardation has been widely used as an indicator to measure the nutritional status of individuals and community groups. Stunted can be influenced by several factors: birth weight, birth length match and genetic factors. Objective: To determine the weight, length of low birth weight and genetic factors as predictors of the occurrence of stunted on elementary school children. Methods: The study was a case control analytic. Research sites in SD Muhammadiyah Ngijon 1 Subdistrict Moyudan. The study was conducted in May and June 2015. The subjects were school children grade 1 to grade 5 the number of cases as many as 47 children and 94 control children. With the inclusion criteria of research subjects willing to become respondents, was present at the time of the study, they have a father and mother, and exclusion criteria have no data BB and PB birth, can not stand upright. The research variables are BBL, PBL, genetic factors and TB / U at this time. Data were analyzed by chi-square test and Odd Ratio (OR) calculation. Results: In case group as much as 91.5% of normal birth weight and length of 80.9% of normal birth weight, most of the height of a normal mother and father as many as 85.1%. In the control group as much as 78.7% of normal birth weight and 61.7% were born normal body length, height mostly normal mom and dad that 96.7% of women and 90.4% normal normal father. Statistical test result is no significant correlation between height mothers with stunted incidence in school children, and the results of chi-square test P = 0.026 with value Odd Ratio (OR) of 3.9 and a range of values from 1.091 to 14.214 Cl95%. Conclusion: High maternal body of mothers can be used as predictors of the occurrence of stunted school children and mothers with stunted nutritional status have 3.9 times the risk of having children with stunted nutritional status.

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals Executive Functions of Six-Year-Old Boys with Normal Birth Weight and Gestational Age

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e36502 ◽  
Author(s):  
Desiree Yee-Ling Phua ◽  
Anne Rifkin-Graboi ◽  
Seang-Mei Saw ◽  
Michael J. Meaney ◽  
Anqi Qiu
Keyword(s):  
Birth Weight ◽  
Executive Functions ◽  
Gestational Age ◽  
Normal Birth Weight ◽  
Normal Birth

scholarly journals Assessment of Serum Uric Acid Levels in Patients with Acute Myocardial Infarction

2020 ◽  
Vol 3 (2) ◽  
pp. 46-48
Author(s):  
Manjiri Ravindra Kulkarni
Keyword(s):  
Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Control Group ◽  
Study Group ◽  
Acute Mi ◽  
St Elevation

Background : Aim of the study was to discover if there is the efficacy of serum uric acid in the prognostication of myocardial infarction subjects. Subjects and Methods: A total of 200 subjects were incorporated into the research. Of them, 74 patients had ST- elevated myocardial infarction, as in 26 subjects they were diagnosed with non-ST elevation myocardial infarction. Of the total of 100 subjects in the study group, there were 70 males and 30 females. A total of 100 healthy individuals as a control group were also incorporated in the study. Serum uric acid was measured on day 0, 3, 7 as well on day 30 of MI. Results: Serum uric acid was calculated on day 0, day 3, and day 7 and on day 30 of the myocardial infarction in the case study group. The mean uric acid levels on day 0 were found to be 6.32 1.45 mg/dl, mean uric acid level on day 3 was found to be 5.98 0.98 mg/dl, mean uric acid level on day 7 was found to be 5.14 2.18 mg/dl and mean uric acid level on day 30 was found to be 4.98 0.44 mg/dl. Conclusion: Serum uric acid stages are elevated in subjects of acute MI in contrast to standard well individuals. Subjects with higher Serum uric acid levels have an elevated probability of transience and it can be measured as a marker of appalling prediction.

scholarly journals Low Birth Weight and First Week Neonatal Mortality in a Tertiary Level Hospital in Bangladesh

2009 ◽  
Vol 1 (1) ◽  
pp. 24-28
Author(s):  
Sabera Khatun ◽  
Fawzia Hossain ◽  
Jannatul Ferdous ◽  
Afroza Chowdhury
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Mortality ◽  
Gestational Age ◽  
Normal Birth Weight ◽  
Group Iii ◽  
Normal Birth ◽  
Group I ◽  
Low Birth Weight Babies ◽  
Group Ii

ABSTRACT Objectives The incidence of low birth weight babies and the perinatal morbidity and mortality is inter-related. An understanding of the risk factors can help us to reduce their incidence and studying their management and outcome could help us to evolve optimal management strategies. The aim of the study was to find out the incidence of low birth weight and first week neonatal mortality rate. Methods The gestational age of the babies were determined and a comparison of the prenatal mortality ratio was done among vaginal and cesarean deliveries. During the study period all the patients irrespective of their gestational age admitted for delivery were recruited for the prospective analysis. Their gestational age, mode of delivery, birth weight and outcome were collected in a preformed data-sheet. Results During the study period there were 2689 deliveries at BSMMU and among them 301 were low birth weight (LBW), rest were normal birth weight babies. Forty-eight from low birth weight and seven from normal birth weight babies died within first-week of delivery. The LBW babies were grouped in to three groups according to their birth weight, 1-1.5 kg = group one, 1.6-2 kg = group two, 2.1- 2.4 kg = group three. It was found that 70% babies of group I, 40% of group II and 17% of group III were in the gestational age of 28-34 weeks. On the other hand 30% babies of group I, 60% of group II and 83% of group III were in the gestational age of 35-40 weeks. 79.36% of group I, 6.67% of group II and 0.63% of group III died within 7 days of birth. Conclusion Significant difference (p value < 0.001) was observed in first-week neonatal mortality among normal and low birth weight babies. Therefore, it can be concluded that birth weight and gestational age is an important determining factor for early neonatal death.

scholarly journals Profil Sindrom Aspirasi Mekonium pada Bayi Baru Lahir di RSUD Dr. Soetrasno Rembang

2019 ◽  
Vol 1 (2) ◽  
pp. 42
Author(s):  
Ahimsa Yoga Anindita ◽  
Dwi Hidayah ◽  
Yulidar Hafidh ◽  
Annang Giri Moelyo ◽  
Mayasari Dewi
Keyword(s):  
Birth Weight ◽  
Amniotic Fluid ◽  
Gestational Age ◽  
Apgar Score ◽  
Meconium Aspiration Syndrome ◽  
Normal Birth Weight ◽  
Term Infants ◽  
Meconium Aspiration ◽  
Normal Birth ◽  
Minute Apgar Score

<p class="TextAbstract"><strong>Introduction</strong>: The presence of meconium in amniotic fluid occurs in 13% of live births in developing countries. This condition develops when the gestational age increases at delivery. Meconium aspiration syndrome occurs in 5% of newborns in meconium stained amniotic fluid. The aim of this study is to determine the profile of newborns who experience meconium aspiration syndrome (MAS) who are treated at Dr. Soetrasno Hospital, Rembang and its outcome.</p><p class="TextAbstract"><strong>Methods</strong>: Prospective study, data were obtained from medical records of Dr. Soetrasno Hospital, Rembang during September to October 2018, on newborns with MAS.</p><p class="TextAbstract"><strong>Results</strong>: Of 12 newborns with MAS were obtained, consisting of 7 (58.3%) male and 5 (41.7%) female. All cases were term infants (gestational age above 37 weeks) and normal birth weight (above 2500 grams). Based on the first minute APGAR score, there were 4 newborns had score 1 and 2, respectively (33.3%). Based on the fifth minute APGAR score, there were 7 newborns had score 3 (58.3%). The outcome of newborns with MAS were 7 alive (58.3%) and 5 died (41.7%).</p><p class="TextAbstract"><strong>Conclusion</strong>: There were 12 newborns suffering from MAS (54.5%) of 22 babies hospitalized at the NICU dr. Soetrasno Hospital Rembang. All newborns with MAS were term infants and normal birth weight. There were 5 newborns with MAS which required invasive mechanical ventilation (intubation) and all died (41.7%).</p><p class="Keywords"> </p>

scholarly journals Profil kejang demam di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2014 – Juni 2016

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Jenyfer P. Kakalang ◽  
Nurhayati Masloman ◽  
Jeanette I.Ch. Manoppo
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Family History ◽  
Body Temperature ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Age Group ◽  
Normal Birth Weight ◽  
Normal Birth ◽  
Spontaneous Delivery

Abstract: Febrile seizure usually occurs during increased body temperature (rectal temperature >380 C) caused by an extracranial process. Although febrile seizure is not a neurological disorder, it occurs most common among children. This study was aimed to obtain the profile of febrile seizure in children. This was a descriptive retrospective study. This study was conducted at the Department of Pediatrics Prof. Dr. R. D. Kandou Hospital from January 2014 to June 2016. The results showed that there were 150 children diagnosed as febrile seizure. The majority of them were as follows: age group of 1 - < 2 years old in 41 children (27.3%), males (50.7%), family history in 104 children (69.3%), respiratory tract infection as the cause of fever in 68 children (45.3%); complex febrile seizure in 91 children (60.7%); normal birth weight in 135 children (90%); normal nutritional status in 101 children (67.3%); and spontaneous delivery with head presentastion ins 127 children (84.7%). Conclusion: In this study, febrile seizure was most common among boys and diagnosed as complex febrile seizure.Keywords: febrile seizures, body temperature, extracranial, children Abstrak: Kejang demam ialah bangkitan kejang yang terjadi pada kenaikan suhu tubuh (suhu rektal >380C) yang disebabkan oleh suatu proses ekstrakranial. Walalupun kejang demam bukan merupakan suatu kelainan neurologis tetapi keadaan ini sering dijumpai pada anak. Penelitian ini bertujuan untuk mengetahui profil kejang demam pada anak. Jenis penelitian ialah deskriptif retrospektif untuk mengetahui profil kejang demam di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou periode Januari 2014 sampai Juni 2016. Hasil penelitian mendapatkan 150 anak yang didiagnosis kejang demam. Kejang demam paling sering ditemukan pada usia 1 - <2 tahun berjumlah 41 anak (27,3%); jenis kelamin laki-laki berjumlah 99 anak (66%); suhu badan >380C berjumlah 76 anak (50,7%); adanya riwayat keluarga 104 anak (69,3%); penyakit yang mendasari infeksi saluran pernafasan berjumlah 68 anak (45,3%); jenis kejang demam kompleks 91anak (60,7%); berat badan lahir normal 135 anak (90%); status gizi normal 101 anak (67,3%); riwayat jenis persalinan spontan LBK 127 anak (84,7%). Simpulan: Kejang demam paling sering terjadi pada anak laki-laki dan diagnosis jenis kejang demam kompleks. Kata kunci: kejang demam, suhu tubuh, ekstrakranial, anak

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