scholarly journals A cross sectional study of coagulation profile in term normotensive pregnancy and hypertensive disorders like preeclampsia, eclampsia

Author(s):  
Madana Jyotsna Priya ◽  
Gomathy Ethiraj ◽  
Sheela Shivamonga Rangappa

Background: Normal pregnancy is a procoagulant state. In preeclampsia, this process of coagulation is exaggerated and will lead to further effects on the mother, placenta and fetus. The purpose of this study is to find out the changes that occur in the coagulation indices in pregnancy induced hypertension as compared to that in normal pregnancy which will help in the better management of patients with pregnancy induced Hypertension.Methods: This was a cross sectional study in 116 patients with normotensive and patients with hypertensive disorders in pregnancy conducted in a tertiary medical facility. Coagulation parameters like platelet count, prothrombin time, activated partial thromboplastin time, bleeding time and clotting time were evaluated. We used the difference of 5% in mean PT between normotensive (control) and hypertensive patients by applying 80% power and alpha error of 5%.Results: Platelet counts of study population were significantly related to the prognosis of the patient. The cut off values of major parameters like aPtt, BT with the outcome were with p value of 0.37 and 0.76 respectively.Conclusions: In cases of pregnant complicated with HDP, parameters like coagulation profile, bleeding time, clotting time were probably useful indicators in the early diagnosis and management of severe morbidity of the mother and the fetus. Further prospective trials with large study population are warranted to evident these results.

2019 ◽  
Vol 8 (22) ◽  
pp. 1813-1815
Author(s):  
Laishram Leimahanbi Chanu ◽  
Rajkumar Bikramjit Singh ◽  
Bishwalata Rajkumari ◽  
Sumpi Rosemary Anal

2021 ◽  
Vol 8 (10) ◽  
pp. 33-36
Author(s):  
Balaji B R ◽  
K N Pujari

Preeclampsia is a pregnancy related high blood pressure disorder. It involves defective trophoblast invasion and decreased spiral artery remodelling. Alterations in micronutrients have been identified as one of the risk factor of preeclampsia. In this study we have estimated the levels of zinc, copper, iron and magnesium in preeclampsia and normal pregnant women. Our study revealed a significant decrease of zinc, copper and magnesium levels and significant increase of iron levels in preeclampsia compared to normal pregnant women. Thus assessment of micronutrients in pregnancy helps in decreasing the incidence of preeclampsia. Keywords: Preeclampsia, Zinc, Copper, Iron, Magnesium.


2020 ◽  
Vol 04 (1) ◽  
pp. 1-9
Author(s):  
Fadheelah Azeez ◽  
Abulhadi Juma ◽  
Hassan Hassan

In medicine, blood groups play an active role. A noticeable relationship is observed linking ABO with the Wilbrand factor and vWF deficiency which results in hemorrhagic disorders, while increased levels are a risk factor for blood clotting. Previous investigations found that individuals in group O have long hemorrhageand blood clotting time. The aim of the current study is to evaluate the bleeding time relationship with the different blood groups and sex also. This cross-sectional study includes 95 students aged between 18 and 20 years. Permission has been takenfrom the students participated in this study before the bleeding time (the method of filter paper for Duke) was determined.The obtained results showed a longer time of bleeding among the AB group. Moreover, the bleeding time is longer in women than men. For more results, it is necessary to involve a larger research group.


2017 ◽  
Vol 56 (6) ◽  
pp. 325
Author(s):  
Surya Jayanti Kadek ◽  
Dewi Kumara Wati Ketut ◽  
Karyana Putu Gede

Background About 60% of individuals with atopic dermatitis (AD) develop their first manifestation during infancy. Cow’s milk (CM) exposure is considered to be a risk factor for AD.Objective To evaluate for an association between cow’s milk exposure and atopic dermatitis in infants > 6 months of age.  Methods This cross-sectional study consisted of subjects from a previous study and new subjects recruited in order to meet the minimum required number of subjects. Our study population comprised 120 infants, born between 1 February and 30 November, 2012 in Sanglah Hospital, Denpasar. Subjects were divided into CM and non-CM groups and analyzed for their risk of AD. Subjects were included to CM group if they were fed with cow’s milk/formula  and included to non-CM group if they were breastfeed exclusively in the first six months of life. Other possible risk factors were assessed by multivariate analysis. Results One hundred twenty subjects were enrolled and analyzed (59 in the CM and 61 in the non-CM groups). The prevalence of AD was 30%. Multiple logistic regression analysis revealed a significant association between CM exposure and AD, with odds ratio (OR) 2.37 (95%CI 1.036 to 5.420; P=0.04). In addition, maternal diet including eggs and/or cow’s milk during the breastfeeding period was significantly associated with AD in infants (OR 3.18; 95%CI 1.073 to 9.427; P=0.04).Conclusion Cow’s milk exposure is significantly associated with atopic dermatitis in infants  > six months of age. 


BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046638
Author(s):  
Sk Masum Billah ◽  
Abdullah Nurus Salam Khan ◽  
S M Rokonuzzaman ◽  
Nafisa Lira Huq ◽  
Marufa Aziz Khan ◽  
...  

Study objectiveTo evaluate the competency of trained health workers in detecting and managing hypertensive disorders of pregnancy during routine antenatal check-ups (ANCs) at primary care facilities in Bangladesh.Study design and settingsCross-sectional study; conducted in 26 primary care facilities.Outcome measuresAccurate diagnosis of the hypertensive disorders of pregnancy.MethodIn total 1560 ANC consultations provided by primary health workers, known as Family Welfare Visitors (FWVs), were observed using a structured checklist between October 2017 and February 2018. All consultations were reassessed by study physicians for validation.ResultOf the ‘true’ cases of gestational hypertension (n=32), pre-eclampsia (n=29) and severe pre-eclampsia (n=16), only 3%, 7% and 25%, respectively, were correctly diagnosed by FWVs. Per cent agreement for the diagnosed cases of any hypertensive disorders of pregnancy was 9% and kappa statistics was 0.50 (p value 0.0125). For identification of any hypertensive disorders by FWVs, sensitivity and positive predictive values were 14% and 50%, respectively. There was a moderate positive correlation between the blood pressure measurements taken by FWVs and study physicians. Only 27% of those who had ‘some protein’ in urine were correctly identified by FWVs. Women diagnosed with any of the hypertensive disorders of pregnancy by FWVs were more likely to be counselled on at least one danger sign of pre-eclampsia (severe headache, blurring of vision and upper abdominal pain) than those without any such diagnosis (41% vs 19%, p value 0.008). All four cases of severe pre-eclampsia diagnosed by FWVs were given a loading dose of intramuscular magnesium sulphate and three among them were referred to a higher facility.ConclusionThe FWVs should be appropriately trained on risk assessment of pregnant women with particular emphasis on accurately assessing the diagnostic criteria of hypertensive disorders of pregnancy and its management.


2021 ◽  
Vol 26 (2) ◽  
pp. 118
Author(s):  
TheresaUkamaka Nwagha ◽  
HelenChioma Okoye ◽  
AngelaOgechukwu Ugwu ◽  
LisaIfenyinwa Eweputanna ◽  
EmmanuelOnyebuchi Ugwu

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 223
Author(s):  
Gayani Amarasinghe ◽  
Vasana Mendis ◽  
Thilini Agampodi

Background: Anaemia in pregnancy, which can lead to adverse maternal and fetal outcomes, is a significant global health problem. Despite Sri Lanka’s strong public health system and commitment towards prevention, maternal anaemia remains a major problem in the country. While prevention is focused on iron deficiency, detailed etiological studies on this topic are scarce. Moreover, estimates of socio demographic and economic factors associated with anaemia in pregnancy, which can provide important clues for anaemia control, are also lacking. This study aims to evaluate the hemoglobin distribution, spatial distribution, etiology and associated factors for anaemia in pregnant women in Anuradhapura, Sri Lanka. Methods: This is a cross sectional study of pregnant women in their first trimester registered for antenatal care from July to September 2019 in the Anuradhapura district. The minimal sample size was calculated to be 1866. Initial data collection has already been carried out in special field clinics for pregnant women between June to October 2019. An interviewer-administered questionnaire, a self-completed dietary questionnaire and an examination checklist were used for data collection. In addition, all participants underwent complete blood count testing. Further investigations are being conducted for predicting the etiology of anaemia based on a developed algorithm (such as high-performance liquid chromatography [HPLC] and peripheral blood film analysis). Discussion: Being the largest study on anaemia during pregnancy in a single geographical area in Sri Lanka, this study will provide important clues about geographical clustering of anaemia cases with similar etiology, associated factors and etiologies which would help to develop interventions to improve the health of pregnant women in the area. The possibility of selection bias is a potential limitation associated with the study design.


Author(s):  
Anupama Pulla ◽  
Asma . ◽  
Nanduri Samyuktha ◽  
Soumya Kasubagula ◽  
Aishwarya Kataih ◽  
...  

Background: Computer vision syndrome is a complex of eye and vision problems related to near work which are experienced due to prolonged computer use. Computers demand near work, for longer duration which increases discomfort of eye and prolonged exposure to the discomfort leads to a cascade of symptoms that can be referred as computer vision syndrome. The aims and objectives of the study were to determine the prevalence of computer vision syndrome among engineering students of Hyderabad, Telangana and to determine the factors related to computer vision syndrome among study population.Methods: A cross sectional study was carried out from March to June 2017 among students of an engineering college in Hyderabad, Telangana. A convenient sample of 300 students was taken and a predesigned, pre tested questionnaire was used to obtain information.Results: Majority of study population were males (56.3%). Around 75.1% of study population were using all the electronic gadgets like computers, laptops and smartphones. The prevalence of computer vision syndrome was found to be 60.3%. Around 46.7% of study population viewed the screen from a distance of 22-40 centimeters.Conclusions: As students pursuing engineering stream are the future IT and Computer software engineers, preventive strategies adopted by them will significantly decrease the burden of computer vision syndrome and improve productivity. In this study a significant proportion of the engineering students were found to be having vision problems, which emphasizes the need to adopt preventive measures to avoid computer vision syndrome. 


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