scholarly journals Cord blood levels of uric acid, lipid profile and HOMA-IR in pregnancy induced hypertension

2021 ◽  
Vol 10 (12) ◽  
pp. 4443
Author(s):  
Priyadharshini R. ◽  
V. Vijayakumari
Keyword(s):  
Uric Acid ◽  
Cardiovascular Diseases ◽  
Cord Blood ◽  
Lipid Profile ◽  
Gestational Hypertension ◽  
Blood Levels ◽  
Strong Positive Correlation ◽  
Related Complication ◽  
Positive Correlation ◽  
Blood Uric Acid

Background: Cardiovascular diseases (CVD) is a major global health burden that results in the greatest number of deaths worldwide. Epigenetic changes induced by pregnancy related complication in umbilical cord blood may appear as a result of dysfunctional placenta and impaired maternal cardiovascular function and may cause later onset of cardiovascular diseases in offspring.Methods: A prospective case control study was conducted at ESIC medical college, Bangalore in 100 PIH women with gestational age 37 to 40 weeks. The study aimed to find the correlation of cord blood uric acid, lipid profile and HOMA -IR in gestational hypertension mothers.Results: We found a strong positive correlation between uric acid and total cholesterol in cases and a moderate positive correlation among uric acid and LDL in cases whereas a strong negative correlation among uric acid and HDL. In addition, mean HOMA-IR value was statistically significant in cases.Conclusions: HOMA -IR values are found to be more in newborns of PIH mothers and cord blood uric acid is a good predictor of lipid metabolism and the glucose homeostasis in neonates.

scholarly journals Correlation of Gamma Glutamyl Transferase with Traditional Risk Markers of Cardiovascular Disease in Different Obesity Phenotypes

2021 ◽  
Author(s):  
Amit Kumar Meena ◽  
Sonali Sharma ◽  
Barkha Gupta ◽  
Asrar Ahmed
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Tertiary Care ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Introduction: The increased prevalence of overweight, obesity, and metabolic syndrome has revealed that liver enzymes have a potential role as determinants of metabolic conditions such as, hyperlipidemia, and Cardiovascular Disease (CVD). Aim: The study aimed to investigate the correlation between liver enzymes with anthropometric indices of obesity and lipid profile in different obese phenotypes at a tertiary care. Materials and Methods: The present observational study was conducted on a total of 180 obese participants of either gender in the age group 18-59 years from December 2018 to May 2019. These were further divided into two phenotypic groups viz., Metabolically Healthy Obese (MHO group; n=90) and Metabolically Unhealthy Obese (MUHO group; n=90) according to NCEP ATP III criteria.Traditional cardiovascular risk factors were evaluated in the study participants through anthropometric viz., Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), waist–hip ratio (WHR), blood pressure and biochemical investigations i.e., serum glucose, lipid profile and liver enzymes. Data was analysed by using Microsoft excel software. Results: Among 180 obese participants, 76 were males and 104 females with mean age 40.42±10.84 years. In MUHO phenotype, Gamma Glutamyl Transferase (GGT) showed a strong positive correlation with BMI (r=0.413, p=0.00001), lipid parameters viz., LDL-C (r=0.3785, p=0.0001), TC (r=0.2953, p=0.0023), TG (r=0.2623, p=0.006) and negative correlation with HDL-C (-r=0.3167, p=0.001). No significant correlation was found in MHO phenotype between liver enzymes, BMI and lipid profile parameters. Conclusion: The results of this study indicated that GGT shows a strong positive correlation with traditional risk factors in MUHO participants. Thus, raised GGT may be considered as a risk marker of CVD in MUHO phenotype.

scholarly journals GAMBARAN KADAR ASAM URAT DARAH PADA MAHASISWA ANGKATAN 2011 FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI DENGAN INDEKS MASSA TUBUH 18,5-22,9 kg/m2

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Enika Tilaar ◽  
Stefana Kaligis ◽  
Diana Purwanto
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
Body Mass ◽  
Sampling Method ◽  
Descriptive Study ◽  
Normal Blood ◽  
Blood Levels ◽  
Purposive Sampling ◽  
Blood Uric Acid ◽  
High Level

Abstract: Increased uric acid levels (hyperuricemia) play a role in the level of morbidity in several diseases. The prevalence of hyperuricemia in Manado and Minahasa is high compared to other regions in Indonesia. Hyperuricemia can occur at a young age. The purpose of this study is to determine the blood levels of uric acid at students Faculty of Medicine year 2011, Sam Ratulangi University with body mass index of 18,5-22,9 kg/m2. This is a descriptive study with purposive sampling as the sampling method. There were 31 respondents that participated in this study. From 31 respondents, 30 respondents (96,8%) had normal blood uric acid levels and only one (3,2%) had high level of blood uric acid (hyperuricemia). Conclusion: majority (96,8%) of students Faculty of Medicine year 2011, Sam Ratulangi University with body mass index of 18,5-22,9 kg/m2 has normal blood uric acid levels. Key words: BMI 18,5-22,9 kg/m2, Hyperuricemia, Uric Acid.     Abstrak: Kadar asamurat yang meningkat (hiperurisemia) berperan dalam tingkat morbiditas pada beberapa penyakit. Prevalensi hiperurisemia di Manado dan Minahasa termasuk tinggi dibandingkan daerah lain di Indonesia. Hiperurisemia dapat terjadi pada usia muda. Tujuan penelitian ini untuk mengetahui kadar asam urat darah pada mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi dengan indeks massa tubuh (IMT) 18,5-22,9 kg/m2. Penelitian ini bersifat deskriptif dengan pengambilan sampel menggunakan metode purposive sampling. Penelitian ini diikuti oleh 31 responden. Dari 31 responden ditemukan jumlah responden yang memiliki kadar asam urat normal sebanyak 30 responden (96,8%) dan hiperurisemia sebanyak satu responden (3,2%). Simpulan: sebagian besar (96,8%) responden mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi dengan indeks massa tubuh 18,5-22,9 kg/m2 mempunyai kadar asam urat darah dalam batas yang normal. Kata Kunci: AsamUrat, Hiperurisemia, IMT 18,5-22,9 kg/m2

scholarly journals Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood

2019 ◽  
Author(s):  
Fu-Ping Lai ◽  
Yi-Fang Tu ◽  
Bor-Shyang Sheu ◽  
Yao-Jong Yang
Keyword(s):  
Early Childhood ◽  
Growth Factor ◽  
Cord Blood ◽  
Fetal Growth ◽  
Growth And Development ◽  
Gestational Hypertension ◽  
Blood Levels ◽  
Childhood Growth ◽  
H Pylori ◽  
Igfbp 3

Abstract Background Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, i t is still unknown whether maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and whether this can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods In this prospective cohort study, we recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined as >12 U/ml of anti- H. pylori IgG in maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA. The growth of the included neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impacts on birth weight, childhood growth and cognitive development were found to be correlated with maternal H. pylori seropositivity during pregnancy. Conclusions Maternal H. pylori infection during pregnancy was more likely to lead to the development of GH, but was not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for mothers with H. pylori infection .

scholarly journals Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Fu-Ping Lai ◽  
Yi-Fang Tu ◽  
Bor-Shyang Sheu ◽  
Yao-Jong Yang
Keyword(s):  
Early Childhood ◽  
Growth Factor ◽  
Cord Blood ◽  
Fetal Growth ◽  
Growth And Development ◽  
Gestational Hypertension ◽  
Blood Levels ◽  
Childhood Growth ◽  
H Pylori ◽  
Igfbp 3

Abstract Background Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, it is still unknown whether maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and whether this can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods In this prospective cohort study, we recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined as > 12 U/ml of anti-H. pylori IgG in maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA. The growth of the included neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results Of the 106 enrolled women, 25 (23.6%) were H. pylori-seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p = 0.04) and lower cord blood levels of IGF-1 (< 35 ng/ml, 70.0% vs. 40.7%, p = 0.02) and IGFBP-3 (< 1120 ng/ml, 100.0% vs. 76.3%, p = 0.02) compared with the seronegative women. No significant impacts on birth weight, childhood growth and cognitive development were found to be correlated with maternal H. pylori seropositivity during pregnancy. Conclusions Maternal H. pylori infection during pregnancy was more likely to lead to the development of GH, but was not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for mothers with H. pylori infection.

scholarly journals Uric Acid Excretion in Patients with Malignant Lymphomas

Blood ◽  
1961 ◽  
Vol 17 (6) ◽  
pp. 701-718 ◽  
Author(s):  
N. PRIMIKIRIOS ◽  
L. STUTZMAN ◽  
A. A. SANDBERG
Keyword(s):  
Uric Acid ◽  
Normal Subjects ◽  
Response To Treatment ◽  
Blood Levels ◽  
Acid Excretion ◽  
Malignant Lymphomas ◽  
Uric Acid Excretion ◽  
Blood Uric Acid ◽  
Objective Clinical Response ◽  
Uric Acid Nephropathy

Abstract Uric acid blood and urine studies were performed in 12 patients with lymphomas while on a measured low purine diet before, during and after cytotoxic therapy. Before treatment, urinary uric acid excretion in these patients was significantly higher than in normal subjects, although only 2 patients had clearly elevated blood uric acid levels. There was no correlation between the estimated size of the tumor masses and pretreatment uric acid excretion. The response to treatment could not have been predicted by measurement of the pretreatment uric acid excretion. In one patient with extensive tumor infiltration of the kidneys, dangerous renal failure, preceded by marked hyperuricemia, developed during therapy. Mechanical hemodialysis resulted in clinical improvement and marked reduction in the blood levels of uric acid and urea. The finding of a large increase in uric acid excretion during the early days of treatment of a patient with lymphoma is indicative of a responsive tumor. Such data also serve as warning of potential obstructive uric acid nephropathy or uropathy before major increases in serum uric acid appear. Small increases of uric acid excretion in association with treatment could not be correlated with objective clinical response.

scholarly journals The Effect of Melinjo (Gnetum gnemon L.) Leaves and Melinjo Peel Extracts on Induced-Hyperuricemia Male Rats Model

2019 ◽  
Vol 2 (4) ◽  
Author(s):  
Nia K Sari ◽  
Andreanus A Soemardji ◽  
Irda Fidrianny
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Male Rats ◽  
Blood Levels ◽  
Crude Drug ◽  
Blood Uric Acid ◽  
Gnetum Gnemon ◽  
Ethanol Extracts ◽  
Peel Extract

Hyperuricemia is condition which blood uric acid levels increase, in men are greater than 7 mg/dL and in women over 6 mg/dL. In Indonesia the prevalence of hyperuricemia was 32% in people under 34 years and increases every year. Beside an emping from melinjo seed there is Indonesian meals made from mixture of seed, peel and leaves of melinjo, namely as sayur asem. Consumption a lot of emping can induced hyperuricemia. This study aims to assess the effect of melinjo leaves and peel extracts to reduce uric acid levels on melinjo seed hyperuricemia male rats model. Methods: Induction was performed by giving high purine diet, melinjo seed crude drug (emping) 4.5 g/kg bw. Ethanol extracts of melinjo leaves and melinjo peel were administered in 3 doses. Results: Ethanol leaves extract of melinjo (Gnetum gnemon L.) 36 mg/kg bw could decrease uric acid levels up to 61.04%, while ethanol peel extract of melinjo 13 mg/kg bw can decrease uric acid levels up to 31.25%. Conclusions:  Melinjo seed crude drug (emping) could increase the bloods uric acid level in rats up to 4.65 mg/dL. Ethanol leaves and peel extracts of melinjo could decrease uric acid blood levels in hyperuricemia rats.   Keywords : Gnetum gnemon L., seed, leaves, peel, antihyperuricemia  

scholarly journals Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood

2019 ◽  
Author(s):  
Fu-Ping Lai ◽  
Yi-Fang Tu ◽  
Bor-Shyang Sheu ◽  
Yao-Jong Yang
Keyword(s):  
Early Childhood ◽  
Growth Factor ◽  
Cord Blood ◽  
Fetal Growth ◽  
Growth And Development ◽  
Gestational Hypertension ◽  
Blood Levels ◽  
Childhood Growth ◽  
H Pylori ◽  
Igfbp 3

Abstract Background Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, it is still unknown whether maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and whether this can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods In this prospective cohort study, we recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined as >12 U/ml of anti-H. pylori IgG in maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA. The growth of the included neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results Of the 106 enrolled women, 25 (23.6%) were H. pylori-seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p=0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p=0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p=0.02) compared with the seronegative women. No significant impacts on birth weight, childhood growth and cognitive development were found to be correlated with maternal H. pylori seropositivity during pregnancy. Conclusions Maternal H. pylori infection during pregnancy was more likely to lead to thedevelopment of GH, but was not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for mothers withH. pyloriinfection.

scholarly journals Cord blood lipid profile in late preterm and term neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 542 ◽  
Author(s):  
Yashodha H. T. ◽  
Syeda Kausar Anjum
Keyword(s):  
Cardiovascular Diseases ◽  
Cord Blood ◽  
Lipid Profile ◽  
Gestational Age ◽  
Tertiary Care ◽  
Blood Lipid ◽  
Late Preterm ◽  
Care Hospital ◽  
Lipid Levels ◽  
Atherogenic Indices

Background: Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity both in developed and developing countries. High concentrations of lipids in neonates with low gestational age may increase the risk of cardiovascular diseases in the future. It has been suggested that early diagnosis along with appropriate diet and drug therapy may provide an opportunity for long term amelioration of risk factors that contribute to atherosclerosis and cardiovascular diseases in adult life. This study is conducted to compare lipid profile and atherogenic indices in late preterm and term neonates.Methods: It is a prospective comparative study conducted over a period of 12 months in a tertiary care hospital, Bangalore. A total of 170 neonates between 34 to 42 weeks were included in the study. Umbilical cord blood was collected immediately after delivery and lipid values were measured. Atherogenic indices were calculated. Results: Out of 170 neonates, 93 (54.7%) were male and 77 (45.3%) were female. 88 (55%) were late preterm and 72 (45%) were term. The cord blood lipid levels were not affected by the gender of the neonates. TG, TC, LDL, VLDL, LDL/HDL, TC/HDL were higher in late preterm babies compared to term babies (p <0.05), HDL levels were not statistically significant. The mean serum lipid levels (TG, TC, LDL and VLDL) and atherogenic indices were higher in SGA babies than AGA, but HDL levels were not statistically significant. (p >0.05)Conclusions: Lipid levels are inversely correlated with the gestational age. This could be regarded as a risk factor for development of atherosclerosis and cardiovascular diseases in later life.

scholarly journals Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

2019 ◽  
Author(s):  
Fu-Ping Lai ◽  
Yi-Fang Tu ◽  
Bor-Shyang Sheu ◽  
Yao-Jong Yang
Keyword(s):  
Early Childhood ◽  
Growth Factor ◽  
Cord Blood ◽  
Fetal Growth ◽  
Growth And Development ◽  
Gestational Hypertension ◽  
Blood Levels ◽  
Childhood Growth ◽  
H Pylori ◽  
Igfbp 3

Abstract Background: Helicobacter pylori infection is known to alter growth-related hormones and cause growth faltering in young children. It is still unknown if maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine the associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods: The prospective cohort study recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined by >12 U/ml of anti- H. pylori IgG in the maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA test. The growth of eligible neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results: Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impact on birth weight, childhood growth and cognitive development was found to correlate with maternal H. pylori seropositivity during pregnancy. Conclusions: Maternal H. pylori infection during pregnancy was more likely to develop GH, but not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for such H. pylori -infected mothers.

scholarly journals Lipid profiles of umbilical cord blood: A comparative study in pre-term and full-term Newborns

2020 ◽  
Vol 11 (4) ◽  
pp. 7630-7633
Author(s):  
Om Prakash ◽  
Pradeep Kumar ◽  
Bhumija Sharma ◽  
Seema Goal ◽  
Preeti Sharma ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cord Blood ◽  
Lipid Profile ◽  
Lipid Profiles ◽  
Full Term ◽  
Atherogenic Index ◽  
College Hospital ◽  
Term Neonates ◽  
Medical College ◽  
Future Risk

The foremost causes of death in developed and developing countries both are cardiovascular disorders. Higher concentration of lipids in pre term neonates may increase their future risk of cardiovascular diseases. Early diagnosis and dietary modifications and proper management may rectify the risk factors and prevent future risk of cardiovascular disease. Our study aims to compare lipid profiles and atherogenic index in the cord blood of pre-term and full-term neonates. It is a retrospective and observational study conducted for a period of one year from December 2018 to November 2019 in the Departments of Biochemistry and Gynecology of Santosh Medical College and Hospitals, Ghaziabad and K D Medical College Hospital and Research center. Among 60 neonates including 30 (50%) term and 30 (50%) preterm, TC, TG, LDL, VLDL, were raised in preterm when compared to term babies while HDL level was significantly increased (<0.05) in a term as compared to preterm babies. This study supports inverse relation between gestational age and lipid profile and this deranged lipid profile preterm group could be a threat or among factors for the future development of Atherosclerotic and cardiovascular diseases in their former part of life.

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