scholarly journals Correlation between ABO blood groups and various cancers in the north eastern region of India: a retrospective observational study

2018 ◽  
Vol 6 (11) ◽  
pp. 3643
Author(s):  
Chandana Kalita ◽  
Anupam Sarma ◽  
Jagannath Dev Sharma ◽  
Manoj Kalita ◽  
Manigreeva Krishnatreya ◽  
...  
Keyword(s):  
Observational Study ◽  
Head And Neck ◽  
Blood Group ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Eastern Region ◽  
Abo Blood Groups ◽  
The North ◽  
Increased Risk ◽  
North Eastern

Background: Numerous studies have documented the association of the ABO blood groups with the occurrence of cancers. Aim was to find out an association of ABO blood groups and various cancers in the North Eastern region of India.Methods: The study was a retrospective observational study that included 1000 cases and 1000 controls. The data included the ABO blood typing of the selected cancer sites which were head and neck, esophagus, stomach, breast, cervix, and ovary. Patients who attended blood bank of regional cancer center with requisition for blood transfusion from 2014 to 2016 were included. The control group was healthy blood donors. Chi square test was used to assess the difference among the compared groups. Risk was calculated by regression analysis. P value <0.05 was considered as statistically significant at 95% confidence interval.Results: Out of 1000 cases and 1000 controls, O blood group were seen in 377 (37.7%) and 395 (39.5%) cases and control, respectively. Significant reduced odds ratio (OR) in non O blood groups for head and neck, esophagus, stomach, and breast was observed. In case of carcinoma cervix, OR for B group was 1.5 (P=0.05), and for blood group A OR=2.2 (P=0.02) was seen in carcinoma ovary.Conclusions: In the studied population, patients with O blood group are at an increased risk of developing head and neck, esophagus, stomach, and breast cancers.

scholarly journals Human ABO Blood Groups and Their Associations with Different Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Silamlak Birhanu Abegaz
Keyword(s):  
Cognitive Impairment ◽  
Cardiovascular Diseases ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Groups ◽  
E Coli ◽  
Salmonella Infections ◽  
Increased Risk ◽  
Abo Blood Type

Introduction. Human ABO blood type antigens exhibit alternative phenotypes and genetically derived glycoconjugate structures that are located on the red cell surface which play an active role in the cells’ physiology and pathology. Associations between the blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. However, due to lack of antigens of some blood groups, there have been some contentious issues with the association between the ABO blood group and vulnerability to certain infectious and noninfectious diseases. Objective. To review different literatures that show the association between ABO blood groups and different diseases. Method. Original, adequate, and recent articles on the same field were researched, and the researcher conducted a comprehensive review on this topic. Thus, taking out critical discussions, not only a descriptive summary of the topic but also contradictory ideas were fully retrieved and presented in a clear impression. In addition, some relevant scientific papers published in previous years were included. The article search was performed by matching the terms blood types/groups with a group of terms related to different diseases. The articles were screened and selected based on the title and abstract presented. Results. The susceptibility to various diseases, such as cancer, cardiovascular diseases, infections and hematologic disorders, cognitive disorders, circulatory diseases, metabolic diseases, and malaria, has been linked with ABO blood groups. Moreover, blood group AB individuals were found to be susceptible to an increased risk of cognitive impairment which was independent of geographic region, age, race, and gender. Disorders such as hypertension, obesity, dyslipidemia, cardiovascular disease (CVD), and diabetes were also more prevalent in individuals with cognitive impairment. Early etiological studies indicated that blood type O has a connection with increased incidence of cholera, plague, tuberculosis infections, and mumps, whereas blood type A is linked with increased incidence of smallpox and Pseudomonas aeruginosa infection; blood type B is also associated with increased incidence of gonorrhea, tuberculosis, and Streptococcus pneumoniae, E. coli, and salmonella infections; and blood type AB is associated with increased incidence of smallpox and E. coli and salmonella infections. Diabetes mellitus, hypercholesterolemia, arterial hypertension, and family history for ischemic heart disease are the most common risk factors for cardiovascular diseases and can be genetically transmitted to offspring. Higher incidence of cancers in the stomach, ovaries, salivary glands, cervix, uterus, and colon/rectum was common in blood type A people than in O type people. The link between the ABO blood type and thromboembolic diseases and bleeding risk are intervened by the glycosyltransferase activity and plasma levels and biologic activity of vWF (Von Willebrand factor), a carrier protein for coagulation factor VIII which is low in O type. Conclusion. Several studies related to the ABO phenotype show that genetically determined human ABO blood groups were correspondingly linked with an increased risk of various infectious and noninfectious diseases. However, further investigations are needed particularly on the molecular level of ABO blood groups and their association with various diseases.

scholarly journals Association between ABO blood groups and susceptibility to COVID-19: profile of age and gender in Iraqi patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali H. Ad’hiah ◽  
Maha H. Abdullah ◽  
Mustafa Y. Alsudani ◽  
Rasool M. S. Shnawa ◽  
Ali J. R. Al-Sa’ady ◽  
...  
Keyword(s):  
Blood Group ◽  
Group Analysis ◽  
Blood Groups ◽  
Control Group ◽  
Age Group ◽  
Abo Blood Groups ◽  
Characteristic Analysis ◽  
Increased Risk ◽  
Study Results ◽  
Group A

Abstract Background A case-control study was performed to examine age, gender, and ABO blood groups in 1014 Iraqi hospitalized cases with Coronavirus disease 2019 (COVID-19) and 901 blood donors (control group). The infection was molecularly diagnosed by detecting coronavirus RNA in nasal swabs of patients. Results Mean age was significantly elevated in cases compared to controls (48.2 ± 13.8 vs. 29.9 ± 9.0 year; probability [p] < 0.001). Receiver operating characteristic analysis demonstrated the predictive significance of age in COVID-19 evolution (Area under curve = 0.858; 95% CI: 0.841 – 0.875; p < 0.001). Males outnumbered females in cases (60.4 vs. 39.6%) and controls (56 vs. 44%). Stratification by age group (< 30, 30 – 39, 40 – 49 and ≥ 50 years) revealed that 48.3% of cases clustered in the age group ≥ 50 years. ABO blood group analysis showed that group A was the most common among cases, while group O was the most common among controls (35.5 and 36.7%, respectively). Blood groups A (35.5 vs. 32.7; corrected p [pc] = 0.021), A+AB (46.3 vs. 41.7%; pc = 0.021) and A+B+AB (68.0 vs. 63.3%; pc = 0.007) showed significantly elevated frequencies in cases compared to controls. Logistic regression analysis estimated odds ratios (ORs) of 1.53 (95% confidence interval [CI]: 1.16 - 2.02), 1.48 (95% CI: 1.14 - 1.93) and 1.50 (95% CI: 1.17 - 1.82) for blood groups A, A+AB and A+B+AB, respectively. Blood group frequencies showed no significant differences between age groups of cases or controls. Regarding gender, male cases were marked with increased frequency of group A (39.9 vs. 28.9%) and decreased frequency of group O (25.9 vs. 41.0%) compared to female cases. Independent re-analysis of ABO blood groups in male and female cases demonstrated that group A was increased in male cases compared to male controls (39.9 vs. 33.1%; OR = 1.65; 95% CI: 1.24 - 2.21; pc = 0.006). On the contrary, no significant differences were found between females of cases and controls. Conclusions The study results indicated that blood group A may be associated with an increased risk of developing COVID-19, particularly in males.

scholarly journals Relationship between blood group phenotypes (ABO, Rh and Kell) and nCOVID-19 susceptibility – A retrospective observational study.

2020 ◽  
Author(s):  
Sudhir Bhandari ◽  
Ajeet Singh Shaktawat ◽  
Amit Tak ◽  
Bhoopendra Patel ◽  
Jyotsna Shukla ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Core Competencies ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Medical College ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Group A

Abstract Since the outbreak of coronavirus disease-19 research has been continued to explore multiple facets of the disease. The objective of the present study is to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility. In this hospital based, retrospective observational study 132 COVID-19 patients were enrolled from SMS Medical College and attached Hospitals, Jaipur, India after the proper approval from the institutional ethics committee. The ABO, Rh and Kell blood group phenotypes and demographic data of the patients were recorded. The observed proportions of ‘A’ , ‘B’, ‘AB’, ‘O’, ‘Rh’, and ‘Kell’ blood groups phenotypes in COVID-19 patients were compared against the expected proportions (our null hypothesis) of the general population using multinomial tests and partition analysis. There were significant differences between observed and expected frequency in ABO and Kell blood group phenotypes. Further partition analysis of ABO blood phenotypes showed that the group ‘A’ phenotypes were more susceptible for COVID-19. The Kell negatives were also more susceptible. The blood groups ‘AB’, ‘B’, ‘O’, and ‘Rh’ phenotypes showed no significantly different susceptibility for COVID-19. The study shows relationship between ABO, Rh, and Kell blood group phenotypes and COVID-19 susceptibility. The application of these relationship in clinical practice requires more exploratory studies. The following core competencies are addressed in this article: Screening Tool, Epidemiology, Patient Management, Medical Research.

scholarly journals Correlation between ABO Blood Groups and Disease Severity and Mortality in Hospitalized COVID-19 Patients

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 43-44
Author(s):  
Aula Ramo ◽  
Harshita Mehrotra ◽  
Ifeoma Onwubiko ◽  
Jawad Sheqwara ◽  
Zaher K. Otrock
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Disease Severity ◽  
Blood Group ◽  
Blood Groups ◽  
Male Gender ◽  
Abo Blood Groups ◽  
Rhesus Factor ◽  
Increased Risk ◽  
Henry Ford

Introduction After appearance of the novel Coronavirus 2019 in Wuhan, China, new epicenters of the now pandemic appeared nationally. The new Coronavirus disease 2019 (COVID-19) is associated with a syndrome of acute hypoxemic respiratory failure that can lead to admission to intensive care unit (ICU), invasive mechanical ventilation, and at times, death. The first two COVID-19 cases in the State of Michigan were reported in March 10, 2020. During the subsequent weeks, Michigan became one of the early national epicenters of the current COVID-19 pandemic. Early observational studies have suggested a correlation between susceptibility to COVID-19 infection and type A blood group, and furthermore, increased risk of respiratory failure and worse outcome. We conducted this retrospective study to evaluate the association between ABO blood groups and disease severity/mortality in hospitalized COVID-19 patients. Methods We reviewed the records of hospitalized patients with PCR-confirmed COVID-19 testing managed at Henry Ford Health System (HFHS) between March 10 and April 30, 2020. Henry Ford Health System (HFHS) serves inner city and metropolitan Detroit in Michigan, with diverse demographics including African American, Middle Eastern, and Caucasian populations. Age, gender, race, ABO blood groups, comorbidities, disease severity (defined as intensive care unit admission), intubation, and mortality variables were collected for 1488 eligible patients. Survival data was updated on July 15, 2020. Results were presented as median plus range, or percentages as indicated. In the univariate analysis, Student's t-test and Pearson's Chi-square/Fisher's exact test were used to determine the significance and odds ratio (OR) for the independent variables as related to outcome. A multivariate analysis was performed using logistic regression to identify the risk factors for mortality. A backward stepwise (Wald) selection model was performed, with significance level for removal from the model set at 0.1. All tests of significance were two-sided, and a p value of &lt; 0.05 was regarded as significant. All statistical analyses were performed using SPSS (Statistical Package for Social Sciences) software, version 22 (SPSS Inc., Chicago, IL, USA). This study was approved by the Institutional Review Board of HFHS. Results 1488 hospitalized COVID-19 positive patients with available ABO blood group were included. The median age of patients was 68 years (Range 19-99 years); 801 (54%) were females. Most patients (n=856; 58%) were African Americans. 485 (32.6%) patients had blood group A, 276 (18.5%) had group B, 658 (44.2%) had group O, and 69 (4.6%) had group AB. 469 (31.5%) patients required ICU admission, 370 of whom were intubated. On last follow up, 411 (27.6%) patients were dead. ABO blood groups and Rhesus factor (D antigen) were not associated with the ICU admission, intubation, or mortality. Male gender, age ≥65 years, some underlying diseases such as obesity, coronary artery disease chronic obstructive pulmonary disease and malignancy were associated with increased mortality. African American patients were almost 40% less likely to die (OR = 0.56; 95% CI: 0.44-0.7; p &lt; 0.001). Table 1 shows the parameters analyzed as predictors of mortality using univariate and multivariate logistic regression. Multivariate analysis showed that age (≥65 years) (OR = 4.27; 95% CI: 3.19-5.71; p &lt; 0.001), male gender (OR = 1.57; 95% CI: 1.23-2.01; p &lt; 0.001), Caucasian race (OR=1.46; 95% CI: 1.14-1.86; p = 0.003), and COPD (OR = 1.49; 95% CI: 1.09-2.04; p = 0.013) were associated with mortality. Conclusion According to our study, ABO blood groups and Rhesus factor did not correlate with disease severity, use of mechanical ventilation, or mortality in hospitalized COVID-19 patients. Elderly patients, male gender, patients with COPD were at increased risk of death. Contrary to perceived belief, African Americans were not at increased risk of mortality, compared to Caucasians with COVID-19 infection. Caucasians were more likely to die from COVID-19 infection. Disclosures No relevant conflicts of interest to declare.

scholarly journals Elucidating the Thrombogenic Risk of Non-O Blood Groups in Children with Acute Lymphoblastic Leukemia (ALL): Is Von Willebrand Factor a Culprit ?

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 4990-4990
Author(s):  
Terry Mizrahi ◽  
Caroline Laverdière ◽  
Michele David ◽  
Jean-Marie Leclerc ◽  
Lehana Thabane ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Lymphoblastic Leukemia ◽  
Blood Groups ◽  
Older Age ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Increased Risk ◽  
Von Willebrand ◽  
The Relationship

Abstract Background: Individuals with non-O blood group are shown to have increased risk of thromboembolism (TE). The exact pathogenesis of the prothrombotic effect of non-O blood group, is however not known. Because individuals with O-blood group have low levels of von Willebrand factor (vWF) compared to those with non-O blood group, vWF has been contemplated as a pathogenetic mechanism in ABO blood group-related prothrombotic risk. However, the available data regarding the role of vWF in the thrombotic risk of non-O blood group are inconclusive. Children with acute lymphoblastic leukemia (ALL) are at increased risk of TE. Several factors such as older age, leukemia phenotype and asparaginase have been shown to impact the risk of TE in children with ALL. We have recently shown that non-O blood group and circulating blasts were significant risk factors for TE in children with ALL. We have also shown that at diagnosis of ALL patients with circulating blasts have significantly higher levels of vWF compared to those without circulating blasts.  Within the context of a larger study aimed to define risk factors for symptomatic TE (sTE) in children with de novo ALL, we undertook a sub-study to evaluate the relationship of ABO blood groups and vWF level at diagnosis of ALL, and to evaluate the impact of circulating blasts on the vWF levels in children with O and non-O blood groups. We hypothesized that compared to patients with O-blood group, those with non-O blood group will have significantly higher levels of vWF and that circulating blasts will have additive effect on the vWF levels in patients with non-O blood group.  Methods : The multicenter, prospective, analytical cohort study included consenting patients (1-≤18 yrs. of age) with de novo ALL enrolled on the Dana-Farber Cancer Institute 05-001 therapeutic trial. Details of patient demography including ABO blood group, ALL diagnosis, therapy and symptomatic TE (sTE) were collected. Samples collected prior to starting ALL-therapy were analyzed centrally for prothrombotic defects (PD) including [protein C, S, antithrombin, Factor VIII:C, vWF, anticardiolipin antibodies and gene polymorphisms of methylene tetrahydrofolate reductase C677T, prothrombin G20210A, Factor V Leiden]. Age-adjusted standardized laboratory data defined PD. Regression analyses evaluated relationship between risk factors and sTE. Thrombosis-free survival was estimated using Kaplan-Meier method.  Results : Of 131 enrolled patients [mean age (range) 6.4 (1-17) yrs.; 70 boys], 21 (16%) developed sTE. ABO blood group information was available for 127 patients; 51 patients had blood group O and 76 non-O (57 with blood group A, 15 with B, and 4 with AB). There was no impact of PD including vWF on the risk of sTE. Older age compared to age ≤ 5 yr. [Odds Ratio (OR) 1.9, p=0.029] and non-O blood-group (OR 4.27, p=0.028) compared to O group were identified as independent predictors for development of sTE. Patients with peripheral blasts had higher odds of developing sTE (OR 7.79; p=0.059).The sTE-free survival was affected by older age (Hazard ratio (HR) 1.1, p 0.03), ALL risk type (HR 3.0, p 0.025) and blood group (O blood group vs non-O blood group, HR 0.23, p 0.03). Table 1 compares the vWF levels in patients with O and non-O blood group and those with and without circulating blasts. Overall, there was no difference in the vWF level at ALL diagnosis between patients with O vs. Non-O blood group. Patients with circulating blasts had higher levels of vWF at ALL diagnosis compared to those without circulating blasts; this comparison was statistically significant for non-O blood group. However, there was no interaction between ABO blood group and circulating blasts on vWF levels (p=0.723)  Conclusion : There was no effect of blood group type on the vWF level at diagnosis of ALL. Patients with circulating blasts had significantly higher levels of vWF at ALL diagnosis and the vWF levels were significantly higher in patients with non-O blood group and circulating blasts. Although it is likely that the relationship between blood group and vWF may be affected by effect of circulating blasts on vWF, we showed no interaction between ABO blood groups and circulating blasts on the vWF levels at diagnosis of ALL in children. Small sample size is a limitation of current study. Further studies with larger sample size are needed to elaborate the relationship between vWF, ABO blood groups, and circulating blasts. Disclosures No relevant conflicts of interest to declare.

scholarly journals Occurrence of pesticide residues in fruit from Podlasie (Poland) in 2012

2015 ◽  
Vol 55 (2) ◽  
pp. 142-150 ◽  
Author(s):  
Bożena Łozowicka ◽  
Izabela Hrynko ◽  
Piotr Kaczyński ◽  
Ewa Rutkowska ◽  
Magdalena Jankowska ◽  
...  
Keyword(s):  
Pesticide Residues ◽  
Residue Level ◽  
Eastern Region ◽  
Pesticide Use ◽  
National Monitoring ◽  
The North ◽  
Maximum Residue Level ◽  
Increased Risk ◽  
Fruit Samples ◽  
North Eastern

Abstract Extensive use of pesticides in agriculture can lead to contamination of fruit harvests and an increased risk of toxic effects on humans. A total of 123 fruit samples harvested in 2012 in the north-eastern region of Poland were analysed for pesticide residues as part of the national monitoring programme, and as part of research commissioned by private customers. Pesticide residues were found in 64.2% of the samples. There were pesticide residues below the maximum residue level (MRL) in 63 (51.2%) of the samples, while 16 (13%) exceeded MRLs set by Regulation (EC) 396/2005. The gooseberry, currant, and strawberry samples showed the most contamination. The most frequently detected pesticides were dithiocarbamates (54) followed by difenoconazole (22), boscalid (17), and alpha-cypermethrin (15). More than half of analysed samples had multiple residues (up to 8 residues), with multiple residues most common in gooseberry and currant samples. This study shows cases of non-authorised pesticide use by farmers who are trying to protect certain fruit.

scholarly journals Non-O Blood Group is Associated With a Higher Risk of Dyslipidaemia Amongst French Women

2020 ◽  
Author(s):  
Conor MacDonald ◽  
Anne-Laure Madika ◽  
Gianluca Severi ◽  
Agnes Fournier ◽  
Marie-Christine Boutron-Ruault
Keyword(s):  
Cardiovascular Disease ◽  
Blood Group ◽  
Blood Groups ◽  
Proportional Hazard ◽  
Abo Blood Groups ◽  
Cross Sectional ◽  
Cox Proportional Hazard ◽  
Increased Risk ◽  
Cox Proportional Hazard Models ◽  
Incident Cases

Abstract IntroductionThe non-O blood groups have previously been associated with higher risk of cardiovascular disease in prospective cohort studies. While cross-sectional studies have identified higher serum cholesterol amongst A-group individuals, there is no evidence from prospective studies whether this translates into a higher risk of dyslipidaemia that requires treatment. This study aimed to prospectively determine potential associations between ABO blood groups and risk of incident dyslipidaemia requiring treatment.MethodsWe assessed associations between blood ABO group and dyslipidaemia in women participating in the E3N cohort. We included women who did not have cardiovascular disease at baseline. We used logistic regression to determine associations between ABO group and prevalent dyslipidaemia at baseline. Cox proportional hazard models were used to determine if blood ABO group was associated with an increased risk of incident dyslipidaemia, controlling for potential confounding.ResultsAt baseline, 55,512 women were included, and 10,058 incident cases of dyslipidaemia were identified at a rate of 17.6/1,000 PY. Of these participants, 24,510 reported being of the O-group, and 31,002 of non-O. Non-O blood groups were associated with prevalent dyslipidaemia (OR = 1.17 [1.13: 1.21]). The non-O blood groups were associated with an increased risk of dyslipidaemia (HR non-O = 1.14 [1.10: 1.19]), specifically the A group (HRA = 1.18 [1.13: 1.23]). Interactions with smoking were considered possible (p-interaction = 0.06), with AB smokers showing the highest risk of dyslipidaemia (HRAB smokers = 1.54 [1.12: 2.11]).ConclusionNon-O blood group, specifically the A group were associated with a moderately increased risk of dyslipidaemia.

scholarly journals Relationship between ABO blood group phenotypes and nCOVID-19 susceptibility: A retrospective observational study

2020 ◽  
Vol 51 (4) ◽  
pp. 217-239
Author(s):  
Sudhir Bhandari ◽  
Ajit Shaktawat ◽  
Amit Tak ◽  
Jyotsna Shukla ◽  
Jitentdra Gupta ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Significant Difference ◽  
Chi Squared ◽  
Group A

Background: Since the outbreak of coronavirus disease-19 (COVID-19) research has been continued to explore multiple facets of the disease. The objective of the present study was to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility. Methods: In this retrospective observational study 132 hospitalised COVID-19 patients were enrolled from the Swai Man Singh (SMS) Medical Hospital in Jaipur, India after receiving approval from the Institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of 'A', 'B', 'AB', 'O', 'Rh' and 'Kell' blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson's Chi-squared test and partition analysis. Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group 'A' phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups 'AB', 'B', 'O' and 'Rh' showed no significant difference for susceptibility to COVID-19. Conclusion: The study shows a relationship between ABO, Rh and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

scholarly journals ABO Blood Groups and Risk of Glioma

2021 ◽  
Author(s):  
Ana Azanjac Arsic
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Increased Risk ◽  
Hereditary Factors ◽  
The One ◽  
Von Willebrand ◽  
Relationship Of ◽  
The Relationship

Gliomas are one of the most common primary brain tumors and the etiology of gliomas remains unknown in most cases. The aim of this case–control study was to investigate possible association between incidence in relation to glioma and certain blood groups. This study included 100 histopathologically verified cases of glioma and 200 age and sex-matched controls without malignant diseases that were admitted to the same hospital. The results revealed that the patients with group AB were at 3.5-fold increased risk of developing glioma compared to the patients with other ABO blood groups. In this particular study, there was more male patients with glioma with the blood group AB. However, mechanisms that explain the relationship between the blood groups ABO and a cancer risk are unclear. Several hypotheses have been proposed, including the one with a modulatory role of blood group ABO antigens. In addition, the blood group ABO system regulates the level of circulating proinflammatory and adhesion molecules which play a significant role in the tumorigenesis process. Additionally, the recent discovery that includes the von Willebrand factor (vWF) as an important modulator of angiogenesis and apoptosis provides one plausible explanation as regards the role of the blood group ABO in the tumorigenesis process. To our knowledge, this is the first study that examined the relationship of blood group in patients diagnosed with glioma among the Serbian population. Moreover, for the first time our study results suggested that blood group AB increased the risk of glioma. The results of this study suggested that the blood group AB could be one of hereditary factors which had an influence on the occurrence of glioma. The further research is needed on a larger sample, to confirm these findings and the possible mechanisms by which the ABO system contributes to the pathology of glioma.

scholarly journals Relationship Between ABO Blood group Phenotypes and nCOVID-19 Susceptibility – A Retrospective Observational Study

2021 ◽  
Author(s):  
Sudhir Bhandari ◽  
Ajeet Singh Shaktawat ◽  
Amit Tak ◽  
Bhoopendra Patel ◽  
Jyotsna Shukla ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Significant Difference ◽  
Chi Squared ◽  
Group A

Abstract Background: Since the outbreak of coronavirus disease-19 research has been continued to explore multiple facets of the disease. The objective of the present study is to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility.Methods: In this hospital based, retrospective observational study 132 COVID-19 patients were enrolled from SMS Medical Hospital in Jaipur, India after receiving approval from the institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of ‘A’ , ‘B’, ‘AB’, ‘O’, ‘Rh’, and ‘Kell’ blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson’s chi-squared test and partition analysis.Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group ‘A’ phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups ‘AB’, ‘B’, ‘O’, and ‘Rh’ showed no significant difference for susceptibility to COVID-19.Conclusion: The study shows a relationship between ABO, Rh, and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

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