scholarly journals Relationship between blood group phenotypes (ABO, Rh and Kell) and nCOVID-19 susceptibility – A retrospective observational study.

2020 ◽  
Author(s):  
Sudhir Bhandari ◽  
Ajeet Singh Shaktawat ◽  
Amit Tak ◽  
Bhoopendra Patel ◽  
Jyotsna Shukla ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Core Competencies ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Medical College ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Group A

Abstract Since the outbreak of coronavirus disease-19 research has been continued to explore multiple facets of the disease. The objective of the present study is to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility. In this hospital based, retrospective observational study 132 COVID-19 patients were enrolled from SMS Medical College and attached Hospitals, Jaipur, India after the proper approval from the institutional ethics committee. The ABO, Rh and Kell blood group phenotypes and demographic data of the patients were recorded. The observed proportions of ‘A’ , ‘B’, ‘AB’, ‘O’, ‘Rh’, and ‘Kell’ blood groups phenotypes in COVID-19 patients were compared against the expected proportions (our null hypothesis) of the general population using multinomial tests and partition analysis. There were significant differences between observed and expected frequency in ABO and Kell blood group phenotypes. Further partition analysis of ABO blood phenotypes showed that the group ‘A’ phenotypes were more susceptible for COVID-19. The Kell negatives were also more susceptible. The blood groups ‘AB’, ‘B’, ‘O’, and ‘Rh’ phenotypes showed no significantly different susceptibility for COVID-19. The study shows relationship between ABO, Rh, and Kell blood group phenotypes and COVID-19 susceptibility. The application of these relationship in clinical practice requires more exploratory studies. The following core competencies are addressed in this article: Screening Tool, Epidemiology, Patient Management, Medical Research.

scholarly journals Relationship between ABO blood group phenotypes and nCOVID-19 susceptibility: A retrospective observational study

2020 ◽  
Vol 51 (4) ◽  
pp. 217-239
Author(s):  
Sudhir Bhandari ◽  
Ajit Shaktawat ◽  
Amit Tak ◽  
Jyotsna Shukla ◽  
Jitentdra Gupta ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Significant Difference ◽  
Chi Squared ◽  
Group A

Background: Since the outbreak of coronavirus disease-19 (COVID-19) research has been continued to explore multiple facets of the disease. The objective of the present study was to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility. Methods: In this retrospective observational study 132 hospitalised COVID-19 patients were enrolled from the Swai Man Singh (SMS) Medical Hospital in Jaipur, India after receiving approval from the Institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of 'A', 'B', 'AB', 'O', 'Rh' and 'Kell' blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson's Chi-squared test and partition analysis. Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group 'A' phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups 'AB', 'B', 'O' and 'Rh' showed no significant difference for susceptibility to COVID-19. Conclusion: The study shows a relationship between ABO, Rh and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

scholarly journals Relationship Between ABO Blood group Phenotypes and nCOVID-19 Susceptibility – A Retrospective Observational Study

2021 ◽  
Author(s):  
Sudhir Bhandari ◽  
Ajeet Singh Shaktawat ◽  
Amit Tak ◽  
Bhoopendra Patel ◽  
Jyotsna Shukla ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Group ◽  
Demographic Data ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Partition Analysis ◽  
Institutional Ethics ◽  
Significant Difference ◽  
Chi Squared ◽  
Group A

Abstract Background: Since the outbreak of coronavirus disease-19 research has been continued to explore multiple facets of the disease. The objective of the present study is to evaluate the relationship between blood group phenotypes and COVID-19 susceptibility.Methods: In this hospital based, retrospective observational study 132 COVID-19 patients were enrolled from SMS Medical Hospital in Jaipur, India after receiving approval from the institutional ethics committee. The ABO, Rh and Kell blood group phenotypes along with demographic data of the patients were recorded. The observed proportions of ‘A’ , ‘B’, ‘AB’, ‘O’, ‘Rh’, and ‘Kell’ blood groups in COVID-19 patients were compared against the expected proportions (the null hypothesis) of the general population using Pearson’s chi-squared test and partition analysis.Results: There were significant differences between observed and expected frequency for the ABO and Kell blood phenotypes. Further partition analysis of ABO phenotypes showed that the group ‘A’ phenotypes were more susceptible to COVID-19. The Kell negatives were also more susceptible. The blood groups ‘AB’, ‘B’, ‘O’, and ‘Rh’ showed no significant difference for susceptibility to COVID-19.Conclusion: The study shows a relationship between ABO, Rh, and Kell blood groups and COVID-19 susceptibility. The application of these relationships in clinics should be explored in future studies.

scholarly journals Association of Pre-hypertension with blood groups in young population.

2019 ◽  
Vol 26 (11) ◽  
pp. 1820-1824
Author(s):  
Benash Altaf ◽  
Shireen Jawed ◽  
Fakiha Behram ◽  
Zeeshan Ali Khan ◽  
Shakeela Naz
Keyword(s):  
Blood Group ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Blood Groups ◽  
P Value ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A

Objectives: Pakistan has highest mortality rate due to hypertension and its complications. Hypertension is a squealed of Pre- hypertension which is believed to start at adolescent and continue to adulthood. Association of blood group with hypertension is evident but still hypothesized. This study aims to find the frequency of prehypertension and its association with blood group. Study Design: Cross sectional study. Setting:  Aziz Fatimah Medical and Dental College, Faisalabad. Period: 15 March’18 to 15 Sep’18. Material and Methods:  It was comprised of in comprised of 100 MBBS students. Demographic data including age, weight, height, waist and hip circumference, and BMI was determined. Blood group was determined with help of conventional slide method. Blood pressure was measured by auscultatory method. Data was analyzed by using SPSS 21. Continuous variables are given in mean and standard deviation. Categorical data was given in frequency and percentages. P value≤ 0.05 is taken as significant. Results: Out of 100 participants most common blood group was group ‘O’ (43%) followed by B (35 %) and AB (13%) and A (9%).36% of total population was pre-hypertensive and 64% were normotensive. Prehypertension is most commonly found in blood group ‘A’ (77%) followed by blood group ‘O’ (46.5%). Significant difference was found in means of SBP (p value= 0.001*) and DBP (p value= 0.000*) among the various blood groups. Conclusion: Most common blood group in studied population was ‘O’ although hypertension was most commonly observed in blood group A followed by ‘O’.

scholarly journals Blood Groups and their Association with Academic Performance among Medical Students in a Nepalese Medical College

2019 ◽  
Vol 41 (3) ◽  
pp. 74-77
Author(s):  
Barun Mahat ◽  
Lava Shrestha ◽  
Shailesh Adhikari ◽  
Bikalp Thapa ◽  
Prakesh Limbu ◽  
...  
Keyword(s):  
Academic Performance ◽  
Medical Students ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Medical College ◽  
Blood Group A ◽  
Group A ◽  
The Difference ◽  
And Behavior

Introduction Knowing a person’s blood type is not only important in transfusion medicine and forensic medicine but is also useful for predicting a person’s characteristics including intelligence, knowledge, skill and behavior. It is recognized that intelligence, knowledge and skill are assessed by performance in examination. The objective of this study was to determine distribution of blood groups among students and its association with their academic performance. MethodsThis was an analytical study that was conducted among the medical students of Nepalese Army Institutes of Health Sciences (NAIHS) in Department of Clinical Physiology from June 2014 to April 2019. This study was conducted among 738 students by using convenient sampling method. Blood group was determined on the basis of agglutination reaction. Academic performance of students was assessed by the marks obtained by them in annual final examination. ResultsBlood group O was the most prevalent at 33.5%, followed by B at 29.5%, A at 29% and AB at 8%. Distribution of Rh positive and Rh negative were 96.6% and 3.4% respectively. The mean scores obtained in final university examination were highest in blood group A (62.9%) and lowest in blood group AB (60.3%) but the difference between different blood groups was not statistically significant. ConclusionBlood group O was the most common blood group. Rh positive was present in 96.6%. Though mean score was highest in blood group A, significant association between blood groups and academic performance was not seen in our study.

scholarly journals Correlation between ABO blood groups and various cancers in the north eastern region of India: a retrospective observational study

2018 ◽  
Vol 6 (11) ◽  
pp. 3643
Author(s):  
Chandana Kalita ◽  
Anupam Sarma ◽  
Jagannath Dev Sharma ◽  
Manoj Kalita ◽  
Manigreeva Krishnatreya ◽  
...  
Keyword(s):  
Observational Study ◽  
Head And Neck ◽  
Blood Group ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Eastern Region ◽  
Abo Blood Groups ◽  
The North ◽  
Increased Risk ◽  
North Eastern

Background: Numerous studies have documented the association of the ABO blood groups with the occurrence of cancers. Aim was to find out an association of ABO blood groups and various cancers in the North Eastern region of India.Methods: The study was a retrospective observational study that included 1000 cases and 1000 controls. The data included the ABO blood typing of the selected cancer sites which were head and neck, esophagus, stomach, breast, cervix, and ovary. Patients who attended blood bank of regional cancer center with requisition for blood transfusion from 2014 to 2016 were included. The control group was healthy blood donors. Chi square test was used to assess the difference among the compared groups. Risk was calculated by regression analysis. P value <0.05 was considered as statistically significant at 95% confidence interval.Results: Out of 1000 cases and 1000 controls, O blood group were seen in 377 (37.7%) and 395 (39.5%) cases and control, respectively. Significant reduced odds ratio (OR) in non O blood groups for head and neck, esophagus, stomach, and breast was observed. In case of carcinoma cervix, OR for B group was 1.5 (P=0.05), and for blood group A OR=2.2 (P=0.02) was seen in carcinoma ovary.Conclusions: In the studied population, patients with O blood group are at an increased risk of developing head and neck, esophagus, stomach, and breast cancers.

scholarly journals Distribution of ABO and Rh blood groups in Nepalese medical students

2013 ◽  
Vol 1 (2) ◽  
pp. 17-20 ◽  
Author(s):  
Kshitiz Uphaday-Dhungel ◽  
GN Banskota ◽  
PK Das ◽  
A Sohal
Keyword(s):  
Blood Group ◽  
Distribution Patterns ◽  
Blood Groups ◽  
Test Method ◽  
Medical Sciences ◽  
Medical College ◽  
Group A ◽  
Group B ◽  
Group Distribution ◽  
Medical Colleges

Background and Objectives: The distribution of ABO and Rh blood groups vary from population to population. With an interest of finding out rare blood group in Nepalese population, we studied the blood group distribution was studied in five different medical colleges in Nepal. Material and Methods: Capillary Blood sample were taken to determine blood group of of 2208 twenty two hundred and eight Nepalese students from five different medical colleges, viz. Manipal College of medical sciences, Pokhara; Nepalgunj Medical College, Chisapani, Banke ; College of Medical sciences, Bharatpur, Chitwan; Kist Medical College, Lalitpur and Janaki Medical College, Janakpur were recorded. Slide test method was used to determine the blood group of the subjects. Results: In our study subjects, 28.17% were blood group A, 30.17% were blood group B, 34.87% were blood group O and 6.79% were blood group AB. Similarly, 95.38% were Rh +ve and 4.62% were Rh –ve. The blood group distribution patterns in male and female were different. Conclusion: This result demonstrates that AB blood group is the most rare blood group among the studied Nepalese population, followed by group A, B and O. Janaki Medical College Journal of Medical Sciences (2013) Vol. 1 (2): 17-20 DOI: http://dx.doi.org/10.3126/jmcjms.v1i2.9263

scholarly journals Variations of prothrombin time among ABO blood groups in healthy adults

2021 ◽  
Vol 11 (3) ◽  
pp. 429-435
Author(s):  
Afrina Binte Azad ◽  
Qazi Shamima Akhter ◽  
Mohammad Aminul Islam ◽  
Farzana Yeasmin Mukta ◽  
Lily Afroz ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Blood Group ◽  
Blood Groups ◽  
Healthy Adults ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Medical College ◽  
Blood Group A ◽  
Group A ◽  
Group B

Background and objectives: ABO blood group distribution defers with racial and geographic variations. They are related with diseases like cardiovascular diseases, cerebral thromboembolism. Prothrombin time may varies among ABO blood group system which may increase the future risk of thrombosis. The present study is to assess prothrombin time among ABO blood groups in healthy adults. Materials and methods: A prospective type of analytical cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2019 to June 2020. After obtaining ethical clearance, a total 190 healthy adults were selected from different areas of Dhaka city based on inclusion and exclusion criteria, with age ranging from 18-45 years. The subjects were interviewed and detailed history regarding personal, family, medical and drug were taken. Prior to sample collection, informed written consent was taken from the participants. Individuals of blood group A was selected as group A, blood group B as group B, blood group AB as group AB and blood group O as group O. Prothrombin time was measured in the Department of Hematology and BMT Unit, Dhaka Medical College Hospital, Dhaka. Blood grouping was done in the Department of Physiology, Dhaka Medical College, Dhaka.For statistical analysis, One way ANOVA followed by Bonferroni test were considered using SPSS 25.0 version. Results: In this study, blood group B was most common (33.2%). Prothrombin time was lower in blood group A (12.93±0.30 sec), B (12.92±0.61 sec), AB (12.98±0.54 sec) than blood group O (13.08±0.39 sec) which was not statistically significant. Conclusion: It can be concluded that blood group A, B, AB individuals may have more chance of thrombosis due to lower prothrombin time than blood group O individuals.

scholarly journals ABO Blood Group: A Risk Factor for a Cardiovascular Disease in Adults in Morocco

2020 ◽  
Vol 1 (1) ◽  
pp. 14-19
Author(s):  
Serbout Saousan ◽  
◽  
Adnane Hind ◽  
Maaroufi Anass ◽  
Arous Salim ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Observational Study ◽  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Ischemic Disease ◽  
Blood Group A ◽  
Group A ◽  
Group B

BACKGROUND The association between antigens A and B and cardiovascular disease is still unclear. Several reports have suggested an important involvement of the ABO blood group system in the susceptibility to thrombosis. Assessing that non-O blood groups in particular A blood group confer a higher risk of venous and arterial thrombosis than group O. Epidemiologic data are typically not available for all racial and ethnics groups. The purpose of this observational study was to identify a probable link between ABO blood group and ischemic and non-ischemic disease in subjects from the province of Casablanca, Morocco and to analyze whether A blood group individuals were at higher risk of ischemic disease or not. METHOD An observational study had been conducted from the beginning of 2017 until the end of 2019 in the Department of Cardiology, University Hospital Centre, Ibn Rochd, Casablanca, Morocco. We recruited consecutive subjects (549 men and 544 woman) at our center between 2017 and 2019. We studied data on age, gender, past history of hypertension, diabetes, smoking, sedentarism, obesity, hyperlipidemia, use of estrogen-progestin contraceptives and blood group distribution. Their ABO blood groups were determined using standard agglutination techniques. In each blood group type, we evaluated the prevalence of ischemic and non-ischemic cardiovascular disease. RESULT Of the 1093 patients whose medical records were reviewed, 482 (44.1%) were carrying blood group A. Of the remaining 611 patients, 353 (32.3%) had blood group O, 212 (19.4%) blood group B, and 46 (4.3%) blood group AB. The diagnosis of ischemic disease (ID) was higher in patients with blood group O (63.3%) than in other blood groups, and the diagnosis of valvular disease was higher in patients with blood group A (48.7%) compared to other groups. In patients with blood group B or AB compared to non-B or non-AB, respectively there was no statistically significant difference in ID incidence. The incidence of ID in men was significantly higher in blood group O (63.2%, p = 0.015) compared with women, while there valvular disease was a statistically higher in women (54.5%, p = 0.035). This difference remains statistically significant after adjustment for common cardiovascular risk factors. CONCLUSION Our study suggests an association between ABO blood group and Ischemic disease and non-ischemic disease in Moroccan population. In African countries, where most of health facilities are understaffed, more rigorous studies with a larger population are needed to give high level of evidence to confirm this association in order to establish the need to be more aggressive in risk factor control in these individuals.

scholarly journals Distribution of ABO and Rh blood Groups Among Tribal Population of Sylhet, Bangladesh

1970 ◽  
Vol 20 (1) ◽  
pp. 44-50 ◽  
Author(s):  
D Begum ◽  
MR Amin ◽  
F Khatun ◽  
SS Ahmed ◽  
SK Sinha ◽  
...  
Keyword(s):  
Blood Group ◽  
Study Groups ◽  
Ethnic Origin ◽  
Blood Groups ◽  
Tribal Population ◽  
Chi Square ◽  
Medical College ◽  
Chi Square Test ◽  
Group A ◽  
Antigen Antibody

Context: Distribution of blood groups varies among ethnic groups throughout the world. Blood groups of tribals should be determined as they are ethnically different from the main population of Bangladesh. Materials and Methods: To observe the distribution pattern of ABO and Rh blood groups and to compare the groups among Manipuris (1434) and Khasias (204), this descriptive crosssectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, from July 2006 to June 2007. Manipuris were divided in Bishnupriya (658), Meitei (460) and Meitei-Pangan (316) according to their ethnic origin. Data were collected from Manipuri (12) and Khasia (2) localities selected by systematic random sampling. ABO and Rh blood groups of participants were determined by the antigen antibody agglutination test of slide method. Data from groups were compared by chi-square test with 95% confidence limit. Results: There are significant variations in the distribution of ABO (p<0.001) and Rh (p<0.001) blood groups among all study groups. Blood group A was more frequent among Meiteis (40%) and Meitei-Pangans (42.41%) whereas blood group O was more frequent in Bishnupriyas (47.72%) and Khasias (35.29%). In all tribal communities, AB blood group was least frequent. Rh positive participants (97.43%) were more than Rh negative (2.57%). In Khasias, no Rh negative group was found. Rh negativity was more in Bishnupriyas (4.9%) which was significantly higher than Meiteis (0.87%) and Meitei-Pangans. (1.94%) (X2=16.7; p<0.001). Conclusion: Distribution of ABO blood groups varies among the Manipuris and Khasias. Significant variation is also found in three groups of Manipuris and the distribution corresponds with the pattern of their ancestors. Key words: ABO blood group; Rh blood group; tribal population; Sylhet. DOI: http://dx.doi.org/10.3329/jdmc.v20i1.8581 J Dhaka Med Coll. 2011; 20(1) :44-50

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